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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 9-35737344-C-G (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=35737344&ref=C&alt=G&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "9",
      "pos": 35737344,
      "ref": "C",
      "alt": "G",
      "effect": "missense_variant",
      "transcript": "NM_020944.3",
      "consequences": [
        {
          "aa_ref": "R",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GBA2",
          "gene_hgnc_id": 18986,
          "hgvs_c": "c.2609G>C",
          "hgvs_p": "p.Arg870Pro",
          "transcript": "NM_020944.3",
          "protein_id": "NP_065995.1",
          "transcript_support_level": null,
          "aa_start": 870,
          "aa_end": null,
          "aa_length": 927,
          "cds_start": 2609,
          "cds_end": null,
          "cds_length": 2784,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000378103.7",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_020944.3"
        },
        {
          "aa_ref": "R",
          "aa_alt": "P",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GBA2",
          "gene_hgnc_id": 18986,
          "hgvs_c": "c.2609G>C",
          "hgvs_p": "p.Arg870Pro",
          "transcript": "ENST00000378103.7",
          "protein_id": "ENSP00000367343.3",
          "transcript_support_level": 1,
          "aa_start": 870,
          "aa_end": null,
          "aa_length": 927,
          "cds_start": 2609,
          "cds_end": null,
          "cds_length": 2784,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_020944.3",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000378103.7"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GBA2",
          "gene_hgnc_id": 18986,
          "hgvs_c": "c.*132G>C",
          "hgvs_p": null,
          "transcript": "ENST00000378094.4",
          "protein_id": "ENSP00000367334.4",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 877,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2634,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000378094.4"
        },
        {
          "aa_ref": "R",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GBA2",
          "gene_hgnc_id": 18986,
          "hgvs_c": "c.2645G>C",
          "hgvs_p": "p.Arg882Pro",
          "transcript": "ENST00000880894.1",
          "protein_id": "ENSP00000550953.1",
          "transcript_support_level": null,
          "aa_start": 882,
          "aa_end": null,
          "aa_length": 939,
          "cds_start": 2645,
          "cds_end": null,
          "cds_length": 2820,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000880894.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GBA2",
          "gene_hgnc_id": 18986,
          "hgvs_c": "c.2609G>C",
          "hgvs_p": "p.Arg870Pro",
          "transcript": "ENST00000880891.1",
          "protein_id": "ENSP00000550950.1",
          "transcript_support_level": null,
          "aa_start": 870,
          "aa_end": null,
          "aa_length": 927,
          "cds_start": 2609,
          "cds_end": null,
          "cds_length": 2784,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000880891.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GBA2",
          "gene_hgnc_id": 18986,
          "hgvs_c": "c.2609G>C",
          "hgvs_p": "p.Arg870Pro",
          "transcript": "ENST00000880893.1",
          "protein_id": "ENSP00000550952.1",
          "transcript_support_level": null,
          "aa_start": 870,
          "aa_end": null,
          "aa_length": 927,
          "cds_start": 2609,
          "cds_end": null,
          "cds_length": 2784,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000880893.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GBA2",
          "gene_hgnc_id": 18986,
          "hgvs_c": "c.2543G>C",
          "hgvs_p": "p.Arg848Pro",
          "transcript": "ENST00000880892.1",
          "protein_id": "ENSP00000550951.1",
          "transcript_support_level": null,
          "aa_start": 848,
          "aa_end": null,
          "aa_length": 905,
          "cds_start": 2543,
          "cds_end": null,
          "cds_length": 2718,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000880892.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GBA2",
          "gene_hgnc_id": 18986,
          "hgvs_c": "c.2543G>C",
          "hgvs_p": "p.Arg848Pro",
          "transcript": "ENST00000964990.1",
          "protein_id": "ENSP00000635049.1",
          "transcript_support_level": null,
          "aa_start": 848,
          "aa_end": null,
          "aa_length": 905,
          "cds_start": 2543,
          "cds_end": null,
          "cds_length": 2718,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000964990.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GBA2",
          "gene_hgnc_id": 18986,
          "hgvs_c": "c.2390G>C",
          "hgvs_p": "p.Arg797Pro",
          "transcript": "ENST00000931073.1",
          "protein_id": "ENSP00000601132.1",
          "transcript_support_level": null,
          "aa_start": 797,
          "aa_end": null,
          "aa_length": 854,
          "cds_start": 2390,
          "cds_end": null,
          "cds_length": 2565,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000931073.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GBA2",
          "gene_hgnc_id": 18986,
          "hgvs_c": "c.2627G>C",
          "hgvs_p": "p.Arg876Pro",
          "transcript": "XM_006716809.5",
          "protein_id": "XP_006716872.1",
          "transcript_support_level": null,
          "aa_start": 876,
          "aa_end": null,
          "aa_length": 933,
          "cds_start": 2627,
          "cds_end": null,
          "cds_length": 2802,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_006716809.5"
        },
        {
          "aa_ref": "R",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GBA2",
          "gene_hgnc_id": 18986,
          "hgvs_c": "c.2561G>C",
          "hgvs_p": "p.Arg854Pro",
          "transcript": "XM_005251526.6",
          "protein_id": "XP_005251583.1",
          "transcript_support_level": null,
          "aa_start": 854,
          "aa_end": null,
          "aa_length": 911,
          "cds_start": 2561,
          "cds_end": null,
          "cds_length": 2736,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_005251526.6"
        },
        {
          "aa_ref": "R",
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GBA2",
          "gene_hgnc_id": 18986,
          "hgvs_c": "c.2543G>C",
          "hgvs_p": "p.Arg848Pro",
          "transcript": "XM_017014937.3",
          "protein_id": "XP_016870426.1",
          "transcript_support_level": null,
          "aa_start": 848,
          "aa_end": null,
          "aa_length": 905,
          "cds_start": 2543,
          "cds_end": null,
          "cds_length": 2718,
          "cdna_start": null,
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          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "XM_017014937.3"
        },
        {
          "aa_ref": "R",
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GBA2",
          "gene_hgnc_id": 18986,
          "hgvs_c": "c.2390G>C",
          "hgvs_p": "p.Arg797Pro",
          "transcript": "XM_017014940.3",
          "protein_id": "XP_016870429.1",
          "transcript_support_level": null,
          "aa_start": 797,
          "aa_end": null,
          "aa_length": 854,
          "cds_start": 2390,
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          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "XM_017014940.3"
        },
        {
          "aa_ref": "R",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GBA2",
          "gene_hgnc_id": 18986,
          "hgvs_c": "c.2174G>C",
          "hgvs_p": "p.Arg725Pro",
          "transcript": "XM_017014942.3",
          "protein_id": "XP_016870431.1",
          "transcript_support_level": null,
          "aa_start": 725,
          "aa_end": null,
          "aa_length": 782,
          "cds_start": 2174,
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          "cdna_start": null,
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        },
        {
          "aa_ref": "R",
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          ],
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          "intron_rank": null,
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          "gene_symbol": "GBA2",
          "gene_hgnc_id": 18986,
          "hgvs_c": "c.2156G>C",
          "hgvs_p": "p.Arg719Pro",
          "transcript": "XM_017014943.3",
          "protein_id": "XP_016870432.1",
          "transcript_support_level": null,
          "aa_start": 719,
          "aa_end": null,
          "aa_length": 776,
          "cds_start": 2156,
          "cds_end": null,
          "cds_length": 2331,
          "cdna_start": null,
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          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "XM_017014943.3"
        },
        {
          "aa_ref": "R",
          "aa_alt": "P",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GBA2",
          "gene_hgnc_id": 18986,
          "hgvs_c": "c.2072G>C",
          "hgvs_p": "p.Arg691Pro",
          "transcript": "XM_017014944.1",
          "protein_id": "XP_016870433.1",
          "transcript_support_level": null,
          "aa_start": 691,
          "aa_end": null,
          "aa_length": 748,
          "cds_start": 2072,
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          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "XM_017014944.1"
        },
        {
          "aa_ref": "R",
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "GBA2",
          "gene_hgnc_id": 18986,
          "hgvs_c": "c.2054G>C",
          "hgvs_p": "p.Arg685Pro",
          "transcript": "XM_017014945.1",
          "protein_id": "XP_016870434.1",
          "transcript_support_level": null,
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        },
        {
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          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
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          "gene_symbol": "GBA2",
          "gene_hgnc_id": 18986,
          "hgvs_c": "c.2054G>C",
          "hgvs_p": "p.Arg685Pro",
          "transcript": "XM_047423612.1",
          "protein_id": "XP_047279568.1",
          "transcript_support_level": null,
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          "biotype": "protein_coding",
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        },
        {
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
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          "gene_symbol": "GBA2",
          "gene_hgnc_id": 18986,
          "hgvs_c": "c.*132G>C",
          "hgvs_p": null,
          "transcript": "NM_001330660.2",
          "protein_id": "NP_001317589.1",
          "transcript_support_level": null,
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          "cds_start": null,
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          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001330660.2"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 9,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CREB3",
          "gene_hgnc_id": 2347,
          "hgvs_c": "c.*618C>G",
          "hgvs_p": null,
          "transcript": "ENST00000881110.1",
          "protein_id": "ENSP00000551169.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 363,
          "cds_start": null,
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          "cds_length": 1092,
          "cdna_start": null,
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        {
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      ],
      "gene_symbol": "GBA2",
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      "dbsnp": "rs199510198",
      "frequency_reference_population": 6.840853e-7,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 1,
      "gnomad_exomes_af": 6.84085e-7,
      "gnomad_genomes_af": null,
      "gnomad_exomes_ac": 1,
      "gnomad_genomes_ac": null,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": null,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.20681145787239075,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.163,
      "revel_prediction": "Benign",
      "alphamissense_score": 0.2696,
      "alphamissense_prediction": "Benign",
      "bayesdelnoaf_score": -0.33,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": -1.241,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": 0,
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,BP4_Moderate",
      "acmg_by_gene": [
        {
          "score": 0,
          "benign_score": 2,
          "pathogenic_score": 2,
          "criteria": [
            "PM2",
            "BP4_Moderate"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "NM_020944.3",
          "gene_symbol": "GBA2",
          "hgnc_id": 18986,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "AR",
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          "hgvs_p": "p.Arg870Pro"
        },
        {
          "score": 0,
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          "pathogenic_score": 2,
          "criteria": [
            "PM2",
            "BP4_Moderate"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "ENST00000881110.1",
          "gene_symbol": "CREB3",
          "hgnc_id": 2347,
          "effects": [
            "3_prime_UTR_variant"
          ],
          "inheritance_mode": "",
          "hgvs_c": "c.*618C>G",
          "hgvs_p": null
        }
      ],
      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "phenotype_combined": null,
      "pathogenicity_classification_combined": null,
      "custom_annotations": null
    }
  ],
  "message": null
}