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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 8-86435669-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=8&pos=86435669&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "8",
"pos": 86435669,
"ref": "T",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_007013.4",
"consequences": [
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WWP1",
"gene_hgnc_id": 17004,
"hgvs_c": "c.1714T>C",
"hgvs_p": "p.Ser572Pro",
"transcript": "NM_007013.4",
"protein_id": "NP_008944.1",
"transcript_support_level": null,
"aa_start": 572,
"aa_end": null,
"aa_length": 922,
"cds_start": 1714,
"cds_end": null,
"cds_length": 2769,
"cdna_start": 2212,
"cdna_end": null,
"cdna_length": 4877,
"mane_select": "ENST00000517970.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_007013.4"
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WWP1",
"gene_hgnc_id": 17004,
"hgvs_c": "c.1714T>C",
"hgvs_p": "p.Ser572Pro",
"transcript": "ENST00000517970.6",
"protein_id": "ENSP00000427793.1",
"transcript_support_level": 1,
"aa_start": 572,
"aa_end": null,
"aa_length": 922,
"cds_start": 1714,
"cds_end": null,
"cds_length": 2769,
"cdna_start": 2212,
"cdna_end": null,
"cdna_length": 4877,
"mane_select": "NM_007013.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000517970.6"
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WWP1",
"gene_hgnc_id": 17004,
"hgvs_c": "c.1714T>C",
"hgvs_p": "p.Ser572Pro",
"transcript": "ENST00000265428.4",
"protein_id": "ENSP00000265428.4",
"transcript_support_level": 1,
"aa_start": 572,
"aa_end": null,
"aa_length": 922,
"cds_start": 1714,
"cds_end": null,
"cds_length": 2769,
"cdna_start": 1724,
"cdna_end": null,
"cdna_length": 3362,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000265428.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WWP1",
"gene_hgnc_id": 17004,
"hgvs_c": "n.1368T>C",
"hgvs_p": null,
"transcript": "ENST00000518683.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2002,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000518683.5"
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WWP1",
"gene_hgnc_id": 17004,
"hgvs_c": "c.1714T>C",
"hgvs_p": "p.Ser572Pro",
"transcript": "ENST00000882789.1",
"protein_id": "ENSP00000552848.1",
"transcript_support_level": null,
"aa_start": 572,
"aa_end": null,
"aa_length": 944,
"cds_start": 1714,
"cds_end": null,
"cds_length": 2835,
"cdna_start": 2040,
"cdna_end": null,
"cdna_length": 3744,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000882789.1"
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WWP1",
"gene_hgnc_id": 17004,
"hgvs_c": "c.1714T>C",
"hgvs_p": "p.Ser572Pro",
"transcript": "ENST00000942574.1",
"protein_id": "ENSP00000612633.1",
"transcript_support_level": null,
"aa_start": 572,
"aa_end": null,
"aa_length": 944,
"cds_start": 1714,
"cds_end": null,
"cds_length": 2835,
"cdna_start": 1948,
"cdna_end": null,
"cdna_length": 4123,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942574.1"
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WWP1",
"gene_hgnc_id": 17004,
"hgvs_c": "c.1738T>C",
"hgvs_p": "p.Ser580Pro",
"transcript": "ENST00000942573.1",
"protein_id": "ENSP00000612632.1",
"transcript_support_level": null,
"aa_start": 580,
"aa_end": null,
"aa_length": 930,
"cds_start": 1738,
"cds_end": null,
"cds_length": 2793,
"cdna_start": 2078,
"cdna_end": null,
"cdna_length": 4192,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942573.1"
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WWP1",
"gene_hgnc_id": 17004,
"hgvs_c": "c.1714T>C",
"hgvs_p": "p.Ser572Pro",
"transcript": "ENST00000942578.1",
"protein_id": "ENSP00000612637.1",
"transcript_support_level": null,
"aa_start": 572,
"aa_end": null,
"aa_length": 927,
"cds_start": 1714,
"cds_end": null,
"cds_length": 2784,
"cdna_start": 1945,
"cdna_end": null,
"cdna_length": 3514,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942578.1"
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WWP1",
"gene_hgnc_id": 17004,
"hgvs_c": "c.1711T>C",
"hgvs_p": "p.Ser571Pro",
"transcript": "ENST00000882781.1",
"protein_id": "ENSP00000552840.1",
"transcript_support_level": null,
"aa_start": 571,
"aa_end": null,
"aa_length": 921,
"cds_start": 1711,
"cds_end": null,
"cds_length": 2766,
"cdna_start": 2183,
"cdna_end": null,
"cdna_length": 4700,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000882781.1"
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WWP1",
"gene_hgnc_id": 17004,
"hgvs_c": "c.1711T>C",
"hgvs_p": "p.Ser571Pro",
"transcript": "ENST00000882783.1",
"protein_id": "ENSP00000552842.1",
"transcript_support_level": null,
"aa_start": 571,
"aa_end": null,
"aa_length": 921,
"cds_start": 1711,
"cds_end": null,
"cds_length": 2766,
"cdna_start": 2077,
"cdna_end": null,
"cdna_length": 4435,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000882783.1"
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WWP1",
"gene_hgnc_id": 17004,
"hgvs_c": "c.1711T>C",
"hgvs_p": "p.Ser571Pro",
"transcript": "ENST00000942571.1",
"protein_id": "ENSP00000612630.1",
"transcript_support_level": null,
"aa_start": 571,
"aa_end": null,
"aa_length": 921,
"cds_start": 1711,
"cds_end": null,
"cds_length": 2766,
"cdna_start": 1834,
"cdna_end": null,
"cdna_length": 3943,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942571.1"
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WWP1",
"gene_hgnc_id": 17004,
"hgvs_c": "c.1648T>C",
"hgvs_p": "p.Ser550Pro",
"transcript": "ENST00000882788.1",
"protein_id": "ENSP00000552847.1",
"transcript_support_level": null,
"aa_start": 550,
"aa_end": null,
"aa_length": 900,
"cds_start": 1648,
"cds_end": null,
"cds_length": 2703,
"cdna_start": 1989,
"cdna_end": null,
"cdna_length": 3627,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000882788.1"
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WWP1",
"gene_hgnc_id": 17004,
"hgvs_c": "c.1576T>C",
"hgvs_p": "p.Ser526Pro",
"transcript": "ENST00000882782.1",
"protein_id": "ENSP00000552841.1",
"transcript_support_level": null,
"aa_start": 526,
"aa_end": null,
"aa_length": 876,
"cds_start": 1576,
"cds_end": null,
"cds_length": 2631,
"cdna_start": 1970,
"cdna_end": null,
"cdna_length": 4487,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000882782.1"
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WWP1",
"gene_hgnc_id": 17004,
"hgvs_c": "c.1576T>C",
"hgvs_p": "p.Ser526Pro",
"transcript": "ENST00000882786.1",
"protein_id": "ENSP00000552845.1",
"transcript_support_level": null,
"aa_start": 526,
"aa_end": null,
"aa_length": 876,
"cds_start": 1576,
"cds_end": null,
"cds_length": 2631,
"cdna_start": 1790,
"cdna_end": null,
"cdna_length": 3904,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000882786.1"
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WWP1",
"gene_hgnc_id": 17004,
"hgvs_c": "c.1534T>C",
"hgvs_p": "p.Ser512Pro",
"transcript": "ENST00000882784.1",
"protein_id": "ENSP00000552843.1",
"transcript_support_level": null,
"aa_start": 512,
"aa_end": null,
"aa_length": 862,
"cds_start": 1534,
"cds_end": null,
"cds_length": 2589,
"cdna_start": 1875,
"cdna_end": null,
"cdna_length": 4282,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000882784.1"
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WWP1",
"gene_hgnc_id": 17004,
"hgvs_c": "c.1525T>C",
"hgvs_p": "p.Ser509Pro",
"transcript": "ENST00000942580.1",
"protein_id": "ENSP00000612639.1",
"transcript_support_level": null,
"aa_start": 509,
"aa_end": null,
"aa_length": 859,
"cds_start": 1525,
"cds_end": null,
"cds_length": 2580,
"cdna_start": 1661,
"cdna_end": null,
"cdna_length": 3215,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942580.1"
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WWP1",
"gene_hgnc_id": 17004,
"hgvs_c": "c.1450T>C",
"hgvs_p": "p.Ser484Pro",
"transcript": "ENST00000882787.1",
"protein_id": "ENSP00000552846.1",
"transcript_support_level": null,
"aa_start": 484,
"aa_end": null,
"aa_length": 834,
"cds_start": 1450,
"cds_end": null,
"cds_length": 2505,
"cdna_start": 1785,
"cdna_end": null,
"cdna_length": 3430,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000882787.1"
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WWP1",
"gene_hgnc_id": 17004,
"hgvs_c": "c.1384T>C",
"hgvs_p": "p.Ser462Pro",
"transcript": "ENST00000942579.1",
"protein_id": "ENSP00000612638.1",
"transcript_support_level": null,
"aa_start": 462,
"aa_end": null,
"aa_length": 812,
"cds_start": 1384,
"cds_end": null,
"cds_length": 2439,
"cdna_start": 1668,
"cdna_end": null,
"cdna_length": 3226,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942579.1"
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WWP1",
"gene_hgnc_id": 17004,
"hgvs_c": "c.1324T>C",
"hgvs_p": "p.Ser442Pro",
"transcript": "ENST00000882785.1",
"protein_id": "ENSP00000552844.1",
"transcript_support_level": null,
"aa_start": 442,
"aa_end": null,
"aa_length": 792,
"cds_start": 1324,
"cds_end": null,
"cds_length": 2379,
"cdna_start": 1608,
"cdna_end": null,
"cdna_length": 4036,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000882785.1"
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WWP1",
"gene_hgnc_id": 17004,
"hgvs_c": "c.1324T>C",
"hgvs_p": "p.Ser442Pro",
"transcript": "ENST00000942577.1",
"protein_id": "ENSP00000612636.1",
"transcript_support_level": null,
"aa_start": 442,
"aa_end": null,
"aa_length": 792,
"cds_start": 1324,
"cds_end": null,
"cds_length": 2379,
"cdna_start": 1555,
"cdna_end": null,
"cdna_length": 3193,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942577.1"
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WWP1",
"gene_hgnc_id": 17004,
"hgvs_c": "c.106T>C",
"hgvs_p": "p.Ser36Pro",
"transcript": "ENST00000520453.5",
"protein_id": "ENSP00000429076.1",
"transcript_support_level": 5,
"aa_start": 36,
"aa_end": null,
"aa_length": 230,
"cds_start": 106,
"cds_end": null,
"cds_length": 695,
"cdna_start": 107,
"cdna_end": null,
"cdna_length": 696,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000520453.5"
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WWP1",
"gene_hgnc_id": 17004,
"hgvs_c": "c.1714T>C",
"hgvs_p": "p.Ser572Pro",
"transcript": "XM_005250760.5",
"protein_id": "XP_005250817.1",
"transcript_support_level": null,
"aa_start": 572,
"aa_end": null,
"aa_length": 922,
"cds_start": 1714,
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}