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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 9-35092166-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=35092166&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "9",
"pos": 35092166,
"ref": "G",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_032634.4",
"consequences": [
{
"aa_ref": "P",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PIGO",
"gene_hgnc_id": 23215,
"hgvs_c": "c.1721C>A",
"hgvs_p": "p.Pro574His",
"transcript": "NM_032634.4",
"protein_id": "NP_116023.2",
"transcript_support_level": null,
"aa_start": 574,
"aa_end": null,
"aa_length": 1089,
"cds_start": 1721,
"cds_end": null,
"cds_length": 3270,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000378617.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_032634.4"
},
{
"aa_ref": "P",
"aa_alt": "H",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PIGO",
"gene_hgnc_id": 23215,
"hgvs_c": "c.1721C>A",
"hgvs_p": "p.Pro574His",
"transcript": "ENST00000378617.4",
"protein_id": "ENSP00000367880.3",
"transcript_support_level": 1,
"aa_start": 574,
"aa_end": null,
"aa_length": 1089,
"cds_start": 1721,
"cds_end": null,
"cds_length": 3270,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_032634.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000378617.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "PIGO",
"gene_hgnc_id": 23215,
"hgvs_c": "c.1344+377C>A",
"hgvs_p": null,
"transcript": "ENST00000298004.9",
"protein_id": "ENSP00000298004.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 672,
"cds_start": null,
"cds_end": null,
"cds_length": 2019,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000298004.9"
},
{
"aa_ref": "P",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PIGO",
"gene_hgnc_id": 23215,
"hgvs_c": "c.1721C>A",
"hgvs_p": "p.Pro574His",
"transcript": "ENST00000907113.1",
"protein_id": "ENSP00000577172.1",
"transcript_support_level": null,
"aa_start": 574,
"aa_end": null,
"aa_length": 1089,
"cds_start": 1721,
"cds_end": null,
"cds_length": 3270,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000907113.1"
},
{
"aa_ref": "P",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PIGO",
"gene_hgnc_id": 23215,
"hgvs_c": "c.1721C>A",
"hgvs_p": "p.Pro574His",
"transcript": "ENST00000929241.1",
"protein_id": "ENSP00000599300.1",
"transcript_support_level": null,
"aa_start": 574,
"aa_end": null,
"aa_length": 1089,
"cds_start": 1721,
"cds_end": null,
"cds_length": 3270,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000929241.1"
},
{
"aa_ref": "P",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PIGO",
"gene_hgnc_id": 23215,
"hgvs_c": "c.1721C>A",
"hgvs_p": "p.Pro574His",
"transcript": "ENST00000907116.1",
"protein_id": "ENSP00000577175.1",
"transcript_support_level": null,
"aa_start": 574,
"aa_end": null,
"aa_length": 1088,
"cds_start": 1721,
"cds_end": null,
"cds_length": 3267,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000907116.1"
},
{
"aa_ref": "P",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PIGO",
"gene_hgnc_id": 23215,
"hgvs_c": "c.1721C>A",
"hgvs_p": "p.Pro574His",
"transcript": "ENST00000929243.1",
"protein_id": "ENSP00000599302.1",
"transcript_support_level": null,
"aa_start": 574,
"aa_end": null,
"aa_length": 1088,
"cds_start": 1721,
"cds_end": null,
"cds_length": 3267,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000929243.1"
},
{
"aa_ref": "P",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PIGO",
"gene_hgnc_id": 23215,
"hgvs_c": "c.1721C>A",
"hgvs_p": "p.Pro574His",
"transcript": "ENST00000929246.1",
"protein_id": "ENSP00000599305.1",
"transcript_support_level": null,
"aa_start": 574,
"aa_end": null,
"aa_length": 1088,
"cds_start": 1721,
"cds_end": null,
"cds_length": 3267,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000929246.1"
},
{
"aa_ref": "P",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PIGO",
"gene_hgnc_id": 23215,
"hgvs_c": "c.1721C>A",
"hgvs_p": "p.Pro574His",
"transcript": "XM_005251619.4",
"protein_id": "XP_005251676.1",
"transcript_support_level": null,
"aa_start": 574,
"aa_end": null,
"aa_length": 1089,
"cds_start": 1721,
"cds_end": null,
"cds_length": 3270,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_005251619.4"
},
{
"aa_ref": "P",
"aa_alt": "H",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PIGO",
"gene_hgnc_id": 23215,
"hgvs_c": "c.1721C>A",
"hgvs_p": "p.Pro574His",
"transcript": "XM_047423974.1",
"protein_id": "XP_047279930.1",
"transcript_support_level": null,
"aa_start": 574,
"aa_end": null,
"aa_length": 965,
"cds_start": 1721,
"cds_end": null,
"cds_length": 2898,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047423974.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "PIGO",
"gene_hgnc_id": 23215,
"hgvs_c": "c.1360+361C>A",
"hgvs_p": null,
"transcript": "ENST00000700261.1",
"protein_id": "ENSP00000514897.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 758,
"cds_start": null,
"cds_end": null,
"cds_length": 2277,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000700261.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "PIGO",
"gene_hgnc_id": 23215,
"hgvs_c": "c.1344+377C>A",
"hgvs_p": null,
"transcript": "NM_001201484.2",
"protein_id": "NP_001188413.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 672,
"cds_start": null,
"cds_end": null,
"cds_length": 2019,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001201484.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "PIGO",
"gene_hgnc_id": 23215,
"hgvs_c": "c.1344+377C>A",
"hgvs_p": null,
"transcript": "NM_152850.4",
"protein_id": "NP_690577.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 672,
"cds_start": null,
"cds_end": null,
"cds_length": 2019,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_152850.4"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "PIGO",
"gene_hgnc_id": 23215,
"hgvs_c": "c.1344+377C>A",
"hgvs_p": null,
"transcript": "ENST00000361778.7",
"protein_id": "ENSP00000354678.2",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
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"cds_start": null,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000361778.7"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "PIGO",
"gene_hgnc_id": 23215,
"hgvs_c": "c.1344+377C>A",
"hgvs_p": null,
"transcript": "ENST00000700254.2",
"protein_id": "ENSP00000514892.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 672,
"cds_start": null,
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"cds_length": 2019,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000700254.2"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "PIGO",
"gene_hgnc_id": 23215,
"hgvs_c": "c.1360+361C>A",
"hgvs_p": null,
"transcript": "ENST00000949398.1",
"protein_id": "ENSP00000619457.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 660,
"cds_start": null,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000949398.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "PIGO",
"gene_hgnc_id": 23215,
"hgvs_c": "c.1344+377C>A",
"hgvs_p": null,
"transcript": "ENST00000907117.1",
"protein_id": "ENSP00000577176.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 647,
"cds_start": null,
"cds_end": null,
"cds_length": 1944,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000907117.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "PIGO",
"gene_hgnc_id": 23215,
"hgvs_c": "c.1344+377C>A",
"hgvs_p": null,
"transcript": "ENST00000949399.1",
"protein_id": "ENSP00000619458.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 646,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000949399.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "PIGO",
"gene_hgnc_id": 23215,
"hgvs_c": "c.1360+361C>A",
"hgvs_p": null,
"transcript": "ENST00000929245.1",
"protein_id": "ENSP00000599304.1",
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000929245.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "PIGO",
"gene_hgnc_id": 23215,
"hgvs_c": "c.1164+377C>A",
"hgvs_p": null,
"transcript": "ENST00000700260.1",
"protein_id": "ENSP00000514896.1",
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"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"biotype": "protein_coding",
"feature": "ENST00000700260.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 11,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "PIGO",
"gene_hgnc_id": 23215,
"hgvs_c": "c.1119+864C>A",
"hgvs_p": null,
"transcript": "ENST00000907114.1",
"protein_id": "ENSP00000577173.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 597,
"cds_start": null,
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"cds_length": 1794,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000907114.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "PIGO",
"gene_hgnc_id": 23215,
"hgvs_c": "c.940-875C>A",
"hgvs_p": null,
"transcript": "ENST00000907115.1",
"protein_id": "ENSP00000577174.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 537,
"cds_start": null,
"cds_end": null,
"cds_length": 1614,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000907115.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
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}
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}