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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 9-111574812-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=111574812&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "9",
"pos": 111574812,
"ref": "C",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_012212.3",
"consequences": [
{
"aa_ref": "G",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.682G>C",
"hgvs_p": "p.Gly228Arg",
"transcript": "NM_001146108.2",
"protein_id": "NP_001139580.1",
"transcript_support_level": null,
"aa_start": 228,
"aa_end": null,
"aa_length": 329,
"cds_start": 682,
"cds_end": null,
"cds_length": 990,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000407693.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001146108.2"
},
{
"aa_ref": "G",
"aa_alt": "R",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.682G>C",
"hgvs_p": "p.Gly228Arg",
"transcript": "ENST00000407693.7",
"protein_id": "ENSP00000385763.2",
"transcript_support_level": 1,
"aa_start": 228,
"aa_end": null,
"aa_length": 329,
"cds_start": 682,
"cds_end": null,
"cds_length": 990,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001146108.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000407693.7"
},
{
"aa_ref": "G",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.682G>C",
"hgvs_p": "p.Gly228Arg",
"transcript": "ENST00000309195.9",
"protein_id": "ENSP00000311572.5",
"transcript_support_level": 1,
"aa_start": 228,
"aa_end": null,
"aa_length": 329,
"cds_start": 682,
"cds_end": null,
"cds_length": 990,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000309195.9"
},
{
"aa_ref": "G",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.682G>C",
"hgvs_p": "p.Gly228Arg",
"transcript": "NM_012212.3",
"protein_id": "NP_036344.2",
"transcript_support_level": null,
"aa_start": 228,
"aa_end": null,
"aa_length": 329,
"cds_start": 682,
"cds_end": null,
"cds_length": 990,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_012212.3"
},
{
"aa_ref": "G",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.682G>C",
"hgvs_p": "p.Gly228Arg",
"transcript": "ENST00000878676.1",
"protein_id": "ENSP00000548735.1",
"transcript_support_level": null,
"aa_start": 228,
"aa_end": null,
"aa_length": 329,
"cds_start": 682,
"cds_end": null,
"cds_length": 990,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878676.1"
},
{
"aa_ref": "G",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.682G>C",
"hgvs_p": "p.Gly228Arg",
"transcript": "ENST00000878677.1",
"protein_id": "ENSP00000548736.1",
"transcript_support_level": null,
"aa_start": 228,
"aa_end": null,
"aa_length": 329,
"cds_start": 682,
"cds_end": null,
"cds_length": 990,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878677.1"
},
{
"aa_ref": "G",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.682G>C",
"hgvs_p": "p.Gly228Arg",
"transcript": "ENST00000878681.1",
"protein_id": "ENSP00000548740.1",
"transcript_support_level": null,
"aa_start": 228,
"aa_end": null,
"aa_length": 329,
"cds_start": 682,
"cds_end": null,
"cds_length": 990,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878681.1"
},
{
"aa_ref": "G",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.682G>C",
"hgvs_p": "p.Gly228Arg",
"transcript": "ENST00000878682.1",
"protein_id": "ENSP00000548741.1",
"transcript_support_level": null,
"aa_start": 228,
"aa_end": null,
"aa_length": 329,
"cds_start": 682,
"cds_end": null,
"cds_length": 990,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878682.1"
},
{
"aa_ref": "G",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.682G>C",
"hgvs_p": "p.Gly228Arg",
"transcript": "ENST00000878683.1",
"protein_id": "ENSP00000548742.1",
"transcript_support_level": null,
"aa_start": 228,
"aa_end": null,
"aa_length": 329,
"cds_start": 682,
"cds_end": null,
"cds_length": 990,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878683.1"
},
{
"aa_ref": "G",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.682G>C",
"hgvs_p": "p.Gly228Arg",
"transcript": "ENST00000878685.1",
"protein_id": "ENSP00000548744.1",
"transcript_support_level": null,
"aa_start": 228,
"aa_end": null,
"aa_length": 329,
"cds_start": 682,
"cds_end": null,
"cds_length": 990,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878685.1"
},
{
"aa_ref": "G",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.682G>C",
"hgvs_p": "p.Gly228Arg",
"transcript": "ENST00000878686.1",
"protein_id": "ENSP00000548745.1",
"transcript_support_level": null,
"aa_start": 228,
"aa_end": null,
"aa_length": 329,
"cds_start": 682,
"cds_end": null,
"cds_length": 990,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878686.1"
},
{
"aa_ref": "G",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.682G>C",
"hgvs_p": "p.Gly228Arg",
"transcript": "ENST00000878687.1",
"protein_id": "ENSP00000548746.1",
"transcript_support_level": null,
"aa_start": 228,
"aa_end": null,
"aa_length": 329,
"cds_start": 682,
"cds_end": null,
"cds_length": 990,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878687.1"
},
{
"aa_ref": "G",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.682G>C",
"hgvs_p": "p.Gly228Arg",
"transcript": "ENST00000916463.1",
"protein_id": "ENSP00000586522.1",
"transcript_support_level": null,
"aa_start": 228,
"aa_end": null,
"aa_length": 329,
"cds_start": 682,
"cds_end": null,
"cds_length": 990,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000916463.1"
},
{
"aa_ref": "G",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.682G>C",
"hgvs_p": "p.Gly228Arg",
"transcript": "ENST00000947724.1",
"protein_id": "ENSP00000617783.1",
"transcript_support_level": null,
"aa_start": 228,
"aa_end": null,
"aa_length": 325,
"cds_start": 682,
"cds_end": null,
"cds_length": 978,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000947724.1"
},
{
"aa_ref": "G",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.682G>C",
"hgvs_p": "p.Gly228Arg",
"transcript": "ENST00000947725.1",
"protein_id": "ENSP00000617784.1",
"transcript_support_level": null,
"aa_start": 228,
"aa_end": null,
"aa_length": 325,
"cds_start": 682,
"cds_end": null,
"cds_length": 978,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000947725.1"
},
{
"aa_ref": "G",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.625G>C",
"hgvs_p": "p.Gly209Arg",
"transcript": "ENST00000916460.1",
"protein_id": "ENSP00000586519.1",
"transcript_support_level": null,
"aa_start": 209,
"aa_end": null,
"aa_length": 310,
"cds_start": 625,
"cds_end": null,
"cds_length": 933,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000916460.1"
},
{
"aa_ref": "G",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.682G>C",
"hgvs_p": "p.Gly228Arg",
"transcript": "NM_001146109.2",
"protein_id": "NP_001139581.1",
"transcript_support_level": null,
"aa_start": 228,
"aa_end": null,
"aa_length": 301,
"cds_start": 682,
"cds_end": null,
"cds_length": 906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001146109.2"
},
{
"aa_ref": "G",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.682G>C",
"hgvs_p": "p.Gly228Arg",
"transcript": "ENST00000538962.7",
"protein_id": "ENSP00000440281.1",
"transcript_support_level": 2,
"aa_start": 228,
"aa_end": null,
"aa_length": 301,
"cds_start": 682,
"cds_end": null,
"cds_length": 906,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000538962.7"
},
{
"aa_ref": "G",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.592G>C",
"hgvs_p": "p.Gly198Arg",
"transcript": "ENST00000878678.1",
"protein_id": "ENSP00000548737.1",
"transcript_support_level": null,
"aa_start": 198,
"aa_end": null,
"aa_length": 299,
"cds_start": 592,
"cds_end": null,
"cds_length": 900,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878678.1"
},
{
"aa_ref": "G",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.592G>C",
"hgvs_p": "p.Gly198Arg",
"transcript": "ENST00000878684.1",
"protein_id": "ENSP00000548743.1",
"transcript_support_level": null,
"aa_start": 198,
"aa_end": null,
"aa_length": 299,
"cds_start": 592,
"cds_end": null,
"cds_length": 900,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878684.1"
},
{
"aa_ref": "G",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.514G>C",
"hgvs_p": "p.Gly172Arg",
"transcript": "ENST00000878675.1",
"protein_id": "ENSP00000548734.1",
"transcript_support_level": null,
"aa_start": 172,
"aa_end": null,
"aa_length": 273,
"cds_start": 514,
"cds_end": null,
"cds_length": 822,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878675.1"
},
{
"aa_ref": "G",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.514G>C",
"hgvs_p": "p.Gly172Arg",
"transcript": "ENST00000916461.1",
"protein_id": "ENSP00000586520.1",
"transcript_support_level": null,
"aa_start": 172,
"aa_end": null,
"aa_length": 273,
"cds_start": 514,
"cds_end": null,
"cds_length": 822,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000916461.1"
},
{
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}