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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: X-154779227-C-G (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=X&pos=154779227&ref=C&alt=G&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "X",
      "pos": 154779227,
      "ref": "C",
      "alt": "G",
      "effect": "missense_variant",
      "transcript": "NM_002436.4",
      "consequences": [
        {
          "aa_ref": "D",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MPP1",
          "gene_hgnc_id": 7219,
          "hgvs_c": "c.1351G>C",
          "hgvs_p": "p.Asp451His",
          "transcript": "NM_002436.4",
          "protein_id": "NP_002427.1",
          "transcript_support_level": null,
          "aa_start": 451,
          "aa_end": null,
          "aa_length": 466,
          "cds_start": 1351,
          "cds_end": null,
          "cds_length": 1401,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000369534.8",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_002436.4"
        },
        {
          "aa_ref": "D",
          "aa_alt": "H",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MPP1",
          "gene_hgnc_id": 7219,
          "hgvs_c": "c.1351G>C",
          "hgvs_p": "p.Asp451His",
          "transcript": "ENST00000369534.8",
          "protein_id": "ENSP00000358547.3",
          "transcript_support_level": 1,
          "aa_start": 451,
          "aa_end": null,
          "aa_length": 466,
          "cds_start": 1351,
          "cds_end": null,
          "cds_length": 1401,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_002436.4",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000369534.8"
        },
        {
          "aa_ref": "D",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MPP1",
          "gene_hgnc_id": 7219,
          "hgvs_c": "c.1291G>C",
          "hgvs_p": "p.Asp431His",
          "transcript": "ENST00000393531.5",
          "protein_id": "ENSP00000377165.1",
          "transcript_support_level": 1,
          "aa_start": 431,
          "aa_end": null,
          "aa_length": 446,
          "cds_start": 1291,
          "cds_end": null,
          "cds_length": 1341,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000393531.5"
        },
        {
          "aa_ref": "D",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MPP1",
          "gene_hgnc_id": 7219,
          "hgvs_c": "c.1351G>C",
          "hgvs_p": "p.Asp451His",
          "transcript": "ENST00000934478.1",
          "protein_id": "ENSP00000604537.1",
          "transcript_support_level": null,
          "aa_start": 451,
          "aa_end": null,
          "aa_length": 466,
          "cds_start": 1351,
          "cds_end": null,
          "cds_length": 1401,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000934478.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MPP1",
          "gene_hgnc_id": 7219,
          "hgvs_c": "c.1348G>C",
          "hgvs_p": "p.Asp450His",
          "transcript": "ENST00000955647.1",
          "protein_id": "ENSP00000625706.1",
          "transcript_support_level": null,
          "aa_start": 450,
          "aa_end": null,
          "aa_length": 465,
          "cds_start": 1348,
          "cds_end": null,
          "cds_length": 1398,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000955647.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MPP1",
          "gene_hgnc_id": 7219,
          "hgvs_c": "c.1300G>C",
          "hgvs_p": "p.Asp434His",
          "transcript": "NM_001166460.2",
          "protein_id": "NP_001159932.1",
          "transcript_support_level": null,
          "aa_start": 434,
          "aa_end": null,
          "aa_length": 449,
          "cds_start": 1300,
          "cds_end": null,
          "cds_length": 1350,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001166460.2"
        },
        {
          "aa_ref": "D",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MPP1",
          "gene_hgnc_id": 7219,
          "hgvs_c": "c.1291G>C",
          "hgvs_p": "p.Asp431His",
          "transcript": "NM_001166461.2",
          "protein_id": "NP_001159933.1",
          "transcript_support_level": null,
          "aa_start": 431,
          "aa_end": null,
          "aa_length": 446,
          "cds_start": 1291,
          "cds_end": null,
          "cds_length": 1341,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001166461.2"
        },
        {
          "aa_ref": "D",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MPP1",
          "gene_hgnc_id": 7219,
          "hgvs_c": "c.1282G>C",
          "hgvs_p": "p.Asp428His",
          "transcript": "ENST00000955646.1",
          "protein_id": "ENSP00000625705.1",
          "transcript_support_level": null,
          "aa_start": 428,
          "aa_end": null,
          "aa_length": 443,
          "cds_start": 1282,
          "cds_end": null,
          "cds_length": 1332,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000955646.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MPP1",
          "gene_hgnc_id": 7219,
          "hgvs_c": "c.1270G>C",
          "hgvs_p": "p.Asp424His",
          "transcript": "ENST00000907097.1",
          "protein_id": "ENSP00000577156.1",
          "transcript_support_level": null,
          "aa_start": 424,
          "aa_end": null,
          "aa_length": 439,
          "cds_start": 1270,
          "cds_end": null,
          "cds_length": 1320,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000907097.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MPP1",
          "gene_hgnc_id": 7219,
          "hgvs_c": "c.1261G>C",
          "hgvs_p": "p.Asp421His",
          "transcript": "NM_001166462.2",
          "protein_id": "NP_001159934.1",
          "transcript_support_level": null,
          "aa_start": 421,
          "aa_end": null,
          "aa_length": 436,
          "cds_start": 1261,
          "cds_end": null,
          "cds_length": 1311,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001166462.2"
        },
        {
          "aa_ref": "D",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MPP1",
          "gene_hgnc_id": 7219,
          "hgvs_c": "c.1261G>C",
          "hgvs_p": "p.Asp421His",
          "transcript": "ENST00000413259.7",
          "protein_id": "ENSP00000400155.3",
          "transcript_support_level": 2,
          "aa_start": 421,
          "aa_end": null,
          "aa_length": 436,
          "cds_start": 1261,
          "cds_end": null,
          "cds_length": 1311,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000413259.7"
        },
        {
          "aa_ref": "D",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MPP1",
          "gene_hgnc_id": 7219,
          "hgvs_c": "c.1210G>C",
          "hgvs_p": "p.Asp404His",
          "transcript": "ENST00000907099.1",
          "protein_id": "ENSP00000577158.1",
          "transcript_support_level": null,
          "aa_start": 404,
          "aa_end": null,
          "aa_length": 419,
          "cds_start": 1210,
          "cds_end": null,
          "cds_length": 1260,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000907099.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MPP1",
          "gene_hgnc_id": 7219,
          "hgvs_c": "c.1207G>C",
          "hgvs_p": "p.Asp403His",
          "transcript": "ENST00000955645.1",
          "protein_id": "ENSP00000625704.1",
          "transcript_support_level": null,
          "aa_start": 403,
          "aa_end": null,
          "aa_length": 418,
          "cds_start": 1207,
          "cds_end": null,
          "cds_length": 1257,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000955645.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MPP1",
          "gene_hgnc_id": 7219,
          "hgvs_c": "c.1201G>C",
          "hgvs_p": "p.Asp401His",
          "transcript": "ENST00000907098.1",
          "protein_id": "ENSP00000577157.1",
          "transcript_support_level": null,
          "aa_start": 401,
          "aa_end": null,
          "aa_length": 416,
          "cds_start": 1201,
          "cds_end": null,
          "cds_length": 1251,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000907098.1"
        },
        {
          "aa_ref": "D",
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MPP1",
          "gene_hgnc_id": 7219,
          "hgvs_c": "c.892G>C",
          "hgvs_p": "p.Asp298His",
          "transcript": "ENST00000907100.1",
          "protein_id": "ENSP00000577159.1",
          "transcript_support_level": null,
          "aa_start": 298,
          "aa_end": null,
          "aa_length": 313,
          "cds_start": 892,
          "cds_end": null,
          "cds_length": 942,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000907100.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 11,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MPP1",
          "gene_hgnc_id": 7219,
          "hgvs_c": "c.1270G>C",
          "hgvs_p": "p.Asp424His",
          "transcript": "XM_011531167.2",
          "protein_id": "XP_011529469.1",
          "transcript_support_level": null,
          "aa_start": 424,
          "aa_end": null,
          "aa_length": 439,
          "cds_start": 1270,
          "cds_end": null,
          "cds_length": 1320,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_011531167.2"
        },
        {
          "aa_ref": "D",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MPP1",
          "gene_hgnc_id": 7219,
          "hgvs_c": "c.1213G>C",
          "hgvs_p": "p.Asp405His",
          "transcript": "XM_047442123.1",
          "protein_id": "XP_047298079.1",
          "transcript_support_level": null,
          "aa_start": 405,
          "aa_end": null,
          "aa_length": 420,
          "cds_start": 1213,
          "cds_end": null,
          "cds_length": 1263,
          "cdna_start": null,
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          "biotype": "protein_coding",
          "feature": "XM_047442123.1"
        },
        {
          "aa_ref": "D",
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          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 12,
          "exon_rank_end": null,
          "exon_count": 12,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MPP1",
          "gene_hgnc_id": 7219,
          "hgvs_c": "c.1180G>C",
          "hgvs_p": "p.Asp394His",
          "transcript": "XM_047442124.1",
          "protein_id": "XP_047298080.1",
          "transcript_support_level": null,
          "aa_start": 394,
          "aa_end": null,
          "aa_length": 409,
          "cds_start": 1180,
          "cds_end": null,
          "cds_length": 1230,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047442124.1"
        },
        {
          "aa_ref": "D",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MPP1",
          "gene_hgnc_id": 7219,
          "hgvs_c": "c.973G>C",
          "hgvs_p": "p.Asp325His",
          "transcript": "XM_011531169.2",
          "protein_id": "XP_011529471.1",
          "transcript_support_level": null,
          "aa_start": 325,
          "aa_end": null,
          "aa_length": 340,
          "cds_start": 973,
          "cds_end": null,
          "cds_length": 1023,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_011531169.2"
        },
        {
          "aa_ref": "D",
          "aa_alt": "H",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MPP1",
          "gene_hgnc_id": 7219,
          "hgvs_c": "c.892G>C",
          "hgvs_p": "p.Asp298His",
          "transcript": "XM_024452385.2",
          "protein_id": "XP_024308153.1",
          "transcript_support_level": null,
          "aa_start": 298,
          "aa_end": null,
          "aa_length": 313,
          "cds_start": 892,
          "cds_end": null,
          "cds_length": 942,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_024452385.2"
        },
        {
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          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
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          "exon_count": 13,
          "intron_rank": null,
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          "gene_symbol": "MPP1",
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          "hgvs_c": "n.*1275G>C",
          "hgvs_p": null,
          "transcript": "ENST00000439370.5",
          "protein_id": "ENSP00000400700.1",
          "transcript_support_level": 5,
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          "cds_start": null,
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          "cds_length": null,
          "cdna_start": null,
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          "mane_select": null,
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          "biotype": "nonsense_mediated_decay",
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        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
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          "exon_count": 2,
          "intron_rank": null,
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          "gene_symbol": "MPP1",
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          "hgvs_c": "n.485G>C",
          "hgvs_p": null,
          "transcript": "ENST00000482757.1",
          "protein_id": null,
          "transcript_support_level": 2,
          "aa_start": null,
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          "aa_length": null,
          "cds_start": null,
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          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "retained_intron",
          "feature": "ENST00000482757.1"
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
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          "gene_symbol": "MPP1",
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          "hgvs_c": "n.1837G>C",
          "hgvs_p": null,
          "transcript": "ENST00000491955.5",
          "protein_id": null,
          "transcript_support_level": 2,
          "aa_start": null,
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          "aa_length": null,
          "cds_start": null,
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          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "retained_intron",
          "feature": "ENST00000491955.5"
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 13,
          "exon_rank_end": null,
          "exon_count": 13,
          "intron_rank": null,
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          "gene_symbol": "MPP1",
          "gene_hgnc_id": 7219,
          "hgvs_c": "n.*1275G>C",
          "hgvs_p": null,
          "transcript": "ENST00000439370.5",
          "protein_id": "ENSP00000400700.1",
          "transcript_support_level": 5,
          "aa_start": null,
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          "cds_start": null,
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          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000439370.5"
        }
      ],
      "gene_symbol": "MPP1",
      "gene_hgnc_id": 7219,
      "dbsnp": "rs782511750",
      "frequency_reference_population": 9.107468e-7,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 1,
      "gnomad_exomes_af": 9.10747e-7,
      "gnomad_genomes_af": null,
      "gnomad_exomes_ac": 1,
      "gnomad_genomes_ac": null,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": null,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.3141147792339325,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.169,
      "revel_prediction": "Benign",
      "alphamissense_score": 0.0958,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.56,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 3.857,
      "phylop100way_prediction": "Uncertain_significance",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": 1,
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,BP4",
      "acmg_by_gene": [
        {
          "score": 1,
          "benign_score": 1,
          "pathogenic_score": 2,
          "criteria": [
            "PM2",
            "BP4"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "NM_002436.4",
          "gene_symbol": "MPP1",
          "hgnc_id": 7219,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "",
          "hgvs_c": "c.1351G>C",
          "hgvs_p": "p.Asp451His"
        }
      ],
      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "phenotype_combined": null,
      "pathogenicity_classification_combined": null,
      "custom_annotations": null
    }
  ],
  "message": null
}