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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 9-6888028-TC-CT (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=6888028&ref=TC&alt=CT&genome=hg38&allGenes=true"API Response
json
{
"message": null,
"variants": [
{
"acmg_by_gene": [
{
"benign_score": 0,
"criteria": [],
"effects": [
"missense_variant"
],
"gene_symbol": "KDM4C",
"hgnc_id": 17071,
"hgvs_c": "c.748_749delTCinsCT",
"hgvs_p": "p.Ser250Leu",
"inheritance_mode": "AR",
"pathogenic_score": 0,
"score": 0,
"transcript": "NM_001353997.3",
"verdict": "Uncertain_significance"
}
],
"acmg_classification": "Uncertain_significance",
"acmg_criteria": "",
"acmg_score": 0,
"allele_count_reference_population": 0,
"alphamissense_prediction": null,
"alphamissense_score": null,
"alt": "CT",
"apogee2_prediction": null,
"apogee2_score": null,
"bayesdelnoaf_prediction": null,
"bayesdelnoaf_score": null,
"chr": "9",
"clinvar_classification": "",
"clinvar_disease": "",
"clinvar_review_status": "",
"clinvar_submissions_summary": "",
"computational_prediction_selected": null,
"computational_score_selected": null,
"computational_source_selected": null,
"consequences": [
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 1056,
"aa_ref": "S",
"aa_start": 250,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 4338,
"cdna_start": 996,
"cds_end": null,
"cds_length": 3171,
"cds_start": 748,
"consequences": [
"missense_variant"
],
"exon_count": 22,
"exon_rank": null,
"exon_rank_end": null,
"feature": "NM_015061.6",
"gene_hgnc_id": 17071,
"gene_symbol": "KDM4C",
"hgvs_c": "c.748_749delTCinsCT",
"hgvs_p": "p.Ser250Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": "ENST00000381309.8",
"protein_coding": true,
"protein_id": "NP_055876.2",
"strand": true,
"transcript": "NM_015061.6",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 1056,
"aa_ref": "S",
"aa_start": 250,
"biotype": "protein_coding",
"canonical": true,
"cdna_end": null,
"cdna_length": 4338,
"cdna_start": 996,
"cds_end": null,
"cds_length": 3171,
"cds_start": 748,
"consequences": [
"missense_variant"
],
"exon_count": 22,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000381309.8",
"gene_hgnc_id": 17071,
"gene_symbol": "KDM4C",
"hgvs_c": "c.748_749delTCinsCT",
"hgvs_p": "p.Ser250Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": "NM_015061.6",
"protein_coding": true,
"protein_id": "ENSP00000370710.3",
"strand": true,
"transcript": "ENST00000381309.8",
"transcript_support_level": 1
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 813,
"aa_ref": "S",
"aa_start": 250,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3406,
"cdna_start": 900,
"cds_end": null,
"cds_length": 2442,
"cds_start": 748,
"consequences": [
"missense_variant"
],
"exon_count": 18,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000536108.7",
"gene_hgnc_id": 17071,
"gene_symbol": "KDM4C",
"hgvs_c": "c.748_749delTCinsCT",
"hgvs_p": "p.Ser250Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000440656.4",
"strand": true,
"transcript": "ENST00000536108.7",
"transcript_support_level": 1
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 1089,
"aa_ref": "S",
"aa_start": 250,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 4437,
"cdna_start": 996,
"cds_end": null,
"cds_length": 3270,
"cds_start": 748,
"consequences": [
"missense_variant"
],
"exon_count": 23,
"exon_rank": null,
"exon_rank_end": null,
"feature": "NM_001353997.3",
"gene_hgnc_id": 17071,
"gene_symbol": "KDM4C",
"hgvs_c": "c.748_749delTCinsCT",
"hgvs_p": "p.Ser250Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "NP_001340926.1",
"strand": true,
"transcript": "NM_001353997.3",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 1056,
"aa_ref": "S",
"aa_start": 250,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 4487,
"cdna_start": 1145,
"cds_end": null,
"cds_length": 3171,
"cds_start": 748,
"consequences": [
"missense_variant"
],
"exon_count": 23,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000948679.1",
"gene_hgnc_id": 17071,
"gene_symbol": "KDM4C",
"hgvs_c": "c.748_749delTCinsCT",
"hgvs_p": "p.Ser250Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000618738.1",
"strand": true,
"transcript": "ENST00000948679.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 1056,
"aa_ref": "S",
"aa_start": 250,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 4218,
"cdna_start": 879,
"cds_end": null,
"cds_length": 3171,
"cds_start": 748,
"consequences": [
"missense_variant"
],
"exon_count": 22,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000948683.1",
"gene_hgnc_id": 17071,
"gene_symbol": "KDM4C",
"hgvs_c": "c.748_749delTCinsCT",
"hgvs_p": "p.Ser250Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000618742.1",
"strand": true,
"transcript": "ENST00000948683.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 1047,
"aa_ref": "S",
"aa_start": 250,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 4601,
"cdna_start": 1313,
"cds_end": null,
"cds_length": 3144,
"cds_start": 748,
"consequences": [
"missense_variant"
],
"exon_count": 21,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000381306.7",
"gene_hgnc_id": 17071,
"gene_symbol": "KDM4C",
"hgvs_c": "c.748_749delTCinsCT",
"hgvs_p": "p.Ser250Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000370707.3",
"strand": true,
"transcript": "ENST00000381306.7",
"transcript_support_level": 2
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 1034,
"aa_ref": "S",
"aa_start": 250,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 4294,
"cdna_start": 1019,
"cds_end": null,
"cds_length": 3105,
"cds_start": 748,
"consequences": [
"missense_variant"
],
"exon_count": 21,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000948680.1",
"gene_hgnc_id": 17071,
"gene_symbol": "KDM4C",
"hgvs_c": "c.748_749delTCinsCT",
"hgvs_p": "p.Ser250Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000618739.1",
"strand": true,
"transcript": "ENST00000948680.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 1023,
"aa_ref": "S",
"aa_start": 250,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 4331,
"cdna_start": 996,
"cds_end": null,
"cds_length": 3072,
"cds_start": 748,
"consequences": [
"missense_variant"
],
"exon_count": 22,
"exon_rank": null,
"exon_rank_end": null,
"feature": "NM_001304339.4",
"gene_hgnc_id": 17071,
"gene_symbol": "KDM4C",
"hgvs_c": "c.748_749delTCinsCT",
"hgvs_p": "p.Ser250Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "NP_001291268.1",
"strand": true,
"transcript": "NM_001304339.4",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 1001,
"aa_ref": "S",
"aa_start": 250,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 4156,
"cdna_start": 979,
"cds_end": null,
"cds_length": 3006,
"cds_start": 748,
"consequences": [
"missense_variant"
],
"exon_count": 20,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000934139.1",
"gene_hgnc_id": 17071,
"gene_symbol": "KDM4C",
"hgvs_c": "c.748_749delTCinsCT",
"hgvs_p": "p.Ser250Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000604198.1",
"strand": true,
"transcript": "ENST00000934139.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 999,
"aa_ref": "S",
"aa_start": 250,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 4140,
"cdna_start": 969,
"cds_end": null,
"cds_length": 3000,
"cds_start": 748,
"consequences": [
"missense_variant"
],
"exon_count": 21,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000871061.1",
"gene_hgnc_id": 17071,
"gene_symbol": "KDM4C",
"hgvs_c": "c.748_749delTCinsCT",
"hgvs_p": "p.Ser250Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000541120.1",
"strand": true,
"transcript": "ENST00000871061.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 994,
"aa_ref": "S",
"aa_start": 250,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 4120,
"cdna_start": 965,
"cds_end": null,
"cds_length": 2985,
"cds_start": 748,
"consequences": [
"missense_variant"
],
"exon_count": 21,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000948681.1",
"gene_hgnc_id": 17071,
"gene_symbol": "KDM4C",
"hgvs_c": "c.748_749delTCinsCT",
"hgvs_p": "p.Ser250Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000618740.1",
"strand": true,
"transcript": "ENST00000948681.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 957,
"aa_ref": "S",
"aa_start": 250,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3961,
"cdna_start": 917,
"cds_end": null,
"cds_length": 2874,
"cds_start": 748,
"consequences": [
"missense_variant"
],
"exon_count": 21,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000871063.1",
"gene_hgnc_id": 17071,
"gene_symbol": "KDM4C",
"hgvs_c": "c.748_749delTCinsCT",
"hgvs_p": "p.Ser250Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000541122.1",
"strand": true,
"transcript": "ENST00000871063.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 924,
"aa_ref": "S",
"aa_start": 250,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3893,
"cdna_start": 1026,
"cds_end": null,
"cds_length": 2775,
"cds_start": 748,
"consequences": [
"missense_variant"
],
"exon_count": 20,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000871062.1",
"gene_hgnc_id": 17071,
"gene_symbol": "KDM4C",
"hgvs_c": "c.748_749delTCinsCT",
"hgvs_p": "p.Ser250Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000541121.1",
"strand": true,
"transcript": "ENST00000871062.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 904,
"aa_ref": "S",
"aa_start": 250,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3778,
"cdna_start": 893,
"cds_end": null,
"cds_length": 2715,
"cds_start": 748,
"consequences": [
"missense_variant"
],
"exon_count": 18,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000948682.1",
"gene_hgnc_id": 17071,
"gene_symbol": "KDM4C",
"hgvs_c": "c.748_749delTCinsCT",
"hgvs_p": "p.Ser250Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000618741.1",
"strand": true,
"transcript": "ENST00000948682.1",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 835,
"aa_ref": "S",
"aa_start": 272,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3406,
"cdna_start": 900,
"cds_end": null,
"cds_length": 2508,
"cds_start": 814,
"consequences": [
"missense_variant"
],
"exon_count": 18,
"exon_rank": null,
"exon_rank_end": null,
"feature": "NM_001146696.2",
"gene_hgnc_id": 17071,
"gene_symbol": "KDM4C",
"hgvs_c": "c.814_815delTCinsCT",
"hgvs_p": "p.Ser272Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "NP_001140168.1",
"strand": true,
"transcript": "NM_001146696.2",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 813,
"aa_ref": "S",
"aa_start": 250,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3502,
"cdna_start": 996,
"cds_end": null,
"cds_length": 2442,
"cds_start": 748,
"consequences": [
"missense_variant"
],
"exon_count": 18,
"exon_rank": null,
"exon_rank_end": null,
"feature": "NM_001146695.4",
"gene_hgnc_id": 17071,
"gene_symbol": "KDM4C",
"hgvs_c": "c.748_749delTCinsCT",
"hgvs_p": "p.Ser250Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "NP_001140167.1",
"strand": true,
"transcript": "NM_001146695.4",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 813,
"aa_ref": "S",
"aa_start": 250,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3332,
"cdna_start": 826,
"cds_end": null,
"cds_length": 2442,
"cds_start": 748,
"consequences": [
"missense_variant"
],
"exon_count": 18,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000543771.5",
"gene_hgnc_id": 17071,
"gene_symbol": "KDM4C",
"hgvs_c": "c.748_749delTCinsCT",
"hgvs_p": "p.Ser250Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000445427.1",
"strand": true,
"transcript": "ENST00000543771.5",
"transcript_support_level": 2
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 801,
"aa_ref": "S",
"aa_start": 69,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3940,
"cdna_start": 820,
"cds_end": null,
"cds_length": 2406,
"cds_start": 205,
"consequences": [
"missense_variant"
],
"exon_count": 20,
"exon_rank": null,
"exon_rank_end": null,
"feature": "NM_001304340.4",
"gene_hgnc_id": 17071,
"gene_symbol": "KDM4C",
"hgvs_c": "c.205_206delTCinsCT",
"hgvs_p": "p.Ser69Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "NP_001291269.1",
"strand": true,
"transcript": "NM_001304340.4",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 793,
"aa_ref": "S",
"aa_start": 250,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 3393,
"cdna_start": 996,
"cds_end": null,
"cds_length": 2382,
"cds_start": 748,
"consequences": [
"missense_variant"
],
"exon_count": 17,
"exon_rank": null,
"exon_rank_end": null,
"feature": "NM_001353998.3",
"gene_hgnc_id": 17071,
"gene_symbol": "KDM4C",
"hgvs_c": "c.748_749delTCinsCT",
"hgvs_p": "p.Ser250Leu",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "NP_001340927.1",
"strand": true,
"transcript": "NM_001353998.3",
"transcript_support_level": null
},
{
"aa_alt": "L",
"aa_end": null,
"aa_length": 999,
"aa_ref": "S",
"aa_start": 250,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 4167,
"cdna_start": 996,
"cds_end": null,
"cds_length": 3000,
"cds_start": 748,
"consequences": [
"missense_variant"
],
"exon_count": 21,
"exon_rank": null,
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