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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 9-76619356-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=76619356&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "9",
"pos": 76619356,
"ref": "A",
"alt": "G",
"effect": "missense_variant",
"transcript": "ENST00000376718.8",
"consequences": [
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRUNE2",
"gene_hgnc_id": 25209,
"hgvs_c": "c.9220T>C",
"hgvs_p": "p.Ser3074Pro",
"transcript": "NM_015225.3",
"protein_id": "NP_056040.2",
"transcript_support_level": null,
"aa_start": 3074,
"aa_end": null,
"aa_length": 3088,
"cds_start": 9220,
"cds_end": null,
"cds_length": 9267,
"cdna_start": 9371,
"cdna_end": null,
"cdna_length": 12612,
"mane_select": "ENST00000376718.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRUNE2",
"gene_hgnc_id": 25209,
"hgvs_c": "c.9220T>C",
"hgvs_p": "p.Ser3074Pro",
"transcript": "ENST00000376718.8",
"protein_id": "ENSP00000365908.3",
"transcript_support_level": 5,
"aa_start": 3074,
"aa_end": null,
"aa_length": 3088,
"cds_start": 9220,
"cds_end": null,
"cds_length": 9267,
"cdna_start": 9371,
"cdna_end": null,
"cdna_length": 12612,
"mane_select": "NM_015225.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRUNE2",
"gene_hgnc_id": 25209,
"hgvs_c": "c.8146T>C",
"hgvs_p": "p.Ser2716Pro",
"transcript": "ENST00000428286.5",
"protein_id": "ENSP00000397425.1",
"transcript_support_level": 5,
"aa_start": 2716,
"aa_end": null,
"aa_length": 2730,
"cds_start": 8146,
"cds_end": null,
"cds_length": 8193,
"cdna_start": 9301,
"cdna_end": null,
"cdna_length": 12437,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRUNE2",
"gene_hgnc_id": 25209,
"hgvs_c": "c.1015T>C",
"hgvs_p": "p.Ser339Pro",
"transcript": "NM_001330680.2",
"protein_id": "NP_001317609.1",
"transcript_support_level": null,
"aa_start": 339,
"aa_end": null,
"aa_length": 353,
"cds_start": 1015,
"cds_end": null,
"cds_length": 1062,
"cdna_start": 1071,
"cdna_end": null,
"cdna_length": 4312,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRUNE2",
"gene_hgnc_id": 25209,
"hgvs_c": "c.1015T>C",
"hgvs_p": "p.Ser339Pro",
"transcript": "ENST00000376717.6",
"protein_id": "ENSP00000365907.2",
"transcript_support_level": 5,
"aa_start": 339,
"aa_end": null,
"aa_length": 353,
"cds_start": 1015,
"cds_end": null,
"cds_length": 1062,
"cdna_start": 1067,
"cdna_end": null,
"cdna_length": 4308,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRUNE2",
"gene_hgnc_id": 25209,
"hgvs_c": "c.1012T>C",
"hgvs_p": "p.Ser338Pro",
"transcript": "NM_001308050.2",
"protein_id": "NP_001294979.1",
"transcript_support_level": null,
"aa_start": 338,
"aa_end": null,
"aa_length": 352,
"cds_start": 1012,
"cds_end": null,
"cds_length": 1059,
"cdna_start": 1068,
"cdna_end": null,
"cdna_length": 4309,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRUNE2",
"gene_hgnc_id": 25209,
"hgvs_c": "c.967T>C",
"hgvs_p": "p.Ser323Pro",
"transcript": "NM_001308049.2",
"protein_id": "NP_001294978.1",
"transcript_support_level": null,
"aa_start": 323,
"aa_end": null,
"aa_length": 337,
"cds_start": 967,
"cds_end": null,
"cds_length": 1014,
"cdna_start": 1213,
"cdna_end": null,
"cdna_length": 4454,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRUNE2",
"gene_hgnc_id": 25209,
"hgvs_c": "c.736T>C",
"hgvs_p": "p.Ser246Pro",
"transcript": "ENST00000424866.1",
"protein_id": "ENSP00000393657.1",
"transcript_support_level": 5,
"aa_start": 246,
"aa_end": null,
"aa_length": 260,
"cds_start": 736,
"cds_end": null,
"cds_length": 783,
"cdna_start": 736,
"cdna_end": null,
"cdna_length": 903,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRUNE2",
"gene_hgnc_id": 25209,
"hgvs_c": "c.9268T>C",
"hgvs_p": "p.Ser3090Pro",
"transcript": "XM_006716982.2",
"protein_id": "XP_006717045.1",
"transcript_support_level": null,
"aa_start": 3090,
"aa_end": null,
"aa_length": 3104,
"cds_start": 9268,
"cds_end": null,
"cds_length": 9315,
"cdna_start": 9419,
"cdna_end": null,
"cdna_length": 12660,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRUNE2",
"gene_hgnc_id": 25209,
"hgvs_c": "c.9265T>C",
"hgvs_p": "p.Ser3089Pro",
"transcript": "XM_006716983.2",
"protein_id": "XP_006717046.1",
"transcript_support_level": null,
"aa_start": 3089,
"aa_end": null,
"aa_length": 3103,
"cds_start": 9265,
"cds_end": null,
"cds_length": 9312,
"cdna_start": 9416,
"cdna_end": null,
"cdna_length": 12657,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRUNE2",
"gene_hgnc_id": 25209,
"hgvs_c": "c.9268T>C",
"hgvs_p": "p.Ser3090Pro",
"transcript": "XM_006716984.3",
"protein_id": "XP_006717047.1",
"transcript_support_level": null,
"aa_start": 3090,
"aa_end": null,
"aa_length": 3101,
"cds_start": 9268,
"cds_end": null,
"cds_length": 9306,
"cdna_start": 9419,
"cdna_end": null,
"cdna_length": 12707,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRUNE2",
"gene_hgnc_id": 25209,
"hgvs_c": "c.9259T>C",
"hgvs_p": "p.Ser3087Pro",
"transcript": "XM_006716985.2",
"protein_id": "XP_006717048.1",
"transcript_support_level": null,
"aa_start": 3087,
"aa_end": null,
"aa_length": 3101,
"cds_start": 9259,
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"cdna_start": 9410,
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"cdna_length": 12651,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRUNE2",
"gene_hgnc_id": 25209,
"hgvs_c": "c.9268T>C",
"hgvs_p": "p.Ser3090Pro",
"transcript": "XM_047422876.1",
"protein_id": "XP_047278832.1",
"transcript_support_level": null,
"aa_start": 3090,
"aa_end": null,
"aa_length": 3101,
"cds_start": 9268,
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"cds_length": 9306,
"cdna_start": 9419,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
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"gene_symbol": "PRUNE2",
"gene_hgnc_id": 25209,
"hgvs_c": "c.9256T>C",
"hgvs_p": "p.Ser3086Pro",
"transcript": "XM_006716986.2",
"protein_id": "XP_006717049.1",
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRUNE2",
"gene_hgnc_id": 25209,
"hgvs_c": "c.9232T>C",
"hgvs_p": "p.Ser3078Pro",
"transcript": "XM_005251745.2",
"protein_id": "XP_005251802.1",
"transcript_support_level": null,
"aa_start": 3078,
"aa_end": null,
"aa_length": 3092,
"cds_start": 9232,
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"cds_length": 9279,
"cdna_start": 9383,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
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"gene_symbol": "PRUNE2",
"gene_hgnc_id": 25209,
"hgvs_c": "c.9229T>C",
"hgvs_p": "p.Ser3077Pro",
"transcript": "XM_005251746.2",
"protein_id": "XP_005251803.1",
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRUNE2",
"gene_hgnc_id": 25209,
"hgvs_c": "c.9226T>C",
"hgvs_p": "p.Ser3076Pro",
"transcript": "XM_005251748.2",
"protein_id": "XP_005251805.1",
"transcript_support_level": null,
"aa_start": 3076,
"aa_end": null,
"aa_length": 3090,
"cds_start": 9226,
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"cdna_start": 9377,
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"cdna_length": 12618,
"mane_select": null,
"mane_plus": null,
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"feature": null
},
{
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"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRUNE2",
"gene_hgnc_id": 25209,
"hgvs_c": "c.9223T>C",
"hgvs_p": "p.Ser3075Pro",
"transcript": "XM_011518323.3",
"protein_id": "XP_011516625.1",
"transcript_support_level": null,
"aa_start": 3075,
"aa_end": null,
"aa_length": 3089,
"cds_start": 9223,
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"cdna_start": 9374,
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"mane_select": null,
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},
{
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"aa_alt": "P",
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRUNE2",
"gene_hgnc_id": 25209,
"hgvs_c": "c.9220T>C",
"hgvs_p": "p.Ser3074Pro",
"transcript": "XM_005251750.2",
"protein_id": "XP_005251807.1",
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},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRUNE2",
"gene_hgnc_id": 25209,
"hgvs_c": "c.9229T>C",
"hgvs_p": "p.Ser3077Pro",
"transcript": "XM_047422878.1",
"protein_id": "XP_047278834.1",
"transcript_support_level": null,
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": 18,
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"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRUNE2",
"gene_hgnc_id": 25209,
"hgvs_c": "c.9217T>C",
"hgvs_p": "p.Ser3073Pro",
"transcript": "XM_017014346.2",
"protein_id": "XP_016869835.1",
"transcript_support_level": null,
"aa_start": 3073,
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"aa_length": 3087,
"cds_start": 9217,
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"cdna_start": 9368,
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"cdna_length": 12609,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PRUNE2",
"gene_hgnc_id": 25209,
"hgvs_c": "c.9193T>C",
"hgvs_p": "p.Ser3065Pro",
"transcript": "XM_011518327.2",
"protein_id": "XP_011516629.1",
"transcript_support_level": null,
"aa_start": 3065,
"aa_end": null,
"aa_length": 3079,
"cds_start": 9193,
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"cds_length": 9240,
"cdna_start": 9344,
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"cdna_length": 12585,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 18,
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