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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 9-113323143-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=113323143&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 12,
          "criteria": [
            "BP4_Strong",
            "BA1"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "WDR31",
          "hgnc_id": 21421,
          "hgvs_c": "c.337C>T",
          "hgvs_p": "p.Pro113Ser",
          "inheritance_mode": "AR",
          "pathogenic_score": 0,
          "score": -12,
          "transcript": "NM_001012361.4",
          "verdict": "Benign"
        }
      ],
      "acmg_classification": "Benign",
      "acmg_criteria": "BP4_Strong,BA1",
      "acmg_score": -12,
      "allele_count_reference_population": 102795,
      "alphamissense_prediction": null,
      "alphamissense_score": 0.0965,
      "alt": "A",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Benign",
      "bayesdelnoaf_score": -0.59,
      "chr": "9",
      "clinvar_classification": "",
      "clinvar_disease": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "computational_prediction_selected": "Benign",
      "computational_score_selected": 0.0017173290252685547,
      "computational_source_selected": "MetaRNN",
      "consequences": [
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 367,
          "aa_ref": "P",
          "aa_start": 113,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4871,
          "cdna_start": 577,
          "cds_end": null,
          "cds_length": 1104,
          "cds_start": 337,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "NM_001012361.4",
          "gene_hgnc_id": 21421,
          "gene_symbol": "WDR31",
          "hgvs_c": "c.337C>T",
          "hgvs_p": "p.Pro113Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000374193.9",
          "protein_coding": true,
          "protein_id": "NP_001012361.1",
          "strand": false,
          "transcript": "NM_001012361.4",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 367,
          "aa_ref": "P",
          "aa_start": 113,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 4871,
          "cdna_start": 577,
          "cds_end": null,
          "cds_length": 1104,
          "cds_start": 337,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000374193.9",
          "gene_hgnc_id": 21421,
          "gene_symbol": "WDR31",
          "hgvs_c": "c.337C>T",
          "hgvs_p": "p.Pro113Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_001012361.4",
          "protein_coding": true,
          "protein_id": "ENSP00000363308.3",
          "strand": false,
          "transcript": "ENST00000374193.9",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "pseudogene",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2371,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 11,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000461942.5",
          "gene_hgnc_id": 21421,
          "gene_symbol": "WDR31",
          "hgvs_c": "n.487C>T",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": false,
          "transcript": "ENST00000461942.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 371,
          "aa_ref": "P",
          "aa_start": 113,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2360,
          "cdna_start": 518,
          "cds_end": null,
          "cds_length": 1116,
          "cds_start": 337,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000944273.1",
          "gene_hgnc_id": 21421,
          "gene_symbol": "WDR31",
          "hgvs_c": "c.337C>T",
          "hgvs_p": "p.Pro113Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000614332.1",
          "strand": false,
          "transcript": "ENST00000944273.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 368,
          "aa_ref": "P",
          "aa_start": 114,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2457,
          "cdna_start": 605,
          "cds_end": null,
          "cds_length": 1107,
          "cds_start": 340,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000865157.1",
          "gene_hgnc_id": 21421,
          "gene_symbol": "WDR31",
          "hgvs_c": "c.340C>T",
          "hgvs_p": "p.Pro114Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000535216.1",
          "strand": false,
          "transcript": "ENST00000865157.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 368,
          "aa_ref": "P",
          "aa_start": 114,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2657,
          "cdna_start": 827,
          "cds_end": null,
          "cds_length": 1107,
          "cds_start": 340,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000944266.1",
          "gene_hgnc_id": 21421,
          "gene_symbol": "WDR31",
          "hgvs_c": "c.340C>T",
          "hgvs_p": "p.Pro114Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000614325.1",
          "strand": false,
          "transcript": "ENST00000944266.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 367,
          "aa_ref": "P",
          "aa_start": 113,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2338,
          "cdna_start": 486,
          "cds_end": null,
          "cds_length": 1104,
          "cds_start": 337,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000865155.1",
          "gene_hgnc_id": 21421,
          "gene_symbol": "WDR31",
          "hgvs_c": "c.337C>T",
          "hgvs_p": "p.Pro113Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000535214.1",
          "strand": false,
          "transcript": "ENST00000865155.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 367,
          "aa_ref": "P",
          "aa_start": 113,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2701,
          "cdna_start": 1203,
          "cds_end": null,
          "cds_length": 1104,
          "cds_start": 337,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000865161.1",
          "gene_hgnc_id": 21421,
          "gene_symbol": "WDR31",
          "hgvs_c": "c.337C>T",
          "hgvs_p": "p.Pro113Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000535220.1",
          "strand": false,
          "transcript": "ENST00000865161.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 367,
          "aa_ref": "P",
          "aa_start": 113,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2681,
          "cdna_start": 849,
          "cds_end": null,
          "cds_length": 1104,
          "cds_start": 337,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000944262.1",
          "gene_hgnc_id": 21421,
          "gene_symbol": "WDR31",
          "hgvs_c": "c.337C>T",
          "hgvs_p": "p.Pro113Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000614321.1",
          "strand": false,
          "transcript": "ENST00000944262.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 367,
          "aa_ref": "P",
          "aa_start": 113,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2474,
          "cdna_start": 622,
          "cds_end": null,
          "cds_length": 1104,
          "cds_start": 337,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000944269.1",
          "gene_hgnc_id": 21421,
          "gene_symbol": "WDR31",
          "hgvs_c": "c.337C>T",
          "hgvs_p": "p.Pro113Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000614328.1",
          "strand": false,
          "transcript": "ENST00000944269.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 367,
          "aa_ref": "P",
          "aa_start": 113,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2068,
          "cdna_start": 574,
          "cds_end": null,
          "cds_length": 1104,
          "cds_start": 337,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000944271.1",
          "gene_hgnc_id": 21421,
          "gene_symbol": "WDR31",
          "hgvs_c": "c.337C>T",
          "hgvs_p": "p.Pro113Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000614330.1",
          "strand": false,
          "transcript": "ENST00000944271.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 366,
          "aa_ref": "P",
          "aa_start": 112,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4868,
          "cdna_start": 574,
          "cds_end": null,
          "cds_length": 1101,
          "cds_start": 334,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "NM_145241.5",
          "gene_hgnc_id": 21421,
          "gene_symbol": "WDR31",
          "hgvs_c": "c.334C>T",
          "hgvs_p": "p.Pro112Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_660284.1",
          "strand": false,
          "transcript": "NM_145241.5",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 366,
          "aa_ref": "P",
          "aa_start": 112,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4862,
          "cdna_start": 568,
          "cds_end": null,
          "cds_length": 1101,
          "cds_start": 334,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 11,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000341761.8",
          "gene_hgnc_id": 21421,
          "gene_symbol": "WDR31",
          "hgvs_c": "c.334C>T",
          "hgvs_p": "p.Pro112Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000345027.3",
          "strand": false,
          "transcript": "ENST00000341761.8",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 366,
          "aa_ref": "P",
          "aa_start": 112,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2316,
          "cdna_start": 464,
          "cds_end": null,
          "cds_length": 1101,
          "cds_start": 334,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000865156.1",
          "gene_hgnc_id": 21421,
          "gene_symbol": "WDR31",
          "hgvs_c": "c.334C>T",
          "hgvs_p": "p.Pro112Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000535215.1",
          "strand": false,
          "transcript": "ENST00000865156.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 366,
          "aa_ref": "P",
          "aa_start": 112,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2663,
          "cdna_start": 811,
          "cds_end": null,
          "cds_length": 1101,
          "cds_start": 334,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 12,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000944265.1",
          "gene_hgnc_id": 21421,
          "gene_symbol": "WDR31",
          "hgvs_c": "c.334C>T",
          "hgvs_p": "p.Pro112Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000614324.1",
          "strand": false,
          "transcript": "ENST00000944265.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 342,
          "aa_ref": "P",
          "aa_start": 88,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2359,
          "cdna_start": 490,
          "cds_end": null,
          "cds_length": 1029,
          "cds_start": 262,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000865159.1",
          "gene_hgnc_id": 21421,
          "gene_symbol": "WDR31",
          "hgvs_c": "c.262C>T",
          "hgvs_p": "p.Pro88Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000535218.1",
          "strand": false,
          "transcript": "ENST00000865159.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 342,
          "aa_ref": "P",
          "aa_start": 88,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2189,
          "cdna_start": 337,
          "cds_end": null,
          "cds_length": 1029,
          "cds_start": 262,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 9,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "ENST00000865160.1",
          "gene_hgnc_id": 21421,
          "gene_symbol": "WDR31",
          "hgvs_c": "c.262C>T",
          "hgvs_p": "p.Pro88Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000535219.1",
          "strand": false,
          "transcript": "ENST00000865160.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 341,
          "aa_ref": "P",
          "aa_start": 87,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2360,
          "cdna_start": 508,
          "cds_end": null,
          "cds_length": 1026,
          "cds_start": 259,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 10,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000865158.1",
          "gene_hgnc_id": 21421,
          "gene_symbol": "WDR31",
          "hgvs_c": "c.259C>T",
          "hgvs_p": "p.Pro87Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000535217.1",
          "strand": false,
          "transcript": "ENST00000865158.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 341,
          "aa_ref": "P",
          "aa_start": 87,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2162,
          "cdna_start": 332,
          "cds_end": null,
          "cds_length": 1026,
          "cds_start": 259,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 9,
          "exon_rank": 4,
          "exon_rank_end": null,
          "feature": "ENST00000944270.1",
          "gene_hgnc_id": 21421,
          "gene_symbol": "WDR31",
          "hgvs_c": "c.259C>T",
          "hgvs_p": "p.Pro87Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000614329.1",
          "strand": false,
          "transcript": "ENST00000944270.1",
          "transcript_support_level": null
        },
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.