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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 9-85021350-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=85021350&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "9",
"pos": 85021350,
"ref": "C",
"alt": "A",
"effect": "synonymous_variant",
"transcript": "ENST00000277120.8",
"consequences": [
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NTRK2",
"gene_hgnc_id": 8032,
"hgvs_c": "c.2430C>A",
"hgvs_p": "p.Pro810Pro",
"transcript": "NM_006180.6",
"protein_id": "NP_006171.2",
"transcript_support_level": null,
"aa_start": 810,
"aa_end": null,
"aa_length": 838,
"cds_start": 2430,
"cds_end": null,
"cds_length": 2517,
"cdna_start": 2962,
"cdna_end": null,
"cdna_length": 8666,
"mane_select": "ENST00000277120.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NTRK2",
"gene_hgnc_id": 8032,
"hgvs_c": "c.2430C>A",
"hgvs_p": "p.Pro810Pro",
"transcript": "ENST00000277120.8",
"protein_id": "ENSP00000277120.3",
"transcript_support_level": 1,
"aa_start": 810,
"aa_end": null,
"aa_length": 838,
"cds_start": 2430,
"cds_end": null,
"cds_length": 2517,
"cdna_start": 2962,
"cdna_end": null,
"cdna_length": 8666,
"mane_select": "NM_006180.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NTRK2",
"gene_hgnc_id": 8032,
"hgvs_c": "c.2346C>A",
"hgvs_p": "p.Pro782Pro",
"transcript": "ENST00000323115.11",
"protein_id": "ENSP00000314586.5",
"transcript_support_level": 1,
"aa_start": 782,
"aa_end": null,
"aa_length": 810,
"cds_start": 2346,
"cds_end": null,
"cds_length": 2433,
"cdna_start": 3023,
"cdna_end": null,
"cdna_length": 8723,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NTRK2",
"gene_hgnc_id": 8032,
"hgvs_c": "c.2430C>A",
"hgvs_p": "p.Pro810Pro",
"transcript": "ENST00000686324.1",
"protein_id": "ENSP00000510134.1",
"transcript_support_level": null,
"aa_start": 810,
"aa_end": null,
"aa_length": 838,
"cds_start": 2430,
"cds_end": null,
"cds_length": 2517,
"cdna_start": 3095,
"cdna_end": null,
"cdna_length": 8795,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NTRK2",
"gene_hgnc_id": 8032,
"hgvs_c": "c.2382C>A",
"hgvs_p": "p.Pro794Pro",
"transcript": "NM_001018064.3",
"protein_id": "NP_001018074.1",
"transcript_support_level": null,
"aa_start": 794,
"aa_end": null,
"aa_length": 822,
"cds_start": 2382,
"cds_end": null,
"cds_length": 2469,
"cdna_start": 2943,
"cdna_end": null,
"cdna_length": 8647,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NTRK2",
"gene_hgnc_id": 8032,
"hgvs_c": "c.2382C>A",
"hgvs_p": "p.Pro794Pro",
"transcript": "NM_001369532.1",
"protein_id": "NP_001356461.1",
"transcript_support_level": null,
"aa_start": 794,
"aa_end": null,
"aa_length": 822,
"cds_start": 2382,
"cds_end": null,
"cds_length": 2469,
"cdna_start": 3227,
"cdna_end": null,
"cdna_length": 8931,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NTRK2",
"gene_hgnc_id": 8032,
"hgvs_c": "c.2382C>A",
"hgvs_p": "p.Pro794Pro",
"transcript": "NM_001369533.1",
"protein_id": "NP_001356462.1",
"transcript_support_level": null,
"aa_start": 794,
"aa_end": null,
"aa_length": 822,
"cds_start": 2382,
"cds_end": null,
"cds_length": 2469,
"cdna_start": 3018,
"cdna_end": null,
"cdna_length": 8722,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NTRK2",
"gene_hgnc_id": 8032,
"hgvs_c": "c.2382C>A",
"hgvs_p": "p.Pro794Pro",
"transcript": "ENST00000376213.6",
"protein_id": "ENSP00000365386.1",
"transcript_support_level": 5,
"aa_start": 794,
"aa_end": null,
"aa_length": 822,
"cds_start": 2382,
"cds_end": null,
"cds_length": 2469,
"cdna_start": 2989,
"cdna_end": null,
"cdna_length": 8693,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NTRK2",
"gene_hgnc_id": 8032,
"hgvs_c": "c.2382C>A",
"hgvs_p": "p.Pro794Pro",
"transcript": "ENST00000686259.1",
"protein_id": "ENSP00000509743.1",
"transcript_support_level": null,
"aa_start": 794,
"aa_end": null,
"aa_length": 822,
"cds_start": 2382,
"cds_end": null,
"cds_length": 2469,
"cdna_start": 3288,
"cdna_end": null,
"cdna_length": 8988,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NTRK2",
"gene_hgnc_id": 8032,
"hgvs_c": "c.2382C>A",
"hgvs_p": "p.Pro794Pro",
"transcript": "ENST00000686496.1",
"protein_id": "ENSP00000510060.1",
"transcript_support_level": null,
"aa_start": 794,
"aa_end": null,
"aa_length": 822,
"cds_start": 2382,
"cds_end": null,
"cds_length": 2469,
"cdna_start": 3733,
"cdna_end": null,
"cdna_length": 9433,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NTRK2",
"gene_hgnc_id": 8032,
"hgvs_c": "c.2382C>A",
"hgvs_p": "p.Pro794Pro",
"transcript": "ENST00000691788.1",
"protein_id": "ENSP00000509401.1",
"transcript_support_level": null,
"aa_start": 794,
"aa_end": null,
"aa_length": 822,
"cds_start": 2382,
"cds_end": null,
"cds_length": 2469,
"cdna_start": 3047,
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"cdna_length": 8747,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NTRK2",
"gene_hgnc_id": 8032,
"hgvs_c": "c.2382C>A",
"hgvs_p": "p.Pro794Pro",
"transcript": "ENST00000692181.1",
"protein_id": "ENSP00000510619.1",
"transcript_support_level": null,
"aa_start": 794,
"aa_end": null,
"aa_length": 822,
"cds_start": 2382,
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"cdna_start": 3496,
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"cdna_length": 9200,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NTRK2",
"gene_hgnc_id": 8032,
"hgvs_c": "c.2346C>A",
"hgvs_p": "p.Pro782Pro",
"transcript": "NM_001369534.1",
"protein_id": "NP_001356463.1",
"transcript_support_level": null,
"aa_start": 782,
"aa_end": null,
"aa_length": 810,
"cds_start": 2346,
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"cdna_start": 2878,
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"cdna_length": 8582,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
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"gene_symbol": "NTRK2",
"gene_hgnc_id": 8032,
"hgvs_c": "c.1962C>A",
"hgvs_p": "p.Pro654Pro",
"transcript": "NM_001369536.1",
"protein_id": "NP_001356465.1",
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"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NTRK2",
"gene_hgnc_id": 8032,
"hgvs_c": "c.1962C>A",
"hgvs_p": "p.Pro654Pro",
"transcript": "ENST00000692473.1",
"protein_id": "ENSP00000509020.1",
"transcript_support_level": null,
"aa_start": 654,
"aa_end": null,
"aa_length": 682,
"cds_start": 1962,
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"cdna_start": 2280,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NTRK2",
"gene_hgnc_id": 8032,
"hgvs_c": "c.1914C>A",
"hgvs_p": "p.Pro638Pro",
"transcript": "NM_001369535.1",
"protein_id": "NP_001356464.1",
"transcript_support_level": null,
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"cds_start": 1914,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NTRK2",
"gene_hgnc_id": 8032,
"hgvs_c": "c.1914C>A",
"hgvs_p": "p.Pro638Pro",
"transcript": "ENST00000689301.1",
"protein_id": "ENSP00000510766.1",
"transcript_support_level": null,
"aa_start": 638,
"aa_end": null,
"aa_length": 666,
"cds_start": 1914,
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"cds_length": 2001,
"cdna_start": 2251,
"cdna_end": null,
"cdna_length": 7951,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NTRK2",
"gene_hgnc_id": 8032,
"hgvs_c": "c.2430C>A",
"hgvs_p": "p.Pro810Pro",
"transcript": "XM_005252001.4",
"protein_id": "XP_005252058.1",
"transcript_support_level": null,
"aa_start": 810,
"aa_end": null,
"aa_length": 838,
"cds_start": 2430,
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"cdna_start": 3188,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NTRK2",
"gene_hgnc_id": 8032,
"hgvs_c": "c.2430C>A",
"hgvs_p": "p.Pro810Pro",
"transcript": "XM_005252003.4",
"protein_id": "XP_005252060.1",
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"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NTRK2",
"gene_hgnc_id": 8032,
"hgvs_c": "c.2430C>A",
"hgvs_p": "p.Pro810Pro",
"transcript": "XM_005252004.3",
"protein_id": "XP_005252061.1",
"transcript_support_level": null,
"aa_start": 810,
"aa_end": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NTRK2",
"gene_hgnc_id": 8032,
"hgvs_c": "c.2430C>A",
"hgvs_p": "p.Pro810Pro",
"transcript": "XM_017014751.3",
"protein_id": "XP_016870240.1",
"transcript_support_level": null,
"aa_start": 810,
"aa_end": null,
"aa_length": 838,
"cds_start": 2430,
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"cdna_start": 3730,
"cdna_end": null,
"cdna_length": 9434,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NTRK2",
"gene_hgnc_id": 8032,
"hgvs_c": "c.2430C>A",
"hgvs_p": "p.Pro810Pro",
"transcript": "XM_047423432.1",
"protein_id": "XP_047279388.1",
"transcript_support_level": null,
"aa_start": 810,
"aa_end": null,
"aa_length": 838,
"cds_start": 2430,
"cds_end": null,
"cds_length": 2517,
"cdna_start": 3397,
"cdna_end": null,
"cdna_length": 9101,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
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}
],
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}