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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 9-18657560-A-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=18657560&ref=A&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "9",
"pos": 18657560,
"ref": "A",
"alt": "C",
"effect": "intron_variant",
"transcript": "ENST00000380548.9",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "ADAMTSL1",
"gene_hgnc_id": 14632,
"hgvs_c": "c.835-79A>C",
"hgvs_p": null,
"transcript": "NM_001040272.6",
"protein_id": "NP_001035362.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1762,
"cds_start": -4,
"cds_end": null,
"cds_length": 5289,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7771,
"mane_select": "ENST00000380548.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "ADAMTSL1",
"gene_hgnc_id": 14632,
"hgvs_c": "c.835-79A>C",
"hgvs_p": null,
"transcript": "ENST00000380548.9",
"protein_id": "ENSP00000369921.4",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 1762,
"cds_start": -4,
"cds_end": null,
"cds_length": 5289,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7771,
"mane_select": "NM_001040272.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "ADAMTSL1",
"gene_hgnc_id": 14632,
"hgvs_c": "c.835-79A>C",
"hgvs_p": null,
"transcript": "ENST00000327883.11",
"protein_id": "ENSP00000327887.7",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 525,
"cds_start": -4,
"cds_end": null,
"cds_length": 1578,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1864,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "ADAMTSL1",
"gene_hgnc_id": 14632,
"hgvs_c": "c.835-79A>C",
"hgvs_p": null,
"transcript": "ENST00000380566.8",
"protein_id": "ENSP00000369940.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 439,
"cds_start": -4,
"cds_end": null,
"cds_length": 1320,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2321,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ENSG00000304884",
"gene_hgnc_id": null,
"hgvs_c": "n.462T>G",
"hgvs_p": null,
"transcript": "ENST00000806874.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1067,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LOC102724102",
"gene_hgnc_id": null,
"hgvs_c": "n.334T>G",
"hgvs_p": null,
"transcript": "XR_428448.4",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 939,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "ADAMTSL1",
"gene_hgnc_id": 14632,
"hgvs_c": "c.979-79A>C",
"hgvs_p": null,
"transcript": "ENST00000680146.1",
"protein_id": "ENSP00000505591.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1810,
"cds_start": -4,
"cds_end": null,
"cds_length": 5433,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5706,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "ADAMTSL1",
"gene_hgnc_id": 14632,
"hgvs_c": "c.835-79A>C",
"hgvs_p": null,
"transcript": "ENST00000276935.6",
"protein_id": "ENSP00000276935.5",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 683,
"cds_start": -4,
"cds_end": null,
"cds_length": 2052,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2906,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "ADAMTSL1",
"gene_hgnc_id": 14632,
"hgvs_c": "c.835-79A>C",
"hgvs_p": null,
"transcript": "NM_052866.5",
"protein_id": "NP_443098.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 525,
"cds_start": -4,
"cds_end": null,
"cds_length": 1578,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1811,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "ADAMTSL1",
"gene_hgnc_id": 14632,
"hgvs_c": "c.1033-79A>C",
"hgvs_p": null,
"transcript": "XM_011518063.3",
"protein_id": "XP_011516365.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1828,
"cds_start": -4,
"cds_end": null,
"cds_length": 5487,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8005,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "ADAMTSL1",
"gene_hgnc_id": 14632,
"hgvs_c": "c.991-79A>C",
"hgvs_p": null,
"transcript": "XM_017015310.2",
"protein_id": "XP_016870799.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1814,
"cds_start": -4,
"cds_end": null,
"cds_length": 5445,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 14616,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "ADAMTSL1",
"gene_hgnc_id": 14632,
"hgvs_c": "c.988-79A>C",
"hgvs_p": null,
"transcript": "XM_011518064.4",
"protein_id": "XP_011516366.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 1813,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "ADAMTSL1",
"gene_hgnc_id": 14632,
"hgvs_c": "c.1033-79A>C",
"hgvs_p": null,
"transcript": "XM_017015311.2",
"protein_id": "XP_016870800.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "ADAMTSL1",
"gene_hgnc_id": 14632,
"hgvs_c": "c.955-79A>C",
"hgvs_p": null,
"transcript": "XM_047424072.1",
"protein_id": "XP_047280028.1",
"transcript_support_level": null,
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},
{
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"strand": true,
"consequences": [
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],
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"exon_count": 29,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "ADAMTSL1",
"gene_hgnc_id": 14632,
"hgvs_c": "c.988-79A>C",
"hgvs_p": null,
"transcript": "XM_017015312.3",
"protein_id": "XP_016870801.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 28,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "ADAMTSL1",
"gene_hgnc_id": 14632,
"hgvs_c": "c.835-79A>C",
"hgvs_p": null,
"transcript": "XM_047424073.1",
"protein_id": "XP_047280029.1",
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},
{
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"strand": true,
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],
"exon_rank": null,
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"exon_count": 30,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "ADAMTSL1",
"gene_hgnc_id": 14632,
"hgvs_c": "c.385-79A>C",
"hgvs_p": null,
"transcript": "XM_017015313.1",
"protein_id": "XP_016870802.1",
"transcript_support_level": null,
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "ADAMTSL1",
"gene_hgnc_id": 14632,
"hgvs_c": "c.385-79A>C",
"hgvs_p": null,
"transcript": "XM_047424074.1",
"protein_id": "XP_047280030.1",
"transcript_support_level": null,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 30,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "ADAMTSL1",
"gene_hgnc_id": 14632,
"hgvs_c": "c.385-79A>C",
"hgvs_p": null,
"transcript": "XM_047424076.1",
"protein_id": "XP_047280032.1",
"transcript_support_level": null,
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "ADAMTSL1",
"gene_hgnc_id": 14632,
"hgvs_c": "c.1033-79A>C",
"hgvs_p": null,
"transcript": "XM_017015314.2",
"protein_id": "XP_016870803.1",
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},
{
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"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"intron_rank": 9,
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"gene_symbol": "ADAMTSL1",
"gene_hgnc_id": 14632,
"hgvs_c": "c.1033-79A>C",
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "ADAMTSL1",
"gene_hgnc_id": 14632,
"hgvs_c": "c.835-79A>C",
"hgvs_p": null,
"transcript": "XM_047424078.1",
"protein_id": "XP_047280034.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1429,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 4997,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "ADAMTSL1",
"gene_hgnc_id": 14632,
"hgvs_c": "c.835-79A>C",
"hgvs_p": null,
"transcript": "XM_047424079.1",
"protein_id": "XP_047280035.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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},
{
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}
],
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"allele_count_reference_population": 0,
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"computational_score_selected": -0.9300000071525574,
"computational_prediction_selected": "Benign",
"computational_source_selected": "BayesDel_noAF",
"splice_score_selected": 0.03999999910593033,
"splice_prediction_selected": "Benign",
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"bayesdelnoaf_score": -0.93,
"bayesdelnoaf_prediction": "Benign",
"phylop100way_score": -3.538,
"phylop100way_prediction": "Benign",
"spliceai_max_score": 0.04,
"spliceai_max_prediction": "Benign",
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"dbscsnv_ada_prediction": null,
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"apogee2_prediction": null,
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"mitotip_prediction": null,
"acmg_score": -2,
"acmg_classification": "Likely_benign",
"acmg_criteria": "PM2,BP4_Strong",
"acmg_by_gene": [
{
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"benign_score": 4,
"pathogenic_score": 2,
"criteria": [
"PM2",
"BP4_Strong"
],
"verdict": "Likely_benign",
"transcript": "ENST00000380548.9",
"gene_symbol": "ADAMTSL1",
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"effects": [
"intron_variant"
],
"inheritance_mode": "AR",
"hgvs_c": "c.835-79A>C",
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},
{
"score": -2,
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"criteria": [
"PM2",
"BP4_Strong"
],
"verdict": "Likely_benign",
"transcript": "ENST00000806874.1",
"gene_symbol": "ENSG00000304884",
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"effects": [
"non_coding_transcript_exon_variant"
],
"inheritance_mode": "",
"hgvs_c": "n.462T>G",
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},
{
"score": -2,
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"criteria": [
"PM2",
"BP4_Strong"
],
"verdict": "Likely_benign",
"transcript": "XR_428448.4",
"gene_symbol": "LOC102724102",
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"effects": [
"non_coding_transcript_exon_variant"
],
"inheritance_mode": "",
"hgvs_c": "n.334T>G",
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}
],
"clinvar_disease": "",
"clinvar_classification": "",
"clinvar_review_status": "",
"clinvar_submissions_summary": "",
"phenotype_combined": null,
"pathogenicity_classification_combined": null,
"custom_annotations": null
}
],
"message": null
}