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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 9-6978321-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=6978321&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "9",
"pos": 6978321,
"ref": "A",
"alt": "G",
"effect": "intron_variant",
"transcript": "ENST00000381309.8",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "KDM4C",
"gene_hgnc_id": 17071,
"hgvs_c": "c.922-2604A>G",
"hgvs_p": null,
"transcript": "NM_015061.6",
"protein_id": "NP_055876.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1056,
"cds_start": -4,
"cds_end": null,
"cds_length": 3171,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4338,
"mane_select": "ENST00000381309.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "KDM4C",
"gene_hgnc_id": 17071,
"hgvs_c": "c.922-2604A>G",
"hgvs_p": null,
"transcript": "ENST00000381309.8",
"protein_id": "ENSP00000370710.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1056,
"cds_start": -4,
"cds_end": null,
"cds_length": 3171,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4338,
"mane_select": "NM_015061.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "KDM4C",
"gene_hgnc_id": 17071,
"hgvs_c": "c.922-2604A>G",
"hgvs_p": null,
"transcript": "ENST00000536108.7",
"protein_id": "ENSP00000440656.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 813,
"cds_start": -4,
"cds_end": null,
"cds_length": 2442,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3406,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "KDM4C",
"gene_hgnc_id": 17071,
"hgvs_c": "c.922-2604A>G",
"hgvs_p": null,
"transcript": "NM_001353997.3",
"protein_id": "NP_001340926.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1089,
"cds_start": -4,
"cds_end": null,
"cds_length": 3270,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4437,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "KDM4C",
"gene_hgnc_id": 17071,
"hgvs_c": "c.922-2604A>G",
"hgvs_p": null,
"transcript": "ENST00000381306.7",
"protein_id": "ENSP00000370707.3",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 1047,
"cds_start": -4,
"cds_end": null,
"cds_length": 3144,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4601,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "KDM4C",
"gene_hgnc_id": 17071,
"hgvs_c": "c.922-2604A>G",
"hgvs_p": null,
"transcript": "NM_001304339.4",
"protein_id": "NP_001291268.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1023,
"cds_start": -4,
"cds_end": null,
"cds_length": 3072,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4331,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "KDM4C",
"gene_hgnc_id": 17071,
"hgvs_c": "c.988-2604A>G",
"hgvs_p": null,
"transcript": "NM_001146696.2",
"protein_id": "NP_001140168.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 835,
"cds_start": -4,
"cds_end": null,
"cds_length": 2508,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3406,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "KDM4C",
"gene_hgnc_id": 17071,
"hgvs_c": "c.922-2604A>G",
"hgvs_p": null,
"transcript": "NM_001146695.4",
"protein_id": "NP_001140167.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 813,
"cds_start": -4,
"cds_end": null,
"cds_length": 2442,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3502,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "KDM4C",
"gene_hgnc_id": 17071,
"hgvs_c": "c.922-2604A>G",
"hgvs_p": null,
"transcript": "ENST00000543771.5",
"protein_id": "ENSP00000445427.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 813,
"cds_start": -4,
"cds_end": null,
"cds_length": 2442,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3332,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "KDM4C",
"gene_hgnc_id": 17071,
"hgvs_c": "c.379-2604A>G",
"hgvs_p": null,
"transcript": "NM_001304340.4",
"protein_id": "NP_001291269.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 801,
"cds_start": -4,
"cds_end": null,
"cds_length": 2406,
"cdna_start": null,
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"cdna_length": 3940,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "KDM4C",
"gene_hgnc_id": 17071,
"hgvs_c": "c.922-2604A>G",
"hgvs_p": null,
"transcript": "NM_001353998.3",
"protein_id": "NP_001340927.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 793,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
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"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 15,
"intron_rank": 1,
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"gene_symbol": "KDM4C",
"gene_hgnc_id": 17071,
"hgvs_c": "c.-18-2604A>G",
"hgvs_p": null,
"transcript": "ENST00000428870.6",
"protein_id": "ENSP00000405739.2",
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"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 24,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "KDM4C",
"gene_hgnc_id": 17071,
"hgvs_c": "c.-1314-2604A>G",
"hgvs_p": null,
"transcript": "NM_001353999.3",
"protein_id": "NP_001340928.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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},
{
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"protein_coding": true,
"strand": true,
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],
"exon_rank": null,
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"exon_count": 23,
"intron_rank": 8,
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"gene_symbol": "KDM4C",
"gene_hgnc_id": 17071,
"hgvs_c": "c.-527-2604A>G",
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"transcript": "NM_001354000.3",
"protein_id": "NP_001340929.1",
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},
{
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],
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"exon_count": 23,
"intron_rank": 8,
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"gene_symbol": "KDM4C",
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"hgvs_c": "c.-1314-2604A>G",
"hgvs_p": null,
"transcript": "NM_001354001.3",
"protein_id": "NP_001340930.1",
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},
{
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"protein_coding": false,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 15,
"intron_rank": 8,
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"gene_symbol": "KDM4C",
"gene_hgnc_id": 17071,
"hgvs_c": "n.922-2604A>G",
"hgvs_p": null,
"transcript": "ENST00000438023.5",
"protein_id": "ENSP00000404756.1",
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},
{
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],
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"intron_rank": 3,
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"gene_symbol": "ENSG00000224972",
"gene_hgnc_id": null,
"hgvs_c": "n.319-304A>G",
"hgvs_p": null,
"transcript": "ENST00000445708.1",
"protein_id": null,
"transcript_support_level": 4,
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},
{
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"protein_coding": false,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 15,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "KDM4C",
"gene_hgnc_id": 17071,
"hgvs_c": "n.1170-2604A>G",
"hgvs_p": null,
"transcript": "NR_130707.4",
"protein_id": null,
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},
{
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"strand": true,
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],
"exon_rank": null,
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"exon_count": 22,
"intron_rank": 8,
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"gene_symbol": "KDM4C",
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"hgvs_c": "n.1170-2604A>G",
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"transcript": "NR_148677.3",
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},
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],
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"intron_rank": 8,
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"gene_symbol": "KDM4C",
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},
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"strand": true,
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],
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"intron_rank": 8,
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"gene_symbol": "KDM4C",
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},
{
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"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 22,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "KDM4C",
"gene_hgnc_id": 17071,
"hgvs_c": "n.1170-2604A>G",
"hgvs_p": null,
"transcript": "NR_148680.3",
"protein_id": null,
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"biotype": null,
"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 21,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "KDM4C",
"gene_hgnc_id": 17071,
"hgvs_c": "c.922-2604A>G",
"hgvs_p": null,
"transcript": "XM_017014498.3",
"protein_id": "XP_016869987.1",
"transcript_support_level": null,
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"cds_start": -4,
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"feature": null
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{
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}
],
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}