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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 9-137110894-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=137110894&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "9",
"pos": 137110894,
"ref": "G",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_001438108.1",
"consequences": [
{
"aa_ref": "H",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPP7",
"gene_hgnc_id": 14892,
"hgvs_c": "c.1329C>G",
"hgvs_p": "p.His443Gln",
"transcript": "NM_013379.3",
"protein_id": "NP_037511.2",
"transcript_support_level": null,
"aa_start": 443,
"aa_end": null,
"aa_length": 492,
"cds_start": 1329,
"cds_end": null,
"cds_length": 1479,
"cdna_start": 1349,
"cdna_end": null,
"cdna_length": 1601,
"mane_select": "ENST00000371579.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_013379.3"
},
{
"aa_ref": "H",
"aa_alt": "Q",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPP7",
"gene_hgnc_id": 14892,
"hgvs_c": "c.1329C>G",
"hgvs_p": "p.His443Gln",
"transcript": "ENST00000371579.7",
"protein_id": "ENSP00000360635.2",
"transcript_support_level": 1,
"aa_start": 443,
"aa_end": null,
"aa_length": 492,
"cds_start": 1329,
"cds_end": null,
"cds_length": 1479,
"cdna_start": 1349,
"cdna_end": null,
"cdna_length": 1601,
"mane_select": "NM_013379.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000371579.7"
},
{
"aa_ref": "H",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPP7",
"gene_hgnc_id": 14892,
"hgvs_c": "c.1467C>G",
"hgvs_p": "p.His489Gln",
"transcript": "ENST00000894946.1",
"protein_id": "ENSP00000565005.1",
"transcript_support_level": null,
"aa_start": 489,
"aa_end": null,
"aa_length": 538,
"cds_start": 1467,
"cds_end": null,
"cds_length": 1617,
"cdna_start": 1487,
"cdna_end": null,
"cdna_length": 1745,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894946.1"
},
{
"aa_ref": "H",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPP7",
"gene_hgnc_id": 14892,
"hgvs_c": "c.1416C>G",
"hgvs_p": "p.His472Gln",
"transcript": "ENST00000894945.1",
"protein_id": "ENSP00000565004.1",
"transcript_support_level": null,
"aa_start": 472,
"aa_end": null,
"aa_length": 521,
"cds_start": 1416,
"cds_end": null,
"cds_length": 1566,
"cdna_start": 1439,
"cdna_end": null,
"cdna_length": 1696,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894945.1"
},
{
"aa_ref": "H",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPP7",
"gene_hgnc_id": 14892,
"hgvs_c": "c.1395C>G",
"hgvs_p": "p.His465Gln",
"transcript": "NM_001438108.1",
"protein_id": "NP_001425037.1",
"transcript_support_level": null,
"aa_start": 465,
"aa_end": null,
"aa_length": 514,
"cds_start": 1395,
"cds_end": null,
"cds_length": 1545,
"cdna_start": 1415,
"cdna_end": null,
"cdna_length": 1667,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001438108.1"
},
{
"aa_ref": "H",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPP7",
"gene_hgnc_id": 14892,
"hgvs_c": "c.1353C>G",
"hgvs_p": "p.His451Gln",
"transcript": "ENST00000894950.1",
"protein_id": "ENSP00000565009.1",
"transcript_support_level": null,
"aa_start": 451,
"aa_end": null,
"aa_length": 500,
"cds_start": 1353,
"cds_end": null,
"cds_length": 1503,
"cdna_start": 1356,
"cdna_end": null,
"cdna_length": 1608,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894950.1"
},
{
"aa_ref": "H",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPP7",
"gene_hgnc_id": 14892,
"hgvs_c": "c.1326C>G",
"hgvs_p": "p.His442Gln",
"transcript": "ENST00000894947.1",
"protein_id": "ENSP00000565006.1",
"transcript_support_level": null,
"aa_start": 442,
"aa_end": null,
"aa_length": 491,
"cds_start": 1326,
"cds_end": null,
"cds_length": 1476,
"cdna_start": 1336,
"cdna_end": null,
"cdna_length": 1593,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894947.1"
},
{
"aa_ref": "H",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPP7",
"gene_hgnc_id": 14892,
"hgvs_c": "c.1314C>G",
"hgvs_p": "p.His438Gln",
"transcript": "ENST00000718335.1",
"protein_id": "ENSP00000520772.1",
"transcript_support_level": null,
"aa_start": 438,
"aa_end": null,
"aa_length": 487,
"cds_start": 1314,
"cds_end": null,
"cds_length": 1464,
"cdna_start": 1334,
"cdna_end": null,
"cdna_length": 1586,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000718335.1"
},
{
"aa_ref": "H",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPP7",
"gene_hgnc_id": 14892,
"hgvs_c": "c.1311C>G",
"hgvs_p": "p.His437Gln",
"transcript": "ENST00000894943.1",
"protein_id": "ENSP00000565002.1",
"transcript_support_level": null,
"aa_start": 437,
"aa_end": null,
"aa_length": 486,
"cds_start": 1311,
"cds_end": null,
"cds_length": 1461,
"cdna_start": 1350,
"cdna_end": null,
"cdna_length": 1607,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894943.1"
},
{
"aa_ref": "H",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPP7",
"gene_hgnc_id": 14892,
"hgvs_c": "c.1308C>G",
"hgvs_p": "p.His436Gln",
"transcript": "ENST00000960840.1",
"protein_id": "ENSP00000630899.1",
"transcript_support_level": null,
"aa_start": 436,
"aa_end": null,
"aa_length": 485,
"cds_start": 1308,
"cds_end": null,
"cds_length": 1458,
"cdna_start": 1324,
"cdna_end": null,
"cdna_length": 1580,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000960840.1"
},
{
"aa_ref": "H",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPP7",
"gene_hgnc_id": 14892,
"hgvs_c": "c.1296C>G",
"hgvs_p": "p.His432Gln",
"transcript": "ENST00000960841.1",
"protein_id": "ENSP00000630900.1",
"transcript_support_level": null,
"aa_start": 432,
"aa_end": null,
"aa_length": 481,
"cds_start": 1296,
"cds_end": null,
"cds_length": 1446,
"cdna_start": 1316,
"cdna_end": null,
"cdna_length": 1568,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000960841.1"
},
{
"aa_ref": "H",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPP7",
"gene_hgnc_id": 14892,
"hgvs_c": "c.1293C>G",
"hgvs_p": "p.His431Gln",
"transcript": "ENST00000894944.1",
"protein_id": "ENSP00000565003.1",
"transcript_support_level": null,
"aa_start": 431,
"aa_end": null,
"aa_length": 480,
"cds_start": 1293,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1324,
"cdna_end": null,
"cdna_length": 1576,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894944.1"
},
{
"aa_ref": "H",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPP7",
"gene_hgnc_id": 14892,
"hgvs_c": "c.1293C>G",
"hgvs_p": "p.His431Gln",
"transcript": "ENST00000894948.1",
"protein_id": "ENSP00000565007.1",
"transcript_support_level": null,
"aa_start": 431,
"aa_end": null,
"aa_length": 480,
"cds_start": 1293,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1300,
"cdna_end": null,
"cdna_length": 1558,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894948.1"
},
{
"aa_ref": "H",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPP7",
"gene_hgnc_id": 14892,
"hgvs_c": "c.1290C>G",
"hgvs_p": "p.His430Gln",
"transcript": "ENST00000960839.1",
"protein_id": "ENSP00000630898.1",
"transcript_support_level": null,
"aa_start": 430,
"aa_end": null,
"aa_length": 479,
"cds_start": 1290,
"cds_end": null,
"cds_length": 1440,
"cdna_start": 1319,
"cdna_end": null,
"cdna_length": 1571,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000960839.1"
},
{
"aa_ref": "H",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPP7",
"gene_hgnc_id": 14892,
"hgvs_c": "c.1257C>G",
"hgvs_p": "p.His419Gln",
"transcript": "ENST00000894949.1",
"protein_id": "ENSP00000565008.1",
"transcript_support_level": null,
"aa_start": 419,
"aa_end": null,
"aa_length": 468,
"cds_start": 1257,
"cds_end": null,
"cds_length": 1407,
"cdna_start": 1269,
"cdna_end": null,
"cdna_length": 1521,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000894949.1"
},
{
"aa_ref": "P",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPP7",
"gene_hgnc_id": 14892,
"hgvs_c": "c.1327C>G",
"hgvs_p": "p.Pro443Ala",
"transcript": "NM_001438109.1",
"protein_id": "NP_001425038.1",
"transcript_support_level": null,
"aa_start": 443,
"aa_end": null,
"aa_length": 458,
"cds_start": 1327,
"cds_end": null,
"cds_length": 1377,
"cdna_start": 1347,
"cdna_end": null,
"cdna_length": 1599,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001438109.1"
},
{
"aa_ref": "P",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPP7",
"gene_hgnc_id": 14892,
"hgvs_c": "c.1261C>G",
"hgvs_p": "p.Pro421Ala",
"transcript": "NM_001438110.1",
"protein_id": "NP_001425039.1",
"transcript_support_level": null,
"aa_start": 421,
"aa_end": null,
"aa_length": 436,
"cds_start": 1261,
"cds_end": null,
"cds_length": 1311,
"cdna_start": 1281,
"cdna_end": null,
"cdna_length": 1533,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001438110.1"
},
{
"aa_ref": "P",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPP7",
"gene_hgnc_id": 14892,
"hgvs_c": "c.1261C>G",
"hgvs_p": "p.Pro421Ala",
"transcript": "ENST00000718334.1",
"protein_id": "ENSP00000520771.1",
"transcript_support_level": null,
"aa_start": 421,
"aa_end": null,
"aa_length": 436,
"cds_start": 1261,
"cds_end": null,
"cds_length": 1311,
"cdna_start": 1281,
"cdna_end": null,
"cdna_length": 1533,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000718334.1"
},
{
"aa_ref": "H",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPP7",
"gene_hgnc_id": 14892,
"hgvs_c": "c.1305C>G",
"hgvs_p": "p.His435Gln",
"transcript": "XM_011518600.2",
"protein_id": "XP_011516902.1",
"transcript_support_level": null,
"aa_start": 435,
"aa_end": null,
"aa_length": 484,
"cds_start": 1305,
"cds_end": null,
"cds_length": 1455,
"cdna_start": 1320,
"cdna_end": null,
"cdna_length": 1572,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011518600.2"
},
{
"aa_ref": "H",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPP7",
"gene_hgnc_id": 14892,
"hgvs_c": "c.1185C>G",
"hgvs_p": "p.His395Gln",
"transcript": "XM_047423280.1",
"protein_id": "XP_047279236.1",
"transcript_support_level": null,
"aa_start": 395,
"aa_end": null,
"aa_length": 444,
"cds_start": 1185,
"cds_end": null,
"cds_length": 1335,
"cdna_start": 1205,
"cdna_end": null,
"cdna_length": 1457,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047423280.1"
},
{
"aa_ref": "H",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPP7",
"gene_hgnc_id": 14892,
"hgvs_c": "c.1095C>G",
"hgvs_p": "p.His365Gln",
"transcript": "XM_047423281.1",
"protein_id": "XP_047279237.1",
"transcript_support_level": null,
"aa_start": 365,
"aa_end": null,
"aa_length": 414,
"cds_start": 1095,
"cds_end": null,
"cds_length": 1245,
"cdna_start": 1436,
"cdna_end": null,
"cdna_length": 1688,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047423281.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPP7",
"gene_hgnc_id": 14892,
"hgvs_c": "n.1882C>G",
"hgvs_p": null,
"transcript": "ENST00000460830.2",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
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"hgvs_p": "p.His465Gln"
}
],
"clinvar_disease": "not specified",
"clinvar_classification": "Uncertain significance",
"clinvar_review_status": "criteria provided, single submitter",
"clinvar_submissions_summary": "US:1",
"phenotype_combined": "not specified",
"pathogenicity_classification_combined": "Uncertain significance",
"custom_annotations": null
}
],
"message": null
}