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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: X-154012856-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=X&pos=154012856&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "X",
"pos": 154012856,
"ref": "G",
"alt": "C",
"effect": "intron_variant",
"transcript": "NM_001569.4",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "IRAK1",
"gene_hgnc_id": 6112,
"hgvs_c": "c.1931-178C>G",
"hgvs_p": null,
"transcript": "NM_001569.4",
"protein_id": "NP_001560.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 712,
"cds_start": null,
"cds_end": null,
"cds_length": 2139,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3581,
"mane_select": "ENST00000369980.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001569.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "IRAK1",
"gene_hgnc_id": 6112,
"hgvs_c": "c.1931-178C>G",
"hgvs_p": null,
"transcript": "ENST00000369980.8",
"protein_id": "ENSP00000358997.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 712,
"cds_start": null,
"cds_end": null,
"cds_length": 2139,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3581,
"mane_select": "NM_001569.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000369980.8"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "IRAK1",
"gene_hgnc_id": 6112,
"hgvs_c": "c.1841-178C>G",
"hgvs_p": null,
"transcript": "ENST00000393687.6",
"protein_id": "ENSP00000377291.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 682,
"cds_start": null,
"cds_end": null,
"cds_length": 2049,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2049,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000393687.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "IRAK1",
"gene_hgnc_id": 6112,
"hgvs_c": "c.1694-178C>G",
"hgvs_p": null,
"transcript": "ENST00000369974.6",
"protein_id": "ENSP00000358991.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 633,
"cds_start": null,
"cds_end": null,
"cds_length": 1902,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3319,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000369974.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "IRAK1",
"gene_hgnc_id": 6112,
"hgvs_c": "c.1931-178C>G",
"hgvs_p": null,
"transcript": "ENST00000927323.1",
"protein_id": "ENSP00000597382.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 712,
"cds_start": null,
"cds_end": null,
"cds_length": 2139,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3576,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927323.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "IRAK1",
"gene_hgnc_id": 6112,
"hgvs_c": "c.1928-178C>G",
"hgvs_p": null,
"transcript": "ENST00000927320.1",
"protein_id": "ENSP00000597379.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 711,
"cds_start": null,
"cds_end": null,
"cds_length": 2136,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3589,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927320.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "IRAK1",
"gene_hgnc_id": 6112,
"hgvs_c": "c.1922-178C>G",
"hgvs_p": null,
"transcript": "ENST00000927318.1",
"protein_id": "ENSP00000597377.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 709,
"cds_start": null,
"cds_end": null,
"cds_length": 2130,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3597,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927318.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "IRAK1",
"gene_hgnc_id": 6112,
"hgvs_c": "c.1919-178C>G",
"hgvs_p": null,
"transcript": "NM_001410701.1",
"protein_id": "NP_001397630.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 708,
"cds_start": null,
"cds_end": null,
"cds_length": 2127,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3569,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001410701.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "IRAK1",
"gene_hgnc_id": 6112,
"hgvs_c": "c.1919-178C>G",
"hgvs_p": null,
"transcript": "ENST00000429936.6",
"protein_id": "ENSP00000392662.2",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 708,
"cds_start": null,
"cds_end": null,
"cds_length": 2127,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2127,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000429936.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "IRAK1",
"gene_hgnc_id": 6112,
"hgvs_c": "c.1919-178C>G",
"hgvs_p": null,
"transcript": "ENST00000927319.1",
"protein_id": "ENSP00000597378.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 708,
"cds_start": null,
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"cds_length": 2127,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3587,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927319.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "IRAK1",
"gene_hgnc_id": 6112,
"hgvs_c": "c.1916-178C>G",
"hgvs_p": null,
"transcript": "ENST00000944209.1",
"protein_id": "ENSP00000614268.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 707,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000944209.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 14,
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"gene_symbol": "IRAK1",
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"hgvs_c": "c.1901-178C>G",
"hgvs_p": null,
"transcript": "ENST00000927322.1",
"protein_id": "ENSP00000597381.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000927322.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 14,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "IRAK1",
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"hgvs_c": "c.1898-178C>G",
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"transcript": "ENST00000927321.1",
"protein_id": "ENSP00000597380.1",
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"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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},
{
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"strand": false,
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],
"exon_rank": null,
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"gene_symbol": "IRAK1",
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"hgvs_c": "c.1841-178C>G",
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"transcript": "NM_001025242.2",
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"feature": "NM_001025242.2"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 14,
"intron_rank": 12,
"intron_rank_end": null,
"gene_symbol": "IRAK1",
"gene_hgnc_id": 6112,
"hgvs_c": "c.1832-178C>G",
"hgvs_p": null,
"transcript": "ENST00000927325.1",
"protein_id": "ENSP00000597384.1",
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"aa_start": null,
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"cds_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
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},
{
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"protein_coding": true,
"strand": false,
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],
"exon_rank": null,
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"exon_count": 13,
"intron_rank": 11,
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"gene_symbol": "IRAK1",
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"hgvs_c": "c.1799-178C>G",
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"transcript": "ENST00000944210.1",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "IRAK1",
"gene_hgnc_id": 6112,
"hgvs_c": "c.1742-178C>G",
"hgvs_p": null,
"transcript": "ENST00000944208.1",
"protein_id": "ENSP00000614267.1",
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000944208.1"
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 13,
"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "IRAK1",
"gene_hgnc_id": 6112,
"hgvs_c": "c.1712-178C>G",
"hgvs_p": null,
"transcript": "ENST00000944212.1",
"protein_id": "ENSP00000614271.1",
"transcript_support_level": null,
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},
{
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"consequences": [
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],
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"intron_rank": 11,
"intron_rank_end": null,
"gene_symbol": "IRAK1",
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"hgvs_c": "c.1694-178C>G",
"hgvs_p": null,
"transcript": "NM_001025243.2",
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},
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],
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"gene_symbol": "IRAK1",
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},
{
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"strand": false,
"consequences": [
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],
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"gene_symbol": "IRAK1",
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"hgvs_c": "c.1652-178C>G",
"hgvs_p": null,
"transcript": "ENST00000944206.1",
"protein_id": "ENSP00000614265.1",
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000944206.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "IRAK1",
"gene_hgnc_id": 6112,
"hgvs_c": "c.1628-178C>G",
"hgvs_p": null,
"transcript": "ENST00000944207.1",
"protein_id": "ENSP00000614266.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000944207.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
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}
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}