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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: X-153909746-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=X&pos=153909746&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "X",
"pos": 153909746,
"ref": "G",
"alt": "C",
"effect": "synonymous_variant",
"transcript": "NM_001164741.2",
"consequences": [
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP4",
"gene_hgnc_id": 674,
"hgvs_c": "c.2409C>G",
"hgvs_p": "p.Pro803Pro",
"transcript": "NM_001666.5",
"protein_id": "NP_001657.3",
"transcript_support_level": null,
"aa_start": 803,
"aa_end": null,
"aa_length": 946,
"cds_start": 2409,
"cds_end": null,
"cds_length": 2841,
"cdna_start": 2471,
"cdna_end": null,
"cdna_length": 3254,
"mane_select": "ENST00000350060.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001666.5"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP4",
"gene_hgnc_id": 674,
"hgvs_c": "c.2409C>G",
"hgvs_p": "p.Pro803Pro",
"transcript": "ENST00000350060.10",
"protein_id": "ENSP00000203786.8",
"transcript_support_level": 1,
"aa_start": 803,
"aa_end": null,
"aa_length": 946,
"cds_start": 2409,
"cds_end": null,
"cds_length": 2841,
"cdna_start": 2471,
"cdna_end": null,
"cdna_length": 3254,
"mane_select": "NM_001666.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000350060.10"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP4",
"gene_hgnc_id": 674,
"hgvs_c": "c.2529C>G",
"hgvs_p": "p.Pro843Pro",
"transcript": "ENST00000370028.7",
"protein_id": "ENSP00000359045.3",
"transcript_support_level": 1,
"aa_start": 843,
"aa_end": null,
"aa_length": 986,
"cds_start": 2529,
"cds_end": null,
"cds_length": 2961,
"cdna_start": 2587,
"cdna_end": null,
"cdna_length": 3372,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000370028.7"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP4",
"gene_hgnc_id": 674,
"hgvs_c": "c.2529C>G",
"hgvs_p": "p.Pro843Pro",
"transcript": "NM_001164741.2",
"protein_id": "NP_001158213.1",
"transcript_support_level": null,
"aa_start": 843,
"aa_end": null,
"aa_length": 986,
"cds_start": 2529,
"cds_end": null,
"cds_length": 2961,
"cdna_start": 2591,
"cdna_end": null,
"cdna_length": 3374,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001164741.2"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP4",
"gene_hgnc_id": 674,
"hgvs_c": "c.2427C>G",
"hgvs_p": "p.Pro809Pro",
"transcript": "ENST00000968871.1",
"protein_id": "ENSP00000638930.1",
"transcript_support_level": null,
"aa_start": 809,
"aa_end": null,
"aa_length": 952,
"cds_start": 2427,
"cds_end": null,
"cds_length": 2859,
"cdna_start": 2491,
"cdna_end": null,
"cdna_length": 3275,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000968871.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP4",
"gene_hgnc_id": 674,
"hgvs_c": "c.2406C>G",
"hgvs_p": "p.Pro802Pro",
"transcript": "ENST00000907990.1",
"protein_id": "ENSP00000578049.1",
"transcript_support_level": null,
"aa_start": 802,
"aa_end": null,
"aa_length": 945,
"cds_start": 2406,
"cds_end": null,
"cds_length": 2838,
"cdna_start": 2478,
"cdna_end": null,
"cdna_length": 3263,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000907990.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP4",
"gene_hgnc_id": 674,
"hgvs_c": "c.2400C>G",
"hgvs_p": "p.Pro800Pro",
"transcript": "ENST00000968870.1",
"protein_id": "ENSP00000638929.1",
"transcript_support_level": null,
"aa_start": 800,
"aa_end": null,
"aa_length": 943,
"cds_start": 2400,
"cds_end": null,
"cds_length": 2832,
"cdna_start": 2509,
"cdna_end": null,
"cdna_length": 3292,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000968870.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP4",
"gene_hgnc_id": 674,
"hgvs_c": "c.2346C>G",
"hgvs_p": "p.Pro782Pro",
"transcript": "ENST00000370016.5",
"protein_id": "ENSP00000359033.1",
"transcript_support_level": 5,
"aa_start": 782,
"aa_end": null,
"aa_length": 925,
"cds_start": 2346,
"cds_end": null,
"cds_length": 2778,
"cdna_start": 2388,
"cdna_end": null,
"cdna_length": 3095,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000370016.5"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP4",
"gene_hgnc_id": 674,
"hgvs_c": "c.2307C>G",
"hgvs_p": "p.Pro769Pro",
"transcript": "ENST00000907988.1",
"protein_id": "ENSP00000578047.1",
"transcript_support_level": null,
"aa_start": 769,
"aa_end": null,
"aa_length": 912,
"cds_start": 2307,
"cds_end": null,
"cds_length": 2739,
"cdna_start": 2422,
"cdna_end": null,
"cdna_length": 3205,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000907988.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP4",
"gene_hgnc_id": 674,
"hgvs_c": "c.2304C>G",
"hgvs_p": "p.Pro768Pro",
"transcript": "ENST00000907989.1",
"protein_id": "ENSP00000578048.1",
"transcript_support_level": null,
"aa_start": 768,
"aa_end": null,
"aa_length": 911,
"cds_start": 2304,
"cds_end": null,
"cds_length": 2736,
"cdna_start": 2399,
"cdna_end": null,
"cdna_length": 3181,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000907989.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP4",
"gene_hgnc_id": 674,
"hgvs_c": "c.2223C>G",
"hgvs_p": "p.Pro741Pro",
"transcript": "ENST00000927210.1",
"protein_id": "ENSP00000597269.1",
"transcript_support_level": null,
"aa_start": 741,
"aa_end": null,
"aa_length": 884,
"cds_start": 2223,
"cds_end": null,
"cds_length": 2655,
"cdna_start": 2334,
"cdna_end": null,
"cdna_length": 3118,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927210.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP4",
"gene_hgnc_id": 674,
"hgvs_c": "c.2175C>G",
"hgvs_p": "p.Pro725Pro",
"transcript": "ENST00000907991.1",
"protein_id": "ENSP00000578050.1",
"transcript_support_level": null,
"aa_start": 725,
"aa_end": null,
"aa_length": 868,
"cds_start": 2175,
"cds_end": null,
"cds_length": 2607,
"cdna_start": 2240,
"cdna_end": null,
"cdna_length": 3023,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000907991.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP4",
"gene_hgnc_id": 674,
"hgvs_c": "c.1875C>G",
"hgvs_p": "p.Pro625Pro",
"transcript": "ENST00000393721.5",
"protein_id": "ENSP00000377322.1",
"transcript_support_level": 5,
"aa_start": 625,
"aa_end": null,
"aa_length": 768,
"cds_start": 1875,
"cds_end": null,
"cds_length": 2307,
"cdna_start": 1927,
"cdna_end": null,
"cdna_length": 2721,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000393721.5"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP4",
"gene_hgnc_id": 674,
"hgvs_c": "c.873C>G",
"hgvs_p": "p.Pro291Pro",
"transcript": "ENST00000442172.1",
"protein_id": "ENSP00000408656.1",
"transcript_support_level": 3,
"aa_start": 291,
"aa_end": null,
"aa_length": 291,
"cds_start": 873,
"cds_end": null,
"cds_length": 878,
"cdna_start": 875,
"cdna_end": null,
"cdna_length": 880,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000442172.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP4",
"gene_hgnc_id": 674,
"hgvs_c": "c.672C>G",
"hgvs_p": "p.Pro224Pro",
"transcript": "ENST00000454164.5",
"protein_id": "ENSP00000412437.1",
"transcript_support_level": 5,
"aa_start": 224,
"aa_end": null,
"aa_length": 247,
"cds_start": 672,
"cds_end": null,
"cds_length": 745,
"cdna_start": 674,
"cdna_end": null,
"cdna_length": 747,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000454164.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP4",
"gene_hgnc_id": 674,
"hgvs_c": "n.*1783C>G",
"hgvs_p": null,
"transcript": "ENST00000404127.6",
"protein_id": "ENSP00000385042.2",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3232,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000404127.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP4",
"gene_hgnc_id": 674,
"hgvs_c": "n.*113C>G",
"hgvs_p": null,
"transcript": "ENST00000420383.5",
"protein_id": "ENSP00000397533.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2817,
"mane_select": null,
"mane_plus": null,
"biotype": "nonsense_mediated_decay",
"feature": "ENST00000420383.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP4",
"gene_hgnc_id": 674,
"hgvs_c": "n.765C>G",
"hgvs_p": null,
"transcript": "ENST00000467421.1",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 798,
"mane_select": null,
"mane_plus": null,
"biotype": "pseudogene",
"feature": "ENST00000467421.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP4",
"gene_hgnc_id": 674,
"hgvs_c": "n.2182C>G",
"hgvs_p": null,
"transcript": "ENST00000470209.5",
"protein_id": null,
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2889,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000470209.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP4",
"gene_hgnc_id": 674,
"hgvs_c": "n.1960C>G",
"hgvs_p": null,
"transcript": "ENST00000494302.5",
"protein_id": null,
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2667,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000494302.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP4",
"gene_hgnc_id": 674,
"hgvs_c": "n.1006C>G",
"hgvs_p": null,
"transcript": "ENST00000494397.5",
"protein_id": null,
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1752,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000494397.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARHGAP4",
"gene_hgnc_id": 674,
"hgvs_c": "n.*632C>G",
"hgvs_p": null,
"transcript": "ENST00000700282.1",
"protein_id": "ENSP00000514915.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
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"splice_prediction_selected": "Benign",
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{
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"BP4_Moderate",
"BP7"
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"verdict": "Likely_benign",
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"clinvar_disease": "",
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"clinvar_review_status": "",
"clinvar_submissions_summary": "",
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"pathogenicity_classification_combined": null,
"custom_annotations": null
}
],
"message": null
}