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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 9-121076879-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=121076879&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "9",
"pos": 121076879,
"ref": "G",
"alt": "C",
"effect": "intron_variant",
"transcript": "ENST00000373855.7",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 44,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "CNTRL",
"gene_hgnc_id": 1858,
"hgvs_c": "c.-205+1812G>C",
"hgvs_p": null,
"transcript": "NM_007018.6",
"protein_id": "NP_008949.4",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2325,
"cds_start": -4,
"cds_end": null,
"cds_length": 6978,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7719,
"mane_select": "ENST00000373855.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 44,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "CNTRL",
"gene_hgnc_id": 1858,
"hgvs_c": "c.-205+1812G>C",
"hgvs_p": null,
"transcript": "ENST00000373855.7",
"protein_id": "ENSP00000362962.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 2325,
"cds_start": -4,
"cds_end": null,
"cds_length": 6978,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7719,
"mane_select": "NM_007018.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "CNTRL",
"gene_hgnc_id": 1858,
"hgvs_c": "c.-32+1812G>C",
"hgvs_p": null,
"transcript": "ENST00000373847.6",
"protein_id": "ENSP00000362953.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1700,
"cds_start": -4,
"cds_end": null,
"cds_length": 5103,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5449,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "CNTRL",
"gene_hgnc_id": 1858,
"hgvs_c": "c.-32+1812G>C",
"hgvs_p": null,
"transcript": "NM_001369893.1",
"protein_id": "NP_001356822.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1700,
"cds_start": -4,
"cds_end": null,
"cds_length": 5103,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5456,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "CNTRL",
"gene_hgnc_id": 1858,
"hgvs_c": "c.-32+1812G>C",
"hgvs_p": null,
"transcript": "NM_001369894.1",
"protein_id": "NP_001356823.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1610,
"cds_start": -4,
"cds_end": null,
"cds_length": 4833,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5462,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "CNTRL",
"gene_hgnc_id": 1858,
"hgvs_c": "c.-575+1812G>C",
"hgvs_p": null,
"transcript": "NM_001369895.1",
"protein_id": "NP_001356824.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1533,
"cds_start": -4,
"cds_end": null,
"cds_length": 4602,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5498,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "CNTRL",
"gene_hgnc_id": 1858,
"hgvs_c": "c.-32+1812G>C",
"hgvs_p": null,
"transcript": "ENST00000373865.8",
"protein_id": "ENSP00000362972.3",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 466,
"cds_start": -4,
"cds_end": null,
"cds_length": 1402,
"cdna_start": null,
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"cdna_length": 1621,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "CNTRL",
"gene_hgnc_id": 1858,
"hgvs_c": "c.-32+1812G>C",
"hgvs_p": null,
"transcript": "NM_001369896.1",
"protein_id": "NP_001356825.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 379,
"cds_start": -4,
"cds_end": null,
"cds_length": 1140,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1695,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "CNTRL",
"gene_hgnc_id": 1858,
"hgvs_c": "n.100+1812G>C",
"hgvs_p": null,
"transcript": "ENST00000685174.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1597,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
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"gene_symbol": "CNTRL",
"gene_hgnc_id": 1858,
"hgvs_c": "n.188+1812G>C",
"hgvs_p": null,
"transcript": "ENST00000687079.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
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"aa_length": null,
"cds_start": -4,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 43,
"intron_rank": 1,
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"gene_symbol": "CNTRL",
"gene_hgnc_id": 1858,
"hgvs_c": "n.106+1812G>C",
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"transcript": "ENST00000687169.1",
"protein_id": null,
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},
{
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"strand": true,
"consequences": [
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],
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"gene_symbol": "CNTRL",
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"hgvs_c": "n.-32+1812G>C",
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},
{
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],
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"gene_symbol": "CNTRL",
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},
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"strand": true,
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],
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},
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],
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},
{
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],
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"intron_rank": 1,
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"gene_symbol": "CNTRL",
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"hgvs_c": "n.-205+1812G>C",
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},
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],
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},
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],
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"gene_symbol": "CNTRL",
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"hgvs_c": "c.-205+1812G>C",
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"transcript": "XM_047422667.1",
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},
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],
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"intron_rank": 1,
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"gene_symbol": "CNTRL",
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"hgvs_c": "c.-32+1812G>C",
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"transcript": "XM_047422668.1",
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],
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],
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},
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],
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"intron_rank": 1,
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"gene_symbol": "CNTRL",
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"hgvs_c": "c.-32+1812G>C",
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},
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"consequences": [
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],
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"intron_rank": 1,
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"gene_symbol": "CNTRL",
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"hgvs_c": "c.-205+1812G>C",
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},
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}
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}