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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 9-128177654-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=128177654&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "9",
"pos": 128177654,
"ref": "G",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_001257975.2",
"consequences": [
{
"aa_ref": "S",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CIZ1",
"gene_hgnc_id": 16744,
"hgvs_c": "c.1730C>A",
"hgvs_p": "p.Ser577Tyr",
"transcript": "NM_001131016.2",
"protein_id": "NP_001124488.1",
"transcript_support_level": null,
"aa_start": 577,
"aa_end": null,
"aa_length": 898,
"cds_start": 1730,
"cds_end": null,
"cds_length": 2697,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000372938.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001131016.2"
},
{
"aa_ref": "S",
"aa_alt": "Y",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CIZ1",
"gene_hgnc_id": 16744,
"hgvs_c": "c.1730C>A",
"hgvs_p": "p.Ser577Tyr",
"transcript": "ENST00000372938.10",
"protein_id": "ENSP00000362029.5",
"transcript_support_level": 1,
"aa_start": 577,
"aa_end": null,
"aa_length": 898,
"cds_start": 1730,
"cds_end": null,
"cds_length": 2697,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001131016.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000372938.10"
},
{
"aa_ref": "S",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CIZ1",
"gene_hgnc_id": 16744,
"hgvs_c": "c.1496C>A",
"hgvs_p": "p.Ser499Tyr",
"transcript": "ENST00000415526.5",
"protein_id": "ENSP00000398011.1",
"transcript_support_level": 1,
"aa_start": 499,
"aa_end": null,
"aa_length": 820,
"cds_start": 1496,
"cds_end": null,
"cds_length": 2463,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000415526.5"
},
{
"aa_ref": "S",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CIZ1",
"gene_hgnc_id": 16744,
"hgvs_c": "c.1490C>A",
"hgvs_p": "p.Ser497Tyr",
"transcript": "ENST00000372954.5",
"protein_id": "ENSP00000362045.1",
"transcript_support_level": 1,
"aa_start": 497,
"aa_end": null,
"aa_length": 818,
"cds_start": 1490,
"cds_end": null,
"cds_length": 2457,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000372954.5"
},
{
"aa_ref": "S",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CIZ1",
"gene_hgnc_id": 16744,
"hgvs_c": "c.1820C>A",
"hgvs_p": "p.Ser607Tyr",
"transcript": "NM_001257975.2",
"protein_id": "NP_001244904.1",
"transcript_support_level": null,
"aa_start": 607,
"aa_end": null,
"aa_length": 954,
"cds_start": 1820,
"cds_end": null,
"cds_length": 2865,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001257975.2"
},
{
"aa_ref": "S",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CIZ1",
"gene_hgnc_id": 16744,
"hgvs_c": "c.1820C>A",
"hgvs_p": "p.Ser607Tyr",
"transcript": "ENST00000538431.5",
"protein_id": "ENSP00000439244.2",
"transcript_support_level": 2,
"aa_start": 607,
"aa_end": null,
"aa_length": 954,
"cds_start": 1820,
"cds_end": null,
"cds_length": 2865,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000538431.5"
},
{
"aa_ref": "S",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CIZ1",
"gene_hgnc_id": 16744,
"hgvs_c": "c.1730C>A",
"hgvs_p": "p.Ser577Tyr",
"transcript": "ENST00000866508.1",
"protein_id": "ENSP00000536567.1",
"transcript_support_level": null,
"aa_start": 577,
"aa_end": null,
"aa_length": 954,
"cds_start": 1730,
"cds_end": null,
"cds_length": 2865,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000866508.1"
},
{
"aa_ref": "S",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CIZ1",
"gene_hgnc_id": 16744,
"hgvs_c": "c.1748C>A",
"hgvs_p": "p.Ser583Tyr",
"transcript": "ENST00000866505.1",
"protein_id": "ENSP00000536564.1",
"transcript_support_level": null,
"aa_start": 583,
"aa_end": null,
"aa_length": 904,
"cds_start": 1748,
"cds_end": null,
"cds_length": 2715,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000866505.1"
},
{
"aa_ref": "S",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CIZ1",
"gene_hgnc_id": 16744,
"hgvs_c": "c.1730C>A",
"hgvs_p": "p.Ser577Tyr",
"transcript": "NM_012127.3",
"protein_id": "NP_036259.2",
"transcript_support_level": null,
"aa_start": 577,
"aa_end": null,
"aa_length": 898,
"cds_start": 1730,
"cds_end": null,
"cds_length": 2697,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_012127.3"
},
{
"aa_ref": "S",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CIZ1",
"gene_hgnc_id": 16744,
"hgvs_c": "c.1730C>A",
"hgvs_p": "p.Ser577Tyr",
"transcript": "ENST00000634901.1",
"protein_id": "ENSP00000489425.1",
"transcript_support_level": 5,
"aa_start": 577,
"aa_end": null,
"aa_length": 898,
"cds_start": 1730,
"cds_end": null,
"cds_length": 2697,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000634901.1"
},
{
"aa_ref": "S",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CIZ1",
"gene_hgnc_id": 16744,
"hgvs_c": "c.1730C>A",
"hgvs_p": "p.Ser577Tyr",
"transcript": "ENST00000866500.1",
"protein_id": "ENSP00000536559.1",
"transcript_support_level": null,
"aa_start": 577,
"aa_end": null,
"aa_length": 898,
"cds_start": 1730,
"cds_end": null,
"cds_length": 2697,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000866500.1"
},
{
"aa_ref": "S",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CIZ1",
"gene_hgnc_id": 16744,
"hgvs_c": "c.1730C>A",
"hgvs_p": "p.Ser577Tyr",
"transcript": "ENST00000866501.1",
"protein_id": "ENSP00000536560.1",
"transcript_support_level": null,
"aa_start": 577,
"aa_end": null,
"aa_length": 898,
"cds_start": 1730,
"cds_end": null,
"cds_length": 2697,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000866501.1"
},
{
"aa_ref": "S",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CIZ1",
"gene_hgnc_id": 16744,
"hgvs_c": "c.1730C>A",
"hgvs_p": "p.Ser577Tyr",
"transcript": "ENST00000866510.1",
"protein_id": "ENSP00000536569.1",
"transcript_support_level": null,
"aa_start": 577,
"aa_end": null,
"aa_length": 898,
"cds_start": 1730,
"cds_end": null,
"cds_length": 2697,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000866510.1"
},
{
"aa_ref": "S",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CIZ1",
"gene_hgnc_id": 16744,
"hgvs_c": "c.1730C>A",
"hgvs_p": "p.Ser577Tyr",
"transcript": "ENST00000866511.1",
"protein_id": "ENSP00000536570.1",
"transcript_support_level": null,
"aa_start": 577,
"aa_end": null,
"aa_length": 898,
"cds_start": 1730,
"cds_end": null,
"cds_length": 2697,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000866511.1"
},
{
"aa_ref": "S",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CIZ1",
"gene_hgnc_id": 16744,
"hgvs_c": "c.1730C>A",
"hgvs_p": "p.Ser577Tyr",
"transcript": "ENST00000866512.1",
"protein_id": "ENSP00000536571.1",
"transcript_support_level": null,
"aa_start": 577,
"aa_end": null,
"aa_length": 898,
"cds_start": 1730,
"cds_end": null,
"cds_length": 2697,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000866512.1"
},
{
"aa_ref": "S",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CIZ1",
"gene_hgnc_id": 16744,
"hgvs_c": "c.1730C>A",
"hgvs_p": "p.Ser577Tyr",
"transcript": "ENST00000866513.1",
"protein_id": "ENSP00000536572.1",
"transcript_support_level": null,
"aa_start": 577,
"aa_end": null,
"aa_length": 898,
"cds_start": 1730,
"cds_end": null,
"cds_length": 2697,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000866513.1"
},
{
"aa_ref": "S",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CIZ1",
"gene_hgnc_id": 16744,
"hgvs_c": "c.1730C>A",
"hgvs_p": "p.Ser577Tyr",
"transcript": "ENST00000965482.1",
"protein_id": "ENSP00000635541.1",
"transcript_support_level": null,
"aa_start": 577,
"aa_end": null,
"aa_length": 898,
"cds_start": 1730,
"cds_end": null,
"cds_length": 2697,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965482.1"
},
{
"aa_ref": "S",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CIZ1",
"gene_hgnc_id": 16744,
"hgvs_c": "c.1730C>A",
"hgvs_p": "p.Ser577Tyr",
"transcript": "ENST00000965485.1",
"protein_id": "ENSP00000635544.1",
"transcript_support_level": null,
"aa_start": 577,
"aa_end": null,
"aa_length": 898,
"cds_start": 1730,
"cds_end": null,
"cds_length": 2697,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965485.1"
},
{
"aa_ref": "S",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CIZ1",
"gene_hgnc_id": 16744,
"hgvs_c": "c.1730C>A",
"hgvs_p": "p.Ser577Tyr",
"transcript": "ENST00000965486.1",
"protein_id": "ENSP00000635545.1",
"transcript_support_level": null,
"aa_start": 577,
"aa_end": null,
"aa_length": 897,
"cds_start": 1730,
"cds_end": null,
"cds_length": 2694,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000965486.1"
},
{
"aa_ref": "S",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CIZ1",
"gene_hgnc_id": 16744,
"hgvs_c": "c.1730C>A",
"hgvs_p": "p.Ser577Tyr",
"transcript": "ENST00000866506.1",
"protein_id": "ENSP00000536565.1",
"transcript_support_level": null,
"aa_start": 577,
"aa_end": null,
"aa_length": 896,
"cds_start": 1730,
"cds_end": null,
"cds_length": 2691,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000866506.1"
},
{
"aa_ref": "S",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CIZ1",
"gene_hgnc_id": 16744,
"hgvs_c": "c.1658C>A",
"hgvs_p": "p.Ser553Tyr",
"transcript": "ENST00000866502.1",
"protein_id": "ENSP00000536561.1",
"transcript_support_level": null,
"aa_start": 553,
"aa_end": null,
"aa_length": 874,
"cds_start": 1658,
"cds_end": null,
"cds_length": 2625,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000866502.1"
},
{
"aa_ref": "S",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CIZ1",
"gene_hgnc_id": 16744,
"hgvs_c": "c.1658C>A",
"hgvs_p": "p.Ser553Tyr",
"transcript": "ENST00000866503.1",
"protein_id": "ENSP00000536562.1",
"transcript_support_level": null,
"aa_start": 553,
"aa_end": null,
"aa_length": 874,
"cds_start": 1658,
"cds_end": null,
"cds_length": 2625,
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