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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 9-137429360-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=137429360&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "9",
"pos": 137429360,
"ref": "G",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_006647.2",
"consequences": [
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOXA1",
"gene_hgnc_id": 10668,
"hgvs_c": "c.589G>C",
"hgvs_p": "p.Val197Leu",
"transcript": "NM_001256067.2",
"protein_id": "NP_001242996.1",
"transcript_support_level": null,
"aa_start": 197,
"aa_end": null,
"aa_length": 476,
"cds_start": 589,
"cds_end": null,
"cds_length": 1431,
"cdna_start": 726,
"cdna_end": null,
"cdna_length": 1614,
"mane_select": "ENST00000683555.1",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001256067.2"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOXA1",
"gene_hgnc_id": 10668,
"hgvs_c": "c.589G>C",
"hgvs_p": "p.Val197Leu",
"transcript": "ENST00000683555.1",
"protein_id": "ENSP00000507846.1",
"transcript_support_level": null,
"aa_start": 197,
"aa_end": null,
"aa_length": 476,
"cds_start": 589,
"cds_end": null,
"cds_length": 1431,
"cdna_start": 726,
"cdna_end": null,
"cdna_length": 1614,
"mane_select": "NM_001256067.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000683555.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOXA1",
"gene_hgnc_id": 10668,
"hgvs_c": "c.589G>C",
"hgvs_p": "p.Val197Leu",
"transcript": "ENST00000341349.6",
"protein_id": "ENSP00000342848.2",
"transcript_support_level": 1,
"aa_start": 197,
"aa_end": null,
"aa_length": 483,
"cds_start": 589,
"cds_end": null,
"cds_length": 1452,
"cdna_start": 769,
"cdna_end": null,
"cdna_length": 1678,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000341349.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "NOXA1",
"gene_hgnc_id": 10668,
"hgvs_c": "c.504+344G>C",
"hgvs_p": null,
"transcript": "ENST00000392815.2",
"protein_id": "ENSP00000376562.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 427,
"cds_start": null,
"cds_end": null,
"cds_length": 1284,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1464,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000392815.2"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOXA1",
"gene_hgnc_id": 10668,
"hgvs_c": "c.781G>C",
"hgvs_p": "p.Val261Leu",
"transcript": "ENST00000967001.1",
"protein_id": "ENSP00000637060.1",
"transcript_support_level": null,
"aa_start": 261,
"aa_end": null,
"aa_length": 540,
"cds_start": 781,
"cds_end": null,
"cds_length": 1623,
"cdna_start": 954,
"cdna_end": null,
"cdna_length": 1841,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000967001.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOXA1",
"gene_hgnc_id": 10668,
"hgvs_c": "c.589G>C",
"hgvs_p": "p.Val197Leu",
"transcript": "ENST00000881446.1",
"protein_id": "ENSP00000551505.1",
"transcript_support_level": null,
"aa_start": 197,
"aa_end": null,
"aa_length": 527,
"cds_start": 589,
"cds_end": null,
"cds_length": 1584,
"cdna_start": 726,
"cdna_end": null,
"cdna_length": 1765,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000881446.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOXA1",
"gene_hgnc_id": 10668,
"hgvs_c": "c.685G>C",
"hgvs_p": "p.Val229Leu",
"transcript": "ENST00000881447.1",
"protein_id": "ENSP00000551506.1",
"transcript_support_level": null,
"aa_start": 229,
"aa_end": null,
"aa_length": 508,
"cds_start": 685,
"cds_end": null,
"cds_length": 1527,
"cdna_start": 813,
"cdna_end": null,
"cdna_length": 1699,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000881447.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOXA1",
"gene_hgnc_id": 10668,
"hgvs_c": "c.589G>C",
"hgvs_p": "p.Val197Leu",
"transcript": "ENST00000881442.1",
"protein_id": "ENSP00000551501.1",
"transcript_support_level": null,
"aa_start": 197,
"aa_end": null,
"aa_length": 505,
"cds_start": 589,
"cds_end": null,
"cds_length": 1518,
"cdna_start": 736,
"cdna_end": null,
"cdna_length": 1710,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000881442.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOXA1",
"gene_hgnc_id": 10668,
"hgvs_c": "c.589G>C",
"hgvs_p": "p.Val197Leu",
"transcript": "ENST00000881444.1",
"protein_id": "ENSP00000551503.1",
"transcript_support_level": null,
"aa_start": 197,
"aa_end": null,
"aa_length": 505,
"cds_start": 589,
"cds_end": null,
"cds_length": 1518,
"cdna_start": 729,
"cdna_end": null,
"cdna_length": 1702,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000881444.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOXA1",
"gene_hgnc_id": 10668,
"hgvs_c": "c.661G>C",
"hgvs_p": "p.Val221Leu",
"transcript": "ENST00000881439.1",
"protein_id": "ENSP00000551498.1",
"transcript_support_level": null,
"aa_start": 221,
"aa_end": null,
"aa_length": 500,
"cds_start": 661,
"cds_end": null,
"cds_length": 1503,
"cdna_start": 829,
"cdna_end": null,
"cdna_length": 1717,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000881439.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOXA1",
"gene_hgnc_id": 10668,
"hgvs_c": "c.589G>C",
"hgvs_p": "p.Val197Leu",
"transcript": "ENST00000881438.1",
"protein_id": "ENSP00000551497.1",
"transcript_support_level": null,
"aa_start": 197,
"aa_end": null,
"aa_length": 498,
"cds_start": 589,
"cds_end": null,
"cds_length": 1497,
"cdna_start": 739,
"cdna_end": null,
"cdna_length": 1738,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000881438.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOXA1",
"gene_hgnc_id": 10668,
"hgvs_c": "c.589G>C",
"hgvs_p": "p.Val197Leu",
"transcript": "NM_006647.2",
"protein_id": "NP_006638.1",
"transcript_support_level": null,
"aa_start": 197,
"aa_end": null,
"aa_length": 483,
"cds_start": 589,
"cds_end": null,
"cds_length": 1452,
"cdna_start": 726,
"cdna_end": null,
"cdna_length": 1635,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_006647.2"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOXA1",
"gene_hgnc_id": 10668,
"hgvs_c": "c.589G>C",
"hgvs_p": "p.Val197Leu",
"transcript": "ENST00000881445.1",
"protein_id": "ENSP00000551504.1",
"transcript_support_level": null,
"aa_start": 197,
"aa_end": null,
"aa_length": 482,
"cds_start": 589,
"cds_end": null,
"cds_length": 1449,
"cdna_start": 726,
"cdna_end": null,
"cdna_length": 1632,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000881445.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOXA1",
"gene_hgnc_id": 10668,
"hgvs_c": "c.562G>C",
"hgvs_p": "p.Val188Leu",
"transcript": "ENST00000881440.1",
"protein_id": "ENSP00000551499.1",
"transcript_support_level": null,
"aa_start": 188,
"aa_end": null,
"aa_length": 467,
"cds_start": 562,
"cds_end": null,
"cds_length": 1404,
"cdna_start": 713,
"cdna_end": null,
"cdna_length": 1601,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000881440.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOXA1",
"gene_hgnc_id": 10668,
"hgvs_c": "c.562G>C",
"hgvs_p": "p.Val188Leu",
"transcript": "ENST00000967005.1",
"protein_id": "ENSP00000637064.1",
"transcript_support_level": null,
"aa_start": 188,
"aa_end": null,
"aa_length": 467,
"cds_start": 562,
"cds_end": null,
"cds_length": 1404,
"cdna_start": 690,
"cdna_end": null,
"cdna_length": 1577,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000967005.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOXA1",
"gene_hgnc_id": 10668,
"hgvs_c": "c.589G>C",
"hgvs_p": "p.Val197Leu",
"transcript": "ENST00000881441.1",
"protein_id": "ENSP00000551500.1",
"transcript_support_level": null,
"aa_start": 197,
"aa_end": null,
"aa_length": 460,
"cds_start": 589,
"cds_end": null,
"cds_length": 1383,
"cdna_start": 738,
"cdna_end": null,
"cdna_length": 1577,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000881441.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOXA1",
"gene_hgnc_id": 10668,
"hgvs_c": "c.589G>C",
"hgvs_p": "p.Val197Leu",
"transcript": "ENST00000967002.1",
"protein_id": "ENSP00000637061.1",
"transcript_support_level": null,
"aa_start": 197,
"aa_end": null,
"aa_length": 441,
"cds_start": 589,
"cds_end": null,
"cds_length": 1326,
"cdna_start": 724,
"cdna_end": null,
"cdna_length": 1512,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000967002.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOXA1",
"gene_hgnc_id": 10668,
"hgvs_c": "c.562G>C",
"hgvs_p": "p.Val188Leu",
"transcript": "ENST00000967003.1",
"protein_id": "ENSP00000637062.1",
"transcript_support_level": null,
"aa_start": 188,
"aa_end": null,
"aa_length": 432,
"cds_start": 562,
"cds_end": null,
"cds_length": 1299,
"cdna_start": 695,
"cdna_end": null,
"cdna_length": 1476,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000967003.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOXA1",
"gene_hgnc_id": 10668,
"hgvs_c": "c.145G>C",
"hgvs_p": "p.Val49Leu",
"transcript": "XM_011518159.2",
"protein_id": "XP_011516461.1",
"transcript_support_level": null,
"aa_start": 49,
"aa_end": null,
"aa_length": 335,
"cds_start": 145,
"cds_end": null,
"cds_length": 1008,
"cdna_start": 526,
"cdna_end": null,
"cdna_length": 1435,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011518159.2"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOXA1",
"gene_hgnc_id": 10668,
"hgvs_c": "c.145G>C",
"hgvs_p": "p.Val49Leu",
"transcript": "XM_047422659.1",
"protein_id": "XP_047278615.1",
"transcript_support_level": null,
"aa_start": 49,
"aa_end": null,
"aa_length": 335,
"cds_start": 145,
"cds_end": null,
"cds_length": 1008,
"cdna_start": 2290,
"cdna_end": null,
"cdna_length": 3199,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047422659.1"
},
{
"aa_ref": "V",
"aa_alt": "L",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOXA1",
"gene_hgnc_id": 10668,
"hgvs_c": "c.589G>C",
"hgvs_p": "p.Val197Leu",
"transcript": "XM_047422660.1",
"protein_id": "XP_047278616.1",
"transcript_support_level": null,
"aa_start": 197,
"aa_end": null,
"aa_length": 246,
"cds_start": 589,
"cds_end": null,
"cds_length": 741,
"cdna_start": 726,
"cdna_end": null,
"cdna_length": 903,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047422660.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "NOXA1",
"gene_hgnc_id": 10668,
"hgvs_c": "c.600+344G>C",
"hgvs_p": null,
"transcript": "ENST00000967004.1",
"protein_id": "ENSP00000637063.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 472,
"cds_start": null,
"cds_end": null,
"cds_length": 1419,
"cdna_start": null,
"cdna_end": null,
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}
],
"message": null
}