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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 9-146108-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=146108&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 0,
          "criteria": [
            "PM2"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "ZNG1A",
          "hgnc_id": 17134,
          "hgvs_c": "c.758G>A",
          "hgvs_p": "p.Gly253Glu",
          "inheritance_mode": "",
          "pathogenic_score": 2,
          "score": 2,
          "transcript": "NM_018491.5",
          "verdict": "Uncertain_significance"
        },
        {
          "benign_score": 0,
          "criteria": [
            "PM2"
          ],
          "effects": [
            "intron_variant"
          ],
          "gene_symbol": "ENSG00000302830",
          "hgnc_id": null,
          "hgvs_c": "n.848+6362C>T",
          "hgvs_p": null,
          "inheritance_mode": "",
          "pathogenic_score": 2,
          "score": 2,
          "transcript": "ENST00000789896.1",
          "verdict": "Uncertain_significance"
        }
      ],
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2",
      "acmg_score": 2,
      "allele_count_reference_population": 0,
      "alphamissense_prediction": null,
      "alphamissense_score": 0.2427,
      "alt": "T",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Benign",
      "bayesdelnoaf_score": -0.15,
      "chr": "9",
      "clinvar_classification": "",
      "clinvar_disease": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "computational_prediction_selected": "Uncertain_significance",
      "computational_score_selected": 0.6959476470947266,
      "computational_source_selected": "MetaRNN",
      "consequences": [
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 395,
          "aa_ref": "G",
          "aa_start": 253,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1905,
          "cdna_start": 845,
          "cds_end": null,
          "cds_length": 1188,
          "cds_start": 758,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 15,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "NM_018491.5",
          "gene_hgnc_id": 17134,
          "gene_symbol": "ZNG1A",
          "hgvs_c": "c.758G>A",
          "hgvs_p": "p.Gly253Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000356521.9",
          "protein_coding": true,
          "protein_id": "NP_060961.3",
          "strand": false,
          "transcript": "NM_018491.5",
          "transcript_support_level": null
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 395,
          "aa_ref": "G",
          "aa_start": 253,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 1905,
          "cdna_start": 845,
          "cds_end": null,
          "cds_length": 1188,
          "cds_start": 758,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 15,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "ENST00000356521.9",
          "gene_hgnc_id": 17134,
          "gene_symbol": "ZNG1A",
          "hgvs_c": "c.758G>A",
          "hgvs_p": "p.Gly253Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_018491.5",
          "protein_coding": true,
          "protein_id": "ENSP00000348915.4",
          "strand": false,
          "transcript": "ENST00000356521.9",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 395,
          "aa_ref": "G",
          "aa_start": 253,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1792,
          "cdna_start": 936,
          "cds_end": null,
          "cds_length": 1188,
          "cds_start": 758,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 15,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "ENST00000377400.8",
          "gene_hgnc_id": 17134,
          "gene_symbol": "ZNG1A",
          "hgvs_c": "c.758G>A",
          "hgvs_p": "p.Gly253Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000366617.5",
          "strand": false,
          "transcript": "ENST00000377400.8",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 359,
          "aa_ref": "G",
          "aa_start": 217,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1771,
          "cdna_start": 934,
          "cds_end": null,
          "cds_length": 1080,
          "cds_start": 650,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 16,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000314367.14",
          "gene_hgnc_id": 17134,
          "gene_symbol": "ZNG1A",
          "hgvs_c": "c.650G>A",
          "hgvs_p": "p.Gly217Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000323433.10",
          "strand": false,
          "transcript": "ENST00000314367.14",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 376,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1241,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 1131,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 14,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000382447.8",
          "gene_hgnc_id": 17134,
          "gene_symbol": "ZNG1A",
          "hgvs_c": "c.707+5926G>A",
          "hgvs_p": null,
          "intron_rank": 9,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000371885.4",
          "strand": false,
          "transcript": "ENST00000382447.8",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 1585,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 15,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "ENST00000465014.6",
          "gene_hgnc_id": 17134,
          "gene_symbol": "ZNG1A",
          "hgvs_c": "n.*356G>A",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": "ENSP00000482298.1",
          "strand": false,
          "transcript": "ENST00000465014.6",
          "transcript_support_level": 2
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "pseudogene",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2553,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 13,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000495302.5",
          "gene_hgnc_id": 17134,
          "gene_symbol": "ZNG1A",
          "hgvs_c": "n.2074G>A",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": false,
          "transcript": "ENST00000495302.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 1813,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 16,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000612045.4",
          "gene_hgnc_id": 17134,
          "gene_symbol": "ZNG1A",
          "hgvs_c": "n.*479G>A",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": "ENSP00000477749.1",
          "strand": false,
          "transcript": "ENST00000612045.4",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 1648,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 14,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000616944.4",
          "gene_hgnc_id": 17134,
          "gene_symbol": "ZNG1A",
          "hgvs_c": "n.*303G>A",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": "ENSP00000482821.1",
          "strand": false,
          "transcript": "ENST00000616944.4",
          "transcript_support_level": 2
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 1227,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 12,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000619157.4",
          "gene_hgnc_id": 17134,
          "gene_symbol": "ZNG1A",
          "hgvs_c": "n.*303G>A",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": "ENSP00000483746.1",
          "strand": false,
          "transcript": "ENST00000619157.4",
          "transcript_support_level": 5
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 1585,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_count": 15,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "ENST00000465014.6",
          "gene_hgnc_id": 17134,
          "gene_symbol": "ZNG1A",
          "hgvs_c": "n.*356G>A",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": "ENSP00000482298.1",
          "strand": false,
          "transcript": "ENST00000465014.6",
          "transcript_support_level": 2
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 1813,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_count": 16,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000612045.4",
          "gene_hgnc_id": 17134,
          "gene_symbol": "ZNG1A",
          "hgvs_c": "n.*479G>A",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": "ENSP00000477749.1",
          "strand": false,
          "transcript": "ENST00000612045.4",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 1648,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_count": 14,
          "exon_rank": 11,
          "exon_rank_end": null,
          "feature": "ENST00000616944.4",
          "gene_hgnc_id": 17134,
          "gene_symbol": "ZNG1A",
          "hgvs_c": "n.*303G>A",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": "ENSP00000482821.1",
          "strand": false,
          "transcript": "ENST00000616944.4",
          "transcript_support_level": 2
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 1227,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_count": 12,
          "exon_rank": 7,
          "exon_rank_end": null,
          "feature": "ENST00000619157.4",
          "gene_hgnc_id": 17134,
          "gene_symbol": "ZNG1A",
          "hgvs_c": "n.*303G>A",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": "ENSP00000483746.1",
          "strand": false,
          "transcript": "ENST00000619157.4",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 393,
          "aa_ref": "G",
          "aa_start": 251,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1321,
          "cdna_start": 834,
          "cds_end": null,
          "cds_length": 1182,
          "cds_start": 752,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 15,
          "exon_rank": 10,
          "exon_rank_end": null,
          "feature": "ENST00000966634.1",
          "gene_hgnc_id": 17134,
          "gene_symbol": "ZNG1A",
          "hgvs_c": "c.752G>A",
          "hgvs_p": "p.Gly251Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000636693.1",
          "strand": false,
          "transcript": "ENST00000966634.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 380,
          "aa_ref": "G",
          "aa_start": 238,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1617,
          "cdna_start": 762,
          "cds_end": null,
          "cds_length": 1143,
          "cds_start": 713,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 14,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "ENST00000905980.1",
          "gene_hgnc_id": 17134,
          "gene_symbol": "ZNG1A",
          "hgvs_c": "c.713G>A",
          "hgvs_p": "p.Gly238Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000576039.1",
          "strand": false,
          "transcript": "ENST00000905980.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 375,
          "aa_ref": "G",
          "aa_start": 233,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1845,
          "cdna_start": 785,
          "cds_end": null,
          "cds_length": 1128,
          "cds_start": 698,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 14,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "NM_001399807.1",
          "gene_hgnc_id": 17134,
          "gene_symbol": "ZNG1A",
          "hgvs_c": "c.698G>A",
          "hgvs_p": "p.Gly233Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001386736.1",
          "strand": false,
          "transcript": "NM_001399807.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 375,
          "aa_ref": "G",
          "aa_start": 233,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3394,
          "cdna_start": 785,
          "cds_end": null,
          "cds_length": 1128,
          "cds_start": 698,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 14,
          "exon_rank": 9,
          "exon_rank_end": null,
          "feature": "ENST00000966633.1",
          "gene_hgnc_id": 17134,
          "gene_symbol": "ZNG1A",
          "hgvs_c": "c.698G>A",
          "hgvs_p": "p.Gly233Glu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000636692.1",
          "strand": false,
          "transcript": "ENST00000966633.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "E",
          "aa_end": null,
          "aa_length": 372,
          "aa_ref": "G",
          "aa_start": 253,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1216,
          "cdna_start": 802,
          "cds_end": null,
          "cds_length": 1119,
          "cds_start": 758,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 14,
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.