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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: X-154532439-A-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=X&pos=154532439&ref=A&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "X",
"pos": 154532439,
"ref": "A",
"alt": "C",
"effect": "stop_gained",
"transcript": "NM_000402.4",
"consequences": [
{
"aa_ref": "Y",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "G6PD",
"gene_hgnc_id": 4057,
"hgvs_c": "c.1311T>G",
"hgvs_p": "p.Tyr437*",
"transcript": "NM_001360016.2",
"protein_id": "NP_001346945.1",
"transcript_support_level": null,
"aa_start": 437,
"aa_end": null,
"aa_length": 515,
"cds_start": 1311,
"cds_end": null,
"cds_length": 1548,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000393562.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001360016.2"
},
{
"aa_ref": "Y",
"aa_alt": "*",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "G6PD",
"gene_hgnc_id": 4057,
"hgvs_c": "c.1311T>G",
"hgvs_p": "p.Tyr437*",
"transcript": "ENST00000393562.10",
"protein_id": "ENSP00000377192.3",
"transcript_support_level": 1,
"aa_start": 437,
"aa_end": null,
"aa_length": 515,
"cds_start": 1311,
"cds_end": null,
"cds_length": 1548,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001360016.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000393562.10"
},
{
"aa_ref": "Y",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "G6PD",
"gene_hgnc_id": 4057,
"hgvs_c": "c.1311T>G",
"hgvs_p": "p.Tyr437*",
"transcript": "ENST00000696421.1",
"protein_id": "ENSP00000512616.1",
"transcript_support_level": null,
"aa_start": 437,
"aa_end": null,
"aa_length": 581,
"cds_start": 1311,
"cds_end": null,
"cds_length": 1746,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000696421.1"
},
{
"aa_ref": "Y",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "G6PD",
"gene_hgnc_id": 4057,
"hgvs_c": "c.1449T>G",
"hgvs_p": "p.Tyr483*",
"transcript": "ENST00000369620.6",
"protein_id": "ENSP00000358633.2",
"transcript_support_level": 5,
"aa_start": 483,
"aa_end": null,
"aa_length": 561,
"cds_start": 1449,
"cds_end": null,
"cds_length": 1686,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000369620.6"
},
{
"aa_ref": "Y",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "G6PD",
"gene_hgnc_id": 4057,
"hgvs_c": "c.1449T>G",
"hgvs_p": "p.Tyr483*",
"transcript": "ENST00000915896.1",
"protein_id": "ENSP00000585955.1",
"transcript_support_level": null,
"aa_start": 483,
"aa_end": null,
"aa_length": 561,
"cds_start": 1449,
"cds_end": null,
"cds_length": 1686,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000915896.1"
},
{
"aa_ref": "Y",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "G6PD",
"gene_hgnc_id": 4057,
"hgvs_c": "c.1401T>G",
"hgvs_p": "p.Tyr467*",
"transcript": "NM_000402.4",
"protein_id": "NP_000393.4",
"transcript_support_level": null,
"aa_start": 467,
"aa_end": null,
"aa_length": 545,
"cds_start": 1401,
"cds_end": null,
"cds_length": 1638,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_000402.4"
},
{
"aa_ref": "Y",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "G6PD",
"gene_hgnc_id": 4057,
"hgvs_c": "c.1314T>G",
"hgvs_p": "p.Tyr438*",
"transcript": "ENST00000439227.6",
"protein_id": "ENSP00000395599.2",
"transcript_support_level": 5,
"aa_start": 438,
"aa_end": null,
"aa_length": 516,
"cds_start": 1314,
"cds_end": null,
"cds_length": 1551,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000439227.6"
},
{
"aa_ref": "Y",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "G6PD",
"gene_hgnc_id": 4057,
"hgvs_c": "c.1314T>G",
"hgvs_p": "p.Tyr438*",
"transcript": "ENST00000907454.1",
"protein_id": "ENSP00000577513.1",
"transcript_support_level": null,
"aa_start": 438,
"aa_end": null,
"aa_length": 516,
"cds_start": 1314,
"cds_end": null,
"cds_length": 1551,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000907454.1"
},
{
"aa_ref": "Y",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "G6PD",
"gene_hgnc_id": 4057,
"hgvs_c": "c.1314T>G",
"hgvs_p": "p.Tyr438*",
"transcript": "ENST00000915895.1",
"protein_id": "ENSP00000585954.1",
"transcript_support_level": null,
"aa_start": 438,
"aa_end": null,
"aa_length": 516,
"cds_start": 1314,
"cds_end": null,
"cds_length": 1551,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000915895.1"
},
{
"aa_ref": "Y",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "G6PD",
"gene_hgnc_id": 4057,
"hgvs_c": "c.1311T>G",
"hgvs_p": "p.Tyr437*",
"transcript": "NM_001042351.3",
"protein_id": "NP_001035810.1",
"transcript_support_level": null,
"aa_start": 437,
"aa_end": null,
"aa_length": 515,
"cds_start": 1311,
"cds_end": null,
"cds_length": 1548,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001042351.3"
},
{
"aa_ref": "Y",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "G6PD",
"gene_hgnc_id": 4057,
"hgvs_c": "c.1311T>G",
"hgvs_p": "p.Tyr437*",
"transcript": "ENST00000393564.7",
"protein_id": "ENSP00000377194.2",
"transcript_support_level": 5,
"aa_start": 437,
"aa_end": null,
"aa_length": 515,
"cds_start": 1311,
"cds_end": null,
"cds_length": 1548,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000393564.7"
},
{
"aa_ref": "Y",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "G6PD",
"gene_hgnc_id": 4057,
"hgvs_c": "c.1311T>G",
"hgvs_p": "p.Tyr437*",
"transcript": "ENST00000696429.1",
"protein_id": "ENSP00000512624.1",
"transcript_support_level": null,
"aa_start": 437,
"aa_end": null,
"aa_length": 515,
"cds_start": 1311,
"cds_end": null,
"cds_length": 1548,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000696429.1"
},
{
"aa_ref": "Y",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "G6PD",
"gene_hgnc_id": 4057,
"hgvs_c": "c.1311T>G",
"hgvs_p": "p.Tyr437*",
"transcript": "ENST00000696430.1",
"protein_id": "ENSP00000512625.1",
"transcript_support_level": null,
"aa_start": 437,
"aa_end": null,
"aa_length": 515,
"cds_start": 1311,
"cds_end": null,
"cds_length": 1548,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000696430.1"
},
{
"aa_ref": "Y",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "G6PD",
"gene_hgnc_id": 4057,
"hgvs_c": "c.1311T>G",
"hgvs_p": "p.Tyr437*",
"transcript": "ENST00000907455.1",
"protein_id": "ENSP00000577514.1",
"transcript_support_level": null,
"aa_start": 437,
"aa_end": null,
"aa_length": 515,
"cds_start": 1311,
"cds_end": null,
"cds_length": 1548,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000907455.1"
},
{
"aa_ref": "Y",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "G6PD",
"gene_hgnc_id": 4057,
"hgvs_c": "c.1311T>G",
"hgvs_p": "p.Tyr437*",
"transcript": "ENST00000907457.1",
"protein_id": "ENSP00000577516.1",
"transcript_support_level": null,
"aa_start": 437,
"aa_end": null,
"aa_length": 515,
"cds_start": 1311,
"cds_end": null,
"cds_length": 1548,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000907457.1"
},
{
"aa_ref": "Y",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "G6PD",
"gene_hgnc_id": 4057,
"hgvs_c": "c.1311T>G",
"hgvs_p": "p.Tyr437*",
"transcript": "ENST00000915897.1",
"protein_id": "ENSP00000585956.1",
"transcript_support_level": null,
"aa_start": 437,
"aa_end": null,
"aa_length": 515,
"cds_start": 1311,
"cds_end": null,
"cds_length": 1548,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000915897.1"
},
{
"aa_ref": "Y",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "G6PD",
"gene_hgnc_id": 4057,
"hgvs_c": "c.1305T>G",
"hgvs_p": "p.Tyr435*",
"transcript": "ENST00000968237.1",
"protein_id": "ENSP00000638296.1",
"transcript_support_level": null,
"aa_start": 435,
"aa_end": null,
"aa_length": 513,
"cds_start": 1305,
"cds_end": null,
"cds_length": 1542,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000968237.1"
},
{
"aa_ref": "Y",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "G6PD",
"gene_hgnc_id": 4057,
"hgvs_c": "c.1311T>G",
"hgvs_p": "p.Tyr437*",
"transcript": "ENST00000696420.1",
"protein_id": "ENSP00000512615.1",
"transcript_support_level": null,
"aa_start": 437,
"aa_end": null,
"aa_length": 491,
"cds_start": 1311,
"cds_end": null,
"cds_length": 1476,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000696420.1"
},
{
"aa_ref": "Y",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "G6PD",
"gene_hgnc_id": 4057,
"hgvs_c": "c.1176T>G",
"hgvs_p": "p.Tyr392*",
"transcript": "ENST00000696423.1",
"protein_id": "ENSP00000512618.1",
"transcript_support_level": null,
"aa_start": 392,
"aa_end": null,
"aa_length": 470,
"cds_start": 1176,
"cds_end": null,
"cds_length": 1413,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000696423.1"
},
{
"aa_ref": "Y",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "G6PD",
"gene_hgnc_id": 4057,
"hgvs_c": "c.1173T>G",
"hgvs_p": "p.Tyr391*",
"transcript": "ENST00000696422.1",
"protein_id": "ENSP00000512617.1",
"transcript_support_level": null,
"aa_start": 391,
"aa_end": null,
"aa_length": 469,
"cds_start": 1173,
"cds_end": null,
"cds_length": 1410,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000696422.1"
},
{
"aa_ref": "Y",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "G6PD",
"gene_hgnc_id": 4057,
"hgvs_c": "c.1152T>G",
"hgvs_p": "p.Tyr384*",
"transcript": "ENST00000915894.1",
"protein_id": "ENSP00000585953.1",
"transcript_support_level": null,
"aa_start": 384,
"aa_end": null,
"aa_length": 462,
"cds_start": 1152,
"cds_end": null,
"cds_length": 1389,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000915894.1"
},
{
"aa_ref": "Y",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"stop_gained"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "G6PD",
"gene_hgnc_id": 4057,
"hgvs_c": "c.765T>G",
"hgvs_p": "p.Tyr255*",
"transcript": "ENST00000907456.1",
"protein_id": "ENSP00000577515.1",
"transcript_support_level": null,
"aa_start": 255,
"aa_end": null,
"aa_length": 333,
"cds_start": 765,
"cds_end": null,
"cds_length": 1002,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
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}
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}