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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 9-120402984-G-GAC (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=120402984&ref=G&alt=GAC&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "9",
      "pos": 120402984,
      "ref": "G",
      "alt": "GAC",
      "effect": "frameshift_variant",
      "transcript": "ENST00000349780.9",
      "consequences": [
        {
          "aa_ref": "S",
          "aa_alt": "C?",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 34,
          "exon_rank_end": null,
          "exon_count": 38,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK5RAP2",
          "gene_hgnc_id": 18672,
          "hgvs_c": "c.5127_5128dupGT",
          "hgvs_p": "p.Ser1710fs",
          "transcript": "NM_018249.6",
          "protein_id": "NP_060719.4",
          "transcript_support_level": null,
          "aa_start": 1710,
          "aa_end": null,
          "aa_length": 1893,
          "cds_start": 5128,
          "cds_end": null,
          "cds_length": 5682,
          "cdna_start": 5317,
          "cdna_end": null,
          "cdna_length": 6232,
          "mane_select": "ENST00000349780.9",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "C?",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 34,
          "exon_rank_end": null,
          "exon_count": 38,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK5RAP2",
          "gene_hgnc_id": 18672,
          "hgvs_c": "c.5127_5128dupGT",
          "hgvs_p": "p.Ser1710fs",
          "transcript": "ENST00000349780.9",
          "protein_id": "ENSP00000343818.4",
          "transcript_support_level": 1,
          "aa_start": 1710,
          "aa_end": null,
          "aa_length": 1893,
          "cds_start": 5128,
          "cds_end": null,
          "cds_length": 5682,
          "cdna_start": 5317,
          "cdna_end": null,
          "cdna_length": 6232,
          "mane_select": "NM_018249.6",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "C?",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 33,
          "exon_rank_end": null,
          "exon_count": 37,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK5RAP2",
          "gene_hgnc_id": 18672,
          "hgvs_c": "c.4890_4891dupGT",
          "hgvs_p": "p.Ser1631fs",
          "transcript": "ENST00000360190.8",
          "protein_id": "ENSP00000353317.4",
          "transcript_support_level": 1,
          "aa_start": 1631,
          "aa_end": null,
          "aa_length": 1814,
          "cds_start": 4891,
          "cds_end": null,
          "cds_length": 5445,
          "cdna_start": 5071,
          "cdna_end": null,
          "cdna_length": 5985,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 35,
          "exon_rank_end": null,
          "exon_count": 39,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK5RAP2",
          "gene_hgnc_id": 18672,
          "hgvs_c": "n.*3951_*3952dupGT",
          "hgvs_p": null,
          "transcript": "ENST00000473282.6",
          "protein_id": "ENSP00000419265.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 5956,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 34,
          "exon_rank_end": null,
          "exon_count": 38,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK5RAP2",
          "gene_hgnc_id": 18672,
          "hgvs_c": "n.*2954_*2955dupGT",
          "hgvs_p": null,
          "transcript": "ENST00000480112.5",
          "protein_id": "ENSP00000418418.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 5826,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 35,
          "exon_rank_end": null,
          "exon_count": 39,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK5RAP2",
          "gene_hgnc_id": 18672,
          "hgvs_c": "n.*3951_*3952dupGT",
          "hgvs_p": null,
          "transcript": "ENST00000473282.6",
          "protein_id": "ENSP00000419265.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 5956,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 34,
          "exon_rank_end": null,
          "exon_count": 38,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK5RAP2",
          "gene_hgnc_id": 18672,
          "hgvs_c": "n.*2954_*2955dupGT",
          "hgvs_p": null,
          "transcript": "ENST00000480112.5",
          "protein_id": "ENSP00000418418.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": -4,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 5826,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "C?",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 34,
          "exon_rank_end": null,
          "exon_count": 38,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK5RAP2",
          "gene_hgnc_id": 18672,
          "hgvs_c": "c.5124_5125dupGT",
          "hgvs_p": "p.Ser1709fs",
          "transcript": "NM_001410994.1",
          "protein_id": "NP_001397923.1",
          "transcript_support_level": null,
          "aa_start": 1709,
          "aa_end": null,
          "aa_length": 1892,
          "cds_start": 5125,
          "cds_end": null,
          "cds_length": 5679,
          "cdna_start": 5314,
          "cdna_end": null,
          "cdna_length": 6229,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "C?",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 34,
          "exon_rank_end": null,
          "exon_count": 38,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK5RAP2",
          "gene_hgnc_id": 18672,
          "hgvs_c": "c.5124_5125dupGT",
          "hgvs_p": "p.Ser1709fs",
          "transcript": "ENST00000687279.1",
          "protein_id": "ENSP00000508692.1",
          "transcript_support_level": null,
          "aa_start": 1709,
          "aa_end": null,
          "aa_length": 1892,
          "cds_start": 5125,
          "cds_end": null,
          "cds_length": 5679,
          "cdna_start": 5170,
          "cdna_end": null,
          "cdna_length": 6079,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "C?",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 33,
          "exon_rank_end": null,
          "exon_count": 36,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK5RAP2",
          "gene_hgnc_id": 18672,
          "hgvs_c": "c.5031_5032dupGT",
          "hgvs_p": "p.Ser1678fs",
          "transcript": "ENST00000693728.1",
          "protein_id": "ENSP00000510580.1",
          "transcript_support_level": null,
          "aa_start": 1678,
          "aa_end": null,
          "aa_length": 1867,
          "cds_start": 5032,
          "cds_end": null,
          "cds_length": 5604,
          "cdna_start": 5075,
          "cdna_end": null,
          "cdna_length": 6071,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "C?",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 33,
          "exon_rank_end": null,
          "exon_count": 37,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK5RAP2",
          "gene_hgnc_id": 18672,
          "hgvs_c": "c.5031_5032dupGT",
          "hgvs_p": "p.Ser1678fs",
          "transcript": "NM_001410993.1",
          "protein_id": "NP_001397922.1",
          "transcript_support_level": null,
          "aa_start": 1678,
          "aa_end": null,
          "aa_length": 1861,
          "cds_start": 5032,
          "cds_end": null,
          "cds_length": 5586,
          "cdna_start": 5221,
          "cdna_end": null,
          "cdna_length": 6136,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "C?",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 33,
          "exon_rank_end": null,
          "exon_count": 37,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK5RAP2",
          "gene_hgnc_id": 18672,
          "hgvs_c": "c.5031_5032dupGT",
          "hgvs_p": "p.Ser1678fs",
          "transcript": "ENST00000416449.6",
          "protein_id": "ENSP00000400395.2",
          "transcript_support_level": 5,
          "aa_start": 1678,
          "aa_end": null,
          "aa_length": 1861,
          "cds_start": 5032,
          "cds_end": null,
          "cds_length": 5586,
          "cdna_start": 5075,
          "cdna_end": null,
          "cdna_length": 5667,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "C?",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 33,
          "exon_rank_end": null,
          "exon_count": 37,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK5RAP2",
          "gene_hgnc_id": 18672,
          "hgvs_c": "c.5028_5029dupGT",
          "hgvs_p": "p.Ser1677fs",
          "transcript": "NM_001410992.1",
          "protein_id": "NP_001397921.1",
          "transcript_support_level": null,
          "aa_start": 1677,
          "aa_end": null,
          "aa_length": 1860,
          "cds_start": 5029,
          "cds_end": null,
          "cds_length": 5583,
          "cdna_start": 5218,
          "cdna_end": null,
          "cdna_length": 6133,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "C?",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 33,
          "exon_rank_end": null,
          "exon_count": 37,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK5RAP2",
          "gene_hgnc_id": 18672,
          "hgvs_c": "c.5028_5029dupGT",
          "hgvs_p": "p.Ser1677fs",
          "transcript": "ENST00000687633.1",
          "protein_id": "ENSP00000510289.1",
          "transcript_support_level": null,
          "aa_start": 1677,
          "aa_end": null,
          "aa_length": 1860,
          "cds_start": 5029,
          "cds_end": null,
          "cds_length": 5583,
          "cdna_start": 5029,
          "cdna_end": null,
          "cdna_length": 5938,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "C?",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 32,
          "exon_rank_end": null,
          "exon_count": 36,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK5RAP2",
          "gene_hgnc_id": 18672,
          "hgvs_c": "c.4953_4954dupGT",
          "hgvs_p": "p.Ser1652fs",
          "transcript": "ENST00000690646.1",
          "protein_id": "ENSP00000510383.1",
          "transcript_support_level": null,
          "aa_start": 1652,
          "aa_end": null,
          "aa_length": 1835,
          "cds_start": 4954,
          "cds_end": null,
          "cds_length": 5508,
          "cdna_start": 4954,
          "cdna_end": null,
          "cdna_length": 5831,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "C?",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 33,
          "exon_rank_end": null,
          "exon_count": 37,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK5RAP2",
          "gene_hgnc_id": 18672,
          "hgvs_c": "c.4890_4891dupGT",
          "hgvs_p": "p.Ser1631fs",
          "transcript": "NM_001011649.3",
          "protein_id": "NP_001011649.1",
          "transcript_support_level": null,
          "aa_start": 1631,
          "aa_end": null,
          "aa_length": 1814,
          "cds_start": 4891,
          "cds_end": null,
          "cds_length": 5445,
          "cdna_start": 5080,
          "cdna_end": null,
          "cdna_length": 5995,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "C?",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 31,
          "exon_rank_end": null,
          "exon_count": 35,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK5RAP2",
          "gene_hgnc_id": 18672,
          "hgvs_c": "c.4437_4438dupGT",
          "hgvs_p": "p.Ser1480fs",
          "transcript": "NM_001272039.2",
          "protein_id": "NP_001258968.1",
          "transcript_support_level": null,
          "aa_start": 1480,
          "aa_end": null,
          "aa_length": 1663,
          "cds_start": 4438,
          "cds_end": null,
          "cds_length": 4992,
          "cdna_start": 4627,
          "cdna_end": null,
          "cdna_length": 5542,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "C?",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 31,
          "exon_rank_end": null,
          "exon_count": 35,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK5RAP2",
          "gene_hgnc_id": 18672,
          "hgvs_c": "c.4437_4438dupGT",
          "hgvs_p": "p.Ser1480fs",
          "transcript": "ENST00000360822.8",
          "protein_id": "ENSP00000354065.4",
          "transcript_support_level": 5,
          "aa_start": 1480,
          "aa_end": null,
          "aa_length": 1663,
          "cds_start": 4438,
          "cds_end": null,
          "cds_length": 4992,
          "cdna_start": 4619,
          "cdna_end": null,
          "cdna_length": 5173,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "C?",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK5RAP2",
          "gene_hgnc_id": 18672,
          "hgvs_c": "c.2157_2158dupGT",
          "hgvs_p": "p.Ser720fs",
          "transcript": "ENST00000425647.1",
          "protein_id": "ENSP00000409941.1",
          "transcript_support_level": 2,
          "aa_start": 720,
          "aa_end": null,
          "aa_length": 903,
          "cds_start": 2158,
          "cds_end": null,
          "cds_length": 2712,
          "cdna_start": 2158,
          "cdna_end": null,
          "cdna_length": 2747,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "C?",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "frameshift_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDK5RAP2",
          "gene_hgnc_id": 18672,
          "hgvs_c": "c.735_736dupGT",
          "hgvs_p": "p.Ser246fs",
          "transcript": "ENST00000688512.1",
          "protein_id": "ENSP00000508546.1",
          "transcript_support_level": null,
          "aa_start": 246,
          "aa_end": null,
          "aa_length": 429,
          "cds_start": 736,
          "cds_end": null,
          "cds_length": 1290,
          "cdna_start": 1518,
          "cdna_end": null,
          "cdna_length": 2417,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "S",
          "aa_alt": "C?",
          "canonical": false,
          "protein_coding": true,
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      "allele_count_reference_population": 0,
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      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": null,
      "computational_prediction_selected": null,
      "computational_source_selected": null,
      "splice_score_selected": null,
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      "bayesdelnoaf_score": null,
      "bayesdelnoaf_prediction": null,
      "phylop100way_score": 1.812,
      "phylop100way_prediction": "Benign",
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      "dbscsnv_ada_score": null,
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      "acmg_classification": "Pathogenic",
      "acmg_criteria": "PVS1,PM2,PP5",
      "acmg_by_gene": [
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          "benign_score": 0,
          "pathogenic_score": 11,
          "criteria": [
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            "PM2",
            "PP5"
          ],
          "verdict": "Pathogenic",
          "transcript": "ENST00000349780.9",
          "gene_symbol": "CDK5RAP2",
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          "effects": [
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          "inheritance_mode": "AR",
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        {
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            "PP5"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "ENST00000776055.1",
          "gene_symbol": "ENSG00000301087",
          "hgnc_id": null,
          "effects": [
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          ],
          "inheritance_mode": "",
          "hgvs_c": "n.414-11867_414-11866dupAC",
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      ],
      "clinvar_disease": " autosomal recessive, primary,Microcephaly 3",
      "clinvar_classification": "Pathogenic",
      "clinvar_review_status": "no assertion criteria provided",
      "clinvar_submissions_summary": "null",
      "phenotype_combined": "Microcephaly 3, primary, autosomal recessive",
      "pathogenicity_classification_combined": "Pathogenic",
      "custom_annotations": null
    }
  ],
  "message": null
}