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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: X-152868900-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=X&pos=152868900&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "X",
"pos": 152868900,
"ref": "C",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "NM_015922.3",
"consequences": [
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSDHL",
"gene_hgnc_id": 13398,
"hgvs_c": "c.906C>T",
"hgvs_p": "p.Tyr302Tyr",
"transcript": "NM_015922.3",
"protein_id": "NP_057006.1",
"transcript_support_level": null,
"aa_start": 302,
"aa_end": null,
"aa_length": 373,
"cds_start": 906,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000370274.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_015922.3"
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSDHL",
"gene_hgnc_id": 13398,
"hgvs_c": "c.906C>T",
"hgvs_p": "p.Tyr302Tyr",
"transcript": "ENST00000370274.8",
"protein_id": "ENSP00000359297.3",
"transcript_support_level": 1,
"aa_start": 302,
"aa_end": null,
"aa_length": 373,
"cds_start": 906,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_015922.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000370274.8"
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSDHL",
"gene_hgnc_id": 13398,
"hgvs_c": "c.942C>T",
"hgvs_p": "p.Tyr314Tyr",
"transcript": "ENST00000915682.1",
"protein_id": "ENSP00000585741.1",
"transcript_support_level": null,
"aa_start": 314,
"aa_end": null,
"aa_length": 385,
"cds_start": 942,
"cds_end": null,
"cds_length": 1158,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000915682.1"
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSDHL",
"gene_hgnc_id": 13398,
"hgvs_c": "c.906C>T",
"hgvs_p": "p.Tyr302Tyr",
"transcript": "NM_001129765.2",
"protein_id": "NP_001123237.1",
"transcript_support_level": null,
"aa_start": 302,
"aa_end": null,
"aa_length": 373,
"cds_start": 906,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001129765.2"
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSDHL",
"gene_hgnc_id": 13398,
"hgvs_c": "c.906C>T",
"hgvs_p": "p.Tyr302Tyr",
"transcript": "NM_001441099.1",
"protein_id": "NP_001428028.1",
"transcript_support_level": null,
"aa_start": 302,
"aa_end": null,
"aa_length": 373,
"cds_start": 906,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001441099.1"
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSDHL",
"gene_hgnc_id": 13398,
"hgvs_c": "c.906C>T",
"hgvs_p": "p.Tyr302Tyr",
"transcript": "ENST00000440023.5",
"protein_id": "ENSP00000391854.1",
"transcript_support_level": 5,
"aa_start": 302,
"aa_end": null,
"aa_length": 373,
"cds_start": 906,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000440023.5"
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSDHL",
"gene_hgnc_id": 13398,
"hgvs_c": "c.906C>T",
"hgvs_p": "p.Tyr302Tyr",
"transcript": "ENST00000881877.1",
"protein_id": "ENSP00000551936.1",
"transcript_support_level": null,
"aa_start": 302,
"aa_end": null,
"aa_length": 373,
"cds_start": 906,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000881877.1"
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSDHL",
"gene_hgnc_id": 13398,
"hgvs_c": "c.906C>T",
"hgvs_p": "p.Tyr302Tyr",
"transcript": "ENST00000881880.1",
"protein_id": "ENSP00000551939.1",
"transcript_support_level": null,
"aa_start": 302,
"aa_end": null,
"aa_length": 373,
"cds_start": 906,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000881880.1"
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSDHL",
"gene_hgnc_id": 13398,
"hgvs_c": "c.906C>T",
"hgvs_p": "p.Tyr302Tyr",
"transcript": "ENST00000881881.1",
"protein_id": "ENSP00000551940.1",
"transcript_support_level": null,
"aa_start": 302,
"aa_end": null,
"aa_length": 373,
"cds_start": 906,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000881881.1"
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSDHL",
"gene_hgnc_id": 13398,
"hgvs_c": "c.906C>T",
"hgvs_p": "p.Tyr302Tyr",
"transcript": "ENST00000881882.1",
"protein_id": "ENSP00000551941.1",
"transcript_support_level": null,
"aa_start": 302,
"aa_end": null,
"aa_length": 373,
"cds_start": 906,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000881882.1"
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSDHL",
"gene_hgnc_id": 13398,
"hgvs_c": "c.906C>T",
"hgvs_p": "p.Tyr302Tyr",
"transcript": "ENST00000881883.1",
"protein_id": "ENSP00000551942.1",
"transcript_support_level": null,
"aa_start": 302,
"aa_end": null,
"aa_length": 373,
"cds_start": 906,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000881883.1"
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSDHL",
"gene_hgnc_id": 13398,
"hgvs_c": "c.906C>T",
"hgvs_p": "p.Tyr302Tyr",
"transcript": "ENST00000881884.1",
"protein_id": "ENSP00000551943.1",
"transcript_support_level": null,
"aa_start": 302,
"aa_end": null,
"aa_length": 373,
"cds_start": 906,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000881884.1"
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSDHL",
"gene_hgnc_id": 13398,
"hgvs_c": "c.906C>T",
"hgvs_p": "p.Tyr302Tyr",
"transcript": "ENST00000881885.1",
"protein_id": "ENSP00000551944.1",
"transcript_support_level": null,
"aa_start": 302,
"aa_end": null,
"aa_length": 373,
"cds_start": 906,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000881885.1"
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSDHL",
"gene_hgnc_id": 13398,
"hgvs_c": "c.906C>T",
"hgvs_p": "p.Tyr302Tyr",
"transcript": "ENST00000881886.1",
"protein_id": "ENSP00000551945.1",
"transcript_support_level": null,
"aa_start": 302,
"aa_end": null,
"aa_length": 373,
"cds_start": 906,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000881886.1"
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSDHL",
"gene_hgnc_id": 13398,
"hgvs_c": "c.906C>T",
"hgvs_p": "p.Tyr302Tyr",
"transcript": "ENST00000915680.1",
"protein_id": "ENSP00000585739.1",
"transcript_support_level": null,
"aa_start": 302,
"aa_end": null,
"aa_length": 373,
"cds_start": 906,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000915680.1"
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSDHL",
"gene_hgnc_id": 13398,
"hgvs_c": "c.906C>T",
"hgvs_p": "p.Tyr302Tyr",
"transcript": "ENST00000915681.1",
"protein_id": "ENSP00000585740.1",
"transcript_support_level": null,
"aa_start": 302,
"aa_end": null,
"aa_length": 373,
"cds_start": 906,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000915681.1"
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSDHL",
"gene_hgnc_id": 13398,
"hgvs_c": "c.906C>T",
"hgvs_p": "p.Tyr302Tyr",
"transcript": "ENST00000915684.1",
"protein_id": "ENSP00000585743.1",
"transcript_support_level": null,
"aa_start": 302,
"aa_end": null,
"aa_length": 373,
"cds_start": 906,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000915684.1"
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSDHL",
"gene_hgnc_id": 13398,
"hgvs_c": "c.906C>T",
"hgvs_p": "p.Tyr302Tyr",
"transcript": "ENST00000969426.1",
"protein_id": "ENSP00000639485.1",
"transcript_support_level": null,
"aa_start": 302,
"aa_end": null,
"aa_length": 373,
"cds_start": 906,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000969426.1"
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSDHL",
"gene_hgnc_id": 13398,
"hgvs_c": "c.906C>T",
"hgvs_p": "p.Tyr302Tyr",
"transcript": "ENST00000969428.1",
"protein_id": "ENSP00000639487.1",
"transcript_support_level": null,
"aa_start": 302,
"aa_end": null,
"aa_length": 373,
"cds_start": 906,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000969428.1"
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSDHL",
"gene_hgnc_id": 13398,
"hgvs_c": "c.906C>T",
"hgvs_p": "p.Tyr302Tyr",
"transcript": "ENST00000969429.1",
"protein_id": "ENSP00000639488.1",
"transcript_support_level": null,
"aa_start": 302,
"aa_end": null,
"aa_length": 373,
"cds_start": 906,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000969429.1"
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSDHL",
"gene_hgnc_id": 13398,
"hgvs_c": "c.906C>T",
"hgvs_p": "p.Tyr302Tyr",
"transcript": "ENST00000969430.1",
"protein_id": "ENSP00000639489.1",
"transcript_support_level": null,
"aa_start": 302,
"aa_end": null,
"aa_length": 373,
"cds_start": 906,
"cds_end": null,
"cds_length": 1122,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000969430.1"
},
{
"aa_ref": "Y",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NSDHL",
"gene_hgnc_id": 13398,
"hgvs_c": "c.870C>T",
"hgvs_p": "p.Tyr290Tyr",
"transcript": "ENST00000881875.1",
"protein_id": "ENSP00000551934.1",
"transcript_support_level": null,
"aa_start": 290,
"aa_end": null,
"aa_length": 361,
"cds_start": 870,
"cds_end": null,
"cds_length": 1086,
"cdna_start": null,
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}
],
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}