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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 9-35059793-T-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=35059793&ref=T&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 0,
          "criteria": [
            "PM2"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "VCP",
          "hgnc_id": 12666,
          "hgvs_c": "c.1704A>T",
          "hgvs_p": "p.Gln568His",
          "inheritance_mode": "AD",
          "pathogenic_score": 2,
          "score": 2,
          "transcript": "NM_007126.5",
          "verdict": "Uncertain_significance"
        }
      ],
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2",
      "acmg_score": 2,
      "allele_count_reference_population": 0,
      "alphamissense_prediction": "Pathogenic",
      "alphamissense_score": 0.6505,
      "alt": "A",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Uncertain_significance",
      "bayesdelnoaf_score": -0.03,
      "chr": "9",
      "clinvar_classification": "",
      "clinvar_disease": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "computational_prediction_selected": "Uncertain_significance",
      "computational_score_selected": 0.5523480176925659,
      "computational_source_selected": "MetaRNN",
      "consequences": [
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 806,
          "aa_ref": "Q",
          "aa_start": 568,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3746,
          "cdna_start": 1976,
          "cds_end": null,
          "cds_length": 2421,
          "cds_start": 1704,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 17,
          "exon_rank": 14,
          "exon_rank_end": null,
          "feature": "NM_007126.5",
          "gene_hgnc_id": 12666,
          "gene_symbol": "VCP",
          "hgvs_c": "c.1704A>T",
          "hgvs_p": "p.Gln568His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000358901.11",
          "protein_coding": true,
          "protein_id": "NP_009057.1",
          "strand": false,
          "transcript": "NM_007126.5",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 806,
          "aa_ref": "Q",
          "aa_start": 568,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 3746,
          "cdna_start": 1976,
          "cds_end": null,
          "cds_length": 2421,
          "cds_start": 1704,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 17,
          "exon_rank": 14,
          "exon_rank_end": null,
          "feature": "ENST00000358901.11",
          "gene_hgnc_id": 12666,
          "gene_symbol": "VCP",
          "hgvs_c": "c.1704A>T",
          "hgvs_p": "p.Gln568His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_007126.5",
          "protein_coding": true,
          "protein_id": "ENSP00000351777.6",
          "strand": false,
          "transcript": "ENST00000358901.11",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "retained_intron",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1159,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 4,
          "exon_rank": 1,
          "exon_rank_end": null,
          "feature": "ENST00000479300.2",
          "gene_hgnc_id": 12666,
          "gene_symbol": "VCP",
          "hgvs_c": "n.232A>T",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": false,
          "transcript": "ENST00000479300.2",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 837,
          "aa_ref": "Q",
          "aa_start": 599,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3350,
          "cdna_start": 2074,
          "cds_end": null,
          "cds_length": 2514,
          "cds_start": 1797,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 18,
          "exon_rank": 15,
          "exon_rank_end": null,
          "feature": "ENST00000969527.1",
          "gene_hgnc_id": 12666,
          "gene_symbol": "VCP",
          "hgvs_c": "c.1797A>T",
          "hgvs_p": "p.Gln599His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000639586.1",
          "strand": false,
          "transcript": "ENST00000969527.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 805,
          "aa_ref": "Q",
          "aa_start": 567,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3789,
          "cdna_start": 2019,
          "cds_end": null,
          "cds_length": 2418,
          "cds_start": 1701,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 17,
          "exon_rank": 14,
          "exon_rank_end": null,
          "feature": "ENST00000940607.1",
          "gene_hgnc_id": 12666,
          "gene_symbol": "VCP",
          "hgvs_c": "c.1701A>T",
          "hgvs_p": "p.Gln567His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000610666.1",
          "strand": false,
          "transcript": "ENST00000940607.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 805,
          "aa_ref": "Q",
          "aa_start": 568,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3785,
          "cdna_start": 2022,
          "cds_end": null,
          "cds_length": 2418,
          "cds_start": 1704,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 17,
          "exon_rank": 14,
          "exon_rank_end": null,
          "feature": "ENST00000969526.1",
          "gene_hgnc_id": 12666,
          "gene_symbol": "VCP",
          "hgvs_c": "c.1704A>T",
          "hgvs_p": "p.Gln568His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000639585.1",
          "strand": false,
          "transcript": "ENST00000969526.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 804,
          "aa_ref": "Q",
          "aa_start": 566,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4404,
          "cdna_start": 1946,
          "cds_end": null,
          "cds_length": 2415,
          "cds_start": 1698,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 17,
          "exon_rank": 14,
          "exon_rank_end": null,
          "feature": "ENST00000677257.1",
          "gene_hgnc_id": 12666,
          "gene_symbol": "VCP",
          "hgvs_c": "c.1698A>T",
          "hgvs_p": "p.Gln566His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000504354.1",
          "strand": false,
          "transcript": "ENST00000677257.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 804,
          "aa_ref": "Q",
          "aa_start": 566,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4476,
          "cdna_start": 1999,
          "cds_end": null,
          "cds_length": 2415,
          "cds_start": 1698,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 17,
          "exon_rank": 14,
          "exon_rank_end": null,
          "feature": "ENST00000969525.1",
          "gene_hgnc_id": 12666,
          "gene_symbol": "VCP",
          "hgvs_c": "c.1698A>T",
          "hgvs_p": "p.Gln566His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000639584.1",
          "strand": false,
          "transcript": "ENST00000969525.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 799,
          "aa_ref": "Q",
          "aa_start": 561,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3232,
          "cdna_start": 1956,
          "cds_end": null,
          "cds_length": 2400,
          "cds_start": 1683,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 17,
          "exon_rank": 14,
          "exon_rank_end": null,
          "feature": "ENST00000969528.1",
          "gene_hgnc_id": 12666,
          "gene_symbol": "VCP",
          "hgvs_c": "c.1683A>T",
          "hgvs_p": "p.Gln561His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000639587.1",
          "strand": false,
          "transcript": "ENST00000969528.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 791,
          "aa_ref": "Q",
          "aa_start": 553,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3190,
          "cdna_start": 1913,
          "cds_end": null,
          "cds_length": 2376,
          "cds_start": 1659,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 17,
          "exon_rank": 14,
          "exon_rank_end": null,
          "feature": "ENST00000969529.1",
          "gene_hgnc_id": 12666,
          "gene_symbol": "VCP",
          "hgvs_c": "c.1659A>T",
          "hgvs_p": "p.Gln553His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000639588.1",
          "strand": false,
          "transcript": "ENST00000969529.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 785,
          "aa_ref": "Q",
          "aa_start": 547,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3194,
          "cdna_start": 1917,
          "cds_end": null,
          "cds_length": 2358,
          "cds_start": 1641,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 17,
          "exon_rank": 14,
          "exon_rank_end": null,
          "feature": "ENST00000940608.1",
          "gene_hgnc_id": 12666,
          "gene_symbol": "VCP",
          "hgvs_c": "c.1641A>T",
          "hgvs_p": "p.Gln547His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000610667.1",
          "strand": false,
          "transcript": "ENST00000940608.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 776,
          "aa_ref": "Q",
          "aa_start": 538,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3161,
          "cdna_start": 1891,
          "cds_end": null,
          "cds_length": 2331,
          "cds_start": 1614,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 17,
          "exon_rank": 14,
          "exon_rank_end": null,
          "feature": "ENST00000854255.1",
          "gene_hgnc_id": 12666,
          "gene_symbol": "VCP",
          "hgvs_c": "c.1614A>T",
          "hgvs_p": "p.Gln538His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000524314.1",
          "strand": false,
          "transcript": "ENST00000854255.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 772,
          "aa_ref": "Q",
          "aa_start": 568,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6033,
          "cdna_start": 1974,
          "cds_end": null,
          "cds_length": 2319,
          "cds_start": 1704,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 16,
          "exon_rank": 14,
          "exon_rank_end": null,
          "feature": "ENST00000679902.1",
          "gene_hgnc_id": 12666,
          "gene_symbol": "VCP",
          "hgvs_c": "c.1704A>T",
          "hgvs_p": "p.Gln568His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000506338.1",
          "strand": false,
          "transcript": "ENST00000679902.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 765,
          "aa_ref": "Q",
          "aa_start": 527,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3623,
          "cdna_start": 1853,
          "cds_end": null,
          "cds_length": 2298,
          "cds_start": 1581,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 16,
          "exon_rank": 13,
          "exon_rank_end": null,
          "feature": "ENST00000854254.1",
          "gene_hgnc_id": 12666,
          "gene_symbol": "VCP",
          "hgvs_c": "c.1581A>T",
          "hgvs_p": "p.Gln527His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000524313.1",
          "strand": false,
          "transcript": "ENST00000854254.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 761,
          "aa_ref": "Q",
          "aa_start": 523,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3806,
          "cdna_start": 2036,
          "cds_end": null,
          "cds_length": 2286,
          "cds_start": 1569,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 17,
          "exon_rank": 14,
          "exon_rank_end": null,
          "feature": "NM_001354927.2",
          "gene_hgnc_id": 12666,
          "gene_symbol": "VCP",
          "hgvs_c": "c.1569A>T",
          "hgvs_p": "p.Gln523His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001341856.1",
          "strand": false,
          "transcript": "NM_001354927.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 761,
          "aa_ref": "Q",
          "aa_start": 523,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4326,
          "cdna_start": 2556,
          "cds_end": null,
          "cds_length": 2286,
          "cds_start": 1569,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 17,
          "exon_rank": 14,
          "exon_rank_end": null,
          "feature": "NM_001354928.2",
          "gene_hgnc_id": 12666,
          "gene_symbol": "VCP",
          "hgvs_c": "c.1569A>T",
          "hgvs_p": "p.Gln523His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001341857.1",
          "strand": false,
          "transcript": "NM_001354928.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 761,
          "aa_ref": "Q",
          "aa_start": 523,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3382,
          "cdna_start": 2136,
          "cds_end": null,
          "cds_length": 2286,
          "cds_start": 1569,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 17,
          "exon_rank": 14,
          "exon_rank_end": null,
          "feature": "ENST00000417448.2",
          "gene_hgnc_id": 12666,
          "gene_symbol": "VCP",
          "hgvs_c": "c.1569A>T",
          "hgvs_p": "p.Gln523His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000399456.2",
          "strand": false,
          "transcript": "ENST00000417448.2",
          "transcript_support_level": 3
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 761,
          "aa_ref": "Q",
          "aa_start": 523,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3849,
          "cdna_start": 2079,
          "cds_end": null,
          "cds_length": 2286,
          "cds_start": 1569,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 17,
          "exon_rank": 14,
          "exon_rank_end": null,
          "feature": "ENST00000448530.6",
          "gene_hgnc_id": 12666,
          "gene_symbol": "VCP",
          "hgvs_c": "c.1569A>T",
          "hgvs_p": "p.Gln523His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000392088.2",
          "strand": false,
          "transcript": "ENST00000448530.6",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "H",
          "aa_end": null,
          "aa_length": 761,
          "aa_ref": "Q",
          "aa_start": 523,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4362,
          "cdna_start": 1904,
          "cds_end": null,
          "cds_length": 2286,
          "cds_start": 1569,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 17,
          "exon_rank": 14,
          "exon_rank_end": null,
          "feature": "ENST00000678650.1",
          "gene_hgnc_id": 12666,
          "gene_symbol": "VCP",
          "hgvs_c": "c.1569A>T",
          "hgvs_p": "p.Gln523His",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.