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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 9-137449656-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=137449656&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "9",
"pos": 137449656,
"ref": "T",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_001130969.3",
"consequences": [
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSMF",
"gene_hgnc_id": 29843,
"hgvs_c": "c.1438A>G",
"hgvs_p": "p.Thr480Ala",
"transcript": "NM_001130969.3",
"protein_id": "NP_001124441.1",
"transcript_support_level": null,
"aa_start": 480,
"aa_end": null,
"aa_length": 530,
"cds_start": 1438,
"cds_end": null,
"cds_length": 1593,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000371475.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001130969.3"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSMF",
"gene_hgnc_id": 29843,
"hgvs_c": "c.1438A>G",
"hgvs_p": "p.Thr480Ala",
"transcript": "ENST00000371475.9",
"protein_id": "ENSP00000360530.3",
"transcript_support_level": 1,
"aa_start": 480,
"aa_end": null,
"aa_length": 530,
"cds_start": 1438,
"cds_end": null,
"cds_length": 1593,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001130969.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000371475.9"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSMF",
"gene_hgnc_id": 29843,
"hgvs_c": "c.1432A>G",
"hgvs_p": "p.Thr478Ala",
"transcript": "ENST00000265663.12",
"protein_id": "ENSP00000265663.7",
"transcript_support_level": 1,
"aa_start": 478,
"aa_end": null,
"aa_length": 528,
"cds_start": 1432,
"cds_end": null,
"cds_length": 1587,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000265663.12"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSMF",
"gene_hgnc_id": 29843,
"hgvs_c": "c.1432A>G",
"hgvs_p": "p.Thr478Ala",
"transcript": "ENST00000371472.6",
"protein_id": "ENSP00000360527.1",
"transcript_support_level": 2,
"aa_start": 478,
"aa_end": null,
"aa_length": 528,
"cds_start": 1432,
"cds_end": null,
"cds_length": 1587,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000371472.6"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSMF",
"gene_hgnc_id": 29843,
"hgvs_c": "c.1363A>G",
"hgvs_p": "p.Thr455Ala",
"transcript": "ENST00000371474.7",
"protein_id": "ENSP00000360529.3",
"transcript_support_level": 1,
"aa_start": 455,
"aa_end": null,
"aa_length": 505,
"cds_start": 1363,
"cds_end": null,
"cds_length": 1518,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000371474.7"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSMF",
"gene_hgnc_id": 29843,
"hgvs_c": "c.1348A>G",
"hgvs_p": "p.Thr450Ala",
"transcript": "ENST00000371473.7",
"protein_id": "ENSP00000360528.3",
"transcript_support_level": 1,
"aa_start": 450,
"aa_end": null,
"aa_length": 500,
"cds_start": 1348,
"cds_end": null,
"cds_length": 1503,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000371473.7"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSMF",
"gene_hgnc_id": 29843,
"hgvs_c": "n.1564A>G",
"hgvs_p": null,
"transcript": "ENST00000371482.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000371482.5"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSMF",
"gene_hgnc_id": 29843,
"hgvs_c": "c.1657A>G",
"hgvs_p": "p.Thr553Ala",
"transcript": "ENST00000934994.1",
"protein_id": "ENSP00000605053.1",
"transcript_support_level": null,
"aa_start": 553,
"aa_end": null,
"aa_length": 603,
"cds_start": 1657,
"cds_end": null,
"cds_length": 1812,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000934994.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSMF",
"gene_hgnc_id": 29843,
"hgvs_c": "c.1618A>G",
"hgvs_p": "p.Thr540Ala",
"transcript": "ENST00000935000.1",
"protein_id": "ENSP00000605059.1",
"transcript_support_level": null,
"aa_start": 540,
"aa_end": null,
"aa_length": 590,
"cds_start": 1618,
"cds_end": null,
"cds_length": 1773,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000935000.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSMF",
"gene_hgnc_id": 29843,
"hgvs_c": "c.1588A>G",
"hgvs_p": "p.Thr530Ala",
"transcript": "ENST00000934996.1",
"protein_id": "ENSP00000605055.1",
"transcript_support_level": null,
"aa_start": 530,
"aa_end": null,
"aa_length": 580,
"cds_start": 1588,
"cds_end": null,
"cds_length": 1743,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000934996.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSMF",
"gene_hgnc_id": 29843,
"hgvs_c": "c.1474A>G",
"hgvs_p": "p.Thr492Ala",
"transcript": "ENST00000961356.1",
"protein_id": "ENSP00000631415.1",
"transcript_support_level": null,
"aa_start": 492,
"aa_end": null,
"aa_length": 542,
"cds_start": 1474,
"cds_end": null,
"cds_length": 1629,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961356.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSMF",
"gene_hgnc_id": 29843,
"hgvs_c": "c.1456A>G",
"hgvs_p": "p.Thr486Ala",
"transcript": "ENST00000861168.1",
"protein_id": "ENSP00000531227.1",
"transcript_support_level": null,
"aa_start": 486,
"aa_end": null,
"aa_length": 536,
"cds_start": 1456,
"cds_end": null,
"cds_length": 1611,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000861168.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSMF",
"gene_hgnc_id": 29843,
"hgvs_c": "c.1432A>G",
"hgvs_p": "p.Thr478Ala",
"transcript": "NM_015537.5",
"protein_id": "NP_056352.3",
"transcript_support_level": null,
"aa_start": 478,
"aa_end": null,
"aa_length": 528,
"cds_start": 1432,
"cds_end": null,
"cds_length": 1587,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_015537.5"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSMF",
"gene_hgnc_id": 29843,
"hgvs_c": "c.1432A>G",
"hgvs_p": "p.Thr478Ala",
"transcript": "ENST00000934993.1",
"protein_id": "ENSP00000605052.1",
"transcript_support_level": null,
"aa_start": 478,
"aa_end": null,
"aa_length": 528,
"cds_start": 1432,
"cds_end": null,
"cds_length": 1587,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000934993.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSMF",
"gene_hgnc_id": 29843,
"hgvs_c": "c.1423A>G",
"hgvs_p": "p.Thr475Ala",
"transcript": "ENST00000934998.1",
"protein_id": "ENSP00000605057.1",
"transcript_support_level": null,
"aa_start": 475,
"aa_end": null,
"aa_length": 525,
"cds_start": 1423,
"cds_end": null,
"cds_length": 1578,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000934998.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSMF",
"gene_hgnc_id": 29843,
"hgvs_c": "c.1423A>G",
"hgvs_p": "p.Thr475Ala",
"transcript": "ENST00000961354.1",
"protein_id": "ENSP00000631413.1",
"transcript_support_level": null,
"aa_start": 475,
"aa_end": null,
"aa_length": 525,
"cds_start": 1423,
"cds_end": null,
"cds_length": 1578,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961354.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSMF",
"gene_hgnc_id": 29843,
"hgvs_c": "c.1423A>G",
"hgvs_p": "p.Thr475Ala",
"transcript": "ENST00000961355.1",
"protein_id": "ENSP00000631414.1",
"transcript_support_level": null,
"aa_start": 475,
"aa_end": null,
"aa_length": 525,
"cds_start": 1423,
"cds_end": null,
"cds_length": 1578,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961355.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSMF",
"gene_hgnc_id": 29843,
"hgvs_c": "c.1417A>G",
"hgvs_p": "p.Thr473Ala",
"transcript": "ENST00000934995.1",
"protein_id": "ENSP00000605054.1",
"transcript_support_level": null,
"aa_start": 473,
"aa_end": null,
"aa_length": 523,
"cds_start": 1417,
"cds_end": null,
"cds_length": 1572,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000934995.1"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSMF",
"gene_hgnc_id": 29843,
"hgvs_c": "c.1369A>G",
"hgvs_p": "p.Thr457Ala",
"transcript": "NM_001130970.2",
"protein_id": "NP_001124442.1",
"transcript_support_level": null,
"aa_start": 457,
"aa_end": null,
"aa_length": 507,
"cds_start": 1369,
"cds_end": null,
"cds_length": 1524,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001130970.2"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSMF",
"gene_hgnc_id": 29843,
"hgvs_c": "c.1369A>G",
"hgvs_p": "p.Thr457Ala",
"transcript": "ENST00000437259.5",
"protein_id": "ENSP00000412007.1",
"transcript_support_level": 5,
"aa_start": 457,
"aa_end": null,
"aa_length": 507,
"cds_start": 1369,
"cds_end": null,
"cds_length": 1524,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000437259.5"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSMF",
"gene_hgnc_id": 29843,
"hgvs_c": "c.1363A>G",
"hgvs_p": "p.Thr455Ala",
"transcript": "NM_001130971.2",
"protein_id": "NP_001124443.1",
"transcript_support_level": null,
"aa_start": 455,
"aa_end": null,
"aa_length": 505,
"cds_start": 1363,
"cds_end": null,
"cds_length": 1518,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001130971.2"
},
{
"aa_ref": "T",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSMF",
"gene_hgnc_id": 29843,
"hgvs_c": "c.1354A>G",
"hgvs_p": "p.Thr452Ala",
"transcript": "ENST00000934999.1",
"protein_id": "ENSP00000605058.1",
"transcript_support_level": null,
"aa_start": 452,
"aa_end": null,
"aa_length": 502,
"cds_start": 1354,
"cds_end": null,
"cds_length": 1509,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
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"biotype": "protein_coding",
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}