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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 8-85107355-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=8&pos=85107355&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "8",
"pos": 85107355,
"ref": "C",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "NM_033402.5",
"consequences": [
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRCC1",
"gene_hgnc_id": 29373,
"hgvs_c": "c.60C>T",
"hgvs_p": "p.Asp20Asp",
"transcript": "NM_033402.5",
"protein_id": "NP_208325.3",
"transcript_support_level": null,
"aa_start": 20,
"aa_end": null,
"aa_length": 1032,
"cds_start": 60,
"cds_end": null,
"cds_length": 3099,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000360375.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_033402.5"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRCC1",
"gene_hgnc_id": 29373,
"hgvs_c": "c.60C>T",
"hgvs_p": "p.Asp20Asp",
"transcript": "ENST00000360375.8",
"protein_id": "ENSP00000353538.3",
"transcript_support_level": 1,
"aa_start": 20,
"aa_end": null,
"aa_length": 1032,
"cds_start": 60,
"cds_end": null,
"cds_length": 3099,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_033402.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000360375.8"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRCC1",
"gene_hgnc_id": 29373,
"hgvs_c": "n.60C>T",
"hgvs_p": null,
"transcript": "ENST00000517875.5",
"protein_id": "ENSP00000430960.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000517875.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRCC1",
"gene_hgnc_id": 29373,
"hgvs_c": "n.60C>T",
"hgvs_p": null,
"transcript": "ENST00000522567.5",
"protein_id": "ENSP00000428794.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000522567.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRCC1",
"gene_hgnc_id": 29373,
"hgvs_c": "n.60C>T",
"hgvs_p": null,
"transcript": "ENST00000523669.5",
"protein_id": "ENSP00000430878.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000523669.5"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRCC1",
"gene_hgnc_id": 29373,
"hgvs_c": "c.60C>T",
"hgvs_p": "p.Asp20Asp",
"transcript": "ENST00000926004.1",
"protein_id": "ENSP00000596063.1",
"transcript_support_level": null,
"aa_start": 20,
"aa_end": null,
"aa_length": 1046,
"cds_start": 60,
"cds_end": null,
"cds_length": 3141,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000926004.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRCC1",
"gene_hgnc_id": 29373,
"hgvs_c": "c.60C>T",
"hgvs_p": "p.Asp20Asp",
"transcript": "ENST00000962243.1",
"protein_id": "ENSP00000632302.1",
"transcript_support_level": null,
"aa_start": 20,
"aa_end": null,
"aa_length": 970,
"cds_start": 60,
"cds_end": null,
"cds_length": 2913,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000962243.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRCC1",
"gene_hgnc_id": 29373,
"hgvs_c": "c.60C>T",
"hgvs_p": "p.Asp20Asp",
"transcript": "ENST00000926003.1",
"protein_id": "ENSP00000596062.1",
"transcript_support_level": null,
"aa_start": 20,
"aa_end": null,
"aa_length": 962,
"cds_start": 60,
"cds_end": null,
"cds_length": 2889,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000926003.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRCC1",
"gene_hgnc_id": 29373,
"hgvs_c": "c.60C>T",
"hgvs_p": "p.Asp20Asp",
"transcript": "XM_017013920.2",
"protein_id": "XP_016869409.1",
"transcript_support_level": null,
"aa_start": 20,
"aa_end": null,
"aa_length": 1046,
"cds_start": 60,
"cds_end": null,
"cds_length": 3141,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017013920.2"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRCC1",
"gene_hgnc_id": 29373,
"hgvs_c": "c.60C>T",
"hgvs_p": "p.Asp20Asp",
"transcript": "XM_017013921.2",
"protein_id": "XP_016869410.1",
"transcript_support_level": null,
"aa_start": 20,
"aa_end": null,
"aa_length": 1025,
"cds_start": 60,
"cds_end": null,
"cds_length": 3078,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017013921.2"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRCC1",
"gene_hgnc_id": 29373,
"hgvs_c": "c.60C>T",
"hgvs_p": "p.Asp20Asp",
"transcript": "XM_047422364.1",
"protein_id": "XP_047278320.1",
"transcript_support_level": null,
"aa_start": 20,
"aa_end": null,
"aa_length": 1011,
"cds_start": 60,
"cds_end": null,
"cds_length": 3036,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047422364.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRCC1",
"gene_hgnc_id": 29373,
"hgvs_c": "c.60C>T",
"hgvs_p": "p.Asp20Asp",
"transcript": "XM_017013922.2",
"protein_id": "XP_016869411.1",
"transcript_support_level": null,
"aa_start": 20,
"aa_end": null,
"aa_length": 984,
"cds_start": 60,
"cds_end": null,
"cds_length": 2955,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017013922.2"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRCC1",
"gene_hgnc_id": 29373,
"hgvs_c": "c.60C>T",
"hgvs_p": "p.Asp20Asp",
"transcript": "XM_047422365.1",
"protein_id": "XP_047278321.1",
"transcript_support_level": null,
"aa_start": 20,
"aa_end": null,
"aa_length": 970,
"cds_start": 60,
"cds_end": null,
"cds_length": 2913,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047422365.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRCC1",
"gene_hgnc_id": 29373,
"hgvs_c": "c.60C>T",
"hgvs_p": "p.Asp20Asp",
"transcript": "XM_047422369.1",
"protein_id": "XP_047278325.1",
"transcript_support_level": null,
"aa_start": 20,
"aa_end": null,
"aa_length": 671,
"cds_start": 60,
"cds_end": null,
"cds_length": 2016,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047422369.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRCC1",
"gene_hgnc_id": 29373,
"hgvs_c": "c.-14C>T",
"hgvs_p": null,
"transcript": "NM_001349636.2",
"protein_id": "NP_001336565.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 939,
"cds_start": null,
"cds_end": null,
"cds_length": 2820,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001349636.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRCC1",
"gene_hgnc_id": 29373,
"hgvs_c": "c.-522C>T",
"hgvs_p": null,
"transcript": "NM_001349637.2",
"protein_id": "NP_001336566.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 890,
"cds_start": null,
"cds_end": null,
"cds_length": 2673,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001349637.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRCC1",
"gene_hgnc_id": 29373,
"hgvs_c": "c.-452C>T",
"hgvs_p": null,
"transcript": "NM_001349638.2",
"protein_id": "NP_001336567.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 733,
"cds_start": null,
"cds_end": null,
"cds_length": 2202,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001349638.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRCC1",
"gene_hgnc_id": 29373,
"hgvs_c": "c.-292C>T",
"hgvs_p": null,
"transcript": "NM_001349639.2",
"protein_id": "NP_001336568.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 653,
"cds_start": null,
"cds_end": null,
"cds_length": 1962,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001349639.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRCC1",
"gene_hgnc_id": 29373,
"hgvs_c": "c.-14C>T",
"hgvs_p": null,
"transcript": "XM_017013923.2",
"protein_id": "XP_016869412.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 953,
"cds_start": null,
"cds_end": null,
"cds_length": 2862,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017013923.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRCC1",
"gene_hgnc_id": 29373,
"hgvs_c": "c.-14C>T",
"hgvs_p": null,
"transcript": "XM_047422367.1",
"protein_id": "XP_047278323.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 918,
"cds_start": null,
"cds_end": null,
"cds_length": 2757,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047422367.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRCC1",
"gene_hgnc_id": 29373,
"hgvs_c": "c.-14C>T",
"hgvs_p": null,
"transcript": "XM_047422368.1",
"protein_id": "XP_047278324.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 877,
"cds_start": null,
"cds_end": null,
"cds_length": 2634,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047422368.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRCC1",
"gene_hgnc_id": 29373,
"hgvs_c": "n.60C>T",
"hgvs_p": null,
"transcript": "ENST00000522770.1",
"protein_id": "ENSP00000428506.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000522770.1"
},
{
"aa_ref": null,
"aa_alt": null,
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"phenotype_combined": "not provided",
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}
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}