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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: X-153907802-C-G (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=X&pos=153907802&ref=C&alt=G&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 2,
          "criteria": [
            "PM2",
            "BP4_Moderate"
          ],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "ARHGAP4",
          "hgnc_id": 674,
          "hgvs_c": "c.2888G>C",
          "hgvs_p": "p.Arg963Pro",
          "inheritance_mode": "XL",
          "pathogenic_score": 2,
          "score": 0,
          "transcript": "NM_001164741.2",
          "verdict": "Uncertain_significance"
        },
        {
          "benign_score": 2,
          "criteria": [
            "PM2",
            "BP4_Moderate"
          ],
          "effects": [
            "intron_variant"
          ],
          "gene_symbol": "ENSG00000284987",
          "hgnc_id": null,
          "hgvs_c": "n.96+1268G>C",
          "hgvs_p": null,
          "inheritance_mode": "",
          "pathogenic_score": 2,
          "score": 0,
          "transcript": "ENST00000646191.1",
          "verdict": "Uncertain_significance"
        }
      ],
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,BP4_Moderate",
      "acmg_score": 0,
      "allele_count_reference_population": 4,
      "alphamissense_prediction": null,
      "alphamissense_score": 0.1334,
      "alt": "G",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Benign",
      "bayesdelnoaf_score": -0.63,
      "chr": "X",
      "clinvar_classification": "",
      "clinvar_disease": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "computational_prediction_selected": "Benign",
      "computational_score_selected": 0.16715571284294128,
      "computational_source_selected": "MetaRNN",
      "consequences": [
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 946,
          "aa_ref": "R",
          "aa_start": 923,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3254,
          "cdna_start": 2830,
          "cds_end": null,
          "cds_length": 2841,
          "cds_start": 2768,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 22,
          "exon_rank": 22,
          "exon_rank_end": null,
          "feature": "NM_001666.5",
          "gene_hgnc_id": 674,
          "gene_symbol": "ARHGAP4",
          "hgvs_c": "c.2768G>C",
          "hgvs_p": "p.Arg923Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000350060.10",
          "protein_coding": true,
          "protein_id": "NP_001657.3",
          "strand": false,
          "transcript": "NM_001666.5",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 946,
          "aa_ref": "R",
          "aa_start": 923,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 3254,
          "cdna_start": 2830,
          "cds_end": null,
          "cds_length": 2841,
          "cds_start": 2768,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 22,
          "exon_rank": 22,
          "exon_rank_end": null,
          "feature": "ENST00000350060.10",
          "gene_hgnc_id": 674,
          "gene_symbol": "ARHGAP4",
          "hgvs_c": "c.2768G>C",
          "hgvs_p": "p.Arg923Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_001666.5",
          "protein_coding": true,
          "protein_id": "ENSP00000203786.8",
          "strand": false,
          "transcript": "ENST00000350060.10",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 986,
          "aa_ref": "R",
          "aa_start": 963,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3372,
          "cdna_start": 2946,
          "cds_end": null,
          "cds_length": 2961,
          "cds_start": 2888,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 23,
          "exon_rank": 23,
          "exon_rank_end": null,
          "feature": "ENST00000370028.7",
          "gene_hgnc_id": 674,
          "gene_symbol": "ARHGAP4",
          "hgvs_c": "c.2888G>C",
          "hgvs_p": "p.Arg963Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000359045.3",
          "strand": false,
          "transcript": "ENST00000370028.7",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 498,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 5,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000646191.1",
          "gene_hgnc_id": null,
          "gene_symbol": "ENSG00000284987",
          "hgvs_c": "n.96+1268G>C",
          "hgvs_p": null,
          "intron_rank": 1,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": "ENSP00000493873.1",
          "strand": false,
          "transcript": "ENST00000646191.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 986,
          "aa_ref": "R",
          "aa_start": 963,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3374,
          "cdna_start": 2950,
          "cds_end": null,
          "cds_length": 2961,
          "cds_start": 2888,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 23,
          "exon_rank": 23,
          "exon_rank_end": null,
          "feature": "NM_001164741.2",
          "gene_hgnc_id": 674,
          "gene_symbol": "ARHGAP4",
          "hgvs_c": "c.2888G>C",
          "hgvs_p": "p.Arg963Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001158213.1",
          "strand": false,
          "transcript": "NM_001164741.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 952,
          "aa_ref": "R",
          "aa_start": 929,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3275,
          "cdna_start": 2850,
          "cds_end": null,
          "cds_length": 2859,
          "cds_start": 2786,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 22,
          "exon_rank": 22,
          "exon_rank_end": null,
          "feature": "ENST00000968871.1",
          "gene_hgnc_id": 674,
          "gene_symbol": "ARHGAP4",
          "hgvs_c": "c.2786G>C",
          "hgvs_p": "p.Arg929Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000638930.1",
          "strand": false,
          "transcript": "ENST00000968871.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 945,
          "aa_ref": "R",
          "aa_start": 922,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3263,
          "cdna_start": 2837,
          "cds_end": null,
          "cds_length": 2838,
          "cds_start": 2765,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 22,
          "exon_rank": 22,
          "exon_rank_end": null,
          "feature": "ENST00000907990.1",
          "gene_hgnc_id": 674,
          "gene_symbol": "ARHGAP4",
          "hgvs_c": "c.2765G>C",
          "hgvs_p": "p.Arg922Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000578049.1",
          "strand": false,
          "transcript": "ENST00000907990.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 943,
          "aa_ref": "R",
          "aa_start": 920,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3292,
          "cdna_start": 2868,
          "cds_end": null,
          "cds_length": 2832,
          "cds_start": 2759,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 22,
          "exon_rank": 22,
          "exon_rank_end": null,
          "feature": "ENST00000968870.1",
          "gene_hgnc_id": 674,
          "gene_symbol": "ARHGAP4",
          "hgvs_c": "c.2759G>C",
          "hgvs_p": "p.Arg920Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000638929.1",
          "strand": false,
          "transcript": "ENST00000968870.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 925,
          "aa_ref": "R",
          "aa_start": 902,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3095,
          "cdna_start": 2747,
          "cds_end": null,
          "cds_length": 2778,
          "cds_start": 2705,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 21,
          "exon_rank": 21,
          "exon_rank_end": null,
          "feature": "ENST00000370016.5",
          "gene_hgnc_id": 674,
          "gene_symbol": "ARHGAP4",
          "hgvs_c": "c.2705G>C",
          "hgvs_p": "p.Arg902Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000359033.1",
          "strand": false,
          "transcript": "ENST00000370016.5",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 912,
          "aa_ref": "R",
          "aa_start": 889,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3205,
          "cdna_start": 2781,
          "cds_end": null,
          "cds_length": 2739,
          "cds_start": 2666,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 21,
          "exon_rank": 21,
          "exon_rank_end": null,
          "feature": "ENST00000907988.1",
          "gene_hgnc_id": 674,
          "gene_symbol": "ARHGAP4",
          "hgvs_c": "c.2666G>C",
          "hgvs_p": "p.Arg889Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000578047.1",
          "strand": false,
          "transcript": "ENST00000907988.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 911,
          "aa_ref": "R",
          "aa_start": 888,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3181,
          "cdna_start": 2758,
          "cds_end": null,
          "cds_length": 2736,
          "cds_start": 2663,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 22,
          "exon_rank": 22,
          "exon_rank_end": null,
          "feature": "ENST00000907989.1",
          "gene_hgnc_id": 674,
          "gene_symbol": "ARHGAP4",
          "hgvs_c": "c.2663G>C",
          "hgvs_p": "p.Arg888Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000578048.1",
          "strand": false,
          "transcript": "ENST00000907989.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 884,
          "aa_ref": "R",
          "aa_start": 861,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3118,
          "cdna_start": 2693,
          "cds_end": null,
          "cds_length": 2655,
          "cds_start": 2582,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 21,
          "exon_rank": 21,
          "exon_rank_end": null,
          "feature": "ENST00000927210.1",
          "gene_hgnc_id": 674,
          "gene_symbol": "ARHGAP4",
          "hgvs_c": "c.2582G>C",
          "hgvs_p": "p.Arg861Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000597269.1",
          "strand": false,
          "transcript": "ENST00000927210.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 868,
          "aa_ref": "R",
          "aa_start": 845,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3023,
          "cdna_start": 2599,
          "cds_end": null,
          "cds_length": 2607,
          "cds_start": 2534,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 21,
          "exon_rank": 21,
          "exon_rank_end": null,
          "feature": "ENST00000907991.1",
          "gene_hgnc_id": 674,
          "gene_symbol": "ARHGAP4",
          "hgvs_c": "c.2534G>C",
          "hgvs_p": "p.Arg845Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000578050.1",
          "strand": false,
          "transcript": "ENST00000907991.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 768,
          "aa_ref": "R",
          "aa_start": 745,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2721,
          "cdna_start": 2286,
          "cds_end": null,
          "cds_length": 2307,
          "cds_start": 2234,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 19,
          "exon_rank": 19,
          "exon_rank_end": null,
          "feature": "ENST00000393721.5",
          "gene_hgnc_id": 674,
          "gene_symbol": "ARHGAP4",
          "hgvs_c": "c.2234G>C",
          "hgvs_p": "p.Arg745Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000377322.1",
          "strand": false,
          "transcript": "ENST00000393721.5",
          "transcript_support_level": 5
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3232,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 22,
          "exon_rank": 22,
          "exon_rank_end": null,
          "feature": "ENST00000404127.6",
          "gene_hgnc_id": 674,
          "gene_symbol": "ARHGAP4",
          "hgvs_c": "n.*2142G>C",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": "ENSP00000385042.2",
          "strand": false,
          "transcript": "ENST00000404127.6",
          "transcript_support_level": 5
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2817,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 19,
          "exon_rank": 19,
          "exon_rank_end": null,
          "feature": "ENST00000420383.5",
          "gene_hgnc_id": 674,
          "gene_symbol": "ARHGAP4",
          "hgvs_c": "n.*472G>C",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": "ENSP00000397533.1",
          "strand": false,
          "transcript": "ENST00000420383.5",
          "transcript_support_level": 2
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "retained_intron",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 840,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 3,
          "exon_rank": 3,
          "exon_rank_end": null,
          "feature": "ENST00000466928.5",
          "gene_hgnc_id": 674,
          "gene_symbol": "ARHGAP4",
          "hgvs_c": "n.477G>C",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": false,
          "transcript": "ENST00000466928.5",
          "transcript_support_level": 2
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "retained_intron",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2889,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 18,
          "exon_rank": 18,
          "exon_rank_end": null,
          "feature": "ENST00000470209.5",
          "gene_hgnc_id": 674,
          "gene_symbol": "ARHGAP4",
          "hgvs_c": "n.2541G>C",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": false,
          "transcript": "ENST00000470209.5",
          "transcript_support_level": 5
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "retained_intron",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2667,
          "cdna_start": null,
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}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.