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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: X-102654773-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=X&pos=102654773&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "X",
"pos": 102654773,
"ref": "C",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_014710.5",
"consequences": [
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPRASP1",
"gene_hgnc_id": 24834,
"hgvs_c": "c.860C>G",
"hgvs_p": "p.Ser287Cys",
"transcript": "NM_001184727.2",
"protein_id": "NP_001171656.1",
"transcript_support_level": null,
"aa_start": 287,
"aa_end": null,
"aa_length": 1395,
"cds_start": 860,
"cds_end": null,
"cds_length": 4188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000537097.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001184727.2"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPRASP1",
"gene_hgnc_id": 24834,
"hgvs_c": "c.860C>G",
"hgvs_p": "p.Ser287Cys",
"transcript": "ENST00000537097.2",
"protein_id": "ENSP00000445683.1",
"transcript_support_level": 2,
"aa_start": 287,
"aa_end": null,
"aa_length": 1395,
"cds_start": 860,
"cds_end": null,
"cds_length": 4188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001184727.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000537097.2"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPRASP1",
"gene_hgnc_id": 24834,
"hgvs_c": "c.860C>G",
"hgvs_p": "p.Ser287Cys",
"transcript": "NM_001099410.2",
"protein_id": "NP_001092880.1",
"transcript_support_level": null,
"aa_start": 287,
"aa_end": null,
"aa_length": 1395,
"cds_start": 860,
"cds_end": null,
"cds_length": 4188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001099410.2"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPRASP1",
"gene_hgnc_id": 24834,
"hgvs_c": "c.860C>G",
"hgvs_p": "p.Ser287Cys",
"transcript": "NM_001099411.2",
"protein_id": "NP_001092881.1",
"transcript_support_level": null,
"aa_start": 287,
"aa_end": null,
"aa_length": 1395,
"cds_start": 860,
"cds_end": null,
"cds_length": 4188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001099411.2"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPRASP1",
"gene_hgnc_id": 24834,
"hgvs_c": "c.860C>G",
"hgvs_p": "p.Ser287Cys",
"transcript": "NM_014710.5",
"protein_id": "NP_055525.3",
"transcript_support_level": null,
"aa_start": 287,
"aa_end": null,
"aa_length": 1395,
"cds_start": 860,
"cds_end": null,
"cds_length": 4188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_014710.5"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPRASP1",
"gene_hgnc_id": 24834,
"hgvs_c": "c.860C>G",
"hgvs_p": "p.Ser287Cys",
"transcript": "ENST00000361600.9",
"protein_id": "ENSP00000355146.4",
"transcript_support_level": 2,
"aa_start": 287,
"aa_end": null,
"aa_length": 1395,
"cds_start": 860,
"cds_end": null,
"cds_length": 4188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000361600.9"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPRASP1",
"gene_hgnc_id": 24834,
"hgvs_c": "c.860C>G",
"hgvs_p": "p.Ser287Cys",
"transcript": "ENST00000415986.5",
"protein_id": "ENSP00000393691.1",
"transcript_support_level": 4,
"aa_start": 287,
"aa_end": null,
"aa_length": 1395,
"cds_start": 860,
"cds_end": null,
"cds_length": 4188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000415986.5"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPRASP1",
"gene_hgnc_id": 24834,
"hgvs_c": "c.860C>G",
"hgvs_p": "p.Ser287Cys",
"transcript": "ENST00000444152.5",
"protein_id": "ENSP00000409420.1",
"transcript_support_level": 3,
"aa_start": 287,
"aa_end": null,
"aa_length": 1395,
"cds_start": 860,
"cds_end": null,
"cds_length": 4188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000444152.5"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPRASP1",
"gene_hgnc_id": 24834,
"hgvs_c": "c.860C>G",
"hgvs_p": "p.Ser287Cys",
"transcript": "ENST00000652542.1",
"protein_id": "ENSP00000498934.1",
"transcript_support_level": null,
"aa_start": 287,
"aa_end": null,
"aa_length": 1395,
"cds_start": 860,
"cds_end": null,
"cds_length": 4188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000652542.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPRASP1",
"gene_hgnc_id": 24834,
"hgvs_c": "c.860C>G",
"hgvs_p": "p.Ser287Cys",
"transcript": "ENST00000892411.1",
"protein_id": "ENSP00000562470.1",
"transcript_support_level": null,
"aa_start": 287,
"aa_end": null,
"aa_length": 1395,
"cds_start": 860,
"cds_end": null,
"cds_length": 4188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892411.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPRASP1",
"gene_hgnc_id": 24834,
"hgvs_c": "c.860C>G",
"hgvs_p": "p.Ser287Cys",
"transcript": "ENST00000892412.1",
"protein_id": "ENSP00000562471.1",
"transcript_support_level": null,
"aa_start": 287,
"aa_end": null,
"aa_length": 1395,
"cds_start": 860,
"cds_end": null,
"cds_length": 4188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892412.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPRASP1",
"gene_hgnc_id": 24834,
"hgvs_c": "c.860C>G",
"hgvs_p": "p.Ser287Cys",
"transcript": "ENST00000892413.1",
"protein_id": "ENSP00000562472.1",
"transcript_support_level": null,
"aa_start": 287,
"aa_end": null,
"aa_length": 1395,
"cds_start": 860,
"cds_end": null,
"cds_length": 4188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892413.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPRASP1",
"gene_hgnc_id": 24834,
"hgvs_c": "c.860C>G",
"hgvs_p": "p.Ser287Cys",
"transcript": "ENST00000892414.1",
"protein_id": "ENSP00000562473.1",
"transcript_support_level": null,
"aa_start": 287,
"aa_end": null,
"aa_length": 1395,
"cds_start": 860,
"cds_end": null,
"cds_length": 4188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892414.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPRASP1",
"gene_hgnc_id": 24834,
"hgvs_c": "c.860C>G",
"hgvs_p": "p.Ser287Cys",
"transcript": "ENST00000892415.1",
"protein_id": "ENSP00000562474.1",
"transcript_support_level": null,
"aa_start": 287,
"aa_end": null,
"aa_length": 1395,
"cds_start": 860,
"cds_end": null,
"cds_length": 4188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892415.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPRASP1",
"gene_hgnc_id": 24834,
"hgvs_c": "c.860C>G",
"hgvs_p": "p.Ser287Cys",
"transcript": "ENST00000892416.1",
"protein_id": "ENSP00000562475.1",
"transcript_support_level": null,
"aa_start": 287,
"aa_end": null,
"aa_length": 1395,
"cds_start": 860,
"cds_end": null,
"cds_length": 4188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892416.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPRASP1",
"gene_hgnc_id": 24834,
"hgvs_c": "c.860C>G",
"hgvs_p": "p.Ser287Cys",
"transcript": "ENST00000892417.1",
"protein_id": "ENSP00000562476.1",
"transcript_support_level": null,
"aa_start": 287,
"aa_end": null,
"aa_length": 1395,
"cds_start": 860,
"cds_end": null,
"cds_length": 4188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892417.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPRASP1",
"gene_hgnc_id": 24834,
"hgvs_c": "c.860C>G",
"hgvs_p": "p.Ser287Cys",
"transcript": "ENST00000892418.1",
"protein_id": "ENSP00000562477.1",
"transcript_support_level": null,
"aa_start": 287,
"aa_end": null,
"aa_length": 1395,
"cds_start": 860,
"cds_end": null,
"cds_length": 4188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892418.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPRASP1",
"gene_hgnc_id": 24834,
"hgvs_c": "c.860C>G",
"hgvs_p": "p.Ser287Cys",
"transcript": "ENST00000892419.1",
"protein_id": "ENSP00000562478.1",
"transcript_support_level": null,
"aa_start": 287,
"aa_end": null,
"aa_length": 1395,
"cds_start": 860,
"cds_end": null,
"cds_length": 4188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892419.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPRASP1",
"gene_hgnc_id": 24834,
"hgvs_c": "c.860C>G",
"hgvs_p": "p.Ser287Cys",
"transcript": "ENST00000892420.1",
"protein_id": "ENSP00000562479.1",
"transcript_support_level": null,
"aa_start": 287,
"aa_end": null,
"aa_length": 1395,
"cds_start": 860,
"cds_end": null,
"cds_length": 4188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892420.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPRASP1",
"gene_hgnc_id": 24834,
"hgvs_c": "c.860C>G",
"hgvs_p": "p.Ser287Cys",
"transcript": "ENST00000892421.1",
"protein_id": "ENSP00000562480.1",
"transcript_support_level": null,
"aa_start": 287,
"aa_end": null,
"aa_length": 1395,
"cds_start": 860,
"cds_end": null,
"cds_length": 4188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000892421.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPRASP1",
"gene_hgnc_id": 24834,
"hgvs_c": "c.860C>G",
"hgvs_p": "p.Ser287Cys",
"transcript": "ENST00000931714.1",
"protein_id": "ENSP00000601773.1",
"transcript_support_level": null,
"aa_start": 287,
"aa_end": null,
"aa_length": 1395,
"cds_start": 860,
"cds_end": null,
"cds_length": 4188,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000931714.1"
},
{
"aa_ref": "S",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GPRASP1",
"gene_hgnc_id": 24834,
"hgvs_c": "c.860C>G",
"hgvs_p": "p.Ser287Cys",
"transcript": "ENST00000931715.1",
"protein_id": "ENSP00000601774.1",
"transcript_support_level": null,
"aa_start": 287,
"aa_end": null,
"aa_length": 1395,
"cds_start": 860,
"cds_end": null,
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}