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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 9-127612427-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=127612427&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "9",
"pos": 127612427,
"ref": "T",
"alt": "C",
"effect": "synonymous_variant",
"transcript": "NM_001032221.6",
"consequences": [
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STXBP1",
"gene_hgnc_id": 11444,
"hgvs_c": "c.24T>C",
"hgvs_p": "p.Ala8Ala",
"transcript": "NM_003165.6",
"protein_id": "NP_003156.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 603,
"cds_start": 24,
"cds_end": null,
"cds_length": 1812,
"cdna_start": 151,
"cdna_end": null,
"cdna_length": 3880,
"mane_select": null,
"mane_plus": "ENST00000373302.8",
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STXBP1",
"gene_hgnc_id": 11444,
"hgvs_c": "c.24T>C",
"hgvs_p": "p.Ala8Ala",
"transcript": "ENST00000373302.8",
"protein_id": "ENSP00000362399.3",
"transcript_support_level": 1,
"aa_start": 8,
"aa_end": null,
"aa_length": 603,
"cds_start": 24,
"cds_end": null,
"cds_length": 1812,
"cdna_start": 151,
"cdna_end": null,
"cdna_length": 3880,
"mane_select": null,
"mane_plus": "NM_003165.6",
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STXBP1",
"gene_hgnc_id": 11444,
"hgvs_c": "c.24T>C",
"hgvs_p": "p.Ala8Ala",
"transcript": "NM_001032221.6",
"protein_id": "NP_001027392.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 594,
"cds_start": 24,
"cds_end": null,
"cds_length": 1785,
"cdna_start": 151,
"cdna_end": null,
"cdna_length": 3754,
"mane_select": "ENST00000373299.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STXBP1",
"gene_hgnc_id": 11444,
"hgvs_c": "c.24T>C",
"hgvs_p": "p.Ala8Ala",
"transcript": "ENST00000373299.5",
"protein_id": "ENSP00000362396.2",
"transcript_support_level": 1,
"aa_start": 8,
"aa_end": null,
"aa_length": 594,
"cds_start": 24,
"cds_end": null,
"cds_length": 1785,
"cdna_start": 151,
"cdna_end": null,
"cdna_length": 3754,
"mane_select": "NM_001032221.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STXBP1",
"gene_hgnc_id": 11444,
"hgvs_c": "c.24T>C",
"hgvs_p": "p.Ala8Ala",
"transcript": "ENST00000494254.4",
"protein_id": "ENSP00000485397.2",
"transcript_support_level": 5,
"aa_start": 8,
"aa_end": null,
"aa_length": 603,
"cds_start": 24,
"cds_end": null,
"cds_length": 1812,
"cdna_start": 142,
"cdna_end": null,
"cdna_length": 4183,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STXBP1",
"gene_hgnc_id": 11444,
"hgvs_c": "c.24T>C",
"hgvs_p": "p.Ala8Ala",
"transcript": "ENST00000647107.2",
"protein_id": "ENSP00000494727.2",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 599,
"cds_start": 24,
"cds_end": null,
"cds_length": 1800,
"cdna_start": 151,
"cdna_end": null,
"cdna_length": 2028,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STXBP1",
"gene_hgnc_id": 11444,
"hgvs_c": "c.24T>C",
"hgvs_p": "p.Ala8Ala",
"transcript": "ENST00000713766.1",
"protein_id": "ENSP00000519067.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 599,
"cds_start": 24,
"cds_end": null,
"cds_length": 1800,
"cdna_start": 151,
"cdna_end": null,
"cdna_length": 3807,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STXBP1",
"gene_hgnc_id": 11444,
"hgvs_c": "c.24T>C",
"hgvs_p": "p.Ala8Ala",
"transcript": "NM_001374306.2",
"protein_id": "NP_001361235.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 591,
"cds_start": 24,
"cds_end": null,
"cds_length": 1776,
"cdna_start": 151,
"cdna_end": null,
"cdna_length": 3745,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STXBP1",
"gene_hgnc_id": 11444,
"hgvs_c": "c.24T>C",
"hgvs_p": "p.Ala8Ala",
"transcript": "NM_001374313.2",
"protein_id": "NP_001361242.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 577,
"cds_start": 24,
"cds_end": null,
"cds_length": 1734,
"cdna_start": 151,
"cdna_end": null,
"cdna_length": 3834,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STXBP1",
"gene_hgnc_id": 11444,
"hgvs_c": "c.24T>C",
"hgvs_p": "p.Ala8Ala",
"transcript": "ENST00000637953.1",
"protein_id": "ENSP00000490613.1",
"transcript_support_level": 5,
"aa_start": 8,
"aa_end": null,
"aa_length": 577,
"cds_start": 24,
"cds_end": null,
"cds_length": 1734,
"cdna_start": 206,
"cdna_end": null,
"cdna_length": 3925,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STXBP1",
"gene_hgnc_id": 11444,
"hgvs_c": "c.24T>C",
"hgvs_p": "p.Ala8Ala",
"transcript": "NM_001374314.1",
"protein_id": "NP_001361243.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 574,
"cds_start": 24,
"cds_end": null,
"cds_length": 1725,
"cdna_start": 151,
"cdna_end": null,
"cdna_length": 2865,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STXBP1",
"gene_hgnc_id": 11444,
"hgvs_c": "c.24T>C",
"hgvs_p": "p.Ala8Ala",
"transcript": "ENST00000636962.2",
"protein_id": "ENSP00000489762.1",
"transcript_support_level": 5,
"aa_start": 8,
"aa_end": null,
"aa_length": 574,
"cds_start": 24,
"cds_end": null,
"cds_length": 1725,
"cdna_start": 206,
"cdna_end": null,
"cdna_length": 2918,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STXBP1",
"gene_hgnc_id": 11444,
"hgvs_c": "c.24T>C",
"hgvs_p": "p.Ala8Ala",
"transcript": "NM_001374315.2",
"protein_id": "NP_001361244.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 567,
"cds_start": 24,
"cds_end": null,
"cds_length": 1704,
"cdna_start": 151,
"cdna_end": null,
"cdna_length": 3772,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STXBP1",
"gene_hgnc_id": 11444,
"hgvs_c": "c.24T>C",
"hgvs_p": "p.Ala8Ala",
"transcript": "ENST00000713765.1",
"protein_id": "ENSP00000519066.1",
"transcript_support_level": null,
"aa_start": 8,
"aa_end": null,
"aa_length": 534,
"cds_start": 24,
"cds_end": null,
"cds_length": 1605,
"cdna_start": 158,
"cdna_end": null,
"cdna_length": 3465,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STXBP1",
"gene_hgnc_id": 11444,
"hgvs_c": "c.24T>C",
"hgvs_p": "p.Ala8Ala",
"transcript": "ENST00000496504.4",
"protein_id": "ENSP00000485361.3",
"transcript_support_level": 2,
"aa_start": 8,
"aa_end": null,
"aa_length": 193,
"cds_start": 24,
"cds_end": null,
"cds_length": 582,
"cdna_start": 158,
"cdna_end": null,
"cdna_length": 1081,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STXBP1",
"gene_hgnc_id": 11444,
"hgvs_c": "c.24T>C",
"hgvs_p": "p.Ala8Ala",
"transcript": "ENST00000476182.3",
"protein_id": "ENSP00000490199.1",
"transcript_support_level": 5,
"aa_start": 8,
"aa_end": null,
"aa_length": 22,
"cds_start": 24,
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"cds_length": 69,
"cdna_start": 67,
"cdna_end": null,
"cdna_length": 566,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STXBP1",
"gene_hgnc_id": 11444,
"hgvs_c": "n.24T>C",
"hgvs_p": null,
"transcript": "ENST00000635950.2",
"protein_id": "ENSP00000490903.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2771,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STXBP1",
"gene_hgnc_id": 11444,
"hgvs_c": "n.24T>C",
"hgvs_p": null,
"transcript": "ENST00000637060.2",
"protein_id": "ENSP00000490674.2",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3825,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STXBP1",
"gene_hgnc_id": 11444,
"hgvs_c": "n.24T>C",
"hgvs_p": null,
"transcript": "ENST00000637464.2",
"protein_id": "ENSP00000489655.2",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STXBP1",
"gene_hgnc_id": 11444,
"hgvs_c": "n.24T>C",
"hgvs_p": null,
"transcript": "ENST00000704681.1",
"protein_id": "ENSP00000515992.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
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"cdna_length": 3381,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STXBP1",
"gene_hgnc_id": 11444,
"hgvs_c": "n.24T>C",
"hgvs_p": null,
"transcript": "ENST00000713763.1",
"protein_id": "ENSP00000519064.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3722,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STXBP1",
"gene_hgnc_id": 11444,
"hgvs_c": "n.24T>C",
"hgvs_p": null,
"transcript": "ENST00000713764.1",
"protein_id": "ENSP00000519065.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3641,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "STXBP1",
"gene_hgnc_id": 11444,
"hgvs_c": "c.-114T>C",
"hgvs_p": null,
"transcript": "NM_001374307.2",
"protein_id": "NP_001361236.1",
"transcript_support_level": null,
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}