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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: X-47567066-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=X&pos=47567066&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "X",
"pos": 47567066,
"ref": "C",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_001256196.2",
"consequences": [
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAF",
"gene_hgnc_id": 646,
"hgvs_c": "c.808C>T",
"hgvs_p": "p.Pro270Ser",
"transcript": "NM_001654.5",
"protein_id": "NP_001645.1",
"transcript_support_level": null,
"aa_start": 270,
"aa_end": null,
"aa_length": 606,
"cds_start": 808,
"cds_end": null,
"cds_length": 1821,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000377045.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001654.5"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAF",
"gene_hgnc_id": 646,
"hgvs_c": "c.808C>T",
"hgvs_p": "p.Pro270Ser",
"transcript": "ENST00000377045.9",
"protein_id": "ENSP00000366244.4",
"transcript_support_level": 1,
"aa_start": 270,
"aa_end": null,
"aa_length": 606,
"cds_start": 808,
"cds_end": null,
"cds_length": 1821,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001654.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000377045.9"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAF",
"gene_hgnc_id": 646,
"hgvs_c": "c.808C>T",
"hgvs_p": "p.Pro270Ser",
"transcript": "ENST00000895646.1",
"protein_id": "ENSP00000565705.1",
"transcript_support_level": null,
"aa_start": 270,
"aa_end": null,
"aa_length": 621,
"cds_start": 808,
"cds_end": null,
"cds_length": 1866,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895646.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAF",
"gene_hgnc_id": 646,
"hgvs_c": "c.841C>T",
"hgvs_p": "p.Pro281Ser",
"transcript": "ENST00000895654.1",
"protein_id": "ENSP00000565713.1",
"transcript_support_level": null,
"aa_start": 281,
"aa_end": null,
"aa_length": 617,
"cds_start": 841,
"cds_end": null,
"cds_length": 1854,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895654.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAF",
"gene_hgnc_id": 646,
"hgvs_c": "c.808C>T",
"hgvs_p": "p.Pro270Ser",
"transcript": "ENST00000895644.1",
"protein_id": "ENSP00000565703.1",
"transcript_support_level": null,
"aa_start": 270,
"aa_end": null,
"aa_length": 616,
"cds_start": 808,
"cds_end": null,
"cds_length": 1851,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895644.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAF",
"gene_hgnc_id": 646,
"hgvs_c": "c.838C>T",
"hgvs_p": "p.Pro280Ser",
"transcript": "ENST00000895655.1",
"protein_id": "ENSP00000565714.1",
"transcript_support_level": null,
"aa_start": 280,
"aa_end": null,
"aa_length": 616,
"cds_start": 838,
"cds_end": null,
"cds_length": 1851,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895655.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAF",
"gene_hgnc_id": 646,
"hgvs_c": "c.826C>T",
"hgvs_p": "p.Pro276Ser",
"transcript": "ENST00000895648.1",
"protein_id": "ENSP00000565707.1",
"transcript_support_level": null,
"aa_start": 276,
"aa_end": null,
"aa_length": 612,
"cds_start": 826,
"cds_end": null,
"cds_length": 1839,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895648.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAF",
"gene_hgnc_id": 646,
"hgvs_c": "c.823C>T",
"hgvs_p": "p.Pro275Ser",
"transcript": "ENST00000895640.1",
"protein_id": "ENSP00000565699.1",
"transcript_support_level": null,
"aa_start": 275,
"aa_end": null,
"aa_length": 611,
"cds_start": 823,
"cds_end": null,
"cds_length": 1836,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895640.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAF",
"gene_hgnc_id": 646,
"hgvs_c": "c.823C>T",
"hgvs_p": "p.Pro275Ser",
"transcript": "ENST00000895653.1",
"protein_id": "ENSP00000565712.1",
"transcript_support_level": null,
"aa_start": 275,
"aa_end": null,
"aa_length": 611,
"cds_start": 823,
"cds_end": null,
"cds_length": 1836,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895653.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAF",
"gene_hgnc_id": 646,
"hgvs_c": "c.823C>T",
"hgvs_p": "p.Pro275Ser",
"transcript": "ENST00000914657.1",
"protein_id": "ENSP00000584716.1",
"transcript_support_level": null,
"aa_start": 275,
"aa_end": null,
"aa_length": 611,
"cds_start": 823,
"cds_end": null,
"cds_length": 1836,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000914657.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAF",
"gene_hgnc_id": 646,
"hgvs_c": "c.823C>T",
"hgvs_p": "p.Pro275Ser",
"transcript": "ENST00000914659.1",
"protein_id": "ENSP00000584718.1",
"transcript_support_level": null,
"aa_start": 275,
"aa_end": null,
"aa_length": 611,
"cds_start": 823,
"cds_end": null,
"cds_length": 1836,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000914659.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAF",
"gene_hgnc_id": 646,
"hgvs_c": "c.817C>T",
"hgvs_p": "p.Pro273Ser",
"transcript": "NM_001256196.2",
"protein_id": "NP_001243125.1",
"transcript_support_level": null,
"aa_start": 273,
"aa_end": null,
"aa_length": 609,
"cds_start": 817,
"cds_end": null,
"cds_length": 1830,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001256196.2"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAF",
"gene_hgnc_id": 646,
"hgvs_c": "c.817C>T",
"hgvs_p": "p.Pro273Ser",
"transcript": "ENST00000895639.1",
"protein_id": "ENSP00000565698.1",
"transcript_support_level": null,
"aa_start": 273,
"aa_end": null,
"aa_length": 609,
"cds_start": 817,
"cds_end": null,
"cds_length": 1830,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895639.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAF",
"gene_hgnc_id": 646,
"hgvs_c": "c.808C>T",
"hgvs_p": "p.Pro270Ser",
"transcript": "ENST00000895638.1",
"protein_id": "ENSP00000565697.1",
"transcript_support_level": null,
"aa_start": 270,
"aa_end": null,
"aa_length": 606,
"cds_start": 808,
"cds_end": null,
"cds_length": 1821,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895638.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAF",
"gene_hgnc_id": 646,
"hgvs_c": "c.808C>T",
"hgvs_p": "p.Pro270Ser",
"transcript": "ENST00000895642.1",
"protein_id": "ENSP00000565701.1",
"transcript_support_level": null,
"aa_start": 270,
"aa_end": null,
"aa_length": 606,
"cds_start": 808,
"cds_end": null,
"cds_length": 1821,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895642.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAF",
"gene_hgnc_id": 646,
"hgvs_c": "c.808C>T",
"hgvs_p": "p.Pro270Ser",
"transcript": "ENST00000895650.1",
"protein_id": "ENSP00000565709.1",
"transcript_support_level": null,
"aa_start": 270,
"aa_end": null,
"aa_length": 606,
"cds_start": 808,
"cds_end": null,
"cds_length": 1821,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895650.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAF",
"gene_hgnc_id": 646,
"hgvs_c": "c.808C>T",
"hgvs_p": "p.Pro270Ser",
"transcript": "ENST00000895651.1",
"protein_id": "ENSP00000565710.1",
"transcript_support_level": null,
"aa_start": 270,
"aa_end": null,
"aa_length": 606,
"cds_start": 808,
"cds_end": null,
"cds_length": 1821,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895651.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAF",
"gene_hgnc_id": 646,
"hgvs_c": "c.808C>T",
"hgvs_p": "p.Pro270Ser",
"transcript": "ENST00000895656.1",
"protein_id": "ENSP00000565715.1",
"transcript_support_level": null,
"aa_start": 270,
"aa_end": null,
"aa_length": 606,
"cds_start": 808,
"cds_end": null,
"cds_length": 1821,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895656.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAF",
"gene_hgnc_id": 646,
"hgvs_c": "c.808C>T",
"hgvs_p": "p.Pro270Ser",
"transcript": "ENST00000914658.1",
"protein_id": "ENSP00000584717.1",
"transcript_support_level": null,
"aa_start": 270,
"aa_end": null,
"aa_length": 606,
"cds_start": 808,
"cds_end": null,
"cds_length": 1821,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000914658.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAF",
"gene_hgnc_id": 646,
"hgvs_c": "c.808C>T",
"hgvs_p": "p.Pro270Ser",
"transcript": "ENST00000895641.1",
"protein_id": "ENSP00000565700.1",
"transcript_support_level": null,
"aa_start": 270,
"aa_end": null,
"aa_length": 605,
"cds_start": 808,
"cds_end": null,
"cds_length": 1818,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895641.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAF",
"gene_hgnc_id": 646,
"hgvs_c": "c.805C>T",
"hgvs_p": "p.Pro269Ser",
"transcript": "ENST00000895647.1",
"protein_id": "ENSP00000565706.1",
"transcript_support_level": null,
"aa_start": 269,
"aa_end": null,
"aa_length": 605,
"cds_start": 805,
"cds_end": null,
"cds_length": 1818,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000895647.1"
},
{
"aa_ref": "P",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ARAF",
"gene_hgnc_id": 646,
"hgvs_c": "c.808C>T",
"hgvs_p": "p.Pro270Ser",
"transcript": "ENST00000914656.1",
"protein_id": "ENSP00000584715.1",
"transcript_support_level": null,
"aa_start": 270,
"aa_end": null,
"aa_length": 605,
"cds_start": 808,
"cds_end": null,
"cds_length": 1818,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000914656.1"
},
{
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}
],
"message": null
}