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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 9-89378809-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=89378809&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "9",
"pos": 89378809,
"ref": "C",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "NM_006378.4",
"consequences": [
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA4D",
"gene_hgnc_id": 10732,
"hgvs_c": "c.2484G>A",
"hgvs_p": "p.Thr828Thr",
"transcript": "NM_001371194.2",
"protein_id": "NP_001358123.1",
"transcript_support_level": null,
"aa_start": 828,
"aa_end": null,
"aa_length": 862,
"cds_start": 2484,
"cds_end": null,
"cds_length": 2589,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000422704.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001371194.2"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA4D",
"gene_hgnc_id": 10732,
"hgvs_c": "c.2484G>A",
"hgvs_p": "p.Thr828Thr",
"transcript": "ENST00000422704.7",
"protein_id": "ENSP00000388768.2",
"transcript_support_level": 1,
"aa_start": 828,
"aa_end": null,
"aa_length": 862,
"cds_start": 2484,
"cds_end": null,
"cds_length": 2589,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001371194.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000422704.7"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA4D",
"gene_hgnc_id": 10732,
"hgvs_c": "c.2484G>A",
"hgvs_p": "p.Thr828Thr",
"transcript": "ENST00000438547.6",
"protein_id": "ENSP00000405102.2",
"transcript_support_level": 1,
"aa_start": 828,
"aa_end": null,
"aa_length": 862,
"cds_start": 2484,
"cds_end": null,
"cds_length": 2589,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000438547.6"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA4D",
"gene_hgnc_id": 10732,
"hgvs_c": "c.2484G>A",
"hgvs_p": "p.Thr828Thr",
"transcript": "ENST00000450295.5",
"protein_id": "ENSP00000416523.1",
"transcript_support_level": 1,
"aa_start": 828,
"aa_end": null,
"aa_length": 862,
"cds_start": 2484,
"cds_end": null,
"cds_length": 2589,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000450295.5"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA4D",
"gene_hgnc_id": 10732,
"hgvs_c": "c.2484G>A",
"hgvs_p": "p.Thr828Thr",
"transcript": "NM_001371195.1",
"protein_id": "NP_001358124.1",
"transcript_support_level": null,
"aa_start": 828,
"aa_end": null,
"aa_length": 862,
"cds_start": 2484,
"cds_end": null,
"cds_length": 2589,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001371195.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA4D",
"gene_hgnc_id": 10732,
"hgvs_c": "c.2484G>A",
"hgvs_p": "p.Thr828Thr",
"transcript": "NM_001371196.1",
"protein_id": "NP_001358125.1",
"transcript_support_level": null,
"aa_start": 828,
"aa_end": null,
"aa_length": 862,
"cds_start": 2484,
"cds_end": null,
"cds_length": 2589,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001371196.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA4D",
"gene_hgnc_id": 10732,
"hgvs_c": "c.2484G>A",
"hgvs_p": "p.Thr828Thr",
"transcript": "NM_001371197.1",
"protein_id": "NP_001358126.1",
"transcript_support_level": null,
"aa_start": 828,
"aa_end": null,
"aa_length": 862,
"cds_start": 2484,
"cds_end": null,
"cds_length": 2589,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001371197.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA4D",
"gene_hgnc_id": 10732,
"hgvs_c": "c.2484G>A",
"hgvs_p": "p.Thr828Thr",
"transcript": "NM_006378.4",
"protein_id": "NP_006369.3",
"transcript_support_level": null,
"aa_start": 828,
"aa_end": null,
"aa_length": 862,
"cds_start": 2484,
"cds_end": null,
"cds_length": 2589,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_006378.4"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA4D",
"gene_hgnc_id": 10732,
"hgvs_c": "c.2484G>A",
"hgvs_p": "p.Thr828Thr",
"transcript": "ENST00000356444.6",
"protein_id": "ENSP00000348822.2",
"transcript_support_level": 5,
"aa_start": 828,
"aa_end": null,
"aa_length": 862,
"cds_start": 2484,
"cds_end": null,
"cds_length": 2589,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000356444.6"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA4D",
"gene_hgnc_id": 10732,
"hgvs_c": "c.2484G>A",
"hgvs_p": "p.Thr828Thr",
"transcript": "ENST00000858567.1",
"protein_id": "ENSP00000528626.1",
"transcript_support_level": null,
"aa_start": 828,
"aa_end": null,
"aa_length": 862,
"cds_start": 2484,
"cds_end": null,
"cds_length": 2589,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000858567.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA4D",
"gene_hgnc_id": 10732,
"hgvs_c": "c.2484G>A",
"hgvs_p": "p.Thr828Thr",
"transcript": "ENST00000858568.1",
"protein_id": "ENSP00000528627.1",
"transcript_support_level": null,
"aa_start": 828,
"aa_end": null,
"aa_length": 862,
"cds_start": 2484,
"cds_end": null,
"cds_length": 2589,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000858568.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA4D",
"gene_hgnc_id": 10732,
"hgvs_c": "c.2484G>A",
"hgvs_p": "p.Thr828Thr",
"transcript": "ENST00000858569.1",
"protein_id": "ENSP00000528628.1",
"transcript_support_level": null,
"aa_start": 828,
"aa_end": null,
"aa_length": 862,
"cds_start": 2484,
"cds_end": null,
"cds_length": 2589,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000858569.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA4D",
"gene_hgnc_id": 10732,
"hgvs_c": "c.2484G>A",
"hgvs_p": "p.Thr828Thr",
"transcript": "ENST00000858570.1",
"protein_id": "ENSP00000528629.1",
"transcript_support_level": null,
"aa_start": 828,
"aa_end": null,
"aa_length": 862,
"cds_start": 2484,
"cds_end": null,
"cds_length": 2589,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000858570.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA4D",
"gene_hgnc_id": 10732,
"hgvs_c": "c.2484G>A",
"hgvs_p": "p.Thr828Thr",
"transcript": "ENST00000858571.1",
"protein_id": "ENSP00000528630.1",
"transcript_support_level": null,
"aa_start": 828,
"aa_end": null,
"aa_length": 862,
"cds_start": 2484,
"cds_end": null,
"cds_length": 2589,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000858571.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA4D",
"gene_hgnc_id": 10732,
"hgvs_c": "c.2484G>A",
"hgvs_p": "p.Thr828Thr",
"transcript": "ENST00000858572.1",
"protein_id": "ENSP00000528631.1",
"transcript_support_level": null,
"aa_start": 828,
"aa_end": null,
"aa_length": 862,
"cds_start": 2484,
"cds_end": null,
"cds_length": 2589,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000858572.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA4D",
"gene_hgnc_id": 10732,
"hgvs_c": "c.2484G>A",
"hgvs_p": "p.Thr828Thr",
"transcript": "ENST00000858573.1",
"protein_id": "ENSP00000528632.1",
"transcript_support_level": null,
"aa_start": 828,
"aa_end": null,
"aa_length": 862,
"cds_start": 2484,
"cds_end": null,
"cds_length": 2589,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000858573.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA4D",
"gene_hgnc_id": 10732,
"hgvs_c": "c.2484G>A",
"hgvs_p": "p.Thr828Thr",
"transcript": "ENST00000858574.1",
"protein_id": "ENSP00000528633.1",
"transcript_support_level": null,
"aa_start": 828,
"aa_end": null,
"aa_length": 862,
"cds_start": 2484,
"cds_end": null,
"cds_length": 2589,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000858574.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA4D",
"gene_hgnc_id": 10732,
"hgvs_c": "c.2484G>A",
"hgvs_p": "p.Thr828Thr",
"transcript": "ENST00000858575.1",
"protein_id": "ENSP00000528634.1",
"transcript_support_level": null,
"aa_start": 828,
"aa_end": null,
"aa_length": 862,
"cds_start": 2484,
"cds_end": null,
"cds_length": 2589,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000858575.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA4D",
"gene_hgnc_id": 10732,
"hgvs_c": "c.2484G>A",
"hgvs_p": "p.Thr828Thr",
"transcript": "ENST00000858576.1",
"protein_id": "ENSP00000528635.1",
"transcript_support_level": null,
"aa_start": 828,
"aa_end": null,
"aa_length": 862,
"cds_start": 2484,
"cds_end": null,
"cds_length": 2589,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000858576.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA4D",
"gene_hgnc_id": 10732,
"hgvs_c": "c.2484G>A",
"hgvs_p": "p.Thr828Thr",
"transcript": "ENST00000858577.1",
"protein_id": "ENSP00000528636.1",
"transcript_support_level": null,
"aa_start": 828,
"aa_end": null,
"aa_length": 862,
"cds_start": 2484,
"cds_end": null,
"cds_length": 2589,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000858577.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA4D",
"gene_hgnc_id": 10732,
"hgvs_c": "c.2484G>A",
"hgvs_p": "p.Thr828Thr",
"transcript": "ENST00000917881.1",
"protein_id": "ENSP00000587940.1",
"transcript_support_level": null,
"aa_start": 828,
"aa_end": null,
"aa_length": 862,
"cds_start": 2484,
"cds_end": null,
"cds_length": 2589,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000917881.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SEMA4D",
"gene_hgnc_id": 10732,
"hgvs_c": "c.2484G>A",
"hgvs_p": "p.Thr828Thr",
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}