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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 9-111585121-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=111585121&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "9",
"pos": 111585121,
"ref": "T",
"alt": "C",
"effect": "intron_variant",
"transcript": "NM_012212.3",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.377+877A>G",
"hgvs_p": null,
"transcript": "NM_001146108.2",
"protein_id": "NP_001139580.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 329,
"cds_start": null,
"cds_end": null,
"cds_length": 990,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000407693.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001146108.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.377+877A>G",
"hgvs_p": null,
"transcript": "ENST00000407693.7",
"protein_id": "ENSP00000385763.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 329,
"cds_start": null,
"cds_end": null,
"cds_length": 990,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001146108.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000407693.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.377+877A>G",
"hgvs_p": null,
"transcript": "ENST00000309195.9",
"protein_id": "ENSP00000311572.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 329,
"cds_start": null,
"cds_end": null,
"cds_length": 990,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000309195.9"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.377+877A>G",
"hgvs_p": null,
"transcript": "NM_012212.3",
"protein_id": "NP_036344.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 329,
"cds_start": null,
"cds_end": null,
"cds_length": 990,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_012212.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.377+877A>G",
"hgvs_p": null,
"transcript": "ENST00000878676.1",
"protein_id": "ENSP00000548735.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 329,
"cds_start": null,
"cds_end": null,
"cds_length": 990,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878676.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.377+877A>G",
"hgvs_p": null,
"transcript": "ENST00000878677.1",
"protein_id": "ENSP00000548736.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 329,
"cds_start": null,
"cds_end": null,
"cds_length": 990,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878677.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.377+877A>G",
"hgvs_p": null,
"transcript": "ENST00000878681.1",
"protein_id": "ENSP00000548740.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 329,
"cds_start": null,
"cds_end": null,
"cds_length": 990,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878681.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.377+877A>G",
"hgvs_p": null,
"transcript": "ENST00000878682.1",
"protein_id": "ENSP00000548741.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 329,
"cds_start": null,
"cds_end": null,
"cds_length": 990,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878682.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.377+877A>G",
"hgvs_p": null,
"transcript": "ENST00000878683.1",
"protein_id": "ENSP00000548742.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 329,
"cds_start": null,
"cds_end": null,
"cds_length": 990,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878683.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.377+877A>G",
"hgvs_p": null,
"transcript": "ENST00000878685.1",
"protein_id": "ENSP00000548744.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 329,
"cds_start": null,
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"cds_length": 990,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000878685.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.377+877A>G",
"hgvs_p": null,
"transcript": "ENST00000878686.1",
"protein_id": "ENSP00000548745.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000878686.1"
},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 10,
"intron_rank": 5,
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"gene_symbol": "PTGR1",
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"hgvs_c": "c.377+877A>G",
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"transcript": "ENST00000878687.1",
"protein_id": "ENSP00000548746.1",
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"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000878687.1"
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 10,
"intron_rank": 5,
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"gene_symbol": "PTGR1",
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"hgvs_c": "c.377+877A>G",
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"transcript": "ENST00000916463.1",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"gene_symbol": "PTGR1",
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},
{
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"strand": false,
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],
"exon_rank": null,
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"exon_count": 10,
"intron_rank": 5,
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"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.377+877A>G",
"hgvs_p": null,
"transcript": "ENST00000947725.1",
"protein_id": "ENSP00000617784.1",
"transcript_support_level": null,
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"cds_start": null,
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"cdna_start": null,
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"biotype": "protein_coding",
"feature": "ENST00000947725.1"
},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 9,
"intron_rank": 4,
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"gene_symbol": "PTGR1",
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"hgvs_c": "c.320+877A>G",
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"transcript": "ENST00000916460.1",
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"feature": "ENST00000916460.1"
},
{
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],
"exon_rank": null,
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"exon_count": 10,
"intron_rank": 5,
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"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.377+877A>G",
"hgvs_p": null,
"transcript": "NM_001146109.2",
"protein_id": "NP_001139581.1",
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"cds_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "NM_001146109.2"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 10,
"intron_rank": 5,
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"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.377+877A>G",
"hgvs_p": null,
"transcript": "ENST00000538962.7",
"protein_id": "ENSP00000440281.1",
"transcript_support_level": 2,
"aa_start": null,
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"cds_start": null,
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 5,
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"gene_symbol": "PTGR1",
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"hgvs_c": "c.287+877A>G",
"hgvs_p": null,
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},
{
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],
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"gene_symbol": "PTGR1",
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"hgvs_c": "c.287+877A>G",
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"transcript": "ENST00000878684.1",
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},
{
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"consequences": [
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],
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"gene_symbol": "PTGR1",
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"hgvs_c": "c.210-1532A>G",
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"transcript": "ENST00000878675.1",
"protein_id": "ENSP00000548734.1",
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"cds_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000878675.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "PTGR1",
"gene_hgnc_id": 18429,
"hgvs_c": "c.210-1532A>G",
"hgvs_p": null,
"transcript": "ENST00000916461.1",
"protein_id": "ENSP00000586520.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 273,
"cds_start": null,
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"cds_length": 822,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000916461.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 3,
"intron_rank_end": null,
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