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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 9-39086767-CC-TG (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=39086767&ref=CC&alt=TG&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 0,
          "criteria": [],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "CNTNAP3",
          "hgnc_id": 13834,
          "hgvs_c": "c.3302_3303delGGinsCA",
          "hgvs_p": "p.Gly1101Ala",
          "inheritance_mode": "AR",
          "pathogenic_score": 0,
          "score": 0,
          "transcript": "NM_033655.5",
          "verdict": "Uncertain_significance"
        }
      ],
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "",
      "acmg_score": 0,
      "allele_count_reference_population": 0,
      "alphamissense_prediction": null,
      "alphamissense_score": null,
      "alt": "TG",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": null,
      "bayesdelnoaf_score": null,
      "chr": "9",
      "clinvar_classification": "",
      "clinvar_disease": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "computational_prediction_selected": null,
      "computational_score_selected": null,
      "computational_source_selected": null,
      "consequences": [
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1288,
          "aa_ref": "G",
          "aa_start": 1101,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 13150,
          "cdna_start": 3406,
          "cds_end": null,
          "cds_length": 3867,
          "cds_start": 3302,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 24,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_033655.5",
          "gene_hgnc_id": 13834,
          "gene_symbol": "CNTNAP3",
          "hgvs_c": "c.3302_3303delGGinsCA",
          "hgvs_p": "p.Gly1101Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000297668.11",
          "protein_coding": true,
          "protein_id": "NP_387504.2",
          "strand": false,
          "transcript": "NM_033655.5",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1288,
          "aa_ref": "G",
          "aa_start": 1101,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 13150,
          "cdna_start": 3406,
          "cds_end": null,
          "cds_length": 3867,
          "cds_start": 3302,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 24,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000297668.11",
          "gene_hgnc_id": 13834,
          "gene_symbol": "CNTNAP3",
          "hgvs_c": "c.3302_3303delGGinsCA",
          "hgvs_p": "p.Gly1101Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_033655.5",
          "protein_coding": true,
          "protein_id": "ENSP00000297668.6",
          "strand": false,
          "transcript": "ENST00000297668.11",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1207,
          "aa_ref": "G",
          "aa_start": 1020,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4986,
          "cdna_start": 3299,
          "cds_end": null,
          "cds_length": 3624,
          "cds_start": 3059,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 23,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000377656.6",
          "gene_hgnc_id": 13834,
          "gene_symbol": "CNTNAP3",
          "hgvs_c": "c.3059_3060delGGinsCA",
          "hgvs_p": "p.Gly1020Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000366884.2",
          "strand": false,
          "transcript": "ENST00000377656.6",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1328,
          "aa_ref": "G",
          "aa_start": 1141,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5203,
          "cdna_start": 3516,
          "cds_end": null,
          "cds_length": 3987,
          "cds_start": 3422,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 25,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000865312.1",
          "gene_hgnc_id": 13834,
          "gene_symbol": "CNTNAP3",
          "hgvs_c": "c.3422_3423delGGinsCA",
          "hgvs_p": "p.Gly1141Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000535371.1",
          "strand": false,
          "transcript": "ENST00000865312.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1298,
          "aa_ref": "G",
          "aa_start": 1111,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 7628,
          "cdna_start": 3601,
          "cds_end": null,
          "cds_length": 3897,
          "cds_start": 3332,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 24,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000941984.1",
          "gene_hgnc_id": 13834,
          "gene_symbol": "CNTNAP3",
          "hgvs_c": "c.3332_3333delGGinsCA",
          "hgvs_p": "p.Gly1111Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000612043.1",
          "strand": false,
          "transcript": "ENST00000941984.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1287,
          "aa_ref": "G",
          "aa_start": 1100,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5534,
          "cdna_start": 3847,
          "cds_end": null,
          "cds_length": 3864,
          "cds_start": 3299,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 24,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000865309.1",
          "gene_hgnc_id": 13834,
          "gene_symbol": "CNTNAP3",
          "hgvs_c": "c.3299_3300delGGinsCA",
          "hgvs_p": "p.Gly1100Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000535368.1",
          "strand": false,
          "transcript": "ENST00000865309.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1254,
          "aa_ref": "G",
          "aa_start": 1067,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5094,
          "cdna_start": 3413,
          "cds_end": null,
          "cds_length": 3765,
          "cds_start": 3200,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 24,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000924962.1",
          "gene_hgnc_id": 13834,
          "gene_symbol": "CNTNAP3",
          "hgvs_c": "c.3200_3201delGGinsCA",
          "hgvs_p": "p.Gly1067Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000595021.1",
          "strand": false,
          "transcript": "ENST00000924962.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1253,
          "aa_ref": "G",
          "aa_start": 1066,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 7677,
          "cdna_start": 3422,
          "cds_end": null,
          "cds_length": 3762,
          "cds_start": 3197,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 24,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000924961.1",
          "gene_hgnc_id": 13834,
          "gene_symbol": "CNTNAP3",
          "hgvs_c": "c.3197_3198delGGinsCA",
          "hgvs_p": "p.Gly1066Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000595020.1",
          "strand": false,
          "transcript": "ENST00000924961.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1241,
          "aa_ref": "G",
          "aa_start": 1054,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4922,
          "cdna_start": 3550,
          "cds_end": null,
          "cds_length": 3726,
          "cds_start": 3161,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 24,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000941986.1",
          "gene_hgnc_id": 13834,
          "gene_symbol": "CNTNAP3",
          "hgvs_c": "c.3161_3162delGGinsCA",
          "hgvs_p": "p.Gly1054Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000612045.1",
          "strand": false,
          "transcript": "ENST00000941986.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1215,
          "aa_ref": "G",
          "aa_start": 1028,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 7708,
          "cdna_start": 3450,
          "cds_end": null,
          "cds_length": 3648,
          "cds_start": 3083,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 23,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000941983.1",
          "gene_hgnc_id": 13834,
          "gene_symbol": "CNTNAP3",
          "hgvs_c": "c.3083_3084delGGinsCA",
          "hgvs_p": "p.Gly1028Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000612042.1",
          "strand": false,
          "transcript": "ENST00000941983.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1207,
          "aa_ref": "G",
          "aa_start": 1020,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 12907,
          "cdna_start": 3163,
          "cds_end": null,
          "cds_length": 3624,
          "cds_start": 3059,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 23,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001393379.1",
          "gene_hgnc_id": 13834,
          "gene_symbol": "CNTNAP3",
          "hgvs_c": "c.3059_3060delGGinsCA",
          "hgvs_p": "p.Gly1020Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001380308.1",
          "strand": false,
          "transcript": "NM_001393379.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1195,
          "aa_ref": "G",
          "aa_start": 1008,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 7446,
          "cdna_start": 3417,
          "cds_end": null,
          "cds_length": 3588,
          "cds_start": 3023,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 22,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000865308.1",
          "gene_hgnc_id": 13834,
          "gene_symbol": "CNTNAP3",
          "hgvs_c": "c.3023_3024delGGinsCA",
          "hgvs_p": "p.Gly1008Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000535367.1",
          "strand": false,
          "transcript": "ENST00000865308.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1194,
          "aa_ref": "G",
          "aa_start": 1007,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5113,
          "cdna_start": 3429,
          "cds_end": null,
          "cds_length": 3585,
          "cds_start": 3020,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 22,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000865310.1",
          "gene_hgnc_id": 13834,
          "gene_symbol": "CNTNAP3",
          "hgvs_c": "c.3020_3021delGGinsCA",
          "hgvs_p": "p.Gly1007Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000535369.1",
          "strand": false,
          "transcript": "ENST00000865310.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1155,
          "aa_ref": "G",
          "aa_start": 968,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 7558,
          "cdna_start": 3299,
          "cds_end": null,
          "cds_length": 3468,
          "cds_start": 2903,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 21,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000865307.1",
          "gene_hgnc_id": 13834,
          "gene_symbol": "CNTNAP3",
          "hgvs_c": "c.2903_2904delGGinsCA",
          "hgvs_p": "p.Gly968Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000535366.1",
          "strand": false,
          "transcript": "ENST00000865307.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1154,
          "aa_ref": "G",
          "aa_start": 967,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4760,
          "cdna_start": 3294,
          "cds_end": null,
          "cds_length": 3465,
          "cds_start": 2900,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 21,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000865311.1",
          "gene_hgnc_id": 13834,
          "gene_symbol": "CNTNAP3",
          "hgvs_c": "c.2900_2901delGGinsCA",
          "hgvs_p": "p.Gly967Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000535370.1",
          "strand": false,
          "transcript": "ENST00000865311.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1092,
          "aa_ref": "G",
          "aa_start": 905,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4882,
          "cdna_start": 3197,
          "cds_end": null,
          "cds_length": 3279,
          "cds_start": 2714,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 20,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000941985.1",
          "gene_hgnc_id": 13834,
          "gene_symbol": "CNTNAP3",
          "hgvs_c": "c.2714_2715delGGinsCA",
          "hgvs_p": "p.Gly905Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000612044.1",
          "strand": false,
          "transcript": "ENST00000941985.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1039,
          "aa_ref": "G",
          "aa_start": 1013,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4885,
          "cdna_start": 3095,
          "cds_end": null,
          "cds_length": 3120,
          "cds_start": 3038,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 18,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000358144.6",
          "gene_hgnc_id": 13834,
          "gene_symbol": "CNTNAP3",
          "hgvs_c": "c.3038_3039delGGinsCA",
          "hgvs_p": "p.Gly1013Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000350863.2",
          "strand": false,
          "transcript": "ENST00000358144.6",
          "transcript_support_level": 5
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "pseudogene",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 765,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 5,
          "exon_rank": 2,
          "exon_rank_end": null,
          "feature": "ENST00000493965.5",
          "gene_hgnc_id": 13834,
          "gene_symbol": "CNTNAP3",
          "hgvs_c": "n.133_134delGGinsCA",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": false,
          "transcript": "ENST00000493965.5",
          "transcript_support_level": 5
        }
      ],
      "custom_annotations": null,
      "dbscsnv_ada_prediction": null,
      "dbscsnv_ada_score": null,
      "dbsnp": null,
      "effect": "missense_variant",
      "frequency_reference_population": null,
      "gene_hgnc_id": 13834,
      "gene_symbol": "CNTNAP3",
      "gnomad_exomes_ac": null,
      "gnomad_exomes_af": null,
      "gnomad_exomes_homalt": null,
      "gnomad_genomes_ac": null,
      "gnomad_genomes_af": null,
      "gnomad_genomes_homalt": null,
      "gnomad_mito_heteroplasmic": null,
      "gnomad_mito_homoplasmic": null,
      "hom_count_reference_population": 0,
      "mitotip_prediction": null,
      "mitotip_score": null,
      "pathogenicity_classification_combined": null,
      "phenotype_combined": null,
      "phylop100way_prediction": "Uncertain_significance",
      "phylop100way_score": 5.831,
      "pos": 39086767,
      "ref": "CC",
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      "transcript": "NM_033655.5"
    }
  ]
}
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