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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: X-155507053-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=X&pos=155507053&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "X",
"pos": 155507053,
"ref": "C",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "NM_018196.4",
"consequences": [
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMLHE",
"gene_hgnc_id": 18308,
"hgvs_c": "c.840G>A",
"hgvs_p": "p.Gln280Gln",
"transcript": "NM_018196.4",
"protein_id": "NP_060666.1",
"transcript_support_level": null,
"aa_start": 280,
"aa_end": null,
"aa_length": 421,
"cds_start": 840,
"cds_end": null,
"cds_length": 1266,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000334398.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_018196.4"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMLHE",
"gene_hgnc_id": 18308,
"hgvs_c": "c.840G>A",
"hgvs_p": "p.Gln280Gln",
"transcript": "ENST00000334398.8",
"protein_id": "ENSP00000335261.3",
"transcript_support_level": 1,
"aa_start": 280,
"aa_end": null,
"aa_length": 421,
"cds_start": 840,
"cds_end": null,
"cds_length": 1266,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_018196.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000334398.8"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMLHE",
"gene_hgnc_id": 18308,
"hgvs_c": "c.840G>A",
"hgvs_p": "p.Gln280Gln",
"transcript": "ENST00000369439.4",
"protein_id": "ENSP00000358447.4",
"transcript_support_level": 1,
"aa_start": 280,
"aa_end": null,
"aa_length": 376,
"cds_start": 840,
"cds_end": null,
"cds_length": 1131,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000369439.4"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMLHE",
"gene_hgnc_id": 18308,
"hgvs_c": "c.909G>A",
"hgvs_p": "p.Gln303Gln",
"transcript": "ENST00000902557.1",
"protein_id": "ENSP00000572616.1",
"transcript_support_level": null,
"aa_start": 303,
"aa_end": null,
"aa_length": 444,
"cds_start": 909,
"cds_end": null,
"cds_length": 1335,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000902557.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMLHE",
"gene_hgnc_id": 18308,
"hgvs_c": "c.873G>A",
"hgvs_p": "p.Gln291Gln",
"transcript": "ENST00000675642.1",
"protein_id": "ENSP00000502604.1",
"transcript_support_level": null,
"aa_start": 291,
"aa_end": null,
"aa_length": 432,
"cds_start": 873,
"cds_end": null,
"cds_length": 1299,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000675642.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMLHE",
"gene_hgnc_id": 18308,
"hgvs_c": "c.840G>A",
"hgvs_p": "p.Gln280Gln",
"transcript": "ENST00000902548.1",
"protein_id": "ENSP00000572607.1",
"transcript_support_level": null,
"aa_start": 280,
"aa_end": null,
"aa_length": 421,
"cds_start": 840,
"cds_end": null,
"cds_length": 1266,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000902548.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMLHE",
"gene_hgnc_id": 18308,
"hgvs_c": "c.840G>A",
"hgvs_p": "p.Gln280Gln",
"transcript": "ENST00000902549.1",
"protein_id": "ENSP00000572608.1",
"transcript_support_level": null,
"aa_start": 280,
"aa_end": null,
"aa_length": 421,
"cds_start": 840,
"cds_end": null,
"cds_length": 1266,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000902549.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMLHE",
"gene_hgnc_id": 18308,
"hgvs_c": "c.840G>A",
"hgvs_p": "p.Gln280Gln",
"transcript": "ENST00000902550.1",
"protein_id": "ENSP00000572609.1",
"transcript_support_level": null,
"aa_start": 280,
"aa_end": null,
"aa_length": 421,
"cds_start": 840,
"cds_end": null,
"cds_length": 1266,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000902550.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMLHE",
"gene_hgnc_id": 18308,
"hgvs_c": "c.840G>A",
"hgvs_p": "p.Gln280Gln",
"transcript": "ENST00000902551.1",
"protein_id": "ENSP00000572610.1",
"transcript_support_level": null,
"aa_start": 280,
"aa_end": null,
"aa_length": 421,
"cds_start": 840,
"cds_end": null,
"cds_length": 1266,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000902551.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMLHE",
"gene_hgnc_id": 18308,
"hgvs_c": "c.840G>A",
"hgvs_p": "p.Gln280Gln",
"transcript": "ENST00000902554.1",
"protein_id": "ENSP00000572613.1",
"transcript_support_level": null,
"aa_start": 280,
"aa_end": null,
"aa_length": 421,
"cds_start": 840,
"cds_end": null,
"cds_length": 1266,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000902554.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMLHE",
"gene_hgnc_id": 18308,
"hgvs_c": "c.840G>A",
"hgvs_p": "p.Gln280Gln",
"transcript": "ENST00000902555.1",
"protein_id": "ENSP00000572614.1",
"transcript_support_level": null,
"aa_start": 280,
"aa_end": null,
"aa_length": 421,
"cds_start": 840,
"cds_end": null,
"cds_length": 1266,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000902555.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMLHE",
"gene_hgnc_id": 18308,
"hgvs_c": "c.840G>A",
"hgvs_p": "p.Gln280Gln",
"transcript": "ENST00000960922.1",
"protein_id": "ENSP00000630981.1",
"transcript_support_level": null,
"aa_start": 280,
"aa_end": null,
"aa_length": 421,
"cds_start": 840,
"cds_end": null,
"cds_length": 1266,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000960922.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMLHE",
"gene_hgnc_id": 18308,
"hgvs_c": "c.840G>A",
"hgvs_p": "p.Gln280Gln",
"transcript": "ENST00000960923.1",
"protein_id": "ENSP00000630982.1",
"transcript_support_level": null,
"aa_start": 280,
"aa_end": null,
"aa_length": 421,
"cds_start": 840,
"cds_end": null,
"cds_length": 1266,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000960923.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMLHE",
"gene_hgnc_id": 18308,
"hgvs_c": "c.720G>A",
"hgvs_p": "p.Gln240Gln",
"transcript": "ENST00000902556.1",
"protein_id": "ENSP00000572615.1",
"transcript_support_level": null,
"aa_start": 240,
"aa_end": null,
"aa_length": 381,
"cds_start": 720,
"cds_end": null,
"cds_length": 1146,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000902556.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMLHE",
"gene_hgnc_id": 18308,
"hgvs_c": "c.840G>A",
"hgvs_p": "p.Gln280Gln",
"transcript": "NM_001184797.2",
"protein_id": "NP_001171726.1",
"transcript_support_level": null,
"aa_start": 280,
"aa_end": null,
"aa_length": 376,
"cds_start": 840,
"cds_end": null,
"cds_length": 1131,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001184797.2"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMLHE",
"gene_hgnc_id": 18308,
"hgvs_c": "c.663G>A",
"hgvs_p": "p.Gln221Gln",
"transcript": "ENST00000902552.1",
"protein_id": "ENSP00000572611.1",
"transcript_support_level": null,
"aa_start": 221,
"aa_end": null,
"aa_length": 362,
"cds_start": 663,
"cds_end": null,
"cds_length": 1089,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000902552.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMLHE",
"gene_hgnc_id": 18308,
"hgvs_c": "c.840G>A",
"hgvs_p": "p.Gln280Gln",
"transcript": "ENST00000960924.1",
"protein_id": "ENSP00000630983.1",
"transcript_support_level": null,
"aa_start": 280,
"aa_end": null,
"aa_length": 323,
"cds_start": 840,
"cds_end": null,
"cds_length": 972,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000960924.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMLHE",
"gene_hgnc_id": 18308,
"hgvs_c": "c.687G>A",
"hgvs_p": "p.Gln229Gln",
"transcript": "XM_011531182.4",
"protein_id": "XP_011529484.1",
"transcript_support_level": null,
"aa_start": 229,
"aa_end": null,
"aa_length": 370,
"cds_start": 687,
"cds_end": null,
"cds_length": 1113,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011531182.4"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMLHE",
"gene_hgnc_id": 18308,
"hgvs_c": "c.687G>A",
"hgvs_p": "p.Gln229Gln",
"transcript": "XM_047442234.1",
"protein_id": "XP_047298190.1",
"transcript_support_level": null,
"aa_start": 229,
"aa_end": null,
"aa_length": 370,
"cds_start": 687,
"cds_end": null,
"cds_length": 1113,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047442234.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMLHE",
"gene_hgnc_id": 18308,
"hgvs_c": "c.636G>A",
"hgvs_p": "p.Gln212Gln",
"transcript": "XM_047442235.1",
"protein_id": "XP_047298191.1",
"transcript_support_level": null,
"aa_start": 212,
"aa_end": null,
"aa_length": 353,
"cds_start": 636,
"cds_end": null,
"cds_length": 1062,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047442235.1"
},
{
"aa_ref": "Q",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TMLHE",
"gene_hgnc_id": 18308,
"hgvs_c": "c.636G>A",
"hgvs_p": "p.Gln212Gln",
"transcript": "XM_047442236.1",
"protein_id": "XP_047298192.1",
"transcript_support_level": null,
"aa_start": 212,
"aa_end": null,
"aa_length": 353,
"cds_start": 636,
"cds_end": null,
"cds_length": 1062,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047442236.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "TMLHE",
"gene_hgnc_id": 18308,
"hgvs_c": "c.758+4620G>A",
"hgvs_p": null,
"transcript": "ENST00000902553.1",
"protein_id": "ENSP00000572612.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 342,
"cds_start": null,
"cds_end": null,
"cds_length": 1029,
"cdna_start": null,
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}