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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 9-113594236-A-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=113594236&ref=A&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "9",
"pos": 113594236,
"ref": "A",
"alt": "C",
"effect": "intron_variant",
"transcript": "ENST00000695401.1",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RGS3",
"gene_hgnc_id": 9999,
"hgvs_c": "c.-41A>C",
"hgvs_p": null,
"transcript": "ENST00000620489.1",
"protein_id": "ENSP00000479017.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 192,
"cds_start": -4,
"cds_end": null,
"cds_length": 579,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1503,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "RGS3",
"gene_hgnc_id": 9999,
"hgvs_c": "c.2745-194A>C",
"hgvs_p": null,
"transcript": "NM_001394167.1",
"protein_id": "NP_001381096.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1086,
"cds_start": -4,
"cds_end": null,
"cds_length": 3261,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4122,
"mane_select": "ENST00000695401.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "RGS3",
"gene_hgnc_id": 9999,
"hgvs_c": "c.2745-194A>C",
"hgvs_p": null,
"transcript": "ENST00000695401.1",
"protein_id": "ENSP00000511882.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1086,
"cds_start": -4,
"cds_end": null,
"cds_length": 3261,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4122,
"mane_select": "NM_001394167.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "RGS3",
"gene_hgnc_id": 9999,
"hgvs_c": "c.2238-194A>C",
"hgvs_p": null,
"transcript": "ENST00000343817.9",
"protein_id": "ENSP00000340284.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 917,
"cds_start": -4,
"cds_end": null,
"cds_length": 2754,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3689,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "RGS3",
"gene_hgnc_id": 9999,
"hgvs_c": "c.1044-194A>C",
"hgvs_p": null,
"transcript": "ENST00000374134.7",
"protein_id": "ENSP00000363249.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 519,
"cds_start": -4,
"cds_end": null,
"cds_length": 1560,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2862,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "RGS3",
"gene_hgnc_id": 9999,
"hgvs_c": "c.579-194A>C",
"hgvs_p": null,
"transcript": "ENST00000467805.6",
"protein_id": "ENSP00000417994.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 246,
"cds_start": -4,
"cds_end": null,
"cds_length": 742,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 913,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "RGS3",
"gene_hgnc_id": 9999,
"hgvs_c": "n.2858-194A>C",
"hgvs_p": null,
"transcript": "ENST00000487344.1",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4158,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RGS3",
"gene_hgnc_id": 9999,
"hgvs_c": "n.93A>C",
"hgvs_p": null,
"transcript": "ENST00000497435.1",
"protein_id": null,
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 564,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RGS3",
"gene_hgnc_id": 9999,
"hgvs_c": "c.-41A>C",
"hgvs_p": null,
"transcript": "NM_144489.4",
"protein_id": "NP_652760.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 192,
"cds_start": -4,
"cds_end": null,
"cds_length": 579,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1512,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "RGS3",
"gene_hgnc_id": 9999,
"hgvs_c": "c.-61A>C",
"hgvs_p": null,
"transcript": "NM_001276262.2",
"protein_id": "NP_001263191.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 168,
"cds_start": -4,
"cds_end": null,
"cds_length": 507,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1460,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 21,
"intron_rank_end": null,
"gene_symbol": "RGS3",
"gene_hgnc_id": 9999,
"hgvs_c": "c.3081-194A>C",
"hgvs_p": null,
"transcript": "ENST00000350696.9",
"protein_id": "ENSP00000259406.7",
"transcript_support_level": 5,
"aa_start": null,
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"aa_length": 1198,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 26,
"intron_rank": 22,
"intron_rank_end": null,
"gene_symbol": "RGS3",
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"hgvs_c": "c.3081-194A>C",
"hgvs_p": null,
"transcript": "ENST00000374140.6",
"protein_id": "ENSP00000363255.2",
"transcript_support_level": 2,
"aa_start": null,
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},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 26,
"intron_rank": 22,
"intron_rank_end": null,
"gene_symbol": "RGS3",
"gene_hgnc_id": 9999,
"hgvs_c": "c.2769-194A>C",
"hgvs_p": null,
"transcript": "NM_144488.8",
"protein_id": "NP_652759.4",
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"aa_start": null,
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 23,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "RGS3",
"gene_hgnc_id": 9999,
"hgvs_c": "c.2751-194A>C",
"hgvs_p": null,
"transcript": "NM_001282923.2",
"protein_id": "NP_001269852.1",
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},
{
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],
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"gene_symbol": "RGS3",
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"hgvs_c": "c.2238-194A>C",
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"transcript": "NM_130795.4",
"protein_id": "NP_570613.2",
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 15,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "RGS3",
"gene_hgnc_id": 9999,
"hgvs_c": "c.1260-194A>C",
"hgvs_p": null,
"transcript": "NM_001276261.2",
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},
{
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],
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"gene_symbol": "RGS3",
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"hgvs_c": "c.1260-194A>C",
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"transcript": "ENST00000394646.7",
"protein_id": "ENSP00000378141.3",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "RGS3",
"gene_hgnc_id": 9999,
"hgvs_c": "c.1098-194A>C",
"hgvs_p": null,
"transcript": "NM_001322215.2",
"protein_id": "NP_001309144.1",
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},
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 3,
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"gene_symbol": "RGS3",
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"hgvs_c": "c.1044-194A>C",
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"transcript": "NM_001276260.2",
"protein_id": "NP_001263189.1",
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},
{
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"strand": true,
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],
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"intron_rank": 4,
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"gene_symbol": "RGS3",
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"hgvs_c": "c.1044-194A>C",
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"transcript": "NM_001282922.2",
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},
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"strand": true,
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],
"exon_rank": null,
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"intron_rank": 5,
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"gene_symbol": "RGS3",
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"hgvs_c": "c.1044-194A>C",
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"transcript": "NM_001351526.2",
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "RGS3",
"gene_hgnc_id": 9999,
"hgvs_c": "c.1044-194A>C",
"hgvs_p": null,
"transcript": "ENST00000462143.5",
"protein_id": "ENSP00000420356.1",
"transcript_support_level": 2,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "RGS3",
"gene_hgnc_id": 9999,
"hgvs_c": "c.-10-194A>C",
"hgvs_p": null,
"transcript": "NM_134427.3",
"protein_id": "NP_602299.1",
"transcript_support_level": null,
"aa_start": null,
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},
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{
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}
],
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}