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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 9-87672272-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=87672272&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "9",
"pos": 87672272,
"ref": "T",
"alt": "C",
"effect": "intron_variant",
"transcript": "NM_004938.4",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "DAPK1",
"gene_hgnc_id": 2674,
"hgvs_c": "c.2001+3598T>C",
"hgvs_p": null,
"transcript": "NM_004938.4",
"protein_id": "NP_004929.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1430,
"cds_start": null,
"cds_end": null,
"cds_length": 4293,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5912,
"mane_select": "ENST00000408954.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_004938.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "DAPK1",
"gene_hgnc_id": 2674,
"hgvs_c": "c.2001+3598T>C",
"hgvs_p": null,
"transcript": "ENST00000408954.8",
"protein_id": "ENSP00000386135.3",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 1430,
"cds_start": null,
"cds_end": null,
"cds_length": 4293,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5912,
"mane_select": "NM_004938.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000408954.8"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "DAPK1",
"gene_hgnc_id": 2674,
"hgvs_c": "c.2001+3598T>C",
"hgvs_p": null,
"transcript": "ENST00000358077.9",
"protein_id": "ENSP00000350785.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1430,
"cds_start": null,
"cds_end": null,
"cds_length": 4293,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5743,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000358077.9"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "DAPK1",
"gene_hgnc_id": 2674,
"hgvs_c": "c.2001+3598T>C",
"hgvs_p": null,
"transcript": "ENST00000472284.5",
"protein_id": "ENSP00000417076.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1430,
"cds_start": null,
"cds_end": null,
"cds_length": 4293,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5759,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000472284.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 18,
"intron_rank_end": null,
"gene_symbol": "DAPK1",
"gene_hgnc_id": 2674,
"hgvs_c": "c.2001+3598T>C",
"hgvs_p": null,
"transcript": "ENST00000491893.5",
"protein_id": "ENSP00000419026.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1364,
"cds_start": null,
"cds_end": null,
"cds_length": 4095,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4186,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000491893.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 17,
"intron_rank_end": null,
"gene_symbol": "DAPK1",
"gene_hgnc_id": 2674,
"hgvs_c": "n.*1385+3598T>C",
"hgvs_p": null,
"transcript": "ENST00000489291.5",
"protein_id": "ENSP00000417746.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4334,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000489291.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "DAPK1",
"gene_hgnc_id": 2674,
"hgvs_c": "c.2001+3598T>C",
"hgvs_p": null,
"transcript": "NM_001288729.2",
"protein_id": "NP_001275658.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1430,
"cds_start": null,
"cds_end": null,
"cds_length": 4293,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5726,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001288729.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "DAPK1",
"gene_hgnc_id": 2674,
"hgvs_c": "c.2001+3598T>C",
"hgvs_p": null,
"transcript": "NM_001288730.2",
"protein_id": "NP_001275659.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1430,
"cds_start": null,
"cds_end": null,
"cds_length": 4293,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5710,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001288730.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "DAPK1",
"gene_hgnc_id": 2674,
"hgvs_c": "c.2001+3598T>C",
"hgvs_p": null,
"transcript": "NM_001288731.2",
"protein_id": "NP_001275660.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1430,
"cds_start": null,
"cds_end": null,
"cds_length": 4293,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5746,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001288731.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "DAPK1",
"gene_hgnc_id": 2674,
"hgvs_c": "c.2001+3598T>C",
"hgvs_p": null,
"transcript": "ENST00000622514.4",
"protein_id": "ENSP00000484267.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 1430,
"cds_start": null,
"cds_end": null,
"cds_length": 4293,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5772,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000622514.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "DAPK1",
"gene_hgnc_id": 2674,
"hgvs_c": "c.2001+3598T>C",
"hgvs_p": null,
"transcript": "ENST00000892177.1",
"protein_id": "ENSP00000562236.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 1430,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"feature": "ENST00000892177.1"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 25,
"intron_rank": 18,
"intron_rank_end": null,
"gene_symbol": "DAPK1",
"gene_hgnc_id": 2674,
"hgvs_c": "c.2001+3598T>C",
"hgvs_p": null,
"transcript": "ENST00000892178.1",
"protein_id": "ENSP00000562237.1",
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"aa_start": null,
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"cds_start": null,
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"biotype": "protein_coding",
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},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 26,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "DAPK1",
"gene_hgnc_id": 2674,
"hgvs_c": "c.2001+3598T>C",
"hgvs_p": null,
"transcript": "ENST00000916390.1",
"protein_id": "ENSP00000586449.1",
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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},
{
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"strand": true,
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],
"exon_rank": null,
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"gene_symbol": "DAPK1",
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"hgvs_c": "c.2001+3598T>C",
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 26,
"intron_rank": 19,
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"gene_symbol": "DAPK1",
"gene_hgnc_id": 2674,
"hgvs_c": "c.2001+3598T>C",
"hgvs_p": null,
"transcript": "ENST00000916399.1",
"protein_id": "ENSP00000586458.1",
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},
{
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"strand": true,
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],
"exon_rank": null,
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"gene_symbol": "DAPK1",
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"hgvs_c": "c.1998+3598T>C",
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},
{
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],
"exon_rank": null,
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"exon_count": 25,
"intron_rank": 18,
"intron_rank_end": null,
"gene_symbol": "DAPK1",
"gene_hgnc_id": 2674,
"hgvs_c": "c.1924-9132T>C",
"hgvs_p": null,
"transcript": "ENST00000916397.1",
"protein_id": "ENSP00000586456.1",
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"aa_start": null,
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"cdna_start": null,
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"mane_select": null,
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 25,
"intron_rank": 18,
"intron_rank_end": null,
"gene_symbol": "DAPK1",
"gene_hgnc_id": 2674,
"hgvs_c": "c.1908+3598T>C",
"hgvs_p": null,
"transcript": "ENST00000916389.1",
"protein_id": "ENSP00000586448.1",
"transcript_support_level": null,
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},
{
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],
"exon_rank": null,
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"intron_rank": 18,
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"gene_symbol": "DAPK1",
"gene_hgnc_id": 2674,
"hgvs_c": "c.1902+3598T>C",
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},
{
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"strand": true,
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],
"exon_rank": null,
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"gene_symbol": "DAPK1",
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"hgvs_c": "c.1902+3598T>C",
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},
{
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"strand": true,
"consequences": [
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],
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"exon_count": 25,
"intron_rank": 18,
"intron_rank_end": null,
"gene_symbol": "DAPK1",
"gene_hgnc_id": 2674,
"hgvs_c": "c.1902+3598T>C",
"hgvs_p": null,
"transcript": "ENST00000916395.1",
"protein_id": "ENSP00000586454.1",
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000916395.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 17,
"intron_rank_end": null,
"gene_symbol": "DAPK1",
"gene_hgnc_id": 2674,
"hgvs_c": "c.1902+3598T>C",
"hgvs_p": null,
"transcript": "ENST00000916400.1",
"protein_id": "ENSP00000586459.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000916400.1"
},
{
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}