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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 9-27949152-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=27949152&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "9",
      "pos": 27949152,
      "ref": "C",
      "alt": "T",
      "effect": "missense_variant",
      "transcript": "ENST00000698399.1",
      "consequences": [
        {
          "aa_ref": "R",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LINGO2",
          "gene_hgnc_id": 21207,
          "hgvs_c": "c.1520G>A",
          "hgvs_p": "p.Arg507His",
          "transcript": "NM_001258282.3",
          "protein_id": "NP_001245211.1",
          "transcript_support_level": null,
          "aa_start": 507,
          "aa_end": null,
          "aa_length": 606,
          "cds_start": 1520,
          "cds_end": null,
          "cds_length": 1821,
          "cdna_start": 2691,
          "cdna_end": null,
          "cdna_length": 14226,
          "mane_select": "ENST00000698399.1",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "H",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LINGO2",
          "gene_hgnc_id": 21207,
          "hgvs_c": "c.1520G>A",
          "hgvs_p": "p.Arg507His",
          "transcript": "ENST00000698399.1",
          "protein_id": "ENSP00000513694.1",
          "transcript_support_level": null,
          "aa_start": 507,
          "aa_end": null,
          "aa_length": 606,
          "cds_start": 1520,
          "cds_end": null,
          "cds_length": 1821,
          "cdna_start": 2691,
          "cdna_end": null,
          "cdna_length": 14226,
          "mane_select": "NM_001258282.3",
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LINGO2",
          "gene_hgnc_id": 21207,
          "hgvs_c": "c.1520G>A",
          "hgvs_p": "p.Arg507His",
          "transcript": "NM_001354574.2",
          "protein_id": "NP_001341503.1",
          "transcript_support_level": null,
          "aa_start": 507,
          "aa_end": null,
          "aa_length": 606,
          "cds_start": 1520,
          "cds_end": null,
          "cds_length": 1821,
          "cdna_start": 2658,
          "cdna_end": null,
          "cdna_length": 14193,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LINGO2",
          "gene_hgnc_id": 21207,
          "hgvs_c": "c.1520G>A",
          "hgvs_p": "p.Arg507His",
          "transcript": "NM_001354575.2",
          "protein_id": "NP_001341504.1",
          "transcript_support_level": null,
          "aa_start": 507,
          "aa_end": null,
          "aa_length": 606,
          "cds_start": 1520,
          "cds_end": null,
          "cds_length": 1821,
          "cdna_start": 2221,
          "cdna_end": null,
          "cdna_length": 13756,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LINGO2",
          "gene_hgnc_id": 21207,
          "hgvs_c": "c.1520G>A",
          "hgvs_p": "p.Arg507His",
          "transcript": "NM_152570.4",
          "protein_id": "NP_689783.1",
          "transcript_support_level": null,
          "aa_start": 507,
          "aa_end": null,
          "aa_length": 606,
          "cds_start": 1520,
          "cds_end": null,
          "cds_length": 1821,
          "cdna_start": 2170,
          "cdna_end": null,
          "cdna_length": 13705,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LINGO2",
          "gene_hgnc_id": 21207,
          "hgvs_c": "c.1520G>A",
          "hgvs_p": "p.Arg507His",
          "transcript": "ENST00000379992.6",
          "protein_id": "ENSP00000369328.1",
          "transcript_support_level": 5,
          "aa_start": 507,
          "aa_end": null,
          "aa_length": 606,
          "cds_start": 1520,
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          "cds_length": 1821,
          "cdna_start": 1970,
          "cdna_end": null,
          "cdna_length": 3044,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LINGO2",
          "gene_hgnc_id": 21207,
          "hgvs_c": "c.1520G>A",
          "hgvs_p": "p.Arg507His",
          "transcript": "ENST00000698400.1",
          "protein_id": "ENSP00000513695.1",
          "transcript_support_level": null,
          "aa_start": 507,
          "aa_end": null,
          "aa_length": 606,
          "cds_start": 1520,
          "cds_end": null,
          "cds_length": 1821,
          "cdna_start": 2129,
          "cdna_end": null,
          "cdna_length": 2731,
          "mane_select": null,
          "mane_plus": null,
          "biotype": null,
          "feature": null
        },
        {
          "aa_ref": "R",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "LINGO2",
          "gene_hgnc_id": 21207,
          "hgvs_c": "c.1520G>A",
          "hgvs_p": "p.Arg507His",
          "transcript": "ENST00000698401.1",
          "protein_id": "ENSP00000513696.1",
          "transcript_support_level": null,
          "aa_start": 507,
          "aa_end": null,
          "aa_length": 606,
          "cds_start": 1520,
          "cds_end": null,
          "cds_length": 1821,
          "cdna_start": 2534,
          "cdna_end": null,
          "cdna_length": 3136,
          "mane_select": null,
          "mane_plus": null,
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          "feature": null
        },
        {
          "aa_ref": "R",
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          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
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          "gene_symbol": "LINGO2",
          "gene_hgnc_id": 21207,
          "hgvs_c": "c.1520G>A",
          "hgvs_p": "p.Arg507His",
          "transcript": "ENST00000698402.1",
          "protein_id": "ENSP00000513697.1",
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          "cdna_start": 2463,
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        {
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          "exon_count": 9,
          "intron_rank": null,
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          "gene_symbol": "LINGO2",
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          "hgvs_c": "c.1520G>A",
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          "transcript": "ENST00000698403.1",
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      "computational_source_selected": "MetaRNN",
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      "splice_source_selected": "max_spliceai",
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      "acmg_classification": "Likely_benign",
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      "acmg_by_gene": [
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          "score": -6,
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            "BS2"
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          "verdict": "Likely_benign",
          "transcript": "ENST00000698399.1",
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      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "phenotype_combined": null,
      "pathogenicity_classification_combined": null,
      "custom_annotations": null
    }
  ],
  "message": null
}