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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: X-19360785-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=X&pos=19360785&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "X",
"pos": 19360785,
"ref": "C",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_001001671.4",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAP3K15",
"gene_hgnc_id": 31689,
"hgvs_c": "c.3906G>T",
"hgvs_p": "p.Arg1302Ser",
"transcript": "NM_001001671.4",
"protein_id": "NP_001001671.3",
"transcript_support_level": null,
"aa_start": 1302,
"aa_end": null,
"aa_length": 1313,
"cds_start": 3906,
"cds_end": null,
"cds_length": 3942,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000338883.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001001671.4"
},
{
"aa_ref": "R",
"aa_alt": "S",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAP3K15",
"gene_hgnc_id": 31689,
"hgvs_c": "c.3906G>T",
"hgvs_p": "p.Arg1302Ser",
"transcript": "ENST00000338883.9",
"protein_id": "ENSP00000345629.4",
"transcript_support_level": 5,
"aa_start": 1302,
"aa_end": null,
"aa_length": 1313,
"cds_start": 3906,
"cds_end": null,
"cds_length": 3942,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001001671.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000338883.9"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PDHA1",
"gene_hgnc_id": 8806,
"hgvs_c": "c.*1132C>A",
"hgvs_p": null,
"transcript": "NM_000284.4",
"protein_id": "NP_000275.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 390,
"cds_start": null,
"cds_end": null,
"cds_length": 1173,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000422285.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_000284.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PDHA1",
"gene_hgnc_id": 8806,
"hgvs_c": "c.*1132C>A",
"hgvs_p": null,
"transcript": "ENST00000422285.7",
"protein_id": "ENSP00000394382.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 390,
"cds_start": null,
"cds_end": null,
"cds_length": 1173,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_000284.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000422285.7"
},
{
"aa_ref": "R",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 30,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAP3K15",
"gene_hgnc_id": 31689,
"hgvs_c": "c.3939G>T",
"hgvs_p": "p.Arg1313Ser",
"transcript": "ENST00000927253.1",
"protein_id": "ENSP00000597312.1",
"transcript_support_level": null,
"aa_start": 1313,
"aa_end": null,
"aa_length": 1324,
"cds_start": 3939,
"cds_end": null,
"cds_length": 3975,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927253.1"
},
{
"aa_ref": "R",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAP3K15",
"gene_hgnc_id": 31689,
"hgvs_c": "c.3903G>T",
"hgvs_p": "p.Arg1301Ser",
"transcript": "ENST00000947404.1",
"protein_id": "ENSP00000617463.1",
"transcript_support_level": null,
"aa_start": 1301,
"aa_end": null,
"aa_length": 1312,
"cds_start": 3903,
"cds_end": null,
"cds_length": 3939,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000947404.1"
},
{
"aa_ref": "R",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAP3K15",
"gene_hgnc_id": 31689,
"hgvs_c": "c.3819G>T",
"hgvs_p": "p.Arg1273Ser",
"transcript": "ENST00000927252.1",
"protein_id": "ENSP00000597311.1",
"transcript_support_level": null,
"aa_start": 1273,
"aa_end": null,
"aa_length": 1284,
"cds_start": 3819,
"cds_end": null,
"cds_length": 3855,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927252.1"
},
{
"aa_ref": "R",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAP3K15",
"gene_hgnc_id": 31689,
"hgvs_c": "c.3810G>T",
"hgvs_p": "p.Arg1270Ser",
"transcript": "ENST00000947405.1",
"protein_id": "ENSP00000617464.1",
"transcript_support_level": null,
"aa_start": 1270,
"aa_end": null,
"aa_length": 1281,
"cds_start": 3810,
"cds_end": null,
"cds_length": 3846,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000947405.1"
},
{
"aa_ref": "R",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 27,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAP3K15",
"gene_hgnc_id": 31689,
"hgvs_c": "c.3684G>T",
"hgvs_p": "p.Arg1228Ser",
"transcript": "ENST00000947406.1",
"protein_id": "ENSP00000617465.1",
"transcript_support_level": null,
"aa_start": 1228,
"aa_end": null,
"aa_length": 1239,
"cds_start": 3684,
"cds_end": null,
"cds_length": 3720,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000947406.1"
},
{
"aa_ref": "R",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 30,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAP3K15",
"gene_hgnc_id": 31689,
"hgvs_c": "c.3939G>T",
"hgvs_p": "p.Arg1313Ser",
"transcript": "XM_011545507.4",
"protein_id": "XP_011543809.4",
"transcript_support_level": null,
"aa_start": 1313,
"aa_end": null,
"aa_length": 1324,
"cds_start": 3939,
"cds_end": null,
"cds_length": 3975,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011545507.4"
},
{
"aa_ref": "R",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 30,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAP3K15",
"gene_hgnc_id": 31689,
"hgvs_c": "c.3852G>T",
"hgvs_p": "p.Arg1284Ser",
"transcript": "XM_011545508.4",
"protein_id": "XP_011543810.4",
"transcript_support_level": null,
"aa_start": 1284,
"aa_end": null,
"aa_length": 1295,
"cds_start": 3852,
"cds_end": null,
"cds_length": 3888,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011545508.4"
},
{
"aa_ref": "R",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAP3K15",
"gene_hgnc_id": 31689,
"hgvs_c": "c.2580G>T",
"hgvs_p": "p.Arg860Ser",
"transcript": "XM_011545510.3",
"protein_id": "XP_011543812.1",
"transcript_support_level": null,
"aa_start": 860,
"aa_end": null,
"aa_length": 871,
"cds_start": 2580,
"cds_end": null,
"cds_length": 2616,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011545510.3"
},
{
"aa_ref": "R",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "MAP3K15",
"gene_hgnc_id": 31689,
"hgvs_c": "c.2211G>T",
"hgvs_p": "p.Arg737Ser",
"transcript": "XM_011545511.2",
"protein_id": "XP_011543813.1",
"transcript_support_level": null,
"aa_start": 737,
"aa_end": null,
"aa_length": 748,
"cds_start": 2211,
"cds_end": null,
"cds_length": 2247,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011545511.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PDHA1",
"gene_hgnc_id": 8806,
"hgvs_c": "c.*1132C>A",
"hgvs_p": null,
"transcript": "ENST00000947567.1",
"protein_id": "ENSP00000617626.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 456,
"cds_start": null,
"cds_end": null,
"cds_length": 1371,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000947567.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PDHA1",
"gene_hgnc_id": 8806,
"hgvs_c": "c.*1132C>A",
"hgvs_p": null,
"transcript": "ENST00000881112.1",
"protein_id": "ENSP00000551171.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 436,
"cds_start": null,
"cds_end": null,
"cds_length": 1311,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000881112.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PDHA1",
"gene_hgnc_id": 8806,
"hgvs_c": "c.*1132C>A",
"hgvs_p": null,
"transcript": "NM_001173454.2",
"protein_id": "NP_001166925.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 428,
"cds_start": null,
"cds_end": null,
"cds_length": 1287,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001173454.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PDHA1",
"gene_hgnc_id": 8806,
"hgvs_c": "c.*1132C>A",
"hgvs_p": null,
"transcript": "ENST00000423505.6",
"protein_id": "ENSP00000406473.2",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 428,
"cds_start": null,
"cds_end": null,
"cds_length": 1287,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000423505.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PDHA1",
"gene_hgnc_id": 8806,
"hgvs_c": "c.*1132C>A",
"hgvs_p": null,
"transcript": "ENST00000927451.1",
"protein_id": "ENSP00000597510.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 404,
"cds_start": null,
"cds_end": null,
"cds_length": 1215,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000927451.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PDHA1",
"gene_hgnc_id": 8806,
"hgvs_c": "c.*1132C>A",
"hgvs_p": null,
"transcript": "NM_001173455.2",
"protein_id": "NP_001166926.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 397,
"cds_start": null,
"cds_end": null,
"cds_length": 1194,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001173455.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PDHA1",
"gene_hgnc_id": 8806,
"hgvs_c": "c.*1132C>A",
"hgvs_p": null,
"transcript": "ENST00000355808.10",
"protein_id": "ENSP00000348062.6",
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": 397,
"cds_start": null,
"cds_end": null,
"cds_length": 1194,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000355808.10"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PDHA1",
"gene_hgnc_id": 8806,
"hgvs_c": "c.*1132C>A",
"hgvs_p": null,
"transcript": "ENST00000947570.1",
"protein_id": "ENSP00000617629.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 388,
"cds_start": null,
"cds_end": null,
"cds_length": 1167,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000947570.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PDHA1",
"gene_hgnc_id": 8806,
"hgvs_c": "c.*1132C>A",
"hgvs_p": null,
"transcript": "ENST00000947568.1",
"protein_id": "ENSP00000617627.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 387,
"cds_start": null,
"cds_end": null,
"cds_length": 1164,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
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}
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}