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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: X-101022037-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=X&pos=101022037&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "X",
"pos": 101022037,
"ref": "A",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_024917.6",
"consequences": [
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRMT2B",
"gene_hgnc_id": 25748,
"hgvs_c": "c.782T>C",
"hgvs_p": "p.Ile261Thr",
"transcript": "NM_024917.6",
"protein_id": "NP_079193.2",
"transcript_support_level": null,
"aa_start": 261,
"aa_end": null,
"aa_length": 504,
"cds_start": 782,
"cds_end": null,
"cds_length": 1515,
"cdna_start": 1583,
"cdna_end": null,
"cdna_length": 3547,
"mane_select": "ENST00000372936.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_024917.6"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRMT2B",
"gene_hgnc_id": 25748,
"hgvs_c": "c.782T>C",
"hgvs_p": "p.Ile261Thr",
"transcript": "ENST00000372936.4",
"protein_id": "ENSP00000362027.3",
"transcript_support_level": 1,
"aa_start": 261,
"aa_end": null,
"aa_length": 504,
"cds_start": 782,
"cds_end": null,
"cds_length": 1515,
"cdna_start": 1583,
"cdna_end": null,
"cdna_length": 3547,
"mane_select": "NM_024917.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000372936.4"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRMT2B",
"gene_hgnc_id": 25748,
"hgvs_c": "c.782T>C",
"hgvs_p": "p.Ile261Thr",
"transcript": "ENST00000372935.5",
"protein_id": "ENSP00000362026.1",
"transcript_support_level": 1,
"aa_start": 261,
"aa_end": null,
"aa_length": 504,
"cds_start": 782,
"cds_end": null,
"cds_length": 1515,
"cdna_start": 1149,
"cdna_end": null,
"cdna_length": 2921,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000372935.5"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRMT2B",
"gene_hgnc_id": 25748,
"hgvs_c": "c.782T>C",
"hgvs_p": "p.Ile261Thr",
"transcript": "ENST00000545398.5",
"protein_id": "ENSP00000438134.1",
"transcript_support_level": 1,
"aa_start": 261,
"aa_end": null,
"aa_length": 504,
"cds_start": 782,
"cds_end": null,
"cds_length": 1515,
"cdna_start": 1138,
"cdna_end": null,
"cdna_length": 3106,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000545398.5"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRMT2B",
"gene_hgnc_id": 25748,
"hgvs_c": "c.647T>C",
"hgvs_p": "p.Ile216Thr",
"transcript": "ENST00000372939.5",
"protein_id": "ENSP00000362030.1",
"transcript_support_level": 1,
"aa_start": 216,
"aa_end": null,
"aa_length": 459,
"cds_start": 647,
"cds_end": null,
"cds_length": 1380,
"cdna_start": 1114,
"cdna_end": null,
"cdna_length": 3078,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000372939.5"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRMT2B",
"gene_hgnc_id": 25748,
"hgvs_c": "c.782T>C",
"hgvs_p": "p.Ile261Thr",
"transcript": "NM_001167970.2",
"protein_id": "NP_001161442.1",
"transcript_support_level": null,
"aa_start": 261,
"aa_end": null,
"aa_length": 504,
"cds_start": 782,
"cds_end": null,
"cds_length": 1515,
"cdna_start": 1190,
"cdna_end": null,
"cdna_length": 3154,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001167970.2"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRMT2B",
"gene_hgnc_id": 25748,
"hgvs_c": "c.782T>C",
"hgvs_p": "p.Ile261Thr",
"transcript": "NM_001167972.2",
"protein_id": "NP_001161444.1",
"transcript_support_level": null,
"aa_start": 261,
"aa_end": null,
"aa_length": 504,
"cds_start": 782,
"cds_end": null,
"cds_length": 1515,
"cdna_start": 1133,
"cdna_end": null,
"cdna_length": 3097,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001167972.2"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRMT2B",
"gene_hgnc_id": 25748,
"hgvs_c": "c.782T>C",
"hgvs_p": "p.Ile261Thr",
"transcript": "ENST00000862825.1",
"protein_id": "ENSP00000532885.1",
"transcript_support_level": null,
"aa_start": 261,
"aa_end": null,
"aa_length": 504,
"cds_start": 782,
"cds_end": null,
"cds_length": 1515,
"cdna_start": 1124,
"cdna_end": null,
"cdna_length": 3092,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862825.1"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRMT2B",
"gene_hgnc_id": 25748,
"hgvs_c": "c.782T>C",
"hgvs_p": "p.Ile261Thr",
"transcript": "ENST00000862833.1",
"protein_id": "ENSP00000532892.1",
"transcript_support_level": null,
"aa_start": 261,
"aa_end": null,
"aa_length": 504,
"cds_start": 782,
"cds_end": null,
"cds_length": 1515,
"cdna_start": 1084,
"cdna_end": null,
"cdna_length": 3045,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862833.1"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRMT2B",
"gene_hgnc_id": 25748,
"hgvs_c": "c.782T>C",
"hgvs_p": "p.Ile261Thr",
"transcript": "ENST00000928862.1",
"protein_id": "ENSP00000598921.1",
"transcript_support_level": null,
"aa_start": 261,
"aa_end": null,
"aa_length": 504,
"cds_start": 782,
"cds_end": null,
"cds_length": 1515,
"cdna_start": 1209,
"cdna_end": null,
"cdna_length": 3173,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000928862.1"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRMT2B",
"gene_hgnc_id": 25748,
"hgvs_c": "c.782T>C",
"hgvs_p": "p.Ile261Thr",
"transcript": "ENST00000943813.1",
"protein_id": "ENSP00000613872.1",
"transcript_support_level": null,
"aa_start": 261,
"aa_end": null,
"aa_length": 504,
"cds_start": 782,
"cds_end": null,
"cds_length": 1515,
"cdna_start": 1085,
"cdna_end": null,
"cdna_length": 3048,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000943813.1"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRMT2B",
"gene_hgnc_id": 25748,
"hgvs_c": "c.779T>C",
"hgvs_p": "p.Ile260Thr",
"transcript": "ENST00000928859.1",
"protein_id": "ENSP00000598918.1",
"transcript_support_level": null,
"aa_start": 260,
"aa_end": null,
"aa_length": 503,
"cds_start": 779,
"cds_end": null,
"cds_length": 1512,
"cdna_start": 1139,
"cdna_end": null,
"cdna_length": 3100,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000928859.1"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRMT2B",
"gene_hgnc_id": 25748,
"hgvs_c": "c.647T>C",
"hgvs_p": "p.Ile216Thr",
"transcript": "NM_001167971.2",
"protein_id": "NP_001161443.1",
"transcript_support_level": null,
"aa_start": 216,
"aa_end": null,
"aa_length": 459,
"cds_start": 647,
"cds_end": null,
"cds_length": 1380,
"cdna_start": 1171,
"cdna_end": null,
"cdna_length": 3135,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001167971.2"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRMT2B",
"gene_hgnc_id": 25748,
"hgvs_c": "c.647T>C",
"hgvs_p": "p.Ile216Thr",
"transcript": "ENST00000862828.1",
"protein_id": "ENSP00000532887.1",
"transcript_support_level": null,
"aa_start": 216,
"aa_end": null,
"aa_length": 459,
"cds_start": 647,
"cds_end": null,
"cds_length": 1380,
"cdna_start": 1056,
"cdna_end": null,
"cdna_length": 3019,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862828.1"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRMT2B",
"gene_hgnc_id": 25748,
"hgvs_c": "c.647T>C",
"hgvs_p": "p.Ile216Thr",
"transcript": "ENST00000862834.1",
"protein_id": "ENSP00000532893.1",
"transcript_support_level": null,
"aa_start": 216,
"aa_end": null,
"aa_length": 459,
"cds_start": 647,
"cds_end": null,
"cds_length": 1380,
"cdna_start": 1006,
"cdna_end": null,
"cdna_length": 2973,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862834.1"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRMT2B",
"gene_hgnc_id": 25748,
"hgvs_c": "c.647T>C",
"hgvs_p": "p.Ile216Thr",
"transcript": "ENST00000928860.1",
"protein_id": "ENSP00000598919.1",
"transcript_support_level": null,
"aa_start": 216,
"aa_end": null,
"aa_length": 459,
"cds_start": 647,
"cds_end": null,
"cds_length": 1380,
"cdna_start": 964,
"cdna_end": null,
"cdna_length": 2932,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000928860.1"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRMT2B",
"gene_hgnc_id": 25748,
"hgvs_c": "c.647T>C",
"hgvs_p": "p.Ile216Thr",
"transcript": "ENST00000943810.1",
"protein_id": "ENSP00000613869.1",
"transcript_support_level": null,
"aa_start": 216,
"aa_end": null,
"aa_length": 459,
"cds_start": 647,
"cds_end": null,
"cds_length": 1380,
"cdna_start": 1112,
"cdna_end": null,
"cdna_length": 3080,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000943810.1"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRMT2B",
"gene_hgnc_id": 25748,
"hgvs_c": "c.647T>C",
"hgvs_p": "p.Ile216Thr",
"transcript": "ENST00000943811.1",
"protein_id": "ENSP00000613870.1",
"transcript_support_level": null,
"aa_start": 216,
"aa_end": null,
"aa_length": 459,
"cds_start": 647,
"cds_end": null,
"cds_length": 1380,
"cdna_start": 998,
"cdna_end": null,
"cdna_length": 2961,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000943811.1"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRMT2B",
"gene_hgnc_id": 25748,
"hgvs_c": "c.635T>C",
"hgvs_p": "p.Ile212Thr",
"transcript": "ENST00000928863.1",
"protein_id": "ENSP00000598922.1",
"transcript_support_level": null,
"aa_start": 212,
"aa_end": null,
"aa_length": 455,
"cds_start": 635,
"cds_end": null,
"cds_length": 1368,
"cdna_start": 993,
"cdna_end": null,
"cdna_length": 2954,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000928863.1"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRMT2B",
"gene_hgnc_id": 25748,
"hgvs_c": "c.626T>C",
"hgvs_p": "p.Ile209Thr",
"transcript": "ENST00000862831.1",
"protein_id": "ENSP00000532890.1",
"transcript_support_level": null,
"aa_start": 209,
"aa_end": null,
"aa_length": 452,
"cds_start": 626,
"cds_end": null,
"cds_length": 1359,
"cdna_start": 925,
"cdna_end": null,
"cdna_length": 2887,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000862831.1"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRMT2B",
"gene_hgnc_id": 25748,
"hgvs_c": "c.536T>C",
"hgvs_p": "p.Ile179Thr",
"transcript": "ENST00000928861.1",
"protein_id": "ENSP00000598920.1",
"transcript_support_level": null,
"aa_start": 179,
"aa_end": null,
"aa_length": 422,
"cds_start": 536,
"cds_end": null,
"cds_length": 1269,
"cdna_start": 852,
"cdna_end": null,
"cdna_length": 2814,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000928861.1"
},
{
"aa_ref": "I",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TRMT2B",
"gene_hgnc_id": 25748,
"hgvs_c": "c.491T>C",
"hgvs_p": "p.Ile164Thr",
"transcript": "ENST00000943815.1",
"protein_id": "ENSP00000613874.1",
"transcript_support_level": null,
"aa_start": 164,
"aa_end": null,
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}
],
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}