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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 9-137564451-T-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=137564451&ref=T&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "9",
"pos": 137564451,
"ref": "T",
"alt": "A",
"effect": "missense_variant",
"transcript": "ENST00000277540.7",
"consequences": [
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPH7",
"gene_hgnc_id": 25199,
"hgvs_c": "c.932A>T",
"hgvs_p": "p.Asn311Ile",
"transcript": "NM_138778.5",
"protein_id": "NP_620133.1",
"transcript_support_level": null,
"aa_start": 311,
"aa_end": null,
"aa_length": 452,
"cds_start": 932,
"cds_end": null,
"cds_length": 1359,
"cdna_start": 1080,
"cdna_end": null,
"cdna_length": 2302,
"mane_select": "ENST00000277540.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPH7",
"gene_hgnc_id": 25199,
"hgvs_c": "c.932A>T",
"hgvs_p": "p.Asn311Ile",
"transcript": "ENST00000277540.7",
"protein_id": "ENSP00000277540.2",
"transcript_support_level": 1,
"aa_start": 311,
"aa_end": null,
"aa_length": 452,
"cds_start": 932,
"cds_end": null,
"cds_length": 1359,
"cdna_start": 1080,
"cdna_end": null,
"cdna_length": 2302,
"mane_select": "NM_138778.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPH7",
"gene_hgnc_id": 25199,
"hgvs_c": "n.549A>T",
"hgvs_p": null,
"transcript": "ENST00000467243.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1311,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPH7",
"gene_hgnc_id": 25199,
"hgvs_c": "c.866A>T",
"hgvs_p": "p.Asn289Ile",
"transcript": "NM_001346370.2",
"protein_id": "NP_001333299.1",
"transcript_support_level": null,
"aa_start": 289,
"aa_end": null,
"aa_length": 430,
"cds_start": 866,
"cds_end": null,
"cds_length": 1293,
"cdna_start": 1014,
"cdna_end": null,
"cdna_length": 2236,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPH7",
"gene_hgnc_id": 25199,
"hgvs_c": "c.932A>T",
"hgvs_p": "p.Asn311Ile",
"transcript": "NM_001346371.2",
"protein_id": "NP_001333300.1",
"transcript_support_level": null,
"aa_start": 311,
"aa_end": null,
"aa_length": 336,
"cds_start": 932,
"cds_end": null,
"cds_length": 1011,
"cdna_start": 1080,
"cdna_end": null,
"cdna_length": 3469,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPH7",
"gene_hgnc_id": 25199,
"hgvs_c": "c.932A>T",
"hgvs_p": "p.Asn311Ile",
"transcript": "NM_001346372.2",
"protein_id": "NP_001333301.1",
"transcript_support_level": null,
"aa_start": 311,
"aa_end": null,
"aa_length": 323,
"cds_start": 932,
"cds_end": null,
"cds_length": 972,
"cdna_start": 1080,
"cdna_end": null,
"cdna_length": 3518,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPH7",
"gene_hgnc_id": 25199,
"hgvs_c": "c.530A>T",
"hgvs_p": "p.Asn177Ile",
"transcript": "NM_001346373.2",
"protein_id": "NP_001333302.1",
"transcript_support_level": null,
"aa_start": 177,
"aa_end": null,
"aa_length": 318,
"cds_start": 530,
"cds_end": null,
"cds_length": 957,
"cdna_start": 636,
"cdna_end": null,
"cdna_length": 1858,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPH7",
"gene_hgnc_id": 25199,
"hgvs_c": "c.866A>T",
"hgvs_p": "p.Asn289Ile",
"transcript": "NM_001346374.2",
"protein_id": "NP_001333303.1",
"transcript_support_level": null,
"aa_start": 289,
"aa_end": null,
"aa_length": 301,
"cds_start": 866,
"cds_end": null,
"cds_length": 906,
"cdna_start": 1014,
"cdna_end": null,
"cdna_length": 3452,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPH7",
"gene_hgnc_id": 25199,
"hgvs_c": "c.404A>T",
"hgvs_p": "p.Asn135Ile",
"transcript": "NM_001346375.2",
"protein_id": "NP_001333304.1",
"transcript_support_level": null,
"aa_start": 135,
"aa_end": null,
"aa_length": 276,
"cds_start": 404,
"cds_end": null,
"cds_length": 831,
"cdna_start": 1320,
"cdna_end": null,
"cdna_length": 2542,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPH7",
"gene_hgnc_id": 25199,
"hgvs_c": "c.404A>T",
"hgvs_p": "p.Asn135Ile",
"transcript": "NM_001346376.2",
"protein_id": "NP_001333305.1",
"transcript_support_level": null,
"aa_start": 135,
"aa_end": null,
"aa_length": 276,
"cds_start": 404,
"cds_end": null,
"cds_length": 831,
"cdna_start": 1548,
"cdna_end": null,
"cdna_length": 2770,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPH7",
"gene_hgnc_id": 25199,
"hgvs_c": "c.404A>T",
"hgvs_p": "p.Asn135Ile",
"transcript": "NM_001346377.2",
"protein_id": "NP_001333306.1",
"transcript_support_level": null,
"aa_start": 135,
"aa_end": null,
"aa_length": 276,
"cds_start": 404,
"cds_end": null,
"cds_length": 831,
"cdna_start": 1174,
"cdna_end": null,
"cdna_length": 2396,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPH7",
"gene_hgnc_id": 25199,
"hgvs_c": "c.404A>T",
"hgvs_p": "p.Asn135Ile",
"transcript": "NM_001346378.2",
"protein_id": "NP_001333307.1",
"transcript_support_level": null,
"aa_start": 135,
"aa_end": null,
"aa_length": 276,
"cds_start": 404,
"cds_end": null,
"cds_length": 831,
"cdna_start": 1177,
"cdna_end": null,
"cdna_length": 2399,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPH7",
"gene_hgnc_id": 25199,
"hgvs_c": "c.404A>T",
"hgvs_p": "p.Asn135Ile",
"transcript": "NM_001346379.2",
"protein_id": "NP_001333308.1",
"transcript_support_level": null,
"aa_start": 135,
"aa_end": null,
"aa_length": 276,
"cds_start": 404,
"cds_end": null,
"cds_length": 831,
"cdna_start": 1363,
"cdna_end": null,
"cdna_length": 2585,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPH7",
"gene_hgnc_id": 25199,
"hgvs_c": "c.404A>T",
"hgvs_p": "p.Asn135Ile",
"transcript": "NM_001346380.2",
"protein_id": "NP_001333309.1",
"transcript_support_level": null,
"aa_start": 135,
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"cds_start": 404,
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"cdna_start": 1360,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPH7",
"gene_hgnc_id": 25199,
"hgvs_c": "c.404A>T",
"hgvs_p": "p.Asn135Ile",
"transcript": "NM_001346381.2",
"protein_id": "NP_001333310.1",
"transcript_support_level": null,
"aa_start": 135,
"aa_end": null,
"aa_length": 276,
"cds_start": 404,
"cds_end": null,
"cds_length": 831,
"cdna_start": 1640,
"cdna_end": null,
"cdna_length": 2862,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPH7",
"gene_hgnc_id": 25199,
"hgvs_c": "c.404A>T",
"hgvs_p": "p.Asn135Ile",
"transcript": "NM_001346382.2",
"protein_id": "NP_001333311.1",
"transcript_support_level": null,
"aa_start": 135,
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"cds_start": 404,
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"cdna_start": 1454,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPH7",
"gene_hgnc_id": 25199,
"hgvs_c": "c.404A>T",
"hgvs_p": "p.Asn135Ile",
"transcript": "NM_001346383.2",
"protein_id": "NP_001333312.1",
"transcript_support_level": null,
"aa_start": 135,
"aa_end": null,
"aa_length": 276,
"cds_start": 404,
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"cds_length": 831,
"cdna_start": 1451,
"cdna_end": null,
"cdna_length": 2673,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPH7",
"gene_hgnc_id": 25199,
"hgvs_c": "c.404A>T",
"hgvs_p": "p.Asn135Ile",
"transcript": "NM_001346384.2",
"protein_id": "NP_001333313.1",
"transcript_support_level": null,
"aa_start": 135,
"aa_end": null,
"aa_length": 276,
"cds_start": 404,
"cds_end": null,
"cds_length": 831,
"cdna_start": 946,
"cdna_end": null,
"cdna_length": 2168,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPH7",
"gene_hgnc_id": 25199,
"hgvs_c": "c.404A>T",
"hgvs_p": "p.Asn135Ile",
"transcript": "NM_001346385.2",
"protein_id": "NP_001333314.1",
"transcript_support_level": null,
"aa_start": 135,
"aa_end": null,
"aa_length": 276,
"cds_start": 404,
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"cdna_start": 1317,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPH7",
"gene_hgnc_id": 25199,
"hgvs_c": "c.404A>T",
"hgvs_p": "p.Asn135Ile",
"transcript": "NM_001346386.2",
"protein_id": "NP_001333315.1",
"transcript_support_level": null,
"aa_start": 135,
"aa_end": null,
"aa_length": 276,
"cds_start": 404,
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"cdna_start": 2371,
"cdna_end": null,
"cdna_length": 3593,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPH7",
"gene_hgnc_id": 25199,
"hgvs_c": "c.404A>T",
"hgvs_p": "p.Asn135Ile",
"transcript": "NM_001346387.2",
"protein_id": "NP_001333316.1",
"transcript_support_level": null,
"aa_start": 135,
"aa_end": null,
"aa_length": 276,
"cds_start": 404,
"cds_end": null,
"cds_length": 831,
"cdna_start": 1040,
"cdna_end": null,
"cdna_length": 2262,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPH7",
"gene_hgnc_id": 25199,
"hgvs_c": "c.404A>T",
"hgvs_p": "p.Asn135Ile",
"transcript": "NM_001346388.2",
"protein_id": "NP_001333317.1",
"transcript_support_level": null,
"aa_start": 135,
"aa_end": null,
"aa_length": 276,
"cds_start": 404,
"cds_end": null,
"cds_length": 831,
"cdna_start": 1041,
"cdna_end": null,
"cdna_length": 2263,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "N",
"aa_alt": "I",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DPH7",
"gene_hgnc_id": 25199,
"hgvs_c": "c.404A>T",
"hgvs_p": "p.Asn135Ile",
"transcript": "NM_001346389.2",
"protein_id": "NP_001333318.1",
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}
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}