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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: X-47448021-GTC-ATT (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=X&pos=47448021&ref=GTC&alt=ATT&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 0,
          "criteria": [],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "ZNF41",
          "hgnc_id": 13107,
          "hgvs_c": "c.1873_1875delGACinsAAT",
          "hgvs_p": "p.Asp625Asn",
          "inheritance_mode": "XL",
          "pathogenic_score": 0,
          "score": 0,
          "transcript": "NM_001324155.1",
          "verdict": "Uncertain_significance"
        }
      ],
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "",
      "acmg_score": 0,
      "allele_count_reference_population": 0,
      "alphamissense_prediction": null,
      "alphamissense_score": null,
      "alt": "ATT",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": null,
      "bayesdelnoaf_score": null,
      "chr": "X",
      "clinvar_classification": "",
      "clinvar_disease": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "computational_prediction_selected": null,
      "computational_score_selected": null,
      "computational_source_selected": null,
      "consequences": [
        {
          "aa_alt": "N",
          "aa_end": null,
          "aa_length": 779,
          "aa_ref": "D",
          "aa_start": 583,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4999,
          "cdna_start": 2156,
          "cds_end": null,
          "cds_length": 2340,
          "cds_start": 1747,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001324144.2",
          "gene_hgnc_id": 13107,
          "gene_symbol": "ZNF41",
          "hgvs_c": "c.1747_1749delGACinsAAT",
          "hgvs_p": "p.Asp583Asn",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000684689.1",
          "protein_coding": true,
          "protein_id": "NP_001311073.1",
          "strand": false,
          "transcript": "NM_001324144.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "N",
          "aa_end": null,
          "aa_length": 779,
          "aa_ref": "D",
          "aa_start": 583,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 4999,
          "cdna_start": 2156,
          "cds_end": null,
          "cds_length": 2340,
          "cds_start": 1747,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000684689.1",
          "gene_hgnc_id": 13107,
          "gene_symbol": "ZNF41",
          "hgvs_c": "c.1747_1749delGACinsAAT",
          "hgvs_p": "p.Asp583Asn",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_001324144.2",
          "protein_coding": true,
          "protein_id": "ENSP00000508254.1",
          "strand": false,
          "transcript": "ENST00000684689.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "N",
          "aa_end": null,
          "aa_length": 779,
          "aa_ref": "D",
          "aa_start": 583,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4297,
          "cdna_start": 2155,
          "cds_end": null,
          "cds_length": 2340,
          "cds_start": 1747,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000313116.11",
          "gene_hgnc_id": 13107,
          "gene_symbol": "ZNF41",
          "hgvs_c": "c.1747_1749delGACinsAAT",
          "hgvs_p": "p.Asp583Asn",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000315173.7",
          "strand": false,
          "transcript": "ENST00000313116.11",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "N",
          "aa_end": null,
          "aa_length": 779,
          "aa_ref": "D",
          "aa_start": 583,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4531,
          "cdna_start": 2389,
          "cds_end": null,
          "cds_length": 2340,
          "cds_start": 1747,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000377065.8",
          "gene_hgnc_id": 13107,
          "gene_symbol": "ZNF41",
          "hgvs_c": "c.1747_1749delGACinsAAT",
          "hgvs_p": "p.Asp583Asn",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000366265.4",
          "strand": false,
          "transcript": "ENST00000377065.8",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "N",
          "aa_end": null,
          "aa_length": 821,
          "aa_ref": "D",
          "aa_start": 625,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4907,
          "cdna_start": 2064,
          "cds_end": null,
          "cds_length": 2466,
          "cds_start": 1873,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 4,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001324155.1",
          "gene_hgnc_id": 13107,
          "gene_symbol": "ZNF41",
          "hgvs_c": "c.1873_1875delGACinsAAT",
          "hgvs_p": "p.Asp625Asn",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001311084.1",
          "strand": false,
          "transcript": "NM_001324155.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "N",
          "aa_end": null,
          "aa_length": 821,
          "aa_ref": "D",
          "aa_start": 625,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3940,
          "cdna_start": 2616,
          "cds_end": null,
          "cds_length": 2466,
          "cds_start": 1873,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000915706.1",
          "gene_hgnc_id": 13107,
          "gene_symbol": "ZNF41",
          "hgvs_c": "c.1873_1875delGACinsAAT",
          "hgvs_p": "p.Asp625Asn",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000585765.1",
          "strand": false,
          "transcript": "ENST00000915706.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "N",
          "aa_end": null,
          "aa_length": 821,
          "aa_ref": "D",
          "aa_start": 625,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5401,
          "cdna_start": 2271,
          "cds_end": null,
          "cds_length": 2466,
          "cds_start": 1873,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000968634.1",
          "gene_hgnc_id": 13107,
          "gene_symbol": "ZNF41",
          "hgvs_c": "c.1873_1875delGACinsAAT",
          "hgvs_p": "p.Asp625Asn",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000638693.1",
          "strand": false,
          "transcript": "ENST00000968634.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "N",
          "aa_end": null,
          "aa_length": 813,
          "aa_ref": "D",
          "aa_start": 617,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4883,
          "cdna_start": 2040,
          "cds_end": null,
          "cds_length": 2442,
          "cds_start": 1849,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 4,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001324154.1",
          "gene_hgnc_id": 13107,
          "gene_symbol": "ZNF41",
          "hgvs_c": "c.1849_1851delGACinsAAT",
          "hgvs_p": "p.Asp617Asn",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001311083.1",
          "strand": false,
          "transcript": "NM_001324154.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "N",
          "aa_end": null,
          "aa_length": 813,
          "aa_ref": "D",
          "aa_start": 617,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3652,
          "cdna_start": 2328,
          "cds_end": null,
          "cds_length": 2442,
          "cds_start": 1849,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 6,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000915708.1",
          "gene_hgnc_id": 13107,
          "gene_symbol": "ZNF41",
          "hgvs_c": "c.1849_1851delGACinsAAT",
          "hgvs_p": "p.Asp617Asn",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000585767.1",
          "strand": false,
          "transcript": "ENST00000915708.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "N",
          "aa_end": null,
          "aa_length": 813,
          "aa_ref": "D",
          "aa_start": 617,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5456,
          "cdna_start": 2217,
          "cds_end": null,
          "cds_length": 2442,
          "cds_start": 1849,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000968632.1",
          "gene_hgnc_id": 13107,
          "gene_symbol": "ZNF41",
          "hgvs_c": "c.1849_1851delGACinsAAT",
          "hgvs_p": "p.Asp617Asn",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000638691.1",
          "strand": false,
          "transcript": "ENST00000968632.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "N",
          "aa_end": null,
          "aa_length": 813,
          "aa_ref": "D",
          "aa_start": 617,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3912,
          "cdna_start": 2592,
          "cds_end": null,
          "cds_length": 2442,
          "cds_start": 1849,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000968640.1",
          "gene_hgnc_id": 13107,
          "gene_symbol": "ZNF41",
          "hgvs_c": "c.1849_1851delGACinsAAT",
          "hgvs_p": "p.Asp617Asn",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000638699.1",
          "strand": false,
          "transcript": "ENST00000968640.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "N",
          "aa_end": null,
          "aa_length": 789,
          "aa_ref": "D",
          "aa_start": 593,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5039,
          "cdna_start": 2196,
          "cds_end": null,
          "cds_length": 2370,
          "cds_start": 1777,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001324151.2",
          "gene_hgnc_id": 13107,
          "gene_symbol": "ZNF41",
          "hgvs_c": "c.1777_1779delGACinsAAT",
          "hgvs_p": "p.Asp593Asn",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001311080.1",
          "strand": false,
          "transcript": "NM_001324151.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "N",
          "aa_end": null,
          "aa_length": 789,
          "aa_ref": "D",
          "aa_start": 593,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4949,
          "cdna_start": 2106,
          "cds_end": null,
          "cds_length": 2370,
          "cds_start": 1777,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001324153.2",
          "gene_hgnc_id": 13107,
          "gene_symbol": "ZNF41",
          "hgvs_c": "c.1777_1779delGACinsAAT",
          "hgvs_p": "p.Asp593Asn",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001311082.1",
          "strand": false,
          "transcript": "NM_001324153.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "N",
          "aa_end": null,
          "aa_length": 781,
          "aa_ref": "D",
          "aa_start": 585,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4925,
          "cdna_start": 2082,
          "cds_end": null,
          "cds_length": 2346,
          "cds_start": 1753,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001324142.2",
          "gene_hgnc_id": 13107,
          "gene_symbol": "ZNF41",
          "hgvs_c": "c.1753_1755delGACinsAAT",
          "hgvs_p": "p.Asp585Asn",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001311071.1",
          "strand": false,
          "transcript": "NM_001324142.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "N",
          "aa_end": null,
          "aa_length": 781,
          "aa_ref": "D",
          "aa_start": 585,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5015,
          "cdna_start": 2172,
          "cds_end": null,
          "cds_length": 2346,
          "cds_start": 1753,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001324148.2",
          "gene_hgnc_id": 13107,
          "gene_symbol": "ZNF41",
          "hgvs_c": "c.1753_1755delGACinsAAT",
          "hgvs_p": "p.Asp585Asn",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001311077.1",
          "strand": false,
          "transcript": "NM_001324148.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "N",
          "aa_end": null,
          "aa_length": 779,
          "aa_ref": "D",
          "aa_start": 583,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4909,
          "cdna_start": 2066,
          "cds_end": null,
          "cds_length": 2340,
          "cds_start": 1747,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001324140.2",
          "gene_hgnc_id": 13107,
          "gene_symbol": "ZNF41",
          "hgvs_c": "c.1747_1749delGACinsAAT",
          "hgvs_p": "p.Asp583Asn",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001311069.1",
          "strand": false,
          "transcript": "NM_001324140.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "N",
          "aa_end": null,
          "aa_length": 779,
          "aa_ref": "D",
          "aa_start": 583,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4970,
          "cdna_start": 2127,
          "cds_end": null,
          "cds_length": 2340,
          "cds_start": 1747,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001324147.2",
          "gene_hgnc_id": 13107,
          "gene_symbol": "ZNF41",
          "hgvs_c": "c.1747_1749delGACinsAAT",
          "hgvs_p": "p.Asp583Asn",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001311076.1",
          "strand": false,
          "transcript": "NM_001324147.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "N",
          "aa_end": null,
          "aa_length": 779,
          "aa_ref": "D",
          "aa_start": 583,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5097,
          "cdna_start": 2254,
          "cds_end": null,
          "cds_length": 2340,
          "cds_start": 1747,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 6,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001324150.2",
          "gene_hgnc_id": 13107,
          "gene_symbol": "ZNF41",
          "hgvs_c": "c.1747_1749delGACinsAAT",
          "hgvs_p": "p.Asp583Asn",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001311079.1",
          "strand": false,
          "transcript": "NM_001324150.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "N",
          "aa_end": null,
          "aa_length": 779,
          "aa_ref": "D",
          "aa_start": 583,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5017,
          "cdna_start": 2174,
          "cds_end": null,
          "cds_length": 2340,
          "cds_start": 1747,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_007130.4",
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.