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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 9-95084986-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=9&pos=95084986&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "9",
"pos": 95084986,
"ref": "C",
"alt": "T",
"effect": "intron_variant",
"transcript": "ENST00000375315.8",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 16,
"intron_rank_end": null,
"gene_symbol": "AOPEP",
"gene_hgnc_id": 1361,
"hgvs_c": "c.*5-1696C>T",
"hgvs_p": null,
"transcript": "NM_001193329.3",
"protein_id": "NP_001180258.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 819,
"cds_start": -4,
"cds_end": null,
"cds_length": 2460,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3130,
"mane_select": "ENST00000375315.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 16,
"intron_rank_end": null,
"gene_symbol": "AOPEP",
"gene_hgnc_id": 1361,
"hgvs_c": "c.*5-1696C>T",
"hgvs_p": null,
"transcript": "ENST00000375315.8",
"protein_id": "ENSP00000364464.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 819,
"cds_start": -4,
"cds_end": null,
"cds_length": 2460,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3130,
"mane_select": "NM_001193329.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 14,
"intron_rank_end": null,
"gene_symbol": "AOPEP",
"gene_hgnc_id": 1361,
"hgvs_c": "c.*5-1696C>T",
"hgvs_p": null,
"transcript": "ENST00000297979.9",
"protein_id": "ENSP00000297979.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 720,
"cds_start": -4,
"cds_end": null,
"cds_length": 2163,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2820,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "AOPEP",
"gene_hgnc_id": 1361,
"hgvs_c": "c.2320-1696C>T",
"hgvs_p": null,
"transcript": "NM_001386066.1",
"protein_id": "NP_001372995.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 859,
"cds_start": -4,
"cds_end": null,
"cds_length": 2580,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2985,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 16,
"intron_rank_end": null,
"gene_symbol": "AOPEP",
"gene_hgnc_id": 1361,
"hgvs_c": "c.2320-1696C>T",
"hgvs_p": null,
"transcript": "NM_001386068.1",
"protein_id": "NP_001372997.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 859,
"cds_start": -4,
"cds_end": null,
"cds_length": 2580,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3166,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 14,
"intron_rank_end": null,
"gene_symbol": "AOPEP",
"gene_hgnc_id": 1361,
"hgvs_c": "c.2203-1696C>T",
"hgvs_p": null,
"transcript": "NM_001386070.1",
"protein_id": "NP_001372999.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 820,
"cds_start": -4,
"cds_end": null,
"cds_length": 2463,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2868,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 14,
"intron_rank_end": null,
"gene_symbol": "AOPEP",
"gene_hgnc_id": 1361,
"hgvs_c": "c.*5-1696C>T",
"hgvs_p": null,
"transcript": "NM_001386063.2",
"protein_id": "NP_001372992.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 773,
"cds_start": -4,
"cds_end": null,
"cds_length": 2322,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2992,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "AOPEP",
"gene_hgnc_id": 1361,
"hgvs_c": "c.2023-1696C>T",
"hgvs_p": null,
"transcript": "NM_001386069.1",
"protein_id": "NP_001372998.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 760,
"cds_start": -4,
"cds_end": null,
"cds_length": 2283,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2688,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 14,
"intron_rank_end": null,
"gene_symbol": "AOPEP",
"gene_hgnc_id": 1361,
"hgvs_c": "c.*5-1696C>T",
"hgvs_p": null,
"transcript": "NM_032823.6",
"protein_id": "NP_116212.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 720,
"cds_start": -4,
"cds_end": null,
"cds_length": 2163,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2833,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": 14,
"intron_rank_end": null,
"gene_symbol": "AOPEP",
"gene_hgnc_id": 1361,
"hgvs_c": "c.*5-1696C>T",
"hgvs_p": null,
"transcript": "NM_001386062.2",
"protein_id": "NP_001372991.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 712,
"cds_start": -4,
"cds_end": null,
"cds_length": 2139,
"cdna_start": null,
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"cdna_length": 2809,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 12,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "AOPEP",
"gene_hgnc_id": 1361,
"hgvs_c": "c.1798-1696C>T",
"hgvs_p": null,
"transcript": "NM_001386067.1",
"protein_id": "NP_001372996.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 12,
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"gene_symbol": "AOPEP",
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"hgvs_c": "c.1030-1696C>T",
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"transcript": "NM_001386061.1",
"protein_id": "NP_001372990.1",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 6,
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"gene_symbol": "AOPEP",
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"hgvs_c": "n.549-1696C>T",
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"transcript": "ENST00000463372.5",
"protein_id": null,
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},
{
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"strand": true,
"consequences": [
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],
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"gene_symbol": "AOPEP",
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"hgvs_c": "n.613-1696C>T",
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"transcript": "ENST00000468164.1",
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},
{
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],
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"gene_symbol": "AOPEP",
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"hgvs_c": "n.429-1696C>T",
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"transcript": "ENST00000471978.5",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 8,
"intron_rank": 6,
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"gene_symbol": "AOPEP",
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"hgvs_c": "n.546-944C>T",
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"transcript": "ENST00000478473.2",
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},
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],
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"gene_symbol": "AOPEP",
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"transcript": "ENST00000710812.1",
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},
{
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"strand": true,
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],
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"exon_count": 15,
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"gene_symbol": "AOPEP",
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"hgvs_c": "n.2401-1696C>T",
"hgvs_p": null,
"transcript": "NR_169862.1",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 14,
"intron_rank": 13,
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"gene_symbol": "AOPEP",
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"hgvs_c": "n.2312-1696C>T",
"hgvs_p": null,
"transcript": "NR_169863.2",
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},
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],
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},
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],
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},
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],
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"intron_rank_end": null,
"gene_symbol": "AOPEP",
"gene_hgnc_id": 1361,
"hgvs_c": "n.2145-1696C>T",
"hgvs_p": null,
"transcript": "NR_169866.1",
"protein_id": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 17,
"intron_rank": 16,
"intron_rank_end": null,
"gene_symbol": "AOPEP",
"gene_hgnc_id": 1361,
"hgvs_c": "c.*5-944C>T",
"hgvs_p": null,
"transcript": "XM_047423978.1",
"protein_id": "XP_047279934.1",
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"aa_start": null,
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"cdna_start": null,
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"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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}
],
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}