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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 9-93289548-C-CG (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=93289548&ref=C&alt=CG&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "9",
"pos": 93289548,
"ref": "C",
"alt": "CG",
"effect": "frameshift_variant",
"transcript": "NM_001282394.3",
"consequences": [
{
"aa_ref": "D",
"aa_alt": "G?",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.4801dupG",
"hgvs_p": "p.Asp1601fs",
"transcript": "NM_006648.4",
"protein_id": "NP_006639.3",
"transcript_support_level": null,
"aa_start": 1601,
"aa_end": null,
"aa_length": 2217,
"cds_start": 4802,
"cds_end": null,
"cds_length": 6654,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000427277.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_006648.4"
},
{
"aa_ref": "D",
"aa_alt": "G?",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.4801dupG",
"hgvs_p": "p.Asp1601fs",
"transcript": "ENST00000427277.7",
"protein_id": "ENSP00000411181.4",
"transcript_support_level": 5,
"aa_start": 1601,
"aa_end": null,
"aa_length": 2217,
"cds_start": 4802,
"cds_end": null,
"cds_length": 6654,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_006648.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000427277.7"
},
{
"aa_ref": "D",
"aa_alt": "G?",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.4912dupG",
"hgvs_p": "p.Asp1638fs",
"transcript": "ENST00000297954.9",
"protein_id": "ENSP00000297954.4",
"transcript_support_level": 1,
"aa_start": 1638,
"aa_end": null,
"aa_length": 2297,
"cds_start": 4913,
"cds_end": null,
"cds_length": 6894,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000297954.9"
},
{
"aa_ref": "D",
"aa_alt": "G?",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.4801dupG",
"hgvs_p": "p.Asp1601fs",
"transcript": "ENST00000432730.6",
"protein_id": "ENSP00000415038.2",
"transcript_support_level": 1,
"aa_start": 1601,
"aa_end": null,
"aa_length": 2224,
"cds_start": 4802,
"cds_end": null,
"cds_length": 6675,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000432730.6"
},
{
"aa_ref": "D",
"aa_alt": "G?",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.3610dupG",
"hgvs_p": "p.Asp1204fs",
"transcript": "ENST00000411624.5",
"protein_id": "ENSP00000414622.1",
"transcript_support_level": 1,
"aa_start": 1204,
"aa_end": null,
"aa_length": 1772,
"cds_start": 3611,
"cds_end": null,
"cds_length": 5319,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000411624.5"
},
{
"aa_ref": "D",
"aa_alt": "G?",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.4912dupG",
"hgvs_p": "p.Asp1638fs",
"transcript": "NM_001282394.3",
"protein_id": "NP_001269323.1",
"transcript_support_level": null,
"aa_start": 1638,
"aa_end": null,
"aa_length": 2297,
"cds_start": 4913,
"cds_end": null,
"cds_length": 6894,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001282394.3"
},
{
"aa_ref": "D",
"aa_alt": "G?",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.4801dupG",
"hgvs_p": "p.Asp1601fs",
"transcript": "ENST00000395477.6",
"protein_id": "ENSP00000378860.2",
"transcript_support_level": 5,
"aa_start": 1601,
"aa_end": null,
"aa_length": 2217,
"cds_start": 4802,
"cds_end": null,
"cds_length": 6654,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000395477.6"
},
{
"aa_ref": "D",
"aa_alt": "G?",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.4801dupG",
"hgvs_p": "p.Asp1601fs",
"transcript": "ENST00000913011.1",
"protein_id": "ENSP00000583070.1",
"transcript_support_level": null,
"aa_start": 1601,
"aa_end": null,
"aa_length": 2169,
"cds_start": 4802,
"cds_end": null,
"cds_length": 6510,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000913011.1"
},
{
"aa_ref": "D",
"aa_alt": "G?",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.4801dupG",
"hgvs_p": "p.Asp1601fs",
"transcript": "ENST00000913009.1",
"protein_id": "ENSP00000583068.1",
"transcript_support_level": null,
"aa_start": 1601,
"aa_end": null,
"aa_length": 2105,
"cds_start": 4802,
"cds_end": null,
"cds_length": 6318,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000913009.1"
},
{
"aa_ref": "D",
"aa_alt": "G?",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.4801dupG",
"hgvs_p": "p.Asp1601fs",
"transcript": "ENST00000913010.1",
"protein_id": "ENSP00000583069.1",
"transcript_support_level": null,
"aa_start": 1601,
"aa_end": null,
"aa_length": 2104,
"cds_start": 4802,
"cds_end": null,
"cds_length": 6315,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000913010.1"
},
{
"aa_ref": "D",
"aa_alt": "G?",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.4798dupG",
"hgvs_p": "p.Asp1600fs",
"transcript": "ENST00000913012.1",
"protein_id": "ENSP00000583071.1",
"transcript_support_level": null,
"aa_start": 1600,
"aa_end": null,
"aa_length": 2104,
"cds_start": 4799,
"cds_end": null,
"cds_length": 6315,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000913012.1"
},
{
"aa_ref": "D",
"aa_alt": "G?",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.4153dupG",
"hgvs_p": "p.Asp1385fs",
"transcript": "ENST00000913013.1",
"protein_id": "ENSP00000583072.1",
"transcript_support_level": null,
"aa_start": 1385,
"aa_end": null,
"aa_length": 1871,
"cds_start": 4154,
"cds_end": null,
"cds_length": 5616,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000913013.1"
},
{
"aa_ref": "D",
"aa_alt": "G?",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.367dupG",
"hgvs_p": "p.Asp123fs",
"transcript": "ENST00000453718.2",
"protein_id": "ENSP00000413325.1",
"transcript_support_level": 5,
"aa_start": 123,
"aa_end": null,
"aa_length": 644,
"cds_start": 368,
"cds_end": null,
"cds_length": 1935,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000453718.2"
},
{
"aa_ref": "D",
"aa_alt": "G?",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.4801dupG",
"hgvs_p": "p.Asp1601fs",
"transcript": "XM_005252137.4",
"protein_id": "XP_005252194.1",
"transcript_support_level": null,
"aa_start": 1601,
"aa_end": null,
"aa_length": 2260,
"cds_start": 4802,
"cds_end": null,
"cds_length": 6783,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_005252137.4"
},
{
"aa_ref": "D",
"aa_alt": "G?",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.4801dupG",
"hgvs_p": "p.Asp1601fs",
"transcript": "XM_017015045.2",
"protein_id": "XP_016870534.1",
"transcript_support_level": null,
"aa_start": 1601,
"aa_end": null,
"aa_length": 2259,
"cds_start": 4802,
"cds_end": null,
"cds_length": 6780,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017015045.2"
},
{
"aa_ref": "D",
"aa_alt": "G?",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.4801dupG",
"hgvs_p": "p.Asp1601fs",
"transcript": "XM_017015047.2",
"protein_id": "XP_016870536.1",
"transcript_support_level": null,
"aa_start": 1601,
"aa_end": null,
"aa_length": 2242,
"cds_start": 4802,
"cds_end": null,
"cds_length": 6729,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017015047.2"
},
{
"aa_ref": "D",
"aa_alt": "G?",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.4801dupG",
"hgvs_p": "p.Asp1601fs",
"transcript": "XM_017015048.2",
"protein_id": "XP_016870537.1",
"transcript_support_level": null,
"aa_start": 1601,
"aa_end": null,
"aa_length": 2241,
"cds_start": 4802,
"cds_end": null,
"cds_length": 6726,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017015048.2"
},
{
"aa_ref": "D",
"aa_alt": "G?",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.4801dupG",
"hgvs_p": "p.Asp1601fs",
"transcript": "XM_017015049.2",
"protein_id": "XP_016870538.1",
"transcript_support_level": null,
"aa_start": 1601,
"aa_end": null,
"aa_length": 2227,
"cds_start": 4802,
"cds_end": null,
"cds_length": 6684,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017015049.2"
},
{
"aa_ref": "D",
"aa_alt": "G?",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.4801dupG",
"hgvs_p": "p.Asp1601fs",
"transcript": "XM_017015050.2",
"protein_id": "XP_016870539.1",
"transcript_support_level": null,
"aa_start": 1601,
"aa_end": null,
"aa_length": 2226,
"cds_start": 4802,
"cds_end": null,
"cds_length": 6681,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017015050.2"
},
{
"aa_ref": "D",
"aa_alt": "G?",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.4801dupG",
"hgvs_p": "p.Asp1601fs",
"transcript": "XM_005252140.3",
"protein_id": "XP_005252197.1",
"transcript_support_level": null,
"aa_start": 1601,
"aa_end": null,
"aa_length": 2224,
"cds_start": 4802,
"cds_end": null,
"cds_length": 6675,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_005252140.3"
},
{
"aa_ref": "D",
"aa_alt": "G?",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.4801dupG",
"hgvs_p": "p.Asp1601fs",
"transcript": "XM_047423741.1",
"protein_id": "XP_047279697.1",
"transcript_support_level": null,
"aa_start": 1601,
"aa_end": null,
"aa_length": 2216,
"cds_start": 4802,
"cds_end": null,
"cds_length": 6651,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047423741.1"
},
{
"aa_ref": "D",
"aa_alt": "G?",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"frameshift_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "WNK2",
"gene_hgnc_id": 14542,
"hgvs_c": "c.4801dupG",
"hgvs_p": "p.Asp1601fs",
"transcript": "XM_047423742.1",
"protein_id": "XP_047279698.1",
"transcript_support_level": null,
"aa_start": 1601,
"aa_end": null,
"aa_length": 2212,
"cds_start": 4802,
"cds_end": null,
"cds_length": 6639,
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}