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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 9-110941779-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=110941779&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "9",
"pos": 110941779,
"ref": "C",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_001401.5",
"consequences": [
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LPAR1",
"gene_hgnc_id": 3166,
"hgvs_c": "c.435G>C",
"hgvs_p": "p.Glu145Asp",
"transcript": "NM_001351411.2",
"protein_id": "NP_001338340.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 364,
"cds_start": 435,
"cds_end": null,
"cds_length": 1095,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000683809.1",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351411.2"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LPAR1",
"gene_hgnc_id": 3166,
"hgvs_c": "c.435G>C",
"hgvs_p": "p.Glu145Asp",
"transcript": "ENST00000683809.1",
"protein_id": "ENSP00000506912.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 364,
"cds_start": 435,
"cds_end": null,
"cds_length": 1095,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001351411.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000683809.1"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LPAR1",
"gene_hgnc_id": 3166,
"hgvs_c": "c.435G>C",
"hgvs_p": "p.Glu145Asp",
"transcript": "ENST00000374430.6",
"protein_id": "ENSP00000363552.1",
"transcript_support_level": 1,
"aa_start": 145,
"aa_end": null,
"aa_length": 364,
"cds_start": 435,
"cds_end": null,
"cds_length": 1095,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000374430.6"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LPAR1",
"gene_hgnc_id": 3166,
"hgvs_c": "c.435G>C",
"hgvs_p": "p.Glu145Asp",
"transcript": "ENST00000374431.7",
"protein_id": "ENSP00000363553.3",
"transcript_support_level": 1,
"aa_start": 145,
"aa_end": null,
"aa_length": 364,
"cds_start": 435,
"cds_end": null,
"cds_length": 1095,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000374431.7"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LPAR1",
"gene_hgnc_id": 3166,
"hgvs_c": "c.435G>C",
"hgvs_p": "p.Glu145Asp",
"transcript": "NM_001351397.2",
"protein_id": "NP_001338326.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 364,
"cds_start": 435,
"cds_end": null,
"cds_length": 1095,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351397.2"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LPAR1",
"gene_hgnc_id": 3166,
"hgvs_c": "c.435G>C",
"hgvs_p": "p.Glu145Asp",
"transcript": "NM_001351398.2",
"protein_id": "NP_001338327.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 364,
"cds_start": 435,
"cds_end": null,
"cds_length": 1095,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351398.2"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LPAR1",
"gene_hgnc_id": 3166,
"hgvs_c": "c.435G>C",
"hgvs_p": "p.Glu145Asp",
"transcript": "NM_001351399.2",
"protein_id": "NP_001338328.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 364,
"cds_start": 435,
"cds_end": null,
"cds_length": 1095,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351399.2"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LPAR1",
"gene_hgnc_id": 3166,
"hgvs_c": "c.435G>C",
"hgvs_p": "p.Glu145Asp",
"transcript": "NM_001351400.2",
"protein_id": "NP_001338329.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 364,
"cds_start": 435,
"cds_end": null,
"cds_length": 1095,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351400.2"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LPAR1",
"gene_hgnc_id": 3166,
"hgvs_c": "c.435G>C",
"hgvs_p": "p.Glu145Asp",
"transcript": "NM_001351401.2",
"protein_id": "NP_001338330.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 364,
"cds_start": 435,
"cds_end": null,
"cds_length": 1095,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351401.2"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LPAR1",
"gene_hgnc_id": 3166,
"hgvs_c": "c.435G>C",
"hgvs_p": "p.Glu145Asp",
"transcript": "NM_001351402.2",
"protein_id": "NP_001338331.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 364,
"cds_start": 435,
"cds_end": null,
"cds_length": 1095,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351402.2"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LPAR1",
"gene_hgnc_id": 3166,
"hgvs_c": "c.435G>C",
"hgvs_p": "p.Glu145Asp",
"transcript": "NM_001351403.2",
"protein_id": "NP_001338332.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 364,
"cds_start": 435,
"cds_end": null,
"cds_length": 1095,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351403.2"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LPAR1",
"gene_hgnc_id": 3166,
"hgvs_c": "c.435G>C",
"hgvs_p": "p.Glu145Asp",
"transcript": "NM_001351404.2",
"protein_id": "NP_001338333.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 364,
"cds_start": 435,
"cds_end": null,
"cds_length": 1095,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351404.2"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LPAR1",
"gene_hgnc_id": 3166,
"hgvs_c": "c.435G>C",
"hgvs_p": "p.Glu145Asp",
"transcript": "NM_001351405.2",
"protein_id": "NP_001338334.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 364,
"cds_start": 435,
"cds_end": null,
"cds_length": 1095,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351405.2"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LPAR1",
"gene_hgnc_id": 3166,
"hgvs_c": "c.435G>C",
"hgvs_p": "p.Glu145Asp",
"transcript": "NM_001351406.2",
"protein_id": "NP_001338335.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 364,
"cds_start": 435,
"cds_end": null,
"cds_length": 1095,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351406.2"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LPAR1",
"gene_hgnc_id": 3166,
"hgvs_c": "c.435G>C",
"hgvs_p": "p.Glu145Asp",
"transcript": "NM_001351407.2",
"protein_id": "NP_001338336.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 364,
"cds_start": 435,
"cds_end": null,
"cds_length": 1095,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351407.2"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LPAR1",
"gene_hgnc_id": 3166,
"hgvs_c": "c.435G>C",
"hgvs_p": "p.Glu145Asp",
"transcript": "NM_001351408.2",
"protein_id": "NP_001338337.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 364,
"cds_start": 435,
"cds_end": null,
"cds_length": 1095,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351408.2"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LPAR1",
"gene_hgnc_id": 3166,
"hgvs_c": "c.435G>C",
"hgvs_p": "p.Glu145Asp",
"transcript": "NM_001351409.2",
"protein_id": "NP_001338338.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 364,
"cds_start": 435,
"cds_end": null,
"cds_length": 1095,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351409.2"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LPAR1",
"gene_hgnc_id": 3166,
"hgvs_c": "c.435G>C",
"hgvs_p": "p.Glu145Asp",
"transcript": "NM_001351410.2",
"protein_id": "NP_001338339.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 364,
"cds_start": 435,
"cds_end": null,
"cds_length": 1095,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351410.2"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LPAR1",
"gene_hgnc_id": 3166,
"hgvs_c": "c.435G>C",
"hgvs_p": "p.Glu145Asp",
"transcript": "NM_001351412.2",
"protein_id": "NP_001338341.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 364,
"cds_start": 435,
"cds_end": null,
"cds_length": 1095,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351412.2"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LPAR1",
"gene_hgnc_id": 3166,
"hgvs_c": "c.435G>C",
"hgvs_p": "p.Glu145Asp",
"transcript": "NM_001351413.2",
"protein_id": "NP_001338342.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 364,
"cds_start": 435,
"cds_end": null,
"cds_length": 1095,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351413.2"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LPAR1",
"gene_hgnc_id": 3166,
"hgvs_c": "c.435G>C",
"hgvs_p": "p.Glu145Asp",
"transcript": "NM_001351414.2",
"protein_id": "NP_001338343.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 364,
"cds_start": 435,
"cds_end": null,
"cds_length": 1095,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351414.2"
},
{
"aa_ref": "E",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LPAR1",
"gene_hgnc_id": 3166,
"hgvs_c": "c.435G>C",
"hgvs_p": "p.Glu145Asp",
"transcript": "NM_001351415.2",
"protein_id": "NP_001338344.1",
"transcript_support_level": null,
"aa_start": 145,
"aa_end": null,
"aa_length": 364,
"cds_start": 435,
"cds_end": null,
"cds_length": 1095,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001351415.2"
},
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{
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"verdict": "Uncertain_significance",
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],
"clinvar_disease": "",
"clinvar_classification": "",
"clinvar_review_status": "",
"clinvar_submissions_summary": "",
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"pathogenicity_classification_combined": null,
"custom_annotations": null
}
],
"message": null
}