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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: X-19659653-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=X&pos=19659653&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "X",
"pos": 19659653,
"ref": "A",
"alt": "G",
"effect": "intron_variant",
"transcript": "ENST00000397821.8",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SH3KBP1",
"gene_hgnc_id": 13867,
"hgvs_c": "c.727-14178T>C",
"hgvs_p": null,
"transcript": "NM_031892.3",
"protein_id": "NP_114098.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 665,
"cds_start": -4,
"cds_end": null,
"cds_length": 1998,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4728,
"mane_select": "ENST00000397821.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SH3KBP1",
"gene_hgnc_id": 13867,
"hgvs_c": "c.727-14178T>C",
"hgvs_p": null,
"transcript": "ENST00000397821.8",
"protein_id": "ENSP00000380921.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 665,
"cds_start": -4,
"cds_end": null,
"cds_length": 1998,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4728,
"mane_select": "NM_031892.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": 5,
"intron_rank_end": null,
"gene_symbol": "SH3KBP1",
"gene_hgnc_id": 13867,
"hgvs_c": "c.616-14178T>C",
"hgvs_p": null,
"transcript": "ENST00000379698.8",
"protein_id": "ENSP00000369020.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 628,
"cds_start": -4,
"cds_end": null,
"cds_length": 1887,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2678,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "SH3KBP1",
"gene_hgnc_id": 13867,
"hgvs_c": "c.859-14178T>C",
"hgvs_p": null,
"transcript": "NM_001410756.1",
"protein_id": "NP_001397685.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 709,
"cds_start": -4,
"cds_end": null,
"cds_length": 2130,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4860,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "SH3KBP1",
"gene_hgnc_id": 13867,
"hgvs_c": "c.859-14178T>C",
"hgvs_p": null,
"transcript": "ENST00000379726.8",
"protein_id": "ENSP00000369049.4",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 709,
"cds_start": -4,
"cds_end": null,
"cds_length": 2130,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4682,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "SH3KBP1",
"gene_hgnc_id": 13867,
"hgvs_c": "c.802-14178T>C",
"hgvs_p": null,
"transcript": "NM_001353891.2",
"protein_id": "NP_001340820.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 690,
"cds_start": -4,
"cds_end": null,
"cds_length": 2073,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4803,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "SH3KBP1",
"gene_hgnc_id": 13867,
"hgvs_c": "c.802-14178T>C",
"hgvs_p": null,
"transcript": "ENST00000699668.1",
"protein_id": "ENSP00000514511.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 690,
"cds_start": -4,
"cds_end": null,
"cds_length": 2073,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4751,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "SH3KBP1",
"gene_hgnc_id": 13867,
"hgvs_c": "c.859-14178T>C",
"hgvs_p": null,
"transcript": "NM_001410757.1",
"protein_id": "NP_001397686.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 666,
"cds_start": -4,
"cds_end": null,
"cds_length": 2001,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4731,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "SH3KBP1",
"gene_hgnc_id": 13867,
"hgvs_c": "c.859-14178T>C",
"hgvs_p": null,
"transcript": "ENST00000699670.1",
"protein_id": "ENSP00000514513.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 666,
"cds_start": -4,
"cds_end": null,
"cds_length": 2001,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4555,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "SH3KBP1",
"gene_hgnc_id": 13867,
"hgvs_c": "c.802-14178T>C",
"hgvs_p": null,
"transcript": "ENST00000699679.1",
"protein_id": "ENSP00000514522.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 658,
"cds_start": -4,
"cds_end": null,
"cds_length": 1977,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3132,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "SH3KBP1",
"gene_hgnc_id": 13867,
"hgvs_c": "c.682-14178T>C",
"hgvs_p": null,
"transcript": "ENST00000699725.1",
"protein_id": "ENSP00000514547.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 650,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 18,
"intron_rank": 7,
"intron_rank_end": null,
"gene_symbol": "SH3KBP1",
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"hgvs_c": "c.802-14178T>C",
"hgvs_p": null,
"transcript": "NM_001353892.2",
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"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 7,
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"gene_symbol": "SH3KBP1",
"gene_hgnc_id": 13867,
"hgvs_c": "c.802-14178T>C",
"hgvs_p": null,
"transcript": "ENST00000699671.1",
"protein_id": "ENSP00000514514.1",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 18,
"intron_rank": 6,
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"gene_symbol": "SH3KBP1",
"gene_hgnc_id": 13867,
"hgvs_c": "c.625-14178T>C",
"hgvs_p": null,
"transcript": "NM_001353893.2",
"protein_id": "NP_001340822.1",
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},
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"strand": false,
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],
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"intron_rank": 6,
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"gene_symbol": "SH3KBP1",
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"hgvs_c": "c.625-14178T>C",
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"transcript": "ENST00000699726.1",
"protein_id": "ENSP00000514711.1",
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},
{
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"strand": false,
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],
"exon_rank": null,
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"intron_rank": 5,
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"gene_symbol": "SH3KBP1",
"gene_hgnc_id": 13867,
"hgvs_c": "c.616-14178T>C",
"hgvs_p": null,
"transcript": "NM_001024666.3",
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},
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],
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"gene_symbol": "SH3KBP1",
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"hgvs_c": "c.616-14178T>C",
"hgvs_p": null,
"transcript": "ENST00000699723.1",
"protein_id": "ENSP00000514545.1",
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},
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],
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"exon_count": 17,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SH3KBP1",
"gene_hgnc_id": 13867,
"hgvs_c": "c.727-14178T>C",
"hgvs_p": null,
"transcript": "NM_001353890.2",
"protein_id": "NP_001340819.1",
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"cds_start": -4,
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},
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"strand": false,
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],
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"intron_rank": 6,
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"gene_symbol": "SH3KBP1",
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"hgvs_c": "c.727-14178T>C",
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],
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"gene_symbol": "SH3KBP1",
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"transcript": "NM_001353895.2",
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},
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],
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},
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],
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"exon_count": 17,
"intron_rank": 6,
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"gene_symbol": "SH3KBP1",
"gene_hgnc_id": 13867,
"hgvs_c": "c.625-14178T>C",
"hgvs_p": null,
"transcript": "NM_001353894.2",
"protein_id": "NP_001340823.1",
"transcript_support_level": null,
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"mane_select": null,
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"feature": null
},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 17,
"intron_rank": 6,
"intron_rank_end": null,
"gene_symbol": "SH3KBP1",
"gene_hgnc_id": 13867,
"hgvs_c": "c.625-14178T>C",
"hgvs_p": null,
"transcript": "ENST00000699674.1",
"protein_id": "ENSP00000514517.1",
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}