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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 9-68299062-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=68299062&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "9",
"pos": 68299062,
"ref": "C",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "NM_201453.4",
"consequences": [
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNG1C",
"gene_hgnc_id": 18519,
"hgvs_c": "c.1050C>T",
"hgvs_p": "p.Asp350Asp",
"transcript": "NM_201453.4",
"protein_id": "NP_958861.2",
"transcript_support_level": null,
"aa_start": 350,
"aa_end": null,
"aa_length": 395,
"cds_start": 1050,
"cds_end": null,
"cds_length": 1188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000360171.11",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_201453.4"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNG1C",
"gene_hgnc_id": 18519,
"hgvs_c": "c.1050C>T",
"hgvs_p": "p.Asp350Asp",
"transcript": "ENST00000360171.11",
"protein_id": "ENSP00000353295.6",
"transcript_support_level": 1,
"aa_start": 350,
"aa_end": null,
"aa_length": 395,
"cds_start": 1050,
"cds_end": null,
"cds_length": 1188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_201453.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000360171.11"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNG1C",
"gene_hgnc_id": 18519,
"hgvs_c": "c.993C>T",
"hgvs_p": "p.Asp331Asp",
"transcript": "ENST00000377342.9",
"protein_id": "ENSP00000366559.6",
"transcript_support_level": 1,
"aa_start": 331,
"aa_end": null,
"aa_length": 376,
"cds_start": 993,
"cds_end": null,
"cds_length": 1131,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000377342.9"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNG1C",
"gene_hgnc_id": 18519,
"hgvs_c": "c.906C>T",
"hgvs_p": "p.Asp302Asp",
"transcript": "ENST00000618217.4",
"protein_id": "ENSP00000480203.1",
"transcript_support_level": 1,
"aa_start": 302,
"aa_end": null,
"aa_length": 347,
"cds_start": 906,
"cds_end": null,
"cds_length": 1044,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000618217.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNG1C",
"gene_hgnc_id": 18519,
"hgvs_c": "n.*771C>T",
"hgvs_p": null,
"transcript": "ENST00000377344.6",
"protein_id": "ENSP00000366561.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000377344.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNG1C",
"gene_hgnc_id": 18519,
"hgvs_c": "n.*646C>T",
"hgvs_p": null,
"transcript": "ENST00000612050.4",
"protein_id": "ENSP00000481705.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000612050.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNG1C",
"gene_hgnc_id": 18519,
"hgvs_c": "n.2091C>T",
"hgvs_p": null,
"transcript": "ENST00000614377.1",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000614377.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNG1C",
"gene_hgnc_id": 18519,
"hgvs_c": "n.2365C>T",
"hgvs_p": null,
"transcript": "ENST00000614398.4",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "pseudogene",
"feature": "ENST00000614398.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNG1C",
"gene_hgnc_id": 18519,
"hgvs_c": "n.*971C>T",
"hgvs_p": null,
"transcript": "ENST00000615061.4",
"protein_id": "ENSP00000478468.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000615061.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNG1C",
"gene_hgnc_id": 18519,
"hgvs_c": "n.*771C>T",
"hgvs_p": null,
"transcript": "ENST00000377344.6",
"protein_id": "ENSP00000366561.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000377344.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNG1C",
"gene_hgnc_id": 18519,
"hgvs_c": "n.*646C>T",
"hgvs_p": null,
"transcript": "ENST00000612050.4",
"protein_id": "ENSP00000481705.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000612050.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNG1C",
"gene_hgnc_id": 18519,
"hgvs_c": "n.*971C>T",
"hgvs_p": null,
"transcript": "ENST00000615061.4",
"protein_id": "ENSP00000478468.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000615061.4"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNG1C",
"gene_hgnc_id": 18519,
"hgvs_c": "c.1035C>T",
"hgvs_p": "p.Asp345Asp",
"transcript": "ENST00000956226.1",
"protein_id": "ENSP00000626285.1",
"transcript_support_level": null,
"aa_start": 345,
"aa_end": null,
"aa_length": 390,
"cds_start": 1035,
"cds_end": null,
"cds_length": 1173,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000956226.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNG1C",
"gene_hgnc_id": 18519,
"hgvs_c": "c.990C>T",
"hgvs_p": "p.Asp330Asp",
"transcript": "NM_001291821.2",
"protein_id": "NP_001278750.1",
"transcript_support_level": null,
"aa_start": 330,
"aa_end": null,
"aa_length": 375,
"cds_start": 990,
"cds_end": null,
"cds_length": 1128,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001291821.2"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNG1C",
"gene_hgnc_id": 18519,
"hgvs_c": "c.990C>T",
"hgvs_p": "p.Asp330Asp",
"transcript": "ENST00000890596.1",
"protein_id": "ENSP00000560655.1",
"transcript_support_level": null,
"aa_start": 330,
"aa_end": null,
"aa_length": 375,
"cds_start": 990,
"cds_end": null,
"cds_length": 1128,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000890596.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNG1C",
"gene_hgnc_id": 18519,
"hgvs_c": "c.981C>T",
"hgvs_p": "p.Asp327Asp",
"transcript": "NM_001378113.1",
"protein_id": "NP_001365042.1",
"transcript_support_level": null,
"aa_start": 327,
"aa_end": null,
"aa_length": 372,
"cds_start": 981,
"cds_end": null,
"cds_length": 1119,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001378113.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNG1C",
"gene_hgnc_id": 18519,
"hgvs_c": "c.981C>T",
"hgvs_p": "p.Asp327Asp",
"transcript": "ENST00000937634.1",
"protein_id": "ENSP00000607693.1",
"transcript_support_level": null,
"aa_start": 327,
"aa_end": null,
"aa_length": 372,
"cds_start": 981,
"cds_end": null,
"cds_length": 1119,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000937634.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNG1C",
"gene_hgnc_id": 18519,
"hgvs_c": "c.978C>T",
"hgvs_p": "p.Asp326Asp",
"transcript": "ENST00000956224.1",
"protein_id": "ENSP00000626283.1",
"transcript_support_level": null,
"aa_start": 326,
"aa_end": null,
"aa_length": 371,
"cds_start": 978,
"cds_end": null,
"cds_length": 1116,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000956224.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNG1C",
"gene_hgnc_id": 18519,
"hgvs_c": "c.963C>T",
"hgvs_p": "p.Asp321Asp",
"transcript": "NM_001378114.1",
"protein_id": "NP_001365043.1",
"transcript_support_level": null,
"aa_start": 321,
"aa_end": null,
"aa_length": 366,
"cds_start": 963,
"cds_end": null,
"cds_length": 1101,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001378114.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNG1C",
"gene_hgnc_id": 18519,
"hgvs_c": "c.963C>T",
"hgvs_p": "p.Asp321Asp",
"transcript": "NM_001378115.1",
"protein_id": "NP_001365044.1",
"transcript_support_level": null,
"aa_start": 321,
"aa_end": null,
"aa_length": 366,
"cds_start": 963,
"cds_end": null,
"cds_length": 1101,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001378115.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNG1C",
"gene_hgnc_id": 18519,
"hgvs_c": "c.963C>T",
"hgvs_p": "p.Asp321Asp",
"transcript": "ENST00000890600.1",
"protein_id": "ENSP00000560659.1",
"transcript_support_level": null,
"aa_start": 321,
"aa_end": null,
"aa_length": 366,
"cds_start": 963,
"cds_end": null,
"cds_length": 1101,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000890600.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNG1C",
"gene_hgnc_id": 18519,
"hgvs_c": "c.957C>T",
"hgvs_p": "p.Asp319Asp",
"transcript": "ENST00000937636.1",
"protein_id": "ENSP00000607695.1",
"transcript_support_level": null,
"aa_start": 319,
"aa_end": null,
"aa_length": 364,
"cds_start": 957,
"cds_end": null,
"cds_length": 1095,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000937636.1"
},
{
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}
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}