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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 9-36635412-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=36635412&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "9",
"pos": 36635412,
"ref": "T",
"alt": "C",
"effect": "intron_variant",
"transcript": "ENST00000298048.7",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "MELK",
"gene_hgnc_id": 16870,
"hgvs_c": "c.834+2212T>C",
"hgvs_p": null,
"transcript": "NM_014791.4",
"protein_id": "NP_055606.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 651,
"cds_start": -4,
"cds_end": null,
"cds_length": 1956,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2452,
"mane_select": "ENST00000298048.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "MELK",
"gene_hgnc_id": 16870,
"hgvs_c": "c.834+2212T>C",
"hgvs_p": null,
"transcript": "ENST00000298048.7",
"protein_id": "ENSP00000298048.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 651,
"cds_start": -4,
"cds_end": null,
"cds_length": 1956,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2452,
"mane_select": "NM_014791.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "MELK",
"gene_hgnc_id": 16870,
"hgvs_c": "c.738+2212T>C",
"hgvs_p": null,
"transcript": "ENST00000543751.5",
"protein_id": "ENSP00000441596.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 619,
"cds_start": -4,
"cds_end": null,
"cds_length": 1860,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2400,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "MELK",
"gene_hgnc_id": 16870,
"hgvs_c": "c.621+2212T>C",
"hgvs_p": null,
"transcript": "ENST00000536329.5",
"protein_id": "ENSP00000443550.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 580,
"cds_start": -4,
"cds_end": null,
"cds_length": 1743,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2283,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "MELK",
"gene_hgnc_id": 16870,
"hgvs_c": "c.738+2212T>C",
"hgvs_p": null,
"transcript": "NM_001256689.2",
"protein_id": "NP_001243618.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 619,
"cds_start": -4,
"cds_end": null,
"cds_length": 1860,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2366,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "MELK",
"gene_hgnc_id": 16870,
"hgvs_c": "c.834+2212T>C",
"hgvs_p": null,
"transcript": "NM_001256685.2",
"protein_id": "NP_001243614.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 610,
"cds_start": -4,
"cds_end": null,
"cds_length": 1833,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2329,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "MELK",
"gene_hgnc_id": 16870,
"hgvs_c": "c.834+2212T>C",
"hgvs_p": null,
"transcript": "ENST00000541717.4",
"protein_id": "ENSP00000437804.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 610,
"cds_start": -4,
"cds_end": null,
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"cdna_start": null,
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"cdna_length": 2363,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "MELK",
"gene_hgnc_id": 16870,
"hgvs_c": "c.690+2212T>C",
"hgvs_p": null,
"transcript": "NM_001256687.2",
"protein_id": "NP_001243616.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 603,
"cds_start": -4,
"cds_end": null,
"cds_length": 1812,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2308,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "MELK",
"gene_hgnc_id": 16870,
"hgvs_c": "c.690+2212T>C",
"hgvs_p": null,
"transcript": "ENST00000536860.5",
"protein_id": "ENSP00000439792.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 603,
"cds_start": -4,
"cds_end": null,
"cds_length": 1812,
"cdna_start": null,
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"cdna_length": 2342,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 16,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "MELK",
"gene_hgnc_id": 16870,
"hgvs_c": "c.621+2212T>C",
"hgvs_p": null,
"transcript": "NM_001256688.2",
"protein_id": "NP_001243617.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 580,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 16,
"intron_rank": 8,
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"gene_symbol": "MELK",
"gene_hgnc_id": 16870,
"hgvs_c": "c.621+2212T>C",
"hgvs_p": null,
"transcript": "NM_001256690.2",
"protein_id": "NP_001243619.1",
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},
{
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],
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"gene_symbol": "MELK",
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"transcript": "ENST00000545008.5",
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},
{
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],
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"gene_symbol": "MELK",
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"hgvs_c": "c.594+2212T>C",
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"protein_id": "NP_001243620.1",
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},
{
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],
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"gene_symbol": "MELK",
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},
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],
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},
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],
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"gene_symbol": "MELK",
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],
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"gene_symbol": "MELK",
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"hgvs_c": "n.*205+2212T>C",
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},
{
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"strand": true,
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],
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"intron_rank": 8,
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"gene_symbol": "MELK",
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"hgvs_c": "n.*191+2212T>C",
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"transcript": "ENST00000626154.2",
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"strand": true,
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],
"exon_rank": null,
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},
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],
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},
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],
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"gene_symbol": "MELK",
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"hgvs_c": "c.834+2212T>C",
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"transcript": "XM_011518077.2",
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},
{
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"strand": true,
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],
"exon_rank": null,
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"exon_count": 19,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "MELK",
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"hgvs_c": "c.834+2212T>C",
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