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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 9-15744627-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=15744627&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "9",
      "pos": 15744627,
      "ref": "C",
      "alt": "T",
      "effect": "missense_variant",
      "transcript": "ENST00000380701.8",
      "consequences": [
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CCDC171",
          "gene_hgnc_id": 29828,
          "hgvs_c": "c.2404C>T",
          "hgvs_p": "p.Arg802Trp",
          "transcript": "NM_173550.4",
          "protein_id": "NP_775821.2",
          "transcript_support_level": null,
          "aa_start": 802,
          "aa_end": null,
          "aa_length": 1326,
          "cds_start": 2404,
          "cds_end": null,
          "cds_length": 3981,
          "cdna_start": 2775,
          "cdna_end": null,
          "cdna_length": 6553,
          "mane_select": "ENST00000380701.8",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CCDC171",
          "gene_hgnc_id": 29828,
          "hgvs_c": "c.2404C>T",
          "hgvs_p": "p.Arg802Trp",
          "transcript": "ENST00000380701.8",
          "protein_id": "ENSP00000370077.3",
          "transcript_support_level": 1,
          "aa_start": 802,
          "aa_end": null,
          "aa_length": 1326,
          "cds_start": 2404,
          "cds_end": null,
          "cds_length": 3981,
          "cdna_start": 2775,
          "cdna_end": null,
          "cdna_length": 6553,
          "mane_select": "NM_173550.4",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CCDC171",
          "gene_hgnc_id": 29828,
          "hgvs_c": "c.2428C>T",
          "hgvs_p": "p.Arg810Trp",
          "transcript": "NM_001355547.1",
          "protein_id": "NP_001342476.1",
          "transcript_support_level": null,
          "aa_start": 810,
          "aa_end": null,
          "aa_length": 1334,
          "cds_start": 2428,
          "cds_end": null,
          "cds_length": 4005,
          "cdna_start": 2539,
          "cdna_end": null,
          "cdna_length": 6319,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 27,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CCDC171",
          "gene_hgnc_id": 29828,
          "hgvs_c": "c.2149C>T",
          "hgvs_p": "p.Arg717Trp",
          "transcript": "NM_001348002.2",
          "protein_id": "NP_001334931.1",
          "transcript_support_level": null,
          "aa_start": 717,
          "aa_end": null,
          "aa_length": 1241,
          "cds_start": 2149,
          "cds_end": null,
          "cds_length": 3726,
          "cdna_start": 2961,
          "cdna_end": null,
          "cdna_length": 6739,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CCDC171",
          "gene_hgnc_id": 29828,
          "hgvs_c": "c.121C>T",
          "hgvs_p": "p.Arg41Trp",
          "transcript": "ENST00000449575.6",
          "protein_id": "ENSP00000409055.2",
          "transcript_support_level": 2,
          "aa_start": 41,
          "aa_end": null,
          "aa_length": 468,
          "cds_start": 121,
          "cds_end": null,
          "cds_length": 1407,
          "cdna_start": 123,
          "cdna_end": null,
          "cdna_length": 2628,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CCDC171",
          "gene_hgnc_id": 29828,
          "hgvs_c": "c.2428C>T",
          "hgvs_p": "p.Arg810Trp",
          "transcript": "XM_005251397.3",
          "protein_id": "XP_005251454.1",
          "transcript_support_level": null,
          "aa_start": 810,
          "aa_end": null,
          "aa_length": 1334,
          "cds_start": 2428,
          "cds_end": null,
          "cds_length": 4005,
          "cdna_start": 2615,
          "cdna_end": null,
          "cdna_length": 6395,
          "mane_select": null,
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          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CCDC171",
          "gene_hgnc_id": 29828,
          "hgvs_c": "c.2428C>T",
          "hgvs_p": "p.Arg810Trp",
          "transcript": "XM_005251398.5",
          "protein_id": "XP_005251455.1",
          "transcript_support_level": null,
          "aa_start": 810,
          "aa_end": null,
          "aa_length": 1334,
          "cds_start": 2428,
          "cds_end": null,
          "cds_length": 4005,
          "cdna_start": 2799,
          "cdna_end": null,
          "cdna_length": 6579,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 27,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CCDC171",
          "gene_hgnc_id": 29828,
          "hgvs_c": "c.2428C>T",
          "hgvs_p": "p.Arg810Trp",
          "transcript": "XM_005251399.5",
          "protein_id": "XP_005251456.1",
          "transcript_support_level": null,
          "aa_start": 810,
          "aa_end": null,
          "aa_length": 1334,
          "cds_start": 2428,
          "cds_end": null,
          "cds_length": 4005,
          "cdna_start": 2859,
          "cdna_end": null,
          "cdna_length": 6639,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
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        },
        {
          "aa_ref": "R",
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          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
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          "exon_count": 26,
          "intron_rank": null,
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          "gene_symbol": "CCDC171",
          "gene_hgnc_id": 29828,
          "hgvs_c": "c.2428C>T",
          "hgvs_p": "p.Arg810Trp",
          "transcript": "XM_011517788.3",
          "protein_id": "XP_011516090.1",
          "transcript_support_level": null,
          "aa_start": 810,
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          "cds_length": 4005,
          "cdna_start": 2679,
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          "mane_select": null,
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        {
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          "protein_coding": true,
          "strand": true,
          "consequences": [
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          "exon_rank": 18,
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          "exon_count": 27,
          "intron_rank": null,
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          "gene_symbol": "CCDC171",
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          "hgvs_c": "c.2428C>T",
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          "transcript": "XM_047422930.1",
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      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "no assertion criteria provided",
      "clinvar_submissions_summary": "null",
      "phenotype_combined": "Prostate cancer",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
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  "message": null
}