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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 9-16804084-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=16804084&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "9",
"pos": 16804084,
"ref": "A",
"alt": "G",
"effect": "intron_variant",
"transcript": "ENST00000380672.9",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "BNC2",
"gene_hgnc_id": 30988,
"hgvs_c": "c.4-65599T>C",
"hgvs_p": null,
"transcript": "NM_017637.6",
"protein_id": "NP_060107.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1099,
"cds_start": -4,
"cds_end": null,
"cds_length": 3300,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 12808,
"mane_select": "ENST00000380672.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "BNC2",
"gene_hgnc_id": 30988,
"hgvs_c": "c.4-65599T>C",
"hgvs_p": null,
"transcript": "ENST00000380672.9",
"protein_id": "ENSP00000370047.3",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 1099,
"cds_start": -4,
"cds_end": null,
"cds_length": 3300,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 12808,
"mane_select": "NM_017637.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "BNC2",
"gene_hgnc_id": 30988,
"hgvs_c": "c.-394+66562T>C",
"hgvs_p": null,
"transcript": "ENST00000545497.5",
"protein_id": "ENSP00000444640.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 729,
"cds_start": -4,
"cds_end": null,
"cds_length": 2190,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3750,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "BNC2",
"gene_hgnc_id": 30988,
"hgvs_c": "c.-106+63275T>C",
"hgvs_p": null,
"transcript": "ENST00000613349.4",
"protein_id": "ENSP00000477717.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 39,
"cds_start": -4,
"cds_end": null,
"cds_length": 122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 561,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "BNC2",
"gene_hgnc_id": 30988,
"hgvs_c": "c.-232+63275T>C",
"hgvs_p": null,
"transcript": "ENST00000617779.1",
"protein_id": "ENSP00000482793.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 39,
"cds_start": -4,
"cds_end": null,
"cds_length": 122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 687,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "BNC2",
"gene_hgnc_id": 30988,
"hgvs_c": "c.4-65599T>C",
"hgvs_p": null,
"transcript": "ENST00000380667.6",
"protein_id": "ENSP00000370042.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 1032,
"cds_start": -4,
"cds_end": null,
"cds_length": 3099,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3361,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "BNC2",
"gene_hgnc_id": 30988,
"hgvs_c": "c.45+28160T>C",
"hgvs_p": null,
"transcript": "NM_001317940.2",
"protein_id": "NP_001304869.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1004,
"cds_start": -4,
"cds_end": null,
"cds_length": 3015,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 12588,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "BNC2",
"gene_hgnc_id": 30988,
"hgvs_c": "c.3+66562T>C",
"hgvs_p": null,
"transcript": "NM_001317939.2",
"protein_id": "NP_001304868.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 861,
"cds_start": -4,
"cds_end": null,
"cds_length": 2586,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 12738,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "BNC2",
"gene_hgnc_id": 30988,
"hgvs_c": "c.-106+63865T>C",
"hgvs_p": null,
"transcript": "ENST00000380666.6",
"protein_id": "ENSP00000370041.3",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 293,
"cds_start": -4,
"cds_end": null,
"cds_length": 884,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1211,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "BNC2",
"gene_hgnc_id": 30988,
"hgvs_c": "c.3+66562T>C",
"hgvs_p": null,
"transcript": "ENST00000486514.5",
"protein_id": "ENSP00000474647.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 163,
"cds_start": -4,
"cds_end": null,
"cds_length": 493,
"cdna_start": null,
"cdna_end": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "BNC2",
"gene_hgnc_id": 30988,
"hgvs_c": "n.4-65599T>C",
"hgvs_p": null,
"transcript": "ENST00000484726.5",
"protein_id": "ENSP00000431516.1",
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"aa_start": null,
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"cds_start": -4,
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 11,
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"gene_symbol": "BNC2",
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"hgvs_c": "c.45+28160T>C",
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"transcript": "XM_047423480.1",
"protein_id": "XP_047279436.1",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 1,
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"gene_symbol": "BNC2",
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"hgvs_c": "c.45+28160T>C",
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"transcript": "XM_047423481.1",
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},
{
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"strand": false,
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],
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"gene_symbol": "BNC2",
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"hgvs_c": "c.45+28160T>C",
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"transcript": "XM_047423482.1",
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},
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],
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"gene_symbol": "BNC2",
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"hgvs_c": "c.4-65599T>C",
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"transcript": "XM_047423483.1",
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},
{
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],
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"gene_symbol": "BNC2",
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"hgvs_c": "c.45+28160T>C",
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],
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"hgvs_c": "c.45+28160T>C",
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},
{
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],
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"gene_symbol": "BNC2",
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"hgvs_c": "c.45+28160T>C",
"hgvs_p": null,
"transcript": "XM_047423486.1",
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],
"exon_rank": null,
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],
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},
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],
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},
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"consequences": [
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],
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"intron_rank": 1,
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"gene_symbol": "BNC2",
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"hgvs_c": "c.45+28160T>C",
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"transcript": "XM_047423490.1",
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"feature": null
},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 8,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "BNC2",
"gene_hgnc_id": 30988,
"hgvs_c": "c.3+66562T>C",
"hgvs_p": null,
"transcript": "XM_047423491.1",
"protein_id": "XP_047279447.1",
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