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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 9-21481484-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=21481484&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "9",
"pos": 21481484,
"ref": "G",
"alt": "A",
"effect": "stop_gained",
"transcript": "ENST00000448696.4",
"consequences": [
{
"aa_ref": "Q",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 1,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IFNE",
"gene_hgnc_id": 18163,
"hgvs_c": "c.211C>T",
"hgvs_p": "p.Gln71*",
"transcript": "NM_176891.5",
"protein_id": "NP_795372.1",
"transcript_support_level": null,
"aa_start": 71,
"aa_end": null,
"aa_length": 208,
"cds_start": 211,
"cds_end": null,
"cds_length": 627,
"cdna_start": 830,
"cdna_end": null,
"cdna_length": 1475,
"mane_select": "ENST00000448696.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "Q",
"aa_alt": "*",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 1,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "IFNE",
"gene_hgnc_id": 18163,
"hgvs_c": "c.211C>T",
"hgvs_p": "p.Gln71*",
"transcript": "ENST00000448696.4",
"protein_id": "ENSP00000418018.2",
"transcript_support_level": 6,
"aa_start": 71,
"aa_end": null,
"aa_length": 208,
"cds_start": 211,
"cds_end": null,
"cds_length": 627,
"cdna_start": 830,
"cdna_end": null,
"cdna_length": 1475,
"mane_select": "NM_176891.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "MIR31HG",
"gene_hgnc_id": 37187,
"hgvs_c": "n.344-4192C>T",
"hgvs_p": null,
"transcript": "ENST00000304425.4",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2702,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "MIR31HG",
"gene_hgnc_id": 37187,
"hgvs_c": "n.134-4192C>T",
"hgvs_p": null,
"transcript": "ENST00000654736.2",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2537,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "MIR31HG",
"gene_hgnc_id": 37187,
"hgvs_c": "n.123-4192C>T",
"hgvs_p": null,
"transcript": "ENST00000663833.2",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1914,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "MIR31HG",
"gene_hgnc_id": 37187,
"hgvs_c": "n.338-4192C>T",
"hgvs_p": null,
"transcript": "ENST00000670459.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2119,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "MIR31HG",
"gene_hgnc_id": 37187,
"hgvs_c": "n.103-60792C>T",
"hgvs_p": null,
"transcript": "ENST00000698343.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1714,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "MIR31HG",
"gene_hgnc_id": 37187,
"hgvs_c": "n.373-4192C>T",
"hgvs_p": null,
"transcript": "ENST00000698344.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4607,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "MIR31HG",
"gene_hgnc_id": 37187,
"hgvs_c": "n.131-4192C>T",
"hgvs_p": null,
"transcript": "ENST00000698345.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3344,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "MIR31HG",
"gene_hgnc_id": 37187,
"hgvs_c": "n.114-4192C>T",
"hgvs_p": null,
"transcript": "ENST00000698346.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 3455,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 1,
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"gene_symbol": "MIR31HG",
"gene_hgnc_id": 37187,
"hgvs_c": "n.54-4192C>T",
"hgvs_p": null,
"transcript": "ENST00000698347.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 3,
"intron_rank": 1,
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"gene_symbol": "MIR31HG",
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"hgvs_c": "n.123-4192C>T",
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"transcript": "ENST00000698349.2",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 3,
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"gene_symbol": "MIR31HG",
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"hgvs_c": "n.266-4192C>T",
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"transcript": "ENST00000698350.1",
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},
{
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],
"exon_rank": null,
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"gene_symbol": "MIR31HG",
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"hgvs_c": "n.131-4192C>T",
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},
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],
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},
{
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"consequences": [
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],
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"gene_symbol": "MIR31HG",
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"hgvs_c": "n.344-4192C>T",
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},
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],
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},
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],
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"gene_symbol": "MIR31HG",
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},
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],
"exon_rank": null,
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"exon_count": 4,
"intron_rank": 1,
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"gene_symbol": "MIR31HG",
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"hgvs_c": "n.131-4192C>T",
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"transcript": "ENST00000698394.1",
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],
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],
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},
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],
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},
{
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"consequences": [
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],
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"exon_count": 4,
"intron_rank": 1,
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"gene_symbol": "MIR31HG",
"gene_hgnc_id": 37187,
"hgvs_c": "n.124-4192C>T",
"hgvs_p": null,
"transcript": "ENST00000701930.1",
"protein_id": null,
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},
{
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"consequences": [
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],
"exon_rank": null,
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"exon_count": 3,
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}