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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 9-117803051-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=117803051&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "9",
"pos": 117803051,
"ref": "G",
"alt": "T",
"effect": "intron_variant",
"transcript": "ENST00000697666.1",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ENSG00000285082",
"gene_hgnc_id": null,
"hgvs_c": "c.141-45014G>T",
"hgvs_p": null,
"transcript": "ENST00000697666.1",
"protein_id": "ENSP00000513391.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 61,
"cds_start": -4,
"cds_end": null,
"cds_length": 186,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 837,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENSG00000284977",
"gene_hgnc_id": null,
"hgvs_c": "n.307G>T",
"hgvs_p": null,
"transcript": "ENST00000644180.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7753,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENSG00000284977",
"gene_hgnc_id": null,
"hgvs_c": "n.1645G>T",
"hgvs_p": null,
"transcript": "ENST00000697626.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2077,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENSG00000284977",
"gene_hgnc_id": null,
"hgvs_c": "n.379G>T",
"hgvs_p": null,
"transcript": "ENST00000697627.2",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 684,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENSG00000284977",
"gene_hgnc_id": null,
"hgvs_c": "n.630G>T",
"hgvs_p": null,
"transcript": "ENST00000697670.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1508,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENSG00000284977",
"gene_hgnc_id": null,
"hgvs_c": "n.557G>T",
"hgvs_p": null,
"transcript": "ENST00000697671.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1823,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENSG00000284977",
"gene_hgnc_id": null,
"hgvs_c": "n.164G>T",
"hgvs_p": null,
"transcript": "ENST00000703416.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4341,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENSG00000284977",
"gene_hgnc_id": null,
"hgvs_c": "n.562G>T",
"hgvs_p": null,
"transcript": "ENST00000725994.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 867,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LOC105376244",
"gene_hgnc_id": null,
"hgvs_c": "n.2899G>T",
"hgvs_p": null,
"transcript": "XR_007061905.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 26155,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LOC105376244",
"gene_hgnc_id": null,
"hgvs_c": "n.2316G>T",
"hgvs_p": null,
"transcript": "XR_007061906.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 25572,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "ENSG00000285082",
"gene_hgnc_id": null,
"hgvs_c": "c.94-45014G>T",
"hgvs_p": null,
"transcript": "ENST00000646089.2",
"protein_id": "ENSP00000496197.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 55,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 934,
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 3,
"intron_rank": 1,
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"gene_symbol": "ENSG00000285082",
"gene_hgnc_id": null,
"hgvs_c": "c.94-45014G>T",
"hgvs_p": null,
"transcript": "ENST00000697637.1",
"protein_id": "ENSP00000513367.1",
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},
{
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"canonical": false,
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"strand": true,
"consequences": [
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],
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"exon_count": 3,
"intron_rank": 1,
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"gene_symbol": "ENSG00000284977",
"gene_hgnc_id": null,
"hgvs_c": "n.121+19483G>T",
"hgvs_p": null,
"transcript": "ENST00000421509.2",
"protein_id": null,
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"aa_start": null,
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},
{
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"protein_coding": false,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 5,
"intron_rank": 2,
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"gene_symbol": "ENSG00000285082",
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"hgvs_c": "n.261-45014G>T",
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"transcript": "ENST00000642985.1",
"protein_id": "ENSP00000493686.1",
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},
{
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],
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},
{
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"protein_coding": false,
"strand": true,
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],
"exon_rank": null,
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"exon_count": 5,
"intron_rank": 4,
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"gene_symbol": "ENSG00000284977",
"gene_hgnc_id": null,
"hgvs_c": "n.542+16226G>T",
"hgvs_p": null,
"transcript": "ENST00000645420.1",
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},
{
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],
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"gene_symbol": "ENSG00000284977",
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"hgvs_c": "n.3324+24777G>T",
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"transcript": "ENST00000647206.1",
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},
{
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"strand": true,
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],
"exon_rank": null,
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"exon_count": 5,
"intron_rank": 3,
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"gene_symbol": "ENSG00000284977",
"gene_hgnc_id": null,
"hgvs_c": "n.1363+24777G>T",
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"transcript": "ENST00000647455.1",
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},
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"strand": true,
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],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "ENSG00000285082",
"gene_hgnc_id": null,
"hgvs_c": "n.94-45014G>T",
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"transcript": "ENST00000665764.1",
"protein_id": "ENSP00000499745.1",
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},
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"strand": true,
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],
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"intron_rank": 1,
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},
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],
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"intron_rank": 1,
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},
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"strand": true,
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],
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"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "ENSG00000284977",
"gene_hgnc_id": null,
"hgvs_c": "n.458+35801G>T",
"hgvs_p": null,
"transcript": "ENST00000697638.1",
"protein_id": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "ENSG00000284977",
"gene_hgnc_id": null,
"hgvs_c": "n.962+16226G>T",
"hgvs_p": null,
"transcript": "ENST00000697639.1",
"protein_id": null,
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},
{
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"protein_coding": false,
"strand": true,
"consequences": [
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