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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: X-38073633-A-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=X&pos=38073633&ref=A&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "X",
"pos": 38073633,
"ref": "A",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "ENST00000297875.7",
"consequences": [
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL5",
"gene_hgnc_id": 15589,
"hgvs_c": "c.489A>T",
"hgvs_p": "p.Ala163Ala",
"transcript": "NM_138780.3",
"protein_id": "NP_620135.1",
"transcript_support_level": null,
"aa_start": 163,
"aa_end": null,
"aa_length": 730,
"cds_start": 489,
"cds_end": null,
"cds_length": 2193,
"cdna_start": 961,
"cdna_end": null,
"cdna_length": 4751,
"mane_select": "ENST00000297875.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL5",
"gene_hgnc_id": 15589,
"hgvs_c": "c.489A>T",
"hgvs_p": "p.Ala163Ala",
"transcript": "ENST00000297875.7",
"protein_id": "ENSP00000297875.2",
"transcript_support_level": 5,
"aa_start": 163,
"aa_end": null,
"aa_length": 730,
"cds_start": 489,
"cds_end": null,
"cds_length": 2193,
"cdna_start": 961,
"cdna_end": null,
"cdna_length": 4751,
"mane_select": "NM_138780.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL5",
"gene_hgnc_id": 15589,
"hgvs_c": "c.489A>T",
"hgvs_p": "p.Ala163Ala",
"transcript": "ENST00000456733.2",
"protein_id": "ENSP00000395220.2",
"transcript_support_level": 1,
"aa_start": 163,
"aa_end": null,
"aa_length": 752,
"cds_start": 489,
"cds_end": null,
"cds_length": 2259,
"cdna_start": 845,
"cdna_end": null,
"cdna_length": 4704,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "ENSG00000250349",
"gene_hgnc_id": null,
"hgvs_c": "c.172-592488A>T",
"hgvs_p": null,
"transcript": "ENST00000465127.1",
"protein_id": "ENSP00000417050.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 279,
"cds_start": -4,
"cds_end": null,
"cds_length": 840,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 954,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_premature_start_codon_gain_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL5",
"gene_hgnc_id": 15589,
"hgvs_c": "c.-364A>T",
"hgvs_p": null,
"transcript": "XM_047442671.1",
"protein_id": "XP_047298627.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 446,
"cds_start": -4,
"cds_end": null,
"cds_length": 1341,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4726,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL5",
"gene_hgnc_id": 15589,
"hgvs_c": "c.489A>T",
"hgvs_p": "p.Ala163Ala",
"transcript": "NM_001163334.1",
"protein_id": "NP_001156806.1",
"transcript_support_level": null,
"aa_start": 163,
"aa_end": null,
"aa_length": 752,
"cds_start": 489,
"cds_end": null,
"cds_length": 2259,
"cdna_start": 845,
"cdna_end": null,
"cdna_length": 4705,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL5",
"gene_hgnc_id": 15589,
"hgvs_c": "c.489A>T",
"hgvs_p": "p.Ala163Ala",
"transcript": "NM_001163335.2",
"protein_id": "NP_001156807.1",
"transcript_support_level": null,
"aa_start": 163,
"aa_end": null,
"aa_length": 730,
"cds_start": 489,
"cds_end": null,
"cds_length": 2193,
"cdna_start": 1052,
"cdna_end": null,
"cdna_length": 4842,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL5",
"gene_hgnc_id": 15589,
"hgvs_c": "c.489A>T",
"hgvs_p": "p.Ala163Ala",
"transcript": "XM_011544001.3",
"protein_id": "XP_011542303.1",
"transcript_support_level": null,
"aa_start": 163,
"aa_end": null,
"aa_length": 752,
"cds_start": 489,
"cds_end": null,
"cds_length": 2259,
"cdna_start": 1222,
"cdna_end": null,
"cdna_length": 5082,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL5",
"gene_hgnc_id": 15589,
"hgvs_c": "c.489A>T",
"hgvs_p": "p.Ala163Ala",
"transcript": "XM_011544002.3",
"protein_id": "XP_011542304.1",
"transcript_support_level": null,
"aa_start": 163,
"aa_end": null,
"aa_length": 752,
"cds_start": 489,
"cds_end": null,
"cds_length": 2259,
"cdna_start": 975,
"cdna_end": null,
"cdna_length": 4835,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL5",
"gene_hgnc_id": 15589,
"hgvs_c": "c.489A>T",
"hgvs_p": "p.Ala163Ala",
"transcript": "XM_017029972.1",
"protein_id": "XP_016885461.1",
"transcript_support_level": null,
"aa_start": 163,
"aa_end": null,
"aa_length": 752,
"cds_start": 489,
"cds_end": null,
"cds_length": 2259,
"cdna_start": 1450,
"cdna_end": null,
"cdna_length": 5310,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL5",
"gene_hgnc_id": 15589,
"hgvs_c": "c.489A>T",
"hgvs_p": "p.Ala163Ala",
"transcript": "XM_017029973.2",
"protein_id": "XP_016885462.1",
"transcript_support_level": null,
"aa_start": 163,
"aa_end": null,
"aa_length": 752,
"cds_start": 489,
"cds_end": null,
"cds_length": 2259,
"cdna_start": 1195,
"cdna_end": null,
"cdna_length": 5055,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL5",
"gene_hgnc_id": 15589,
"hgvs_c": "c.489A>T",
"hgvs_p": "p.Ala163Ala",
"transcript": "XM_017029974.2",
"protein_id": "XP_016885463.1",
"transcript_support_level": null,
"aa_start": 163,
"aa_end": null,
"aa_length": 752,
"cds_start": 489,
"cds_end": null,
"cds_length": 2259,
"cdna_start": 1083,
"cdna_end": null,
"cdna_length": 4943,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL5",
"gene_hgnc_id": 15589,
"hgvs_c": "c.489A>T",
"hgvs_p": "p.Ala163Ala",
"transcript": "XM_047442652.1",
"protein_id": "XP_047298608.1",
"transcript_support_level": null,
"aa_start": 163,
"aa_end": null,
"aa_length": 752,
"cds_start": 489,
"cds_end": null,
"cds_length": 2259,
"cdna_start": 1114,
"cdna_end": null,
"cdna_length": 4974,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL5",
"gene_hgnc_id": 15589,
"hgvs_c": "c.486A>T",
"hgvs_p": "p.Ala162Ala",
"transcript": "XM_047442653.1",
"protein_id": "XP_047298609.1",
"transcript_support_level": null,
"aa_start": 162,
"aa_end": null,
"aa_length": 751,
"cds_start": 486,
"cds_end": null,
"cds_length": 2256,
"cdna_start": 972,
"cdna_end": null,
"cdna_length": 4832,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL5",
"gene_hgnc_id": 15589,
"hgvs_c": "c.489A>T",
"hgvs_p": "p.Ala163Ala",
"transcript": "XM_047442654.1",
"protein_id": "XP_047298610.1",
"transcript_support_level": null,
"aa_start": 163,
"aa_end": null,
"aa_length": 730,
"cds_start": 489,
"cds_end": null,
"cds_length": 2193,
"cdna_start": 1222,
"cdna_end": null,
"cdna_length": 5016,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL5",
"gene_hgnc_id": 15589,
"hgvs_c": "c.489A>T",
"hgvs_p": "p.Ala163Ala",
"transcript": "XM_047442655.1",
"protein_id": "XP_047298611.1",
"transcript_support_level": null,
"aa_start": 163,
"aa_end": null,
"aa_length": 730,
"cds_start": 489,
"cds_end": null,
"cds_length": 2193,
"cdna_start": 1083,
"cdna_end": null,
"cdna_length": 4877,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL5",
"gene_hgnc_id": 15589,
"hgvs_c": "c.489A>T",
"hgvs_p": "p.Ala163Ala",
"transcript": "XM_047442656.1",
"protein_id": "XP_047298612.1",
"transcript_support_level": null,
"aa_start": 163,
"aa_end": null,
"aa_length": 730,
"cds_start": 489,
"cds_end": null,
"cds_length": 2193,
"cdna_start": 975,
"cdna_end": null,
"cdna_length": 4769,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL5",
"gene_hgnc_id": 15589,
"hgvs_c": "c.489A>T",
"hgvs_p": "p.Ala163Ala",
"transcript": "XM_047442657.1",
"protein_id": "XP_047298613.1",
"transcript_support_level": null,
"aa_start": 163,
"aa_end": null,
"aa_length": 730,
"cds_start": 489,
"cds_end": null,
"cds_length": 2193,
"cdna_start": 1114,
"cdna_end": null,
"cdna_length": 4908,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL5",
"gene_hgnc_id": 15589,
"hgvs_c": "c.489A>T",
"hgvs_p": "p.Ala163Ala",
"transcript": "XM_047442658.1",
"protein_id": "XP_047298614.1",
"transcript_support_level": null,
"aa_start": 163,
"aa_end": null,
"aa_length": 730,
"cds_start": 489,
"cds_end": null,
"cds_length": 2193,
"cdna_start": 1552,
"cdna_end": null,
"cdna_length": 5346,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL5",
"gene_hgnc_id": 15589,
"hgvs_c": "c.489A>T",
"hgvs_p": "p.Ala163Ala",
"transcript": "XM_047442659.1",
"protein_id": "XP_047298615.1",
"transcript_support_level": null,
"aa_start": 163,
"aa_end": null,
"aa_length": 730,
"cds_start": 489,
"cds_end": null,
"cds_length": 2193,
"cdna_start": 1195,
"cdna_end": null,
"cdna_length": 4989,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL5",
"gene_hgnc_id": 15589,
"hgvs_c": "c.486A>T",
"hgvs_p": "p.Ala162Ala",
"transcript": "XM_047442660.1",
"protein_id": "XP_047298616.1",
"transcript_support_level": null,
"aa_start": 162,
"aa_end": null,
"aa_length": 729,
"cds_start": 486,
"cds_end": null,
"cds_length": 2190,
"cdna_start": 1080,
"cdna_end": null,
"cdna_length": 4874,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL5",
"gene_hgnc_id": 15589,
"hgvs_c": "c.486A>T",
"hgvs_p": "p.Ala162Ala",
"transcript": "XM_047442661.1",
"protein_id": "XP_047298617.1",
"transcript_support_level": null,
"aa_start": 162,
"aa_end": null,
"aa_length": 729,
"cds_start": 486,
"cds_end": null,
"cds_length": 2190,
"cdna_start": 958,
"cdna_end": null,
"cdna_length": 4752,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SYTL5",
"gene_hgnc_id": 15589,
"hgvs_c": "c.486A>T",
"hgvs_p": "p.Ala162Ala",
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{
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}
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}